NO20050666L - 2,7-substituerte indoler og deres anvendelse som 5-HT6 modulatorer - Google Patents
2,7-substituerte indoler og deres anvendelse som 5-HT6 modulatorerInfo
- Publication number
- NO20050666L NO20050666L NO20050666A NO20050666A NO20050666L NO 20050666 L NO20050666 L NO 20050666L NO 20050666 A NO20050666 A NO 20050666A NO 20050666 A NO20050666 A NO 20050666A NO 20050666 L NO20050666 L NO 20050666L
- Authority
- NO
- Norway
- Prior art keywords
- modulators
- substituted indoles
- formula
- methods
- present
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Foreliggende oppfinnelse tilveiebringer en forbindelse med formelen: S(0)n-R' I et farmasøytisk akseptabelt salt eller et prodrug derav, hvor R', R^, R^, R^ og n er de som er definert her. Foreliggende oppfinnelse tilveiebringer også preparater som omfatter, metoder for anvendelse av og metoder for fi-emstilling av Forbindelse med formel I.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41123902P | 2002-09-17 | 2002-09-17 | |
PCT/EP2003/010101 WO2004026830A1 (en) | 2002-09-17 | 2003-09-11 | 2,7-substituted indoles and their use as 5-ht6 modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20050666L true NO20050666L (no) | 2005-03-11 |
Family
ID=32030655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20050666A NO20050666L (no) | 2002-09-17 | 2005-02-08 | 2,7-substituerte indoler og deres anvendelse som 5-HT6 modulatorer |
Country Status (29)
Country | Link |
---|---|
US (1) | US7247651B2 (no) |
EP (1) | EP1587788B9 (no) |
JP (1) | JP4327091B2 (no) |
KR (1) | KR100686758B1 (no) |
CN (1) | CN1314669C (no) |
AR (1) | AR041255A1 (no) |
AT (1) | ATE362469T1 (no) |
AU (1) | AU2003273855B2 (no) |
BR (1) | BR0314352A (no) |
CA (1) | CA2496765A1 (no) |
DE (1) | DE60313895T2 (no) |
DK (1) | DK1587788T3 (no) |
ES (1) | ES2287518T3 (no) |
GT (1) | GT200300199A (no) |
HK (1) | HK1083500A1 (no) |
HR (1) | HRP20050229A2 (no) |
MX (1) | MXPA05002696A (no) |
MY (1) | MY138826A (no) |
NO (1) | NO20050666L (no) |
NZ (1) | NZ537982A (no) |
PA (1) | PA8582201A1 (no) |
PE (1) | PE20050054A1 (no) |
PL (1) | PL376020A1 (no) |
PT (1) | PT1587788E (no) |
RU (1) | RU2327685C2 (no) |
TW (1) | TWI249402B (no) |
UY (1) | UY27980A1 (no) |
WO (1) | WO2004026830A1 (no) |
ZA (1) | ZA200501306B (no) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE398108T1 (de) | 2002-03-27 | 2008-07-15 | Glaxo Group Ltd | Chinolinderivate und deren verwendung als 5-ht6 liganden |
CN101875961B (zh) | 2003-07-22 | 2015-01-07 | 艾尼纳制药公司 | 用于预防和治疗相关病症而作为5-ht2a血清素受体调节剂的二芳基和芳基杂芳基脲衍生物 |
WO2005061455A1 (en) * | 2003-12-23 | 2005-07-07 | H. Lundbeck A/S | 2-(1h-indolylsulfanyl)-benzyl amine derivatives as ssri |
AR052308A1 (es) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
CN102114244A (zh) | 2004-09-30 | 2011-07-06 | 弗·哈夫曼-拉罗切有限公司 | 治疗认知障碍的组合物和方法 |
US7713954B2 (en) * | 2004-09-30 | 2010-05-11 | Roche Palo Alto Llc | Compositions and methods for treating cognitive disorders |
WO2006062481A1 (en) * | 2004-12-09 | 2006-06-15 | Biovitrum Ab | New benzofuran derivatives and their use in the treatment of obesity, type ii diabetes and cns disorders . |
US7629473B2 (en) * | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
AR054393A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
EP2084131A1 (en) * | 2006-11-09 | 2009-08-05 | F. Hoffmann-Roche AG | Indole and benzofuran 2-carboxamide derivatives |
EP2508177A1 (en) | 2007-12-12 | 2012-10-10 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
CN103288707B (zh) * | 2013-05-28 | 2015-12-23 | 浙江大学 | 一种3-苯巯基吲哚衍生物的制备方法 |
US9663498B2 (en) | 2013-12-20 | 2017-05-30 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic compounds and their application in pharmaceuticals |
US9974785B2 (en) | 2014-07-08 | 2018-05-22 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
AU2016276966A1 (en) | 2015-06-12 | 2018-01-18 | Axovant Sciences Gmbh | Diaryl and arylheteroaryl urea derivatives useful for the prophylaxis and treatment of REM sleep behavior disorder |
JP2018520187A (ja) | 2015-07-15 | 2018-07-26 | アクソヴァント サイエンシーズ ゲゼルシャフト ミット ベシュレンクテル ハフツングAxovant Sciences GmbH | 神経変性疾患と関連する幻覚の予防および処置のために有用な5−ht2aセロトニン受容体のモジュレーターとしてのジアリールおよびアリールヘテロアリール尿素誘導体 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2194984C (en) | 1994-07-26 | 2002-07-02 | John Eugene Macor | 4-indole derivatives as serotonin agonists and antagonists |
US6114532A (en) * | 1998-02-03 | 2000-09-05 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals |
CO5080791A1 (es) | 1998-06-30 | 2001-09-25 | Lilly Co Eli | Derivados de la piperidina que tienen efectos sobre sistemas con serotonina |
FR2788772B1 (fr) * | 1999-01-26 | 2001-03-02 | Adir | Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
GB9912413D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
YU96103A (sh) * | 2001-06-07 | 2006-08-17 | F.Hoffmann-La Roche Ag. | Novi derivati indola sa afinitetom za 5-ht6 receptor |
ATE331707T1 (de) * | 2001-06-15 | 2006-07-15 | Hoffmann La Roche | 4 piperazinylindolderivate mit affinität zum 5- ht6-rezeptor |
WO2003013510A1 (en) * | 2001-08-07 | 2003-02-20 | Smithkline Beecham P.L.C. | 3-arylsulfonyl-7-piperazinyl- indoles, -benzofurans and -benzothiophenes with 5-ht6 receptor affinity for treating cns disorders |
JP4754821B2 (ja) | 2002-06-20 | 2011-08-24 | プロキシマゲン・リミテッド | 肥満症、ii型糖尿病およびcns障害の治療に有用な新規化合物 |
-
2003
- 2003-09-11 PT PT03757820T patent/PT1587788E/pt unknown
- 2003-09-11 KR KR1020057004480A patent/KR100686758B1/ko not_active IP Right Cessation
- 2003-09-11 ES ES03757820T patent/ES2287518T3/es not_active Expired - Lifetime
- 2003-09-11 DE DE60313895T patent/DE60313895T2/de not_active Expired - Lifetime
- 2003-09-11 RU RU2005111587/04A patent/RU2327685C2/ru not_active IP Right Cessation
- 2003-09-11 AT AT03757820T patent/ATE362469T1/de not_active IP Right Cessation
- 2003-09-11 JP JP2004537044A patent/JP4327091B2/ja not_active Expired - Fee Related
- 2003-09-11 EP EP03757820A patent/EP1587788B9/en not_active Expired - Lifetime
- 2003-09-11 DK DK03757820T patent/DK1587788T3/da active
- 2003-09-11 WO PCT/EP2003/010101 patent/WO2004026830A1/en active IP Right Grant
- 2003-09-11 AU AU2003273855A patent/AU2003273855B2/en not_active Ceased
- 2003-09-11 BR BR0314352-0A patent/BR0314352A/pt not_active IP Right Cessation
- 2003-09-11 NZ NZ537982A patent/NZ537982A/en unknown
- 2003-09-11 CN CNB03821590XA patent/CN1314669C/zh not_active Expired - Fee Related
- 2003-09-11 MX MXPA05002696A patent/MXPA05002696A/es active IP Right Grant
- 2003-09-11 PL PL03376020A patent/PL376020A1/xx not_active Application Discontinuation
- 2003-09-11 CA CA002496765A patent/CA2496765A1/en not_active Abandoned
- 2003-09-12 PE PE2003000929A patent/PE20050054A1/es not_active Application Discontinuation
- 2003-09-12 TW TW092125197A patent/TWI249402B/zh not_active IP Right Cessation
- 2003-09-12 PA PA20038582201A patent/PA8582201A1/es unknown
- 2003-09-15 AR ARP030103331A patent/AR041255A1/es unknown
- 2003-09-15 UY UY27980A patent/UY27980A1/es not_active Application Discontinuation
- 2003-09-16 US US10/663,314 patent/US7247651B2/en not_active Expired - Fee Related
- 2003-09-16 MY MYPI20033528A patent/MY138826A/en unknown
- 2003-09-16 GT GT200300199A patent/GT200300199A/es unknown
-
2005
- 2005-02-08 NO NO20050666A patent/NO20050666L/no not_active Application Discontinuation
- 2005-02-14 ZA ZA200501306A patent/ZA200501306B/xx unknown
- 2005-03-09 HR HR20050229A patent/HRP20050229A2/hr not_active Application Discontinuation
-
2006
- 2006-03-20 HK HK06103482A patent/HK1083500A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20050666L (no) | 2,7-substituerte indoler og deres anvendelse som 5-HT6 modulatorer | |
NO20050664L (no) | 2,4 substituerte indoler og anvendelse derav som 5-HT6 modulatorer | |
NO20021328L (no) | Pyrazolopyrimidier som terapeutiske midler | |
NO20054848L (no) | Substituerte p-diaminobenzenderivater | |
NO20050088L (no) | Kationisk substituerte difenylazefidinoner, fremgangsmate for deres fremstilling, medikamenter inneholdende nevnte forbindelser og anvendelse derav | |
DK1392714T3 (da) | Steroider som agonister for FXR | |
SG151254A1 (en) | Substituted morpholine and thiomorpholine derivatives | |
SE0202463D0 (sv) | Novel compounds | |
NO20062491L (no) | Benzoksazinderivter og deres anvendelse | |
NO20053748L (no) | Pyrrolopyridazinderivater. | |
NO20070224L (no) | 2-karbamid-4-fenyltiazolderivater, fremstilling og terapeutisk anvendelse derav | |
NO20054905L (no) | 2-acylamino-4-fenyltiazolderivater, fremgangsmate for deres fremstilling og anvendelse av de samme som i terapeutika | |
NO20060147L (no) | Benzimidazolderivater, sammensetninger som inneholder slike, fremstilling derav og anvendelse derav | |
NO20055562L (no) | Substituerte indolin- og indolderivater | |
WO2006100081A3 (de) | Substituierte oxindol-derivate, diese enthaltende arzneimittel und deren verwendung | |
NO20081844L (no) | Terapeutiske forbindelser | |
NO20062021L (no) | Omleirede pentanoler, fremgangsmpte for fremstilling av dette, og deres anvendelse som antiflogistika | |
NO20052074L (no) | Substituerte benzoksazinoner og anvendelser derav. | |
NO20054135L (no) | Kipolinon/benzoksazin derivater og anvendelser derav | |
NO20060146L (no) | Benzimidazolderivater, sammensetninger som inneholder slike, fremstilling derav og anvendelse derav | |
ATE346067T1 (de) | Carbolinderivate | |
RS97004A (en) | Benzoxazine derivatives as 5-ht6 modulators and uses thereof | |
DK1643984T3 (da) | Anvendelse af parthenolidderivater som antileukæmiske og cytotoksske midler | |
NO20080033L (no) | Kinolinderivater som NK3-antagonister | |
NO20082214L (no) | 1,1-Diokso-tiomorfolinyl-indolyl-metanonderivater for anvendelse som H3-modulatorer |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |