BR0213790A - Derivados de aminobenzamida como inibidores de glicogênio sintase cinase 3beta - Google Patents
Derivados de aminobenzamida como inibidores de glicogênio sintase cinase 3betaInfo
- Publication number
- BR0213790A BR0213790A BR0213790-9A BR0213790A BR0213790A BR 0213790 A BR0213790 A BR 0213790A BR 0213790 A BR0213790 A BR 0213790A BR 0213790 A BR0213790 A BR 0213790A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- hydrogen
- optionally substituted
- polyalkylc
- alkyloxycarbonyl
- Prior art date
Links
- PXBFMLJZNCDSMP-UHFFFAOYSA-N 2-Aminobenzamide Chemical class NC(=O)C1=CC=CC=C1N PXBFMLJZNCDSMP-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000019058 Glycogen Synthase Kinase 3 beta Human genes 0.000 title 1
- 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 229920002527 Glycogen Polymers 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 229940096919 glycogen Drugs 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
"DERIVADOS DE AMINOBENZAMIDA COMO INIBIDORES DE GLICOGêNIO SINTASE CINASE 3BETA". A presente invenção refere-se a um composto da fórmula (I), um N-óxido, um sal de adição farmaceuticamente aceitável, uma amina quaternária e uma forma estereoquimicamente isomérica deste, em que o anel A representa um heterociclo de 6 membros; R^ 1^ é hidrogênio; arila; formila; C~ 1-6~alquilcarbonila; C~ 1-6~alquila opcionalmente substituída; C~ 1-6~alquiloxicarbonila; C~ 1-6~alquiloxiC~ 1-6~alquilcarbonila opcionalmente substituída; X é uma ligação direta ou um átomo ou grupo ligante; Z é O ou S; R^ 2^ é hidrogênio, C~ 1-10~alquila, C~ 2-10~alquenila, C~ 2-10~alquinila, um carbociclo ou um heterociclo, cada um dos ditos grupos pode opcionalmente ser substituído; R^ 3^ é hidrogênio; hidróxi; halo; C~ 1-6~alquila opcionalmente substituída ou C~ 2-6~alquenila ou C~ 2-6~alquinila; C~ 1-6~alquilóxi; C~ 1-6~alquiltio; C~ 1-6~alquiloxicarbonila; C~ 1-6~alquilcarbonilóxi; carboxila; ciano; nitro; amino; mono ou di(C~ 1-6~alquil)amino; polialoC~ 1-6~alquila; polialoC~ 1-6~alquilóxi: PolialoC~ 1-6~alquiltio; R^ 21^, R^ 21^ -C~ 1-6~alquila; R^ 21^-O-; R^ 21^-S-; R~ 21^-C(=O)-; R^ 21^-S(=O)~ p~; R^ 7^ -S(=O)~ p~-; R^ 7^ -S(=O)~ p~-NH; R^ 21^ -S(=O)~ p~-NH-; R^ 7^ -C(=O)-; -NHC(=O)H; -C(=O)NHNH~ 2~; R^ 7^ -C(=O)-NH-; R^ 21^-C(=O)-NH-; -C(=NH)R^ 7^; -C(=NH)R^ 21^; R^ 4a^ ou R^ 4b^ cada um independentemente representa hidrogênio, R^ 8^, -Y~ 1~-NR~ 9^-Y~ 2~-NR^ 10^R^ 11^, -Y~ 1~-NR^ 9^-Y~ 1~-R^ 8^ -Y~ 1~-NR^ 9^R^ 10^; contanto que -X-R^ 2^ e/ou R^ 3^ seja(m) diferente(s) de hidrogênio; seu uso, composições farmacêuticas compreendendo os mesmos e processos para sua preparação.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01204192 | 2001-11-01 | ||
PCT/EP2002/012079 WO2003037877A1 (en) | 2001-11-01 | 2002-10-29 | AMINOBENZAMIDE DERIVATIVES AS GLYCOGEN SYNTHASE KINASE 3β INHIBITORS |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0213790A true BR0213790A (pt) | 2004-12-07 |
Family
ID=8181175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0213790-9A BR0213790A (pt) | 2001-11-01 | 2002-10-29 | Derivados de aminobenzamida como inibidores de glicogênio sintase cinase 3beta |
Country Status (21)
Country | Link |
---|---|
US (1) | US20060063789A1 (pt) |
EP (1) | EP1442024B1 (pt) |
JP (1) | JP2005507420A (pt) |
KR (1) | KR20040062557A (pt) |
CN (1) | CN100436427C (pt) |
AT (1) | ATE389638T1 (pt) |
AU (1) | AU2002363177B2 (pt) |
BR (1) | BR0213790A (pt) |
CA (1) | CA2463823A1 (pt) |
DE (1) | DE60225709T2 (pt) |
DK (1) | DK1442024T3 (pt) |
EA (1) | EA007063B1 (pt) |
ES (1) | ES2303565T3 (pt) |
HU (1) | HUP0402245A3 (pt) |
IL (1) | IL161663A0 (pt) |
MX (1) | MXPA04004176A (pt) |
NO (1) | NO326889B1 (pt) |
NZ (1) | NZ531854A (pt) |
PL (1) | PL368920A1 (pt) |
PT (1) | PT1442024E (pt) |
WO (1) | WO2003037877A1 (pt) |
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EP0164204A1 (en) * | 1984-05-12 | 1985-12-11 | FISONS plc | Novel pharmaceutically useful pyrimidines |
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EP0233461B2 (en) * | 1986-01-13 | 2002-05-29 | American Cyanamid Company | 4,5,6-Substituted-2-pyrimidinamines |
US4966622A (en) * | 1988-04-12 | 1990-10-30 | Ciba-Geigy Corporation | N-phenyl-N-pyrimidin-2-ylureas |
GB9012592D0 (en) * | 1990-06-06 | 1990-07-25 | Smithkline Beecham Intercredit | Compounds |
US5516775A (en) * | 1992-08-31 | 1996-05-14 | Ciba-Geigy Corporation | Further use of pyrimidine derivatives |
GB9705361D0 (en) * | 1997-03-14 | 1997-04-30 | Celltech Therapeutics Ltd | Chemical compounds |
EP0945443B9 (en) * | 1998-03-27 | 2003-08-13 | Janssen Pharmaceutica N.V. | HIV inhibiting pyrimidine derivatives |
WO1999065897A1 (en) * | 1998-06-19 | 1999-12-23 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
GB9914258D0 (en) * | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
GB0004890D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
ATE430742T1 (de) * | 2000-12-21 | 2009-05-15 | Smithkline Beecham Corp | Pyrimidinamine als angiogenesemodulatoren |
AU2002316421B2 (en) * | 2001-06-26 | 2008-05-15 | Bristol-Myers Squibb Company | N-heterocyclic inhibitors of TNF-ALPHA expression |
US6939874B2 (en) * | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
CA2463989C (en) * | 2001-10-17 | 2012-01-31 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pyrimidine derivatives, pharmaceutical compositions containing these compounds, the use thereof and process for the preparation thereof |
-
2002
- 2002-10-29 AT AT02802307T patent/ATE389638T1/de active
- 2002-10-29 US US10/493,446 patent/US20060063789A1/en not_active Abandoned
- 2002-10-29 AU AU2002363177A patent/AU2002363177B2/en not_active Ceased
- 2002-10-29 DE DE60225709T patent/DE60225709T2/de not_active Expired - Lifetime
- 2002-10-29 PT PT02802307T patent/PT1442024E/pt unknown
- 2002-10-29 DK DK02802307T patent/DK1442024T3/da active
- 2002-10-29 BR BR0213790-9A patent/BR0213790A/pt not_active IP Right Cessation
- 2002-10-29 IL IL16166302A patent/IL161663A0/xx unknown
- 2002-10-29 CN CNB028219163A patent/CN100436427C/zh not_active Expired - Fee Related
- 2002-10-29 MX MXPA04004176A patent/MXPA04004176A/es active IP Right Grant
- 2002-10-29 EA EA200400616A patent/EA007063B1/ru not_active IP Right Cessation
- 2002-10-29 HU HU0402245A patent/HUP0402245A3/hu unknown
- 2002-10-29 KR KR10-2004-7004829A patent/KR20040062557A/ko active IP Right Grant
- 2002-10-29 CA CA002463823A patent/CA2463823A1/en not_active Abandoned
- 2002-10-29 WO PCT/EP2002/012079 patent/WO2003037877A1/en active IP Right Grant
- 2002-10-29 JP JP2003540159A patent/JP2005507420A/ja active Pending
- 2002-10-29 ES ES02802307T patent/ES2303565T3/es not_active Expired - Lifetime
- 2002-10-29 PL PL02368920A patent/PL368920A1/xx not_active Application Discontinuation
- 2002-10-29 EP EP02802307A patent/EP1442024B1/en not_active Expired - Lifetime
- 2002-10-29 NZ NZ531854A patent/NZ531854A/xx not_active IP Right Cessation
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2004
- 2004-06-01 NO NO20042253A patent/NO326889B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN100436427C (zh) | 2008-11-26 |
EP1442024B1 (en) | 2008-03-19 |
NZ531854A (en) | 2006-03-31 |
EA007063B1 (ru) | 2006-06-30 |
AU2002363177B2 (en) | 2008-09-18 |
NO326889B1 (no) | 2009-03-16 |
EP1442024A1 (en) | 2004-08-04 |
EA200400616A1 (ru) | 2004-08-26 |
US20060063789A1 (en) | 2006-03-23 |
DK1442024T3 (da) | 2008-06-30 |
CN1703405A (zh) | 2005-11-30 |
IL161663A0 (en) | 2004-09-27 |
DE60225709D1 (de) | 2008-04-30 |
DE60225709T2 (de) | 2009-05-07 |
CA2463823A1 (en) | 2003-05-08 |
HUP0402245A2 (hu) | 2005-02-28 |
WO2003037877A1 (en) | 2003-05-08 |
KR20040062557A (ko) | 2004-07-07 |
HUP0402245A3 (en) | 2010-03-29 |
ES2303565T3 (es) | 2008-08-16 |
NO20042253L (no) | 2004-06-01 |
JP2005507420A (ja) | 2005-03-17 |
PL368920A1 (en) | 2005-04-04 |
ATE389638T1 (de) | 2008-04-15 |
PT1442024E (pt) | 2008-06-12 |
MXPA04004176A (es) | 2004-09-06 |
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