BRPI0413353A - composição farmacêutica contendo droga solúvel em água - Google Patents
composição farmacêutica contendo droga solúvel em águaInfo
- Publication number
- BRPI0413353A BRPI0413353A BRPI0413353-6A BRPI0413353A BRPI0413353A BR PI0413353 A BRPI0413353 A BR PI0413353A BR PI0413353 A BRPI0413353 A BR PI0413353A BR PI0413353 A BRPI0413353 A BR PI0413353A
- Authority
- BR
- Brazil
- Prior art keywords
- temperature
- drug
- pharmaceutical composition
- water soluble
- soluble drug
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"COMPOSIçãO FARMACêUTICA CONTENDO DROGA SOLúVEL EM áGUA". A presente invenção é direcionada a um processo de preparação de microesferas revestidas com uma droga solúvel em água para incorporação em uma composição farmacêutica compreendendo: (a) preparação de uma solução supersaturada de droga contendo uma quantidade da droga desejada, a qual é completamente saturada a uma primeira temperatura mas a qual é supersaturada a uma segunda temperatura que é inferior a primeira temperatura; e (b) revestindo microesferas inertes com a solução da droga, a referida solução da droga sendo mantida a primeira temperatura ou abaixo da mesma mas acima da segunda temperatura, e as referidas microesferas mantidas a segunda temperatura, em que a segunda temperatura é menor que a primeira e em que a solução contendo a droga é supersaturada à segunda temperatura, bem como as composições farmacêuticas contendo a mesma.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49292303P | 2003-08-06 | 2003-08-06 | |
PCT/US2004/025445 WO2005013939A1 (en) | 2003-08-06 | 2004-08-06 | Pharmaceutical composition containing water soluble drug |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0413353A true BRPI0413353A (pt) | 2006-10-10 |
Family
ID=34135178
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0413353-6A BRPI0413353A (pt) | 2003-08-06 | 2004-08-06 | composição farmacêutica contendo droga solúvel em água |
Country Status (12)
Country | Link |
---|---|
US (2) | US7897179B2 (pt) |
EP (1) | EP1651192A1 (pt) |
JP (1) | JP2007501256A (pt) |
KR (1) | KR20060095863A (pt) |
CN (1) | CN1845725A (pt) |
AU (1) | AU2004263130A1 (pt) |
BR (1) | BRPI0413353A (pt) |
CA (1) | CA2534367A1 (pt) |
IL (1) | IL173527A0 (pt) |
MX (1) | MXPA06001401A (pt) |
NZ (1) | NZ545145A (pt) |
WO (1) | WO2005013939A1 (pt) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7314640B2 (en) * | 2003-07-11 | 2008-01-01 | Mongkol Sriwongjanya | Formulation and process for drug loaded cores |
RU2372893C2 (ru) * | 2003-10-31 | 2009-11-20 | Хексал Аг | Содержащий фармацевтический агент состав с покрытием |
US7201920B2 (en) | 2003-11-26 | 2007-04-10 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of opioid containing dosage forms |
US10624858B2 (en) * | 2004-08-23 | 2020-04-21 | Intellipharmaceutics Corp | Controlled release composition using transition coating, and method of preparing same |
CA2599340C (en) | 2005-02-25 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Method for producing granules |
EP2007360B1 (en) | 2006-04-03 | 2014-11-26 | Isa Odidi | Controlled release delivery device comprising an organosol coat |
US10960077B2 (en) | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
CN102579387A (zh) * | 2006-09-26 | 2012-07-18 | 诺瓦提斯公司 | 包含s1p调节剂的药物组合物 |
NL1032851C2 (nl) * | 2006-11-10 | 2008-05-14 | Fondel Finance B V | Kit en werkwijze voor het fixeren van een prothese of deel daarvan en/of het vullen van benige defecten. |
RU2510274C2 (ru) | 2008-05-07 | 2014-03-27 | Дзе Реджентс Оф Дзе Юниверсити Оф Калифорния | Терапевтическое восстановление и усиление увлажнения поверхности глаза |
US8506944B2 (en) | 2008-05-07 | 2013-08-13 | The Regents Of The University Of California | Replenishment and enrichment of ocular surface lubrication |
WO2011041414A1 (en) | 2009-09-30 | 2011-04-07 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse |
GB2479213B (en) | 2010-04-01 | 2013-07-10 | Theravida Inc | Pharmaceutical formulations for the treatment of overactive bladder |
KR101307367B1 (ko) * | 2010-09-14 | 2013-09-25 | 주식회사 이노테라피 | 탄닌, 폴리에틸렌글리콜 및 물, 저급 알코올 또는 이들의 혼합물을 포함하는 접착제 조성물 |
EP3446685A1 (en) | 2012-11-30 | 2019-02-27 | Acura Pharmaceuticals, Inc. | Self-regulated release of active pharmaceutical ingredient |
US9546236B2 (en) | 2013-09-19 | 2017-01-17 | Terumo Corporation | Polymer particles |
CN105555847B (zh) | 2013-09-19 | 2018-08-10 | 微仙美国有限公司 | 聚合物膜 |
CN105916495B (zh) | 2013-11-08 | 2019-11-12 | 泰尔茂株式会社 | 聚合物颗粒 |
US9856475B2 (en) | 2014-03-25 | 2018-01-02 | Arcturus Therapeutics, Inc. | Formulations for treating amyloidosis |
CA2946719C (en) | 2014-03-25 | 2023-09-26 | Arcturus Therapeutics, Inc. | Una oligomers having reduced off-target effects in gene silencing |
WO2015148582A1 (en) * | 2014-03-25 | 2015-10-01 | Arcturus Therapeutics, Inc. | Transthyretin allele selective una oligomers for gene silencing |
AU2015237721B2 (en) | 2014-03-26 | 2018-04-26 | Sun Pharma Advanced Research Company Ltd. | Abuse deterrent immediate release coated reservoir solid dosage form |
US9907880B2 (en) | 2015-03-26 | 2018-03-06 | Microvention, Inc. | Particles |
US10519447B2 (en) | 2015-04-01 | 2019-12-31 | Arcturus Therapeutics, Inc. | Therapeutic UNA oligomers and uses thereof |
WO2017015671A1 (en) | 2015-07-23 | 2017-01-26 | Arcturus Therapeutics, Inc. | Compositions for treating amyloidosis |
WO2017040607A1 (en) | 2015-08-31 | 2017-03-09 | Acura Pharmaceuticals, Inc. | Methods and compositions for self-regulated release of active pharmaceutical ingredient |
JP6841834B2 (ja) | 2016-01-20 | 2021-03-10 | テラヴィダ, インコーポレイテッドTheraVida, Inc. | 多汗症の処置のための方法および組成物 |
CA3038719C (en) | 2016-09-28 | 2020-04-21 | Terumo Corporation | Polymer particles |
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CA1076480A (en) * | 1975-04-28 | 1980-04-29 | John S. Kent | Inert core implant pellet |
GB8518301D0 (en) * | 1985-07-19 | 1985-08-29 | Fujisawa Pharmaceutical Co | Hydrodynamically explosive systems |
JP2542122B2 (ja) * | 1990-04-18 | 1996-10-09 | 旭化成工業株式会社 | 球状核、球形顆粒およびその製造方法 |
US5128082A (en) * | 1990-04-20 | 1992-07-07 | James River Corporation | Method of making an absorbant structure |
GB9110719D0 (en) * | 1991-05-17 | 1991-07-10 | Allied Colloids Ltd | Polymeric compositions and methods of making and using them |
US5213811A (en) * | 1991-09-13 | 1993-05-25 | Sterling Drug Inc. | Oral sustained-release drug compositions |
US5348747A (en) * | 1992-03-05 | 1994-09-20 | American Home Products Corporation | Pharmaceutical coating sugars |
GB9207988D0 (en) * | 1992-04-10 | 1992-05-27 | Smithkline Beecham Plc | Topical composition |
US5302400A (en) * | 1992-06-22 | 1994-04-12 | Digestive Care Inc. | Preparation of gastric acid-resistant microspheres containing digestive enzymes and buffered-bile acids |
ZA937382B (en) | 1992-10-06 | 1994-04-29 | Warner Lambert Co | Novel composition for peroral therapy of cognitionimpairment and a process therefor |
US5267985A (en) * | 1993-02-11 | 1993-12-07 | Trancell, Inc. | Drug delivery by multiple frequency phonophoresis |
JPH06256169A (ja) * | 1993-02-18 | 1994-09-13 | Amano Pharmaceut Co Ltd | 顆粒の製造法 |
US5431916A (en) | 1993-04-29 | 1995-07-11 | The Procter & Gamble Company | Pharmaceutical compositions and process of manufacture thereof |
CZ206896A3 (en) | 1994-01-27 | 1996-12-11 | Univ Oklahoma | Quick dissolving oral therapeutic dosage |
US5395626A (en) * | 1994-03-23 | 1995-03-07 | Ortho Pharmaceutical Corporation | Multilayered controlled release pharmaceutical dosage form |
US6150556A (en) * | 1995-03-10 | 2000-11-21 | G. D. Dearle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
FR2744456A1 (fr) * | 1996-02-07 | 1997-08-08 | Atochem Elf Sa | Polymeres superabsorbants a structure coeur-coquille et leur procede d'obtention |
US5833891A (en) * | 1996-10-09 | 1998-11-10 | The University Of Kansas | Methods for a particle precipitation and coating using near-critical and supercritical antisolvents |
ATE241969T1 (de) * | 1997-03-26 | 2003-06-15 | Janssen Pharmaceutica Nv | Tabletten mit einem kern, der mit einem pilzbekämpfungsmittel und einem polymeren beschichtet ist |
FR2768140B1 (fr) * | 1997-09-05 | 1999-10-08 | Atochem Elf Sa | Solution sursaturee stable de perborate de sodium et son application dans la fabrication des particules de percarbonate de sodium stabilisees |
SE9801705D0 (sv) * | 1998-05-14 | 1998-05-14 | Bioglan Ab | Biologically active composition |
US6353148B1 (en) * | 1998-06-08 | 2002-03-05 | Bki Holding Corporation | Fracture resistant superabsorbent polymers |
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JP3814533B2 (ja) * | 2001-12-27 | 2006-08-30 | 株式会社林原生物化学研究所 | 被覆構造を有する可食性固状成形物およびその製造方法 |
US20060257482A1 (en) * | 2002-06-07 | 2006-11-16 | Patrik Kumar | Modified release, multiple unit drug delivery systems |
CA2507685A1 (en) * | 2002-11-28 | 2004-06-10 | Themis Laboratories Private Limited | Process for manufacturing sustained release microbeads containing venlafaxine hci |
KR20060060001A (ko) * | 2003-08-06 | 2006-06-02 | 바스프 악티엔게젤샤프트 | 코팅된 수팽윤성 중합체를 포함하는 수팽윤성 물질 |
-
2004
- 2004-08-06 CN CNA2004800255804A patent/CN1845725A/zh active Pending
- 2004-08-06 US US10/913,048 patent/US7897179B2/en not_active Expired - Fee Related
- 2004-08-06 MX MXPA06001401A patent/MXPA06001401A/es unknown
- 2004-08-06 CA CA002534367A patent/CA2534367A1/en not_active Abandoned
- 2004-08-06 BR BRPI0413353-6A patent/BRPI0413353A/pt not_active IP Right Cessation
- 2004-08-06 AU AU2004263130A patent/AU2004263130A1/en not_active Abandoned
- 2004-08-06 WO PCT/US2004/025445 patent/WO2005013939A1/en active Application Filing
- 2004-08-06 EP EP04780302A patent/EP1651192A1/en not_active Withdrawn
- 2004-08-06 KR KR1020067002493A patent/KR20060095863A/ko not_active Application Discontinuation
- 2004-08-06 NZ NZ545145A patent/NZ545145A/en unknown
- 2004-08-06 JP JP2006522751A patent/JP2007501256A/ja active Pending
-
2006
- 2006-02-05 IL IL173527A patent/IL173527A0/en unknown
-
2011
- 2011-01-24 US US13/012,363 patent/US8906419B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US8906419B2 (en) | 2014-12-09 |
EP1651192A1 (en) | 2006-05-03 |
JP2007501256A (ja) | 2007-01-25 |
US20110117203A1 (en) | 2011-05-19 |
CN1845725A (zh) | 2006-10-11 |
US20050129778A1 (en) | 2005-06-16 |
MXPA06001401A (es) | 2006-05-19 |
KR20060095863A (ko) | 2006-09-04 |
CA2534367A1 (en) | 2005-02-17 |
AU2004263130A1 (en) | 2005-02-17 |
IL173527A0 (en) | 2006-07-05 |
US7897179B2 (en) | 2011-03-01 |
NZ545145A (en) | 2009-07-31 |
WO2005013939A1 (en) | 2005-02-17 |
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Legal Events
Date | Code | Title | Description |
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: PARA: INT. CL. A61K 9/24; A61P 9/00, 11/00, 25/00 Ipc: A61K 9/24 (2011.01), A61P 9/00 (2011.01), A61P 11/ |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012. |