BR0310032A - Derivados de benzoxazina como moduladores de 5-ht6 e usos dos mesmos - Google Patents

Derivados de benzoxazina como moduladores de 5-ht6 e usos dos mesmos

Info

Publication number
BR0310032A
BR0310032A BR0310032-4A BR0310032A BR0310032A BR 0310032 A BR0310032 A BR 0310032A BR 0310032 A BR0310032 A BR 0310032A BR 0310032 A BR0310032 A BR 0310032A
Authority
BR
Brazil
Prior art keywords
modulators
benzoxazine derivatives
compound
formula
methods
Prior art date
Application number
BR0310032-4A
Other languages
English (en)
Other versions
BRPI0310032B8 (pt
BRPI0310032B1 (pt
Inventor
Jacob Berger
Robin Douglas Clark
Shu-Hai Zhao
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0310032A publication Critical patent/BR0310032A/pt
Publication of BRPI0310032B1 publication Critical patent/BRPI0310032B1/pt
Publication of BRPI0310032B8 publication Critical patent/BRPI0310032B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

"DERIVADOS DE BENZOXAZINA COMO MODULADORES DE 5-HT6 E USOS DOS MESMOS". A presente invenção refere-se a um composto que tem uma afinidade de receptor 5-HT~ 6~ da fórmula (I); um sal farmaceuticamente aceitável ou uma pró-droga do mesmo, sendo que R^ 1^, R^ 2^, R^ 3^, R^ 4^, R^ 5^, R^ 6^, R^ 7^, R^ 8^, R^ 9^, Y, Z^ 1^, m, n e p são tal como definidos no presente. A presente invenção também refere-se a composições que compreendem o Composto da Fórmula (I), métodos que usam o mesmo e métodos para preparar o mesmo.
BRPI0310032A 2002-05-13 2003-05-05 derivados de benzoxazina, seus usos e seus processos de produção, e composição farmacêutica BRPI0310032B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37800302P 2002-05-13 2002-05-13
PCT/EP2003/004671 WO2003095434A1 (en) 2002-05-13 2003-05-05 Benzoxazine derivatives as 5-ht6 modulators and uses thereof

Publications (3)

Publication Number Publication Date
BR0310032A true BR0310032A (pt) 2005-02-15
BRPI0310032B1 BRPI0310032B1 (pt) 2019-01-08
BRPI0310032B8 BRPI0310032B8 (pt) 2021-05-25

Family

ID=29420358

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0310032A BRPI0310032B8 (pt) 2002-05-13 2003-05-05 derivados de benzoxazina, seus usos e seus processos de produção, e composição farmacêutica

Country Status (37)

Country Link
US (4) US6867204B2 (pt)
EP (1) EP1506179B1 (pt)
JP (1) JP4307377B2 (pt)
KR (1) KR100636475B1 (pt)
CN (1) CN100429206C (pt)
AR (1) AR039988A1 (pt)
AT (1) ATE316523T1 (pt)
AU (1) AU2003233231B2 (pt)
BR (1) BRPI0310032B8 (pt)
CA (1) CA2485136C (pt)
DE (1) DE60303376T2 (pt)
DK (1) DK1506179T3 (pt)
EA (1) EA009982B1 (pt)
EC (1) ECSP045420A (pt)
EG (1) EG25683A (pt)
ES (1) ES2256744T3 (pt)
GT (1) GT200300108A (pt)
HK (1) HK1080846A1 (pt)
HR (1) HRP20041030B1 (pt)
IL (1) IL164928A0 (pt)
JO (1) JO2413B1 (pt)
MA (1) MA27118A1 (pt)
MX (1) MXPA04011254A (pt)
MY (1) MY139612A (pt)
NO (1) NO329380B1 (pt)
NZ (1) NZ536230A (pt)
PA (1) PA8573501A1 (pt)
PE (1) PE20040757A1 (pt)
PL (1) PL211057B1 (pt)
PT (1) PT1506179E (pt)
RS (1) RS51042B (pt)
TN (1) TNSN04225A1 (pt)
TW (1) TWI258479B (pt)
UA (1) UA76877C2 (pt)
UY (1) UY27803A1 (pt)
WO (1) WO2003095434A1 (pt)
ZA (1) ZA200408783B (pt)

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CA2485136C (en) * 2002-05-13 2011-12-20 F. Hoffmann-La Roche Ag Benzoxazine derivatives as 5-ht6 modulators and uses thereof
DE60318733T2 (de) * 2002-11-08 2009-01-15 F. Hoffmann-La Roche Ag Substituierte benzoxazinones und ihre verwendung
BRPI0412263B1 (pt) 2003-07-22 2019-10-15 Arena Pharmaceuticals, Inc. Derivados de diaril e aril heteroaril uréia, uso e composição farmacêutica contendo os mesmos, bem como processo para preparação da dita composição
ATE371653T1 (de) * 2003-12-09 2007-09-15 Hoffmann La Roche Benzoxazinderivate und deren verwendungen
CN1909909B (zh) * 2004-01-16 2010-12-15 弗·哈夫曼-拉罗切有限公司 作为5-羟色胺受体(5-ht)调节剂用于治疗中枢神经***疾病的1-苄基-5-哌嗪-1-基-3，4二氢-1h-喹唑啉-2-酮衍生物和各个1h-苯并(1，2，6)噻二嗪-2，2-二氧化物和1，4-二氢-苯并(d)(1，3)*嗪-2-酮衍生物
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AR078770A1 (es) * 2009-10-27 2011-11-30 Elara Pharmaceuticals Gmbh Derivados de dihidrobenzo oxacinas y tiazinas, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades inflamatorias e hiperproliferativas.
KR101293384B1 (ko) * 2010-10-13 2013-08-05 주식회사 대웅제약 신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도
US9403800B2 (en) * 2012-01-24 2016-08-02 Chemregen, Inc. Compounds for inhibition of cancer cell proliferation
JP6510539B2 (ja) * 2014-01-09 2019-05-08 ザ ジェイ． デヴィッド グラッドストーン インスティテューツ， ア テスタメンタリー トラスト エスタブリッシュド アンダー ザ ウィル オブ ジェイ． デヴィッド グラッドストーン 置換ベンゾオキサジン及び関連化合物
RU2017145976A (ru) 2015-06-12 2019-07-15 Аксовант Сайенсиз Гмбх Производные диарил- и арилгетероарилмочевины, применимые для профилактики и лечения нарушения поведения во время REM-фазы сна
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Also Published As

Publication number Publication date
NZ536230A (en) 2007-05-31
HRP20041030A2 (en) 2005-06-30
IL164928A0 (en) 2005-12-18
DE60303376D1 (de) 2006-04-13
HK1080846A1 (en) 2006-05-04
MXPA04011254A (es) 2005-01-25
BRPI0310032B8 (pt) 2021-05-25
US20090325950A1 (en) 2009-12-31
EP1506179A1 (en) 2005-02-16
MY139612A (en) 2009-10-30
NO20044665L (no) 2004-12-03
RS97004A (en) 2006-10-27
ZA200408783B (en) 2005-12-28
TWI258479B (en) 2006-07-21
ATE316523T1 (de) 2006-02-15
PE20040757A1 (es) 2004-11-06
KR100636475B1 (ko) 2006-10-18
GT200300108A (es) 2004-03-15
AR039988A1 (es) 2005-03-09
ES2256744T3 (es) 2006-07-16
US20050130962A1 (en) 2005-06-16
TNSN04225A1 (fr) 2007-03-12
EG25683A (en) 2012-05-16
MA27118A1 (fr) 2004-12-20
CN1653054A (zh) 2005-08-10
DE60303376T2 (de) 2006-11-16
CA2485136C (en) 2011-12-20
US20130123251A1 (en) 2013-05-16
NO329380B1 (no) 2010-10-04
US20030232825A1 (en) 2003-12-18
RS51042B (sr) 2010-10-31
BRPI0310032B1 (pt) 2019-01-08
AU2003233231A1 (en) 2003-11-11
CN100429206C (zh) 2008-10-29
HRP20041030B1 (hr) 2013-03-31
DK1506179T3 (da) 2006-06-06
EP1506179B1 (en) 2006-01-25
UY27803A1 (es) 2003-11-28
ECSP045420A (es) 2005-01-03
TW200400188A (en) 2004-01-01
PL211057B1 (pl) 2012-04-30
UA76877C2 (uk) 2006-09-15
JO2413B1 (en) 2007-11-11
AU2003233231B2 (en) 2009-02-26
US8377931B2 (en) 2013-02-19
WO2003095434A1 (en) 2003-11-20
JP2005530774A (ja) 2005-10-13
PL374019A1 (en) 2005-09-19
JP4307377B2 (ja) 2009-08-05
PA8573501A1 (es) 2003-12-10
KR20040106538A (ko) 2004-12-17
CA2485136A1 (en) 2003-11-20
EA009982B1 (ru) 2008-04-28
US6867204B2 (en) 2005-03-15
PT1506179E (pt) 2006-06-30
EA200401455A1 (ru) 2005-06-30

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
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