NO329380B1 - Benzoksazin-derivater, fremgangsmate for fremstilling av slike, farmasoytiske preparater omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling eller forebygging av sykdom - Google Patents

Benzoksazin-derivater, fremgangsmate for fremstilling av slike, farmasoytiske preparater omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling eller forebygging av sykdom Download PDF

Info

Publication number: NO329380B1
Authority: NO; Norway
Prior art keywords: dihydro; benzo; compound according; oxazine; piperazin
Prior art date: 2002-05-13

Application number

NO20044665A

Other languages

English (en)

Norwegian (no)

Other versions

NO20044665L (no

Inventor

Jacob Berger

Robin Douglas Clark

Shu Hai Zhao

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-13

Filing date

2004-10-28

Publication date

2010-10-04

2004-10-28 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-12-03 Publication of NO20044665L publication Critical patent/NO20044665L/no

2010-10-04 Publication of NO329380B1 publication Critical patent/NO329380B1/no

Links

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230000000699 topical effect Effects 0.000 description 1
230000037317 transdermal delivery Effects 0.000 description 1
229910052723 transition metal Inorganic materials 0.000 description 1
150000003624 transition metals Chemical class 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
COIOYMYWGDAQPM-UHFFFAOYSA-N tris(2-methylphenyl)phosphane Chemical compound CC1=CC=CC=C1P(C=1C(=CC=CC=1)C)C1=CC=CC=C1C COIOYMYWGDAQPM-UHFFFAOYSA-N 0.000 description 1
229960000281 trometamol Drugs 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000011345 viscous material Substances 0.000 description 1
238000009736 wetting Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
239000008096 xylene Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

NO20044665A 2002-05-13 2004-10-28 Benzoksazin-derivater, fremgangsmate for fremstilling av slike, farmasoytiske preparater omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling eller forebygging av sykdom NO329380B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US37800302P	2002-05-13	2002-05-13
PCT/EP2003/004671 WO2003095434A1 (en)	2002-05-13	2003-05-05	Benzoxazine derivatives as 5-ht6 modulators and uses thereof

Publications (2)

Publication Number	Publication Date
NO20044665L NO20044665L (no)	2004-12-03
NO329380B1 true NO329380B1 (no)	2010-10-04

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NO20044665A NO329380B1 (no)	2002-05-13	2004-10-28	Benzoksazin-derivater, fremgangsmate for fremstilling av slike, farmasoytiske preparater omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling eller forebygging av sykdom

Country Status (37)

Country	Link
US (4)	US6867204B2 (pt)
EP (1)	EP1506179B1 (pt)
JP (1)	JP4307377B2 (pt)
KR (1)	KR100636475B1 (pt)
CN (1)	CN100429206C (pt)
AR (1)	AR039988A1 (pt)
AT (1)	ATE316523T1 (pt)
AU (1)	AU2003233231B2 (pt)
BR (1)	BRPI0310032B8 (pt)
CA (1)	CA2485136C (pt)
DE (1)	DE60303376T2 (pt)
DK (1)	DK1506179T3 (pt)
EA (1)	EA009982B1 (pt)
EC (1)	ECSP045420A (pt)
EG (1)	EG25683A (pt)
ES (1)	ES2256744T3 (pt)
GT (1)	GT200300108A (pt)
HK (1)	HK1080846A1 (pt)
HR (1)	HRP20041030B1 (pt)
IL (1)	IL164928A0 (pt)
JO (1)	JO2413B1 (pt)
MA (1)	MA27118A1 (pt)
MX (1)	MXPA04011254A (pt)
MY (1)	MY139612A (pt)
NO (1)	NO329380B1 (pt)
NZ (1)	NZ536230A (pt)
PA (1)	PA8573501A1 (pt)
PE (1)	PE20040757A1 (pt)
PL (1)	PL211057B1 (pt)
PT (1)	PT1506179E (pt)
RS (1)	RS51042B (pt)
TN (1)	TNSN04225A1 (pt)
TW (1)	TWI258479B (pt)
UA (1)	UA76877C2 (pt)
UY (1)	UY27803A1 (pt)
WO (1)	WO2003095434A1 (pt)
ZA (1)	ZA200408783B (pt)

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KR100843053B1 (ko) *	2004-01-16	2008-07-01	에프. 호프만-라 로슈 아게	중추 신경계 질환의 치료를 위한 5-하이드록시트립트아민수용체(5-ｈｔ)의 조절제로서1-벤질-5-피페라진-1-일-3,4-다이하이드로-1ｈ-퀴나졸린-2-온 유도체 및 각각의1ｈ-벤조(1,2,6)티아다이아진-2,2-다이옥사이드 및1,4-다이하이드로-벤조(ｄ)(1,3)옥사진-2-온 유도체
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AR078770A1 (es) *	2009-10-27	2011-11-30	Elara Pharmaceuticals Gmbh	Derivados de dihidrobenzo oxacinas y tiazinas, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades inflamatorias e hiperproliferativas.
KR101293384B1 (ko) *	2010-10-13	2013-08-05	주식회사 대웅제약	신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도
US9403800B2 (en) *	2012-01-24	2016-08-02	Chemregen, Inc.	Compounds for inhibition of cancer cell proliferation
JP6510539B2 (ja)	2014-01-09	2019-05-08	ザジェイ．デヴィッドグラッドストーンインスティテューツ，アテスタメンタリートラストエスタブリッシュドアンダーザウィルオブジェイ．デヴィッドグラッドストーン	置換ベンゾオキサジン及び関連化合物
JP2018516992A (ja)	2015-06-12	2018-06-28	アクソファントサイエンシーズゲーエムベーハーＡｘｏｖａｎｔＳｃｉｅｎｃｅｓＧｍｂｈ	レム睡眠行動障害の予防および処置のために有用なジアリールおよびアリールヘテロアリール尿素誘導体
RU2018103338A (ru)	2015-07-15	2019-08-15	Аксовант Сайенсиз Гмбх	Производные диарил- и арилгетероарилмочевины для профилактики и лечения галлюцинаций, ассоциированных с нейродегенеративным заболеванием

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2003
- 2003-05-05 DE DE60303376T patent/DE60303376T2/de not_active Expired - Lifetime
- 2003-05-05 NZ NZ536230A patent/NZ536230A/en not_active IP Right Cessation
- 2003-05-05 AU AU2003233231A patent/AU2003233231B2/en not_active Expired
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- 2003-05-05 UA UA20041210144A patent/UA76877C2/uk unknown
- 2003-05-05 JP JP2004503451A patent/JP4307377B2/ja not_active Expired - Lifetime
- 2003-05-05 PL PL374019A patent/PL211057B1/pl unknown
- 2003-05-05 WO PCT/EP2003/004671 patent/WO2003095434A1/en active IP Right Grant
- 2003-05-05 EA EA200401455A patent/EA009982B1/ru not_active IP Right Cessation
- 2003-05-05 CN CNB038109972A patent/CN100429206C/zh not_active Expired - Lifetime
- 2003-05-05 ES ES03727430T patent/ES2256744T3/es not_active Expired - Lifetime
- 2003-05-05 RS YUP-970/04A patent/RS51042B/sr unknown
- 2003-05-05 EP EP03727430A patent/EP1506179B1/en not_active Expired - Lifetime
- 2003-05-05 KR KR1020047018299A patent/KR100636475B1/ko active IP Right Grant
- 2003-05-05 BR BRPI0310032A patent/BRPI0310032B8/pt not_active IP Right Cessation
- 2003-05-05 MX MXPA04011254A patent/MXPA04011254A/es active IP Right Grant
- 2003-05-05 AT AT03727430T patent/ATE316523T1/de active
- 2003-05-05 PT PT03727430T patent/PT1506179E/pt unknown
- 2003-05-05 DK DK03727430T patent/DK1506179T3/da active
- 2003-05-08 JO JO200352A patent/JO2413B1/en active
- 2003-05-08 TW TW092112575A patent/TWI258479B/zh not_active IP Right Cessation
- 2003-05-09 PE PE2003000452A patent/PE20040757A1/es active IP Right Grant
- 2003-05-09 AR ARP030101624A patent/AR039988A1/es active IP Right Grant
- 2003-05-09 US US10/435,732 patent/US6867204B2/en not_active Expired - Lifetime
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- 2003-05-09 PA PA20038573501A patent/PA8573501A1/es unknown
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- 2003-05-12 UY UY27803A patent/UY27803A1/es not_active IP Right Cessation
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2004
- 2004-10-28 NO NO20044665A patent/NO329380B1/no not_active IP Right Cessation
- 2004-10-28 IL IL16492804A patent/IL164928A0/xx unknown
- 2004-10-29 ZA ZA2004/08783A patent/ZA200408783B/en unknown
- 2004-11-03 HR HRP20041030AA patent/HRP20041030B1/hr not_active IP Right Cessation
- 2004-11-10 EC EC2004005420A patent/ECSP045420A/es unknown
- 2004-11-11 TN TNP2004000225A patent/TNSN04225A1/fr unknown
- 2004-11-12 MA MA27944A patent/MA27118A1/fr unknown
2005
- 2005-01-31 US US11/047,284 patent/US20050130962A1/en not_active Abandoned
2006
- 2006-01-18 HK HK06100802.2A patent/HK1080846A1/xx not_active IP Right Cessation
2009
- 2009-09-04 US US12/584,373 patent/US8377931B2/en active Active
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- 2012-12-13 US US13/713,484 patent/US20130123251A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PL211057B1 (pl)	2012-04-30
KR100636475B1 (ko)	2006-10-18
ECSP045420A (es)	2005-01-03
US20130123251A1 (en)	2013-05-16
KR20040106538A (ko)	2004-12-17
BR0310032A (pt)	2005-02-15
JP2005530774A (ja)	2005-10-13
AU2003233231A1 (en)	2003-11-11
PE20040757A1 (es)	2004-11-06
UA76877C2 (uk)	2006-09-15
NZ536230A (en)	2007-05-31
EP1506179B1 (en)	2006-01-25
CN1653054A (zh)	2005-08-10
EG25683A (en)	2012-05-16
GT200300108A (es)	2004-03-15
EA200401455A1 (ru)	2005-06-30
CA2485136A1 (en)	2003-11-20
MA27118A1 (fr)	2004-12-20
DK1506179T3 (da)	2006-06-06
TNSN04225A1 (fr)	2007-03-12
HRP20041030A2 (en)	2005-06-30
IL164928A0 (en)	2005-12-18
HRP20041030B1 (hr)	2013-03-31
US20050130962A1 (en)	2005-06-16
DE60303376D1 (de)	2006-04-13
PL374019A1 (en)	2005-09-19
EP1506179A1 (en)	2005-02-16
PT1506179E (pt)	2006-06-30
US20090325950A1 (en)	2009-12-31
BRPI0310032B8 (pt)	2021-05-25
MXPA04011254A (es)	2005-01-25
ES2256744T3 (es)	2006-07-16
TW200400188A (en)	2004-01-01
US6867204B2 (en)	2005-03-15
AU2003233231B2 (en)	2009-02-26
CN100429206C (zh)	2008-10-29
ZA200408783B (en)	2005-12-28
AR039988A1 (es)	2005-03-09
WO2003095434A1 (en)	2003-11-20
JO2413B1 (en)	2007-11-11
MY139612A (en)	2009-10-30
NO20044665L (no)	2004-12-03
UY27803A1 (es)	2003-11-28
RS51042B (sr)	2010-10-31
ATE316523T1 (de)	2006-02-15
CA2485136C (en)	2011-12-20
DE60303376T2 (de)	2006-11-16
BRPI0310032B1 (pt)	2019-01-08
US8377931B2 (en)	2013-02-19
JP4307377B2 (ja)	2009-08-05
PA8573501A1 (es)	2003-12-10
HK1080846A1 (en)	2006-05-04
RS97004A (en)	2006-10-27
TWI258479B (en)	2006-07-21
EA009982B1 (ru)	2008-04-28
US20030232825A1 (en)	2003-12-18

Legal Events

Date	Code	Title	Description
2023-07-10	MK1K	Patent expired

Publication	Publication Date	Title
US8377931B2 (en)	2013-02-19	Benzoxazine derivatives and uses thereof
IL168343A (en)	2010-05-31	Substituted benzoxazinones, pharmaceutical compositions comprising them, processes for their preparation and use thereof in the preparation of medicaments
ES2302174T3 (es)	2008-07-01	Derivados 1-bencil-5-piperacin-1-il-3,4-dihidro-1h-quinazolin-2-ona y derivados respectivos de 1h-benzo(1,2,6)tiadiacin-2,2-dioxido y 1,4-dihidro-benzo(d)(1,3)oxacin-2-ona como moduladores del receptor 5-hidroxitriptamina(5-ht) para tratamiento enfermed. sistema nervioso central.
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