BR0211888A - Materiais e métodos para promoção de reparo de tecido nervoso - Google Patents
Materiais e métodos para promoção de reparo de tecido nervosoInfo
- Publication number
- BR0211888A BR0211888A BR0211888-2A BR0211888A BR0211888A BR 0211888 A BR0211888 A BR 0211888A BR 0211888 A BR0211888 A BR 0211888A BR 0211888 A BR0211888 A BR 0211888A
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- materials
- tissue repair
- nerve tissue
- promoting nerve
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 230000001737 promoting effect Effects 0.000 title abstract 3
- 239000000463 material Substances 0.000 title abstract 2
- 230000017423 tissue regeneration Effects 0.000 title abstract 2
- 210000000944 nerve tissue Anatomy 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 210000005036 nerve Anatomy 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 230000000472 traumatic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3675—Nerve tissue, e.g. brain, spinal cord, nerves, dura mater
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/383—Nerve cells, e.g. dendritic cells, Schwann cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3878—Nerve tissue, brain, spinal cord, nerves, dura mater
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/043—Proteins; Polypeptides; Degradation products thereof
- A61L31/047—Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"MATERIAIS E MéTODOS PARA PROMOçãO DE REPARO DE TECIDO NERVOSO". A presente invenção refere-se a composições e métodos para promoção de reparo de tecido nervoso danificado e preparação de enxertos de nervo. As composições e métodos da presente invenção podem ser empregados para restaurar a continuidade do nervo interrompido por uma doença, casos traumáticos ou procedimentos cirúrgicos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31187001P | 2001-08-13 | 2001-08-13 | |
PCT/US2002/025922 WO2003015612A2 (en) | 2001-08-13 | 2002-08-13 | Materials and methods to promote repair of nerve tissue |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0211888A true BR0211888A (pt) | 2004-08-24 |
Family
ID=23208862
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0211888-2A BR0211888A (pt) | 2001-08-13 | 2002-08-13 | Materiais e métodos para promoção de reparo de tecido nervoso |
Country Status (13)
Country | Link |
---|---|
US (8) | US6972168B2 (pt) |
EP (1) | EP1425390B1 (pt) |
JP (1) | JP4749667B2 (pt) |
KR (1) | KR20040021697A (pt) |
CN (1) | CN1553952A (pt) |
AT (1) | ATE543509T1 (pt) |
BR (1) | BR0211888A (pt) |
CA (1) | CA2455827C (pt) |
ES (1) | ES2378227T3 (pt) |
HU (1) | HUP0500634A3 (pt) |
IL (1) | IL160188A0 (pt) |
MX (1) | MXPA04001334A (pt) |
WO (1) | WO2003015612A2 (pt) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6670179B1 (en) * | 2001-08-01 | 2003-12-30 | University Of Kentucky Research Foundation | Molecular functionalization of carbon nanotubes and use as substrates for neuronal growth |
ATE543509T1 (de) * | 2001-08-13 | 2012-02-15 | Univ Florida | Material und verfahren zur förderung der reparatur von nervengewebe |
GB0205022D0 (en) * | 2002-03-04 | 2002-04-17 | Univ Cambridge Tech | Materials and methods for the treatment of cns damage |
ES2362648T3 (es) * | 2002-05-04 | 2011-07-08 | Acorda Therapeutics, Inc. | Composiciones y métodos para promover la proyección neuronal. |
US7163545B2 (en) * | 2002-07-29 | 2007-01-16 | Mayo Foundation For Medical Education And Research | Spinal cord surgical implant |
DE60337009D1 (de) * | 2002-08-15 | 2011-06-16 | Acorda Therapeutics Inc | Chimärisches protein |
US7135027B2 (en) * | 2002-10-04 | 2006-11-14 | Baxter International, Inc. | Devices and methods for mixing and extruding medically useful compositions |
EP3514238B1 (en) | 2003-05-16 | 2021-05-05 | Acorda Therapeutics, Inc. | Proteoglycan degrading mutants for treatment of cns |
MXPA05012306A (es) * | 2003-05-16 | 2006-04-18 | Acorda Therapeutics Inc | Proteinas de fusion para el tratamiento del snc. |
US7959914B2 (en) | 2003-05-16 | 2011-06-14 | Acorda Therapeutics, Inc. | Methods of reducing extravasation of inflammatory cells |
MXPA05012305A (es) * | 2003-05-16 | 2006-04-18 | Acorda Therapeutics Inc | Composiciones y metodos para el tratamiento de lesiones del snc. |
US7772185B2 (en) * | 2004-01-30 | 2010-08-10 | Emory University | Method for promoting axonal outgrowth in damaged nerves |
WO2005112986A2 (en) * | 2004-05-18 | 2005-12-01 | Acorda Therapeutics, Inc. | Purifying chondroitinase and stable formulations thereof |
WO2005122734A2 (en) * | 2004-06-14 | 2005-12-29 | The Research Foundation Of State University Of New York | Nanosphere/microsphere delivery system for the treatment of spinal cord injury |
US20060041318A1 (en) * | 2004-08-19 | 2006-02-23 | Shannon Donald T | Laminar skin-bone fixation transcutaneous implant and method for use thereof |
CA2623635C (en) | 2005-09-26 | 2013-04-02 | Acorda Therapeutics, Inc. | Compositions and methods of using chondroitinase abci mutants |
US7599774B2 (en) * | 2006-03-10 | 2009-10-06 | Gm Global Technology Operations, Inc. | Method and system for adaptively compensating closed-loop front-wheel steering control |
CN101489582B (zh) * | 2006-05-19 | 2015-11-25 | 爱知县 | 脑损伤改善药 |
ES2473610T3 (es) | 2006-10-10 | 2014-07-07 | Acorda Therapeutics, Inc. | Composiciones y métodos de uso de mutantes de condroitinasa ABCI |
WO2008149428A1 (ja) * | 2007-06-05 | 2008-12-11 | Glycoscience Laboratories, Inc. | 自己免疫疾患、炎症及び神経疾患の治療剤及び予防剤 |
US9820747B2 (en) * | 2008-04-04 | 2017-11-21 | The Cleveland Clinic Foundation | Use of epineural sheath grafts for neural regeneration and protection |
EP3020410A1 (en) | 2008-04-18 | 2016-05-18 | Collplant Ltd. | Methods of generating and using procollagen |
EP2405920A1 (en) | 2009-03-06 | 2012-01-18 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Novel therapy for anxiety |
US8758374B2 (en) | 2010-09-15 | 2014-06-24 | University Of Utah Research Foundation | Method for connecting nerves via a side-to-side epineurial window using artificial conduits |
WO2012177238A1 (en) * | 2011-06-21 | 2012-12-27 | Tamara Tennison | System and method of repairing of neural networks |
US10842494B2 (en) | 2011-10-17 | 2020-11-24 | University Of Utah Research Foundation | Methods and devices for connecting nerves |
US9931121B2 (en) | 2011-10-17 | 2018-04-03 | University Of Utah Research Foundation | Methods and devices for connecting nerves |
EP2798057B1 (en) | 2011-12-30 | 2018-08-22 | Vivex Biomedical, Inc. | Regenerative tissue matrix |
CN102716470B (zh) * | 2012-06-28 | 2015-02-04 | 中国人民解放军第三军医大学第三附属医院 | 一种治疗周围神经损伤的药物组合物 |
WO2016145452A1 (en) * | 2015-03-12 | 2016-09-15 | Myoscience, Inc. | Methods and systems for preventing neuroma formations |
US11156595B2 (en) | 2015-05-28 | 2021-10-26 | Axogen Corporation | Organotypic DRG-peripheral nerve culture system |
US11513039B2 (en) | 2015-05-28 | 2022-11-29 | Axogen Corporation | Nerve culture system |
US9690975B2 (en) | 2015-05-28 | 2017-06-27 | Axogen Corporation | Quantitative structural assay of a nerve graft |
CN105239137A (zh) * | 2015-10-29 | 2016-01-13 | 无锡桥阳机械制造有限公司 | 一种电镀工艺 |
US10064938B2 (en) | 2016-03-11 | 2018-09-04 | University Of Wyoming | Localized immunosuppression of allografts for peripheral nerve repair |
CN110475528A (zh) * | 2016-12-12 | 2019-11-19 | 加利福尼亚大学董事会 | 仿生植入物 |
WO2018127554A1 (en) * | 2017-01-06 | 2018-07-12 | Novahep Ab | Methods of preparing bioengineered or bioprinted organ or tissue, and uses thereof |
JPWO2019054407A1 (ja) * | 2017-09-15 | 2020-10-29 | 東洋紡株式会社 | 神経保護材 |
US11623022B2 (en) | 2017-11-15 | 2023-04-11 | University of Pittsburgh—of the Commonwealth System of Higher Education | Systems and methods for reconstruction of nerve defects |
WO2019200144A1 (en) * | 2018-04-12 | 2019-10-17 | Axogen Corporation | Tissue grafts with pre-made attachment points |
WO2020014889A1 (zh) * | 2018-07-18 | 2020-01-23 | 中山大学附属第一医院 | 四肢主干神经的仿生修复体模型的建立方法 |
CN108992709B (zh) * | 2018-07-27 | 2021-05-14 | 山东省眼科研究所 | 一种脱细胞神经基质材料及其制备方法和应用 |
US11376219B2 (en) | 2018-07-30 | 2022-07-05 | University Of Wyoming | Localized immunosuppression of allografts for peripheral nerve repair |
US20200054467A1 (en) * | 2018-08-20 | 2020-02-20 | Zakary Llamo-Cohen | Method for establishing an electrically conductive artificial nerve |
IL283079B2 (en) * | 2018-11-15 | 2024-01-01 | Axogen Corp | Materials and methods for nerve repair with nerve grafts of animal origin |
US11147558B2 (en) * | 2018-11-15 | 2021-10-19 | Axogen Corporation | Materials and methods for nerve repair with animal-sourced grafts |
CN109893680B (zh) * | 2019-03-07 | 2021-10-08 | 宁波光远致信生物科技有限公司 | 一种修复纤维膜、修复套接管及其制备方法和用途 |
US11998661B2 (en) * | 2020-10-22 | 2024-06-04 | Axogen Corporation | Fasciculated nerve grafts, methods of making the same, and methods of treatment using the same |
WO2022256401A1 (en) * | 2021-06-01 | 2022-12-08 | Xenotherapeutics, Inc. | Xenogeneic nerve transplants and methods |
CA3232270A1 (en) * | 2021-09-30 | 2023-04-06 | Renerva, Llc | Nerve graft systems, devices, and methods |
WO2023212531A1 (en) * | 2022-04-27 | 2023-11-02 | Board Of Regents, The University Of Texas System | Polyethylene glycol-fusion in nerve repair |
CN116570770B (zh) * | 2023-07-12 | 2023-11-07 | 天新福(北京)医疗器材股份有限公司 | 一种双层冻干管状物及其制备方法与应用 |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US40112A (en) * | 1863-09-29 | Improvement in metallic cartridges | ||
US77258A (en) * | 1868-04-28 | Improvement in weeding-hoe | ||
US4778467A (en) * | 1984-04-25 | 1988-10-18 | The University Of Utah | Prostheses and methods for promoting nerve regeneration and for inhibiting the formation of neuromas |
US4696816A (en) * | 1985-11-07 | 1987-09-29 | Brown Mark D | Method for treating intervertebral disc displacement with enzymes |
US4933185A (en) * | 1986-09-24 | 1990-06-12 | Massachusetts Institute Of Technology | System for controlled release of biologically active compounds |
US4877029A (en) * | 1987-03-30 | 1989-10-31 | Brown University Research Foundation | Semipermeable nerve guidance channels |
US4870966A (en) * | 1988-02-01 | 1989-10-03 | American Cyanamid Company | Bioabsorbable surgical device for treating nerve defects |
AU6872691A (en) | 1989-10-27 | 1991-05-31 | Case Western Reserve University | Inhibition of cell growth by keratan sulfate, chondroitin sulfate, dermatan sulfate and other glycans |
AU6734190A (en) | 1989-10-31 | 1991-05-31 | La Jolla Cancer Research Foundation | Inhibitor of laminin neurite promoting activity |
ZA912770B (en) * | 1990-04-16 | 1992-01-29 | Bethesda Eye Inst | Enzymatic disinsertion of vitreous body |
US5173295A (en) * | 1990-10-05 | 1992-12-22 | Advance Biofactures Of Curacao, N.V. | Method of enhancing the regeneration of injured nerves and adhesive pharamaceutical formulation therefor |
US5231580A (en) | 1991-04-01 | 1993-07-27 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Automated method and apparatus for determining characteristics of nerve fibers |
US5496718A (en) | 1992-06-26 | 1996-03-05 | Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) | Chondroitinase ABC isolated from proteus vulgaris ATCC 6896 |
JP3419811B2 (ja) | 1993-02-24 | 2003-06-23 | マルハ株式会社 | コンドロイチナーゼ遺伝子 |
CA2169191C (en) * | 1993-08-26 | 2008-01-15 | Elizabeth A. Wang | Neural regeneration using human bone morphogenetic proteins |
US5916557A (en) * | 1993-11-12 | 1999-06-29 | The Trustees Of Columbia University In The City Of New York | Methods of repairing connective tissues |
AU7949394A (en) * | 1993-11-19 | 1995-06-06 | Chugai Seiyaku Kabushiki Kaisha | Reconstituted human antibody against human medulloblastomatous cell |
CA2188159A1 (en) * | 1994-04-22 | 1995-11-02 | Kiran Manohar Khandke | Chondroitinases i and ii, methods of preparation, and use thereof |
US5997863A (en) * | 1994-07-08 | 1999-12-07 | Ibex Technologies R And D, Inc. | Attenuation of wound healing processes |
US6093563A (en) | 1994-07-08 | 2000-07-25 | Ibex Technologies R And D, Inc. | Chondroitin lyase enzymes |
US6214987B1 (en) * | 1994-09-02 | 2001-04-10 | Andrew C. Hiatt | Compositions for enzyme catalyzed template-independent formation of phosphodiester bonds using protected nucleotides |
US6057137A (en) * | 1994-10-06 | 2000-05-02 | Regents Of The University Of Minnesota | Tissue-equivalent rods containing aligned collagen fibrils and schwann cells |
US5487756A (en) * | 1994-12-23 | 1996-01-30 | Simon Fraser University | Implantable cuff having improved closure |
DK0807185T3 (da) | 1995-01-30 | 2002-10-07 | Lunamed Ag | Antitumorpræparater indeholdende en lipoteichoinsyre fra streptococcus |
US6033660A (en) * | 1995-05-10 | 2000-03-07 | Genentech, Inc. | Method of treating a nervous system injury with cultured schwann cells |
US5830468A (en) | 1995-05-17 | 1998-11-03 | The New York Blood Center, Inc. | Fibrin(ogen) degradation by fibrinolytic matrix metalloproteinase |
US6231608B1 (en) * | 1995-06-07 | 2001-05-15 | Crosscart, Inc. | Aldehyde and glycosidase-treated soft and bone tissue xenografts |
JP3093974B2 (ja) | 1995-06-27 | 2000-10-03 | 住友ベークライト株式会社 | 神経細胞用培養液、その製造方法及びこれを用いる神経細胞の培養方法 |
US6313265B1 (en) * | 1995-07-24 | 2001-11-06 | The Scripps Research Institute | Neurite outgrowth-promoting polypeptides containing fibronectin type III repeats and methods of use |
DE19530556C1 (de) | 1995-07-28 | 1996-09-05 | Will Prof Dr Minuth | Verfahren zum Kultivieren von Zellen des menschlichen oder tierischen Körpers |
US5866120A (en) * | 1995-11-22 | 1999-02-02 | Advanced Corneal Systems, Inc. | Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase |
SE9602879D0 (sv) * | 1996-07-26 | 1996-07-26 | Henrich Cheng | Medical device |
WO1998046258A2 (en) | 1997-04-11 | 1998-10-22 | Beth Israel Deaconess Medical Center, Inc. | Use of chondroitinase in the manufacture of a medicament in the treatment and prevention of mucoid secretions |
DE69829605T2 (de) | 1997-05-02 | 2006-02-09 | Seikagaku Corp. | Chondroitinase enthaltende Zusammensetzungen |
US6448076B2 (en) * | 1998-09-15 | 2002-09-10 | The Regents Of The University Of Michigan | Method for chemically acellularizing a biological tissue sample |
EP1119611B1 (en) * | 1998-10-06 | 2006-10-18 | Rush University Medical Center | Composition for use in chemonucleolysis |
US20030068815A1 (en) | 1999-02-11 | 2003-04-10 | Stone Kevin R. | Sterilized xenograft tissue |
US6267786B1 (en) | 1999-02-11 | 2001-07-31 | Crosscart, Inc. | Proteoglycan-reduced soft tissue xenografts |
ES2319857T3 (es) | 1999-11-17 | 2009-05-14 | Biomarin Pharmaceutical Inc. | Atenuacion de la angiogenesis mediante el uso de enzimas que degradan sulfato de condroitina. |
CA2393186A1 (en) | 1999-12-02 | 2001-06-07 | Ibex Technologies, Inc. | Attenuation of fibroblast proliferation |
AU5790801A (en) | 2000-01-21 | 2001-07-31 | Biomarin Pharmaceutical Inc. | Flavobacterium heparinum expression system |
JP4975231B2 (ja) * | 2000-07-28 | 2012-07-11 | 大日本住友製薬株式会社 | セマフォリン阻害剤を有効成分とする神経再生促進剤 |
ATE543509T1 (de) * | 2001-08-13 | 2012-02-15 | Univ Florida | Material und verfahren zur förderung der reparatur von nervengewebe |
US7638503B2 (en) * | 2004-05-26 | 2009-12-29 | California Institute Of Technology | Small molecule stimulators of neuronal growth |
-
2002
- 2002-08-13 AT AT02763451T patent/ATE543509T1/de active
- 2002-08-13 US US10/218,864 patent/US6972168B2/en not_active Expired - Lifetime
- 2002-08-13 US US10/218,315 patent/US20030077258A1/en not_active Abandoned
- 2002-08-13 EP EP02763451A patent/EP1425390B1/en not_active Expired - Lifetime
- 2002-08-13 BR BR0211888-2A patent/BR0211888A/pt not_active IP Right Cessation
- 2002-08-13 JP JP2003520377A patent/JP4749667B2/ja not_active Expired - Lifetime
- 2002-08-13 MX MXPA04001334A patent/MXPA04001334A/es active IP Right Grant
- 2002-08-13 WO PCT/US2002/025922 patent/WO2003015612A2/en active Application Filing
- 2002-08-13 ES ES02763451T patent/ES2378227T3/es not_active Expired - Lifetime
- 2002-08-13 IL IL16018802A patent/IL160188A0/xx unknown
- 2002-08-13 KR KR10-2004-7002131A patent/KR20040021697A/ko not_active Application Discontinuation
- 2002-08-13 HU HU0500634A patent/HUP0500634A3/hu unknown
- 2002-08-13 CN CNA028178866A patent/CN1553952A/zh active Pending
- 2002-08-13 US US10/218,316 patent/US7851447B2/en not_active Expired - Lifetime
- 2002-08-13 CA CA2455827A patent/CA2455827C/en not_active Expired - Lifetime
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2004
- 2004-03-29 US US10/812,776 patent/US7732200B2/en not_active Expired - Lifetime
-
2008
- 2008-08-12 US US12/190,359 patent/US20080299536A1/en not_active Abandoned
-
2010
- 2010-12-13 US US12/966,540 patent/US8986733B2/en not_active Expired - Fee Related
-
2013
- 2013-02-25 US US13/776,606 patent/US9402868B2/en not_active Expired - Lifetime
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Also Published As
Publication number | Publication date |
---|---|
JP4749667B2 (ja) | 2011-08-17 |
EP1425390A4 (en) | 2009-03-04 |
US20030072749A1 (en) | 2003-04-17 |
JP2005500375A (ja) | 2005-01-06 |
ATE543509T1 (de) | 2012-02-15 |
HUP0500634A2 (hu) | 2005-09-28 |
CA2455827C (en) | 2015-06-09 |
US8986733B2 (en) | 2015-03-24 |
CA2455827A1 (en) | 2003-02-27 |
WO2003015612A2 (en) | 2003-02-27 |
US6972168B2 (en) | 2005-12-06 |
US7851447B2 (en) | 2010-12-14 |
EP1425390A2 (en) | 2004-06-09 |
US20030077258A1 (en) | 2003-04-24 |
US20080299536A1 (en) | 2008-12-04 |
MXPA04001334A (es) | 2004-05-05 |
US20130337549A1 (en) | 2013-12-19 |
WO2003015612A9 (en) | 2004-04-29 |
US10441681B2 (en) | 2019-10-15 |
IL160188A0 (en) | 2004-07-25 |
KR20040021697A (ko) | 2004-03-10 |
ES2378227T3 (es) | 2012-04-10 |
US20110082482A1 (en) | 2011-04-07 |
CN1553952A (zh) | 2004-12-08 |
US20030040112A1 (en) | 2003-02-27 |
US9402868B2 (en) | 2016-08-02 |
EP1425390B1 (en) | 2012-02-01 |
WO2003015612A3 (en) | 2004-03-25 |
US20040180434A1 (en) | 2004-09-16 |
US7732200B2 (en) | 2010-06-08 |
HUP0500634A3 (en) | 2006-03-28 |
US20160339148A1 (en) | 2016-11-24 |
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