BR0116793A - Produtos de hormÈnio de esteróide e métodos para prepará-los - Google Patents

Produtos de hormÈnio de esteróide e métodos para prepará-los

Info

Publication number
BR0116793A
BR0116793A BR0116793-6A BR0116793A BR0116793A BR 0116793 A BR0116793 A BR 0116793A BR 0116793 A BR0116793 A BR 0116793A BR 0116793 A BR0116793 A BR 0116793A
Authority
BR
Brazil
Prior art keywords
methods
products
steroid hormone
preparing
excipient
Prior art date
Application number
BR0116793-6A
Other languages
English (en)
Other versions
BRPI0116793B8 (pt
BRPI0116793B1 (pt
Inventor
Thomas Schultz
Bradley A Clark
Angela Falzone
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of BR0116793A publication Critical patent/BR0116793A/pt
Publication of BRPI0116793B1 publication Critical patent/BRPI0116793B1/pt
Publication of BRPI0116793B8 publication Critical patent/BRPI0116793B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"PRODUTOS DE HORMÈNIO DE ESTERóIDE E MéTODOS PARA PREPARá-LOS". A presente invenção refere-se a produtos de hormónio de esteróide, tal como os produtos contraceptivos orais, incluindo pelo menos um ingrediente ativo de esteróide misturado com um excipiente e tendo propriedades de dissolução e taxa de liberação melhoradas. A invenção também refere-se a métodos de preparação de tais produtos de hormónio de esteróide, nos quais uma mistura do hormónio e o excipiente é submetida à suficiente energia mecânica para formar uma mistura de pó, na qual o hormónio é estabilizado pelo excipiente de forma substancialmente não-cristalina.
BRPI0116793A 2000-12-14 2001-12-13 produtos de hormônio de esteróide e métodos para prepará-los BRPI0116793B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25566900P 2000-12-14 2000-12-14
PCT/US2001/048862 WO2002047693A2 (en) 2000-12-14 2001-12-13 Steroid hormone products comprising a stabilizing agent in non-crystalline form

Publications (3)

Publication Number Publication Date
BR0116793A true BR0116793A (pt) 2004-01-27
BRPI0116793B1 BRPI0116793B1 (pt) 2015-06-23
BRPI0116793B8 BRPI0116793B8 (pt) 2021-05-25

Family

ID=22969374

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0116793A BRPI0116793B8 (pt) 2000-12-14 2001-12-13 produtos de hormônio de esteróide e métodos para prepará-los

Country Status (31)

Country Link
US (4) US7867990B2 (pt)
EP (2) EP1591121B1 (pt)
KR (1) KR100899032B1 (pt)
CN (1) CN1290507C (pt)
AT (2) ATE307591T1 (pt)
AU (2) AU2742102A (pt)
BG (1) BG66178B1 (pt)
BR (1) BRPI0116793B8 (pt)
CA (1) CA2431521E (pt)
CR (1) CR7022A (pt)
CY (1) CY1109404T1 (pt)
CZ (1) CZ306435B6 (pt)
DE (2) DE60114467T2 (pt)
DK (2) DK1361881T3 (pt)
EC (1) ECSP034654A (pt)
EE (1) EE05358B1 (pt)
ES (2) ES2327538T3 (pt)
HK (2) HK1057174A1 (pt)
HU (1) HU230400B1 (pt)
IL (2) IL156423A0 (pt)
ME (1) ME00339B (pt)
MX (1) MXPA03005339A (pt)
NO (2) NO334341B1 (pt)
NZ (1) NZ526517A (pt)
PT (1) PT1591121E (pt)
RS (1) RS50414B (pt)
RU (1) RU2286155C2 (pt)
SK (1) SK288222B6 (pt)
UA (1) UA77404C2 (pt)
WO (1) WO2002047693A2 (pt)
ZA (1) ZA200305342B (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6787531B1 (en) * 1999-08-31 2004-09-07 Schering Ag Pharmaceutical composition for use as a contraceptive
US20020132801A1 (en) * 2001-01-11 2002-09-19 Schering Aktiengesellschaft Drospirenone for hormone replacement therapy
WO2002047693A2 (en) * 2000-12-14 2002-06-20 Ortho-Mcneil Pharmaceutical, Inc. Steroid hormone products comprising a stabilizing agent in non-crystalline form
US7858607B2 (en) * 2003-03-14 2010-12-28 Mamchur Stephen A System for use by compounding pharmacists to produce hormone replacement medicine customized for each consumer
ES2537551T3 (es) * 2003-06-13 2015-06-09 Skendi Finance, Ltd. Formulación de estradiol-progesterona de liberación lenta
US8101244B2 (en) 2004-06-09 2012-01-24 Smithkline Beecham Corporation Apparatus and method for producing or processing a product or sample
TWI356036B (en) * 2004-06-09 2012-01-11 Smithkline Beecham Corp Apparatus and method for pharmaceutical production
EP1625849A1 (en) * 2004-08-09 2006-02-15 Liconsa, Liberacion Controlada de Sustancias Activas, S.A. Pharmaceutical composition comprising drospirenone and ethynylestradiol
US8486926B2 (en) * 2006-11-17 2013-07-16 Harbor Therapeutics, Inc. Steroid tetrol solid state forms
EP2249838A4 (en) * 2008-02-05 2012-05-02 Harbor Biosciences Inc PHARMACEUTICAL FORMS IN SOLID STATE
DK2273994T3 (en) * 2008-04-03 2016-02-01 Neurmedix Inc PHARMACEUTICAL FORMS OF A MEDICINE
EP2172190A1 (en) * 2008-10-02 2010-04-07 Laboratorios Liconsa, S.A. Inhalable particles comprising tiotropium
US10987361B2 (en) 2010-02-08 2021-04-27 Shenzhen Evergreen Therapeutics Co., Ltd. Treating auto-immune and auto-inflammatory diseases
US10993879B2 (en) 2010-02-08 2021-05-04 Shenzhen Evergreen Therapeutics Co., Ltd. Pulmonary delivery of progestogen
RU2016101363A (ru) * 2010-02-08 2018-11-21 Прэари Фармасьютикалз, Ллк Способ лечения заболеваний, связанных с глюкокортикоидной нечувствительностью
BR112014012444B1 (pt) 2011-11-23 2021-12-14 Therapeuticsmd, Inc Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
CN102793929B (zh) * 2012-09-07 2013-12-11 上海奥科达生物医药科技有限公司 一种制备稳定非晶态药物制剂的方法
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
JP2017516768A (ja) 2014-05-22 2017-06-22 セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． 天然の併用ホルモン補充療法剤及び療法
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
EP3435977A4 (en) 2016-04-01 2019-10-16 Therapeuticsmd, Inc. PHARMACEUTICAL COMPOSITION OF STEROID HORMONE
US20200129438A1 (en) * 2018-10-31 2020-04-30 Edenbridge Pharmaceuticals, LLC Finished pharmaceutical dosage form comprising a low dose/high potency active pharmaceutical ingredient and one or more excipients
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2648700A (en) * 1946-11-02 1953-08-11 Searle & Co 2-methyl-2,7-dihydroxy-octahydrophenanthrene-1-propionic acid and derivatives thereof
US2636042A (en) * 1949-07-08 1953-04-21 S B Penick And Company Water-soluble hormone compounds
US2642427A (en) * 1951-08-01 1953-06-16 Abbott Lab Piperazine salts of cyclopentanopolyhydrophenanthrene-3-monosulfates
US2666066A (en) * 1951-09-28 1954-01-12 Abbott Lab Ethylenediamine salts of cyclopen-tanopolyhydrophenanthrene-3-monosulfates
US3032469A (en) * 1958-05-02 1962-05-01 Charles E Frosst & Company Long acting steroid compounds
US3568828A (en) * 1967-03-01 1971-03-09 Squibb & Sons Inc Modified sequential oral contraceptive
US3691212A (en) * 1970-04-24 1972-09-12 British Drug Houses Ltd 17alpha-(1',3'-alkadiynyl)-17beta-acyloxy(17beta-aroyloxy) steroids
US4046874A (en) * 1974-02-13 1977-09-06 Mead Johnson & Company Soapless shave composition
US4511551A (en) * 1982-11-18 1985-04-16 Unique Technologies, Incorporated Method and composition for the detection of a precancerous or leukemic condition in mammals
US4616006A (en) * 1983-09-26 1986-10-07 Ortho Pharmaceutical Corporation Triphasic oral contraceptive
US4544554A (en) * 1983-09-26 1985-10-01 Ortho Pharmaceutical Corporation Triphasic oral contraceptive
DE3663668D1 (de) * 1985-03-07 1989-07-06 Teikoku Hormone Mfg Co Ltd 2-oxa- or aza-pregnane compounds
US4906169A (en) * 1986-12-29 1990-03-06 Rutgers, The State University Of New Jersey Transdermal estrogen/progestin dosage unit, system and process
US5407928A (en) * 1990-08-15 1995-04-18 Schering Aktiengesellschaft 11β-aryl-gona-4,9-dien-3-ones
US5344392A (en) * 1990-09-28 1994-09-06 Baxter International Inc. Method and apparatus for preparation of solutions from concentrates
FR2668945B1 (fr) * 1990-11-12 1993-02-19 Theramex Nouveau procede de cristallisation des substances organiques et les composes ainsi obtenus.
IE67345B1 (en) 1991-03-12 1996-03-20 Akzo Nv Low dose dry pharmaceutical preparations
ATE133331T1 (de) * 1991-11-13 1996-02-15 Glaxo Canada Vorrichtung zur kontrollierten wirkstoffreigabe
US5395627A (en) * 1992-09-04 1995-03-07 Akzo N.V. Pharmaceutical granulate
DE4229820C2 (de) * 1992-09-07 1998-12-03 Jenapharm Gmbh Pharmazeutische Zubereitung auf Gestagen-Basis
IT1270831B (it) * 1993-09-17 1997-05-13 Romano Deghenghi Composizioni farmaceutiche orali effervescenti contenenti estrone
US6290991B1 (en) * 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
DE4429374C1 (de) * 1994-08-12 1996-02-01 Jenapharm Gmbh Pharmazeutische Präparate zur Kontrazeption/Hormonsubstitution mit biogener Estrogenkomponente
AR004178A1 (es) 1995-07-29 1998-11-04 Smithkline Beecham Plc Procedimiento para la formulacion de un farmaco, una composicion farmaceutica obtenible mediante este procedimiento y el uso de la misma.
DE19616486C5 (de) * 1996-04-25 2016-06-30 Royalty Pharma Collection Trust Verfahren zur Senkung des Blutglukosespiegels in Säugern
US5858405A (en) * 1996-07-26 1999-01-12 American Home Products Corporation Oral contraceptive
ES2223081T3 (es) * 1996-07-26 2005-02-16 Wyeth Metodo anticonceptivo oral monofasico y kit que comprende una combinacion de progestina y estrogeno.
US6495532B1 (en) * 1997-03-19 2002-12-17 Sky High, Llc Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
TR200002995T2 (tr) * 1998-04-17 2001-01-22 Ortho-Mcneil Pharmaceutical,Inc. Folik asit ihtiva eden farmasötik bileşimler, bununla ilgili yöntemler ve uygulama sistemleri
DE19906152B4 (de) * 1999-02-10 2005-02-10 Jenapharm Gmbh & Co. Kg Wirkstoffhaltige Laminate für Transdermalsysteme
US6667050B1 (en) * 1999-04-06 2003-12-23 Galen (Chemicals) Limited Chewable oral contraceptive
WO2002047693A2 (en) * 2000-12-14 2002-06-20 Ortho-Mcneil Pharmaceutical, Inc. Steroid hormone products comprising a stabilizing agent in non-crystalline form

Also Published As

Publication number Publication date
EE05358B1 (et) 2010-12-15
KR100899032B1 (ko) 2009-05-21
HK1057174A1 (en) 2004-03-19
ATE307591T1 (de) 2005-11-15
WO2002047693A3 (en) 2002-11-07
NO20032708D0 (no) 2003-06-13
DE60139087D1 (de) 2009-08-06
HUP0400646A3 (en) 2012-08-28
US20020173669A1 (en) 2002-11-21
NO334341B1 (no) 2014-02-10
BRPI0116793B8 (pt) 2021-05-25
PT1591121E (pt) 2009-07-20
AU2742102A (en) 2002-06-24
ES2327538T3 (es) 2009-10-30
US20110046095A1 (en) 2011-02-24
AU2002227421B2 (en) 2007-08-23
DE60114467T2 (de) 2006-07-20
EP1591121A1 (en) 2005-11-02
MXPA03005339A (es) 2004-03-26
EP1361881A2 (en) 2003-11-19
CN1290507C (zh) 2006-12-20
DE60114467D1 (de) 2005-12-01
ECSP034654A (es) 2003-07-25
CN1489468A (zh) 2004-04-14
CA2431521C (en) 2010-03-16
ZA200305342B (en) 2004-10-11
CR7022A (es) 2009-02-23
ES2253451T3 (es) 2006-06-01
EE200300229A (et) 2003-08-15
UA77404C2 (en) 2006-12-15
ATE434439T1 (de) 2009-07-15
RS50414B (sr) 2009-12-31
HU230400B1 (hu) 2016-04-28
RU2003121240A (ru) 2005-02-10
EP1361881B1 (en) 2005-10-26
BRPI0116793B1 (pt) 2015-06-23
CA2431521E (en) 2013-04-16
NO20131334L (no) 2003-07-04
CZ20031896A3 (en) 2004-03-17
CZ306435B6 (cs) 2017-01-25
ME00339B (me) 2011-05-10
NZ526517A (en) 2005-09-30
HK1083457A1 (en) 2006-07-07
CA2431521A1 (en) 2002-06-20
HUP0400646A2 (hu) 2004-06-28
EP1591121B1 (en) 2009-06-24
YU47903A (sh) 2006-08-17
CY1109404T1 (el) 2014-07-02
WO2002047693A2 (en) 2002-06-20
KR20030061856A (ko) 2003-07-22
US20110046099A1 (en) 2011-02-24
MEP48808A (en) 2011-02-10
NO20032708L (no) 2003-07-04
SK288222B6 (sk) 2014-09-04
DK1361881T3 (da) 2006-02-20
IL156423A (en) 2010-04-29
SK8802003A3 (en) 2004-04-06
US20140309204A1 (en) 2014-10-16
DK1591121T3 (da) 2009-10-05
US7867990B2 (en) 2011-01-11
BG107958A (bg) 2004-11-30
BG66178B1 (bg) 2011-11-30
RU2286155C2 (ru) 2006-10-27
IL156423A0 (en) 2004-01-04

Similar Documents

Publication Publication Date Title
BR0116793A (pt) Produtos de hormÈnio de esteróide e métodos para prepará-los
PT102548A (pt) Formulacao farmaceutica para administracao por injeccao do composto 7alfa-¬9-(4,4,5,5,5-pentafluoropentilsulfinil)-nonil| estra-1,3,5(10)-trieno-3,17beta-diol (fulvestrant)
BR9808888A (pt) Formas de dosagem e método de melhorar disfunção erétil masculina
PT1137400E (pt) Composicoes contendo um peptideo e um acido polilactico-glicolico apropriado para preparar implantes subscutaneos com um periodo de libertacao prolongado
ES2174920T3 (es) Producto de combinacion para la contracepcion que contiene agentes antagonistas de progesterona y un agente gestageno.
BR9915285A (pt) Composição farmacêutica para liberação modificada de um sensitivador de insulina e um outro agente antidiabético
CO5190672A1 (es) Composicion para la dosificacion oral, de disolucion instantanea
BR0014142A (pt) Composição de vacina e método de empregar a mesma
BRPI0400214A (pt) Composições e aplicações farmacêuticas para a obtenção confiável de nìveis aceitáveis de testosterona no soro
BR0210261A (pt) Formulações farmacêuticas para a administração eficiente de apomorfina, 6ar-(-)-n-propil-norapomorfina e seus derivados e pró-drogas destes
TW200514560A (en) Pharmaceutical formulation for contraception and hormone-replacement therapy
ITMI20040367A1 (it) Processo per la preparazione di drospirenone
BR0312054A (pt) Uso de derivados de tio-oxindol na preparação de medicamentos úteis no tratamento de condições relacionadas com hormÈnio, e kit farmacêutico
BR0210595A (pt) Regime de dosagem e composição farmacêutica para contracepção de emergência
BR9812404A (pt) Combinação de um antagonista de endotelina, preparação farmacêutica, processo para preparar uma preparação farmacêutica, e , uso de uma combinação de um bloqueador de beta receptor e de um antagonista de endotelina
LT2002035A (lt) Mezoprogestinai (progesterono receptoriaus moduliatoriai) kaip moterų kontraceptikų komponentas
TW200640468A (en) Pharmaceutical product for oral contraception
TR200301552A1 (tr) Rofekoksib' in yeni oral farmakolojik formülasyonları.
PE20020520A1 (es) Uso de antiprogestinas para la profilaxis y el tratamiento de enfermedades dependientes de hormonas
BR0016092A (pt) Composto, uso de um composto kit para contracepção hormonal em um macho, e, método de tratamento

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Free format text: JOHNSON & JOHNSON (US)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/06/2015, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 13/12/2001 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 13/12/2021