AR033681A1 - A COMPOUND DERIVED FROM 7-OXO-PYRIDOPIRIMIDINES, A PROCESS FOR OBTAINING IT, A COMPOSITION THAT CONTAINS IT AND A METHOD OF MANUFACTURE OF A MEDICINAL PRODUCT - Google Patents
A COMPOUND DERIVED FROM 7-OXO-PYRIDOPIRIMIDINES, A PROCESS FOR OBTAINING IT, A COMPOSITION THAT CONTAINS IT AND A METHOD OF MANUFACTURE OF A MEDICINAL PRODUCTInfo
- Publication number
- AR033681A1 AR033681A1 ARP010104132A ARP010104132A AR033681A1 AR 033681 A1 AR033681 A1 AR 033681A1 AR P010104132 A ARP010104132 A AR P010104132A AR P010104132 A ARP010104132 A AR P010104132A AR 033681 A1 AR033681 A1 AR 033681A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkyl
- hydrogen
- oxo
- compound derived
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Un compuesto derivado de 7-oxo-piridopirimidina de fórmula (1) en la cual R1 es hidrógeno o alquilo; R2 es cicloalquilo sustituido, cicloalquilo heterosustituido, cicloalquilo heteroalquilsustituido, cicloalquilalquilo, heterosustituido, heterociclilo, heterociclilo- espiro-cicloalquilo, aralcoxi, alcoxi, alquil-S(O)n-alquileno-(en el que n es el número 1 o 2) o -SO2-Ar2;; R3 es hidrogeno, amino, monoalquilamino, dialquilamino, acilamino, -NRa-C(=O)-Rb (en el que Ra es hidrógeno o alquilo y Rb es heterociclilo o heteroalquilo), alquilo, cicloalquilo, arilo, aralquilo, haloalquilo, heteroalquilo, cianoalquilo, -alquileno-C(O)-R (en el que R es hidrógeno, alquilo, hidroxi, alcoxi, amino, monoalquilamino o dialquilamino), acilo o ftalimidoalquilo; y Ar1 y Ar2 con independencia entre sí son en cada caso arilo; o sales farmacéuticamente aceptables o profármacos del mismo. Un proceso para su obtención, una composición que lo contiene y un método para la fabricación de un medicamento. El compuesto derivado de 7-oxo-piridopirimidina es útil para los trastornos causados por p38, en el que el trastorno causado por p38 se selecciona entre la artritis, la enfermedad de Crohn, la enfermedad de Alzheimer, el síndrome de intestino irritable, el síndrome de la deficiencia respiratoria adulta y la enfermedad pulmonar obstructiva crónica.A compound derived from 7-oxo-pyridopyrimidine of formula (1) in which R1 is hydrogen or alkyl; R2 is substituted cycloalkyl, heterosubstituted cycloalkyl, substituted heteroalkyl cycloalkyl, cycloalkylalkyl, hetero substituted, heterocyclyl, heterocyclyl-spiro-cycloalkyl, aralkoxy, alkoxy, alkyl-S (O) n-alkylene- (in which n is number 1 or 2) -SO2-Ar2 ;; R3 is hydrogen, amino, monoalkylamino, dialkylamino, acylamino, -NRa-C (= O) -Rb (where Ra is hydrogen or alkyl and Rb is heterocyclyl or heteroalkyl), alkyl, cycloalkyl, aryl, aralkyl, haloalkyl, heteroalkyl , cyanoalkyl, -alkylene-C (O) -R (where R is hydrogen, alkyl, hydroxy, alkoxy, amino, monoalkylamino or dialkylamino), acyl or phthalimidoalkyl; and Ar1 and Ar2 independently of each other are in each case aryl; or pharmaceutically acceptable salts or prodrugs thereof. A process for obtaining it, a composition that contains it and a method for the manufacture of a medicine. The compound derived from 7-oxo-pyridopyrimidine is useful for disorders caused by p38, in which the disorder caused by p38 is selected from arthritis, Crohn's disease, Alzheimer's disease, irritable bowel syndrome, syndrome of adult respiratory deficiency and chronic obstructive pulmonary disease.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22958400P | 2000-08-31 | 2000-08-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR033681A1 true AR033681A1 (en) | 2004-01-07 |
Family
ID=22861859
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010104132A AR033681A1 (en) | 2000-08-31 | 2001-08-30 | A COMPOUND DERIVED FROM 7-OXO-PYRIDOPIRIMIDINES, A PROCESS FOR OBTAINING IT, A COMPOSITION THAT CONTAINS IT AND A METHOD OF MANUFACTURE OF A MEDICINAL PRODUCT |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP1315726A1 (en) |
JP (1) | JP4141830B2 (en) |
KR (1) | KR100571339B1 (en) |
CN (1) | CN1275964C (en) |
AR (1) | AR033681A1 (en) |
AU (2) | AU9378401A (en) |
BR (1) | BR0113628A (en) |
CA (1) | CA2420286A1 (en) |
GT (1) | GT200100191A (en) |
MX (1) | MXPA03001821A (en) |
PA (1) | PA8527301A1 (en) |
PE (1) | PE20020406A1 (en) |
UY (1) | UY26918A1 (en) |
WO (1) | WO2002018380A1 (en) |
ZA (1) | ZA200301079B (en) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA03001733A (en) * | 2000-08-31 | 2003-05-27 | Hoffmann La Roche | 7-oxo pyridopyrimidines. |
US6518276B2 (en) | 2000-08-31 | 2003-02-11 | Syntex (U.S.A.) Llc | 7-oxo-pyridopyrimidines (II) |
EP1492790A1 (en) * | 2002-04-03 | 2005-01-05 | F. Hoffmann-La Roche Ag | Imidazo fused compounds |
PL373339A1 (en) * | 2002-04-19 | 2005-08-22 | Smithkline Beecham Corporation | Novel compounds |
US7084270B2 (en) | 2002-08-14 | 2006-08-01 | Hoffman-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
UY27939A1 (en) | 2002-08-21 | 2004-03-31 | Glaxo Group Ltd | COMPOUNDS |
US7112676B2 (en) | 2002-11-04 | 2006-09-26 | Hoffmann-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
JP2006514624A (en) * | 2002-11-18 | 2006-05-11 | エフ.ホフマン−ラ ロシュ アーゲー | Diazinopyrimidines |
US7098332B2 (en) | 2002-12-20 | 2006-08-29 | Hoffmann-La Roche Inc. | 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones |
EP1615928A1 (en) | 2003-04-10 | 2006-01-18 | F.Hoffmann-La Roche Ag | Pyrimido compounds |
ATE451115T1 (en) * | 2003-07-07 | 2009-12-15 | Van Andel Res Inst | INHIBITION OF TUMOR ANGIOGENESIS BY A COMBINATION OF THROMBOSPONDIN-1 AND VASCULAR ENDOTHELIAL GROWTH FACTOR INHIBITORS |
DK1685131T3 (en) * | 2003-11-13 | 2007-07-09 | Hoffmann La Roche | Hydroxyalkyl-substituted pyrido-7-pyrimidin-7-ones |
WO2005105097A2 (en) * | 2004-04-28 | 2005-11-10 | Gpc Biotech Ag | Pyridopyrimidines for treating inflammatory and other diseases |
US20070054916A1 (en) * | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
WO2006056863A1 (en) * | 2004-11-23 | 2006-06-01 | Ranbaxy Laboratories Limited | Pyrido’2, 3-d!pyrimidines as anti-inflammatory agents |
WO2006082492A1 (en) * | 2005-02-02 | 2006-08-10 | Ranbaxy Laboratories Limited | Azabicyclo derivatives as anti-inflammatory agents |
EP1931667A1 (en) * | 2005-09-28 | 2008-06-18 | Ranbaxy Laboratories Limited | Pyrido-pyridimidine derivatives useful as antiinflammatory agents |
CN101374840B (en) | 2006-01-31 | 2011-09-28 | 霍夫曼-拉罗奇有限公司 | 7h-pyrido[3,4-d]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors |
KR100661523B1 (en) * | 2006-06-09 | 2006-12-26 | 주식회사 청용산기 | Box correcting device of stitching progress for carton box erecting |
EP1914234A1 (en) | 2006-10-16 | 2008-04-23 | GPC Biotech Inc. | Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors |
EP2094698A1 (en) | 2006-11-09 | 2009-09-02 | F. Hoffmann-Roche AG | Substituted 6-phenyl-pyrido [2,3-d]pyrimidin-7-one derivatives as kinase inhibitors and methods for using the same |
WO2008078249A1 (en) * | 2006-12-21 | 2008-07-03 | Ranbaxy Laboratories Limited | Anti-inflammatory agents |
EP2112150B1 (en) | 2008-04-22 | 2013-10-16 | Forma Therapeutics, Inc. | Improved raf inhibitors |
KR101106162B1 (en) * | 2010-04-20 | 2012-01-20 | 주식회사 청용산기 | Stitching device for packing box making apparatus |
ES2694223T3 (en) * | 2012-03-22 | 2018-12-19 | Oscotec, Inc. | Pyridopyrimidine compounds and their use as FLT3 inhibitors |
CN111793068A (en) | 2013-03-15 | 2020-10-20 | 西建卡尔有限责任公司 | Heteroaryl compounds and uses thereof |
US9321786B2 (en) | 2013-03-15 | 2016-04-26 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
EP3943087A1 (en) | 2013-03-15 | 2022-01-26 | Celgene CAR LLC | Heteroaryl compounds and uses thereof |
CA2958331C (en) | 2014-09-12 | 2019-12-17 | Biolab Sanus Farmaceutica Ltda. | New pyridopyrimidines derivatives compounds |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
CA3128468A1 (en) | 2017-10-05 | 2019-04-11 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd |
TWI748317B (en) | 2019-01-03 | 2021-12-01 | 美商建南德克公司 | Pyrido-pyrimidinone and pteridinone compounds and methods of use |
PE20220387A1 (en) * | 2019-05-31 | 2022-03-18 | Servier Lab | HETEROBICYCLIC MAT2A INHIBITORS AND METHODS OF USE FOR THE TREATMENT OF CANCER |
WO2022052924A1 (en) * | 2020-09-11 | 2022-03-17 | 上海凌达生物医药有限公司 | Preparation method for class of nitrogen-containing fused ring compounds and use thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0790997B1 (en) * | 1994-11-14 | 2000-03-22 | Warner-Lambert Company | 6-ARYL PYRIDO[2,3-d]PYRIMIDINES AND NAPHTHYRIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION |
IL117923A (en) * | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
ID27589A (en) * | 1998-05-26 | 2001-04-12 | Warner Lambert Comapny | BICYCLIC PYYRIMINE AND DIHYDROPIRYMIDINE BICYCLIC 3,4 AS A RESULTS OF MOBILE PROLIFERATION |
-
2001
- 2001-08-22 AU AU9378401A patent/AU9378401A/en active Pending
- 2001-08-22 KR KR1020037002936A patent/KR100571339B1/en not_active IP Right Cessation
- 2001-08-22 AU AU2001293784A patent/AU2001293784B2/en not_active Ceased
- 2001-08-22 MX MXPA03001821A patent/MXPA03001821A/en active IP Right Grant
- 2001-08-22 BR BR0113628-3A patent/BR0113628A/en not_active Application Discontinuation
- 2001-08-22 CA CA002420286A patent/CA2420286A1/en not_active Abandoned
- 2001-08-22 WO PCT/EP2001/009689 patent/WO2002018380A1/en not_active Application Discontinuation
- 2001-08-22 JP JP2002523895A patent/JP4141830B2/en not_active Expired - Fee Related
- 2001-08-22 CN CNB018150306A patent/CN1275964C/en not_active Expired - Fee Related
- 2001-08-22 EP EP01974206A patent/EP1315726A1/en not_active Withdrawn
- 2001-08-28 PE PE2001000860A patent/PE20020406A1/en not_active Application Discontinuation
- 2001-08-28 PA PA20018527301A patent/PA8527301A1/en unknown
- 2001-08-30 AR ARP010104132A patent/AR033681A1/en unknown
- 2001-08-30 UY UY26918A patent/UY26918A1/en not_active Application Discontinuation
- 2001-09-18 GT GT200100191A patent/GT200100191A/en unknown
-
2003
- 2003-02-07 ZA ZA200301079A patent/ZA200301079B/en unknown
Also Published As
Publication number | Publication date |
---|---|
MXPA03001821A (en) | 2003-06-04 |
AU2001293784B2 (en) | 2007-08-30 |
BR0113628A (en) | 2003-07-01 |
UY26918A1 (en) | 2002-02-28 |
CN1451005A (en) | 2003-10-22 |
ZA200301079B (en) | 2004-05-07 |
JP4141830B2 (en) | 2008-08-27 |
CN1275964C (en) | 2006-09-20 |
KR100571339B1 (en) | 2006-04-17 |
AU9378401A (en) | 2002-03-13 |
CA2420286A1 (en) | 2002-03-07 |
JP2004507541A (en) | 2004-03-11 |
PE20020406A1 (en) | 2002-05-17 |
WO2002018380A1 (en) | 2002-03-07 |
GT200100191A (en) | 2002-05-16 |
PA8527301A1 (en) | 2002-07-30 |
EP1315726A1 (en) | 2003-06-04 |
KR20030022422A (en) | 2003-03-15 |
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