BR0113628A - 7-oxopyridopyrimidines as inhibitors of cell proliferation - Google Patents

7-oxopyridopyrimidines as inhibitors of cell proliferation

Info

Publication number
BR0113628A
BR0113628A BR0113628-3A BR0113628A BR0113628A BR 0113628 A BR0113628 A BR 0113628A BR 0113628 A BR0113628 A BR 0113628A BR 0113628 A BR0113628 A BR 0113628A
Authority
BR
Brazil
Prior art keywords
alkyl
cycloalkyl
hydrogen
heterocyclyl
aryl
Prior art date
Application number
BR0113628-3A
Other languages
Portuguese (pt)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0113628A publication Critical patent/BR0113628A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

"7-OXO-PIRIDOPIRIMIDINAS COMO INIBIDORES DE UMA PROLIFERAçãO CELULAR". Compostos de fórmula (I) nos quais R^ 1^ é hidrogênio ou alquila; R^ 2^ é cicloalquila substituída, cicloalquila heterossubstituída, cicloalquila heteroalquilsubstituída, cicloalquil-arila heterossubstituída, heterociclila, heterociclil espiro cicloalquila, aralcóxi, alcóxi, -alquileno-S(O)~ n~-alquila (onde n é 1 ou 2) ou -SO~ 2~Ar^ 2^; R^ 3^ é hidrogênio, amino, monoalquilamino, dialquilamino, acilamino, -NR^ a^-C(=O)-R^ b^ (onde R^ a^ é hidrogênio ou alquila e R^ b^ heterociclila ou heteroalquila), alquila, cicloalquila, arila, aralquila, haloalquila, heteroalquila, cianoalquila, -alquileno-C(O)-R (onde R é hidrogênio, alquila, hidróxi, alcóxi, amino, monoalquilamino ou dialquilamino), acila, ou ftalimidoalquila; e cada um dentre Ar^ 1^ e Ar^ 2^ é independentemente arila, e seu emprego para o tratamento de distúrbios selecionados do grupo consistindo em artrite, doença de Crohn, doença de Alzheimer, síndrome do intestino irritável, síndrome da dificuldade respiratória do adulto, e doença pulmonar obstrutiva crónica."7-OXYPYROPYPYRIMIDINES AS INHIBITORS OF CELL PROLIFERATION". Compounds of formula (I) wherein R2 is hydrogen or alkyl; R 2 is substituted cycloalkyl, heterosubstituted cycloalkyl, heterosubstituted cycloalkyl, heterosubstituted cycloalkyl aryl, heterocyclyl, heterocyclyl spiro cycloalkyl, aralkoxy, alkoxy, S (O) n -alkyl (where n is 1 or 2) -SO-2-Ar ^ 2 ^; R3 is hydrogen, amino, monoalkylamino, dialkylamino, acylamino, -NR4 a4 -C (= O) -R4b4 (where R4a4 is hydrogen or alkyl and R4b4 heterocyclyl or heteroalkyl) alkyl, cycloalkyl, aryl, aralkyl, haloalkyl, heteroalkyl, cyanoalkyl, -C (O) alkylene -R (where R is hydrogen, alkyl, hydroxy, alkoxy, amino, monoalkylamino or dialkylamino), acyl, or phthalimidoalkyl; and each of Ar ^ 1 ^ and Ar ^ 2 ^ is independently aryl, and its use for the treatment of disorders selected from the group consisting of arthritis, Crohn's disease, Alzheimer's disease, irritable bowel syndrome, respiratory distress syndrome. adult, and chronic obstructive pulmonary disease.

BR0113628-3A 2000-08-31 2001-08-22 7-oxopyridopyrimidines as inhibitors of cell proliferation BR0113628A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22958400P 2000-08-31 2000-08-31
PCT/EP2001/009689 WO2002018380A1 (en) 2000-08-31 2001-08-22 7-oxo pyridopyrimidines as inhibitors of a cellular proliferation

Publications (1)

Publication Number Publication Date
BR0113628A true BR0113628A (en) 2003-07-01

Family

ID=22861859

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0113628-3A BR0113628A (en) 2000-08-31 2001-08-22 7-oxopyridopyrimidines as inhibitors of cell proliferation

Country Status (15)

Country Link
EP (1) EP1315726A1 (en)
JP (1) JP4141830B2 (en)
KR (1) KR100571339B1 (en)
CN (1) CN1275964C (en)
AR (1) AR033681A1 (en)
AU (2) AU9378401A (en)
BR (1) BR0113628A (en)
CA (1) CA2420286A1 (en)
GT (1) GT200100191A (en)
MX (1) MXPA03001821A (en)
PA (1) PA8527301A1 (en)
PE (1) PE20020406A1 (en)
UY (1) UY26918A1 (en)
WO (1) WO2002018380A1 (en)
ZA (1) ZA200301079B (en)

Families Citing this family (34)

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Publication number Priority date Publication date Assignee Title
US6518276B2 (en) 2000-08-31 2003-02-11 Syntex (U.S.A.) Llc 7-oxo-pyridopyrimidines (II)
BR0113590A (en) * 2000-08-31 2003-07-22 Hoffmann La Roche 7-oxopyridopyrimidines
AU2003215675B2 (en) * 2002-04-03 2007-07-12 F. Hoffmann-La Roche Ag Imidazo fused compounds
PL373339A1 (en) * 2002-04-19 2005-08-22 Smithkline Beecham Corporation Novel compounds
US7084270B2 (en) 2002-08-14 2006-08-01 Hoffman-La Roche Inc. Pyrimido compounds having antiproliferative activity
UY27939A1 (en) 2002-08-21 2004-03-31 Glaxo Group Ltd COMPOUNDS
US7129351B2 (en) 2002-11-04 2006-10-31 Hoffmann-La Roche Inc. Pyrimido compounds having antiproliferative activity
DE60327097D1 (en) * 2002-11-18 2009-05-20 Hoffmann La Roche DIAZINOPYRIMIDINE AND ITS USE AS PROTEIN KINASE INHIBITORS
US7098332B2 (en) 2002-12-20 2006-08-29 Hoffmann-La Roche Inc. 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones
BRPI0409366A (en) 2003-04-10 2006-04-25 Hoffmann La Roche pyrimidine compounds
CA2539190A1 (en) * 2003-07-07 2005-01-27 George F. Vande Woude Inhibition of tumor angiogenesis by combination of thrombospondin-1 and inhibitors of vascular endothelial growth factor
NZ546634A (en) * 2003-11-13 2010-01-29 Hoffmann La Roche Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones
WO2005105097A2 (en) * 2004-04-28 2005-11-10 Gpc Biotech Ag Pyridopyrimidines for treating inflammatory and other diseases
US20070054916A1 (en) * 2004-10-01 2007-03-08 Amgen Inc. Aryl nitrogen-containing bicyclic compounds and methods of use
WO2006056863A1 (en) * 2004-11-23 2006-06-01 Ranbaxy Laboratories Limited Pyrido’2, 3-d!pyrimidines as anti-inflammatory agents
WO2006082492A1 (en) * 2005-02-02 2006-08-10 Ranbaxy Laboratories Limited Azabicyclo derivatives as anti-inflammatory agents
EP1931667A1 (en) * 2005-09-28 2008-06-18 Ranbaxy Laboratories Limited Pyrido-pyridimidine derivatives useful as antiinflammatory agents
DE602007001952D1 (en) 2006-01-31 2009-09-24 Hoffmann La Roche 7H-PYRIDOÄ3,4-DÜPYRIMIDIN-8-ONE, THEIR PREPARATION AND THEIR USE AS PROTEIN KINASE INHIBITORS
KR100661523B1 (en) * 2006-06-09 2006-12-26 주식회사 청용산기 Box correcting device of stitching progress for carton box erecting
EP1914234A1 (en) 2006-10-16 2008-04-23 GPC Biotech Inc. Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors
CN101535308A (en) 2006-11-09 2009-09-16 霍夫曼-拉罗奇有限公司 Substituted 6-phenyl-pyrido [2,3-D] pyrimidin-7-one derivatives as kinase inhibitors and methods for using the same
WO2008078249A1 (en) * 2006-12-21 2008-07-03 Ranbaxy Laboratories Limited Anti-inflammatory agents
EP2112150B1 (en) 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Improved raf inhibitors
KR101106162B1 (en) * 2010-04-20 2012-01-20 주식회사 청용산기 Stitching device for packing box making apparatus
TR201816480T4 (en) * 2012-03-22 2018-11-21 Oscotec Inc SUBSTITUTED PYRIDOPYRIMIDE COMPOUNDS AND USES AS FLT3 INHIBITORS.
CN105307657B (en) 2013-03-15 2020-07-10 西建卡尔有限责任公司 Heteroaryl compounds and uses thereof
AR095464A1 (en) 2013-03-15 2015-10-21 Celgene Avilomics Res Inc HETEROARILO COMPOUNDS AND USES OF THE SAME
EP3943087A1 (en) 2013-03-15 2022-01-26 Celgene CAR LLC Heteroaryl compounds and uses thereof
HUE040387T2 (en) 2014-09-12 2019-03-28 Biolab Sanus Farmaceutica Ltda Derivatives of pyridopyrimidines
WO2019071144A1 (en) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. Use of p38 inhibitors to reduce expression of dux4
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
CN113508115A (en) 2019-01-03 2021-10-15 基因泰克公司 Pyridopyrimidinone and pteridinone compounds as inhibitors of endoribonuclease inositol requiring enzyme I (IRE I A) for the treatment of cancer diseases
TW202110841A (en) * 2019-05-31 2021-03-16 美商阿吉歐斯製藥公司 Heterobicyclic inhibitors of mat2a and methods of use for treating cancer
CN115960098A (en) * 2020-09-11 2023-04-14 上海凌达生物医药有限公司 Preparation method and application of nitrogen-containing fused ring compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
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EP0790997B1 (en) * 1994-11-14 2000-03-22 Warner-Lambert Company 6-ARYL PYRIDO[2,3-d]PYRIMIDINES AND NAPHTHYRIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION
IL117923A (en) * 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
ES2310039T3 (en) * 1998-05-26 2008-12-16 Warner-Lambert Company Llc BICYCLE PYRIMIDINES AND BICYCLE 3,4-DIHYDROPIRIMIDINS AS INHIBITORS OF CELL PROLIFERATION.

Also Published As

Publication number Publication date
PE20020406A1 (en) 2002-05-17
KR20030022422A (en) 2003-03-15
PA8527301A1 (en) 2002-07-30
AR033681A1 (en) 2004-01-07
ZA200301079B (en) 2004-05-07
WO2002018380A1 (en) 2002-03-07
EP1315726A1 (en) 2003-06-04
CN1275964C (en) 2006-09-20
GT200100191A (en) 2002-05-16
JP2004507541A (en) 2004-03-11
CA2420286A1 (en) 2002-03-07
KR100571339B1 (en) 2006-04-17
MXPA03001821A (en) 2003-06-04
UY26918A1 (en) 2002-02-28
JP4141830B2 (en) 2008-08-27
CN1451005A (en) 2003-10-22
AU9378401A (en) 2002-03-13
AU2001293784B2 (en) 2007-08-30

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Legal Events

Date Code Title Description
B07A Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.