BR0113628A - 7-oxo-piridopirimidinas como inibidores de uma proliferação celular - Google Patents

7-oxo-piridopirimidinas como inibidores de uma proliferação celular

Info

Publication number
BR0113628A
BR0113628A BR0113628-3A BR0113628A BR0113628A BR 0113628 A BR0113628 A BR 0113628A BR 0113628 A BR0113628 A BR 0113628A BR 0113628 A BR0113628 A BR 0113628A
Authority
BR
Brazil
Prior art keywords
alkyl
cycloalkyl
hydrogen
heterocyclyl
aryl
Prior art date
Application number
BR0113628-3A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0113628A publication Critical patent/BR0113628A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

"7-OXO-PIRIDOPIRIMIDINAS COMO INIBIDORES DE UMA PROLIFERAçãO CELULAR". Compostos de fórmula (I) nos quais R^ 1^ é hidrogênio ou alquila; R^ 2^ é cicloalquila substituída, cicloalquila heterossubstituída, cicloalquila heteroalquilsubstituída, cicloalquil-arila heterossubstituída, heterociclila, heterociclil espiro cicloalquila, aralcóxi, alcóxi, -alquileno-S(O)~ n~-alquila (onde n é 1 ou 2) ou -SO~ 2~Ar^ 2^; R^ 3^ é hidrogênio, amino, monoalquilamino, dialquilamino, acilamino, -NR^ a^-C(=O)-R^ b^ (onde R^ a^ é hidrogênio ou alquila e R^ b^ heterociclila ou heteroalquila), alquila, cicloalquila, arila, aralquila, haloalquila, heteroalquila, cianoalquila, -alquileno-C(O)-R (onde R é hidrogênio, alquila, hidróxi, alcóxi, amino, monoalquilamino ou dialquilamino), acila, ou ftalimidoalquila; e cada um dentre Ar^ 1^ e Ar^ 2^ é independentemente arila, e seu emprego para o tratamento de distúrbios selecionados do grupo consistindo em artrite, doença de Crohn, doença de Alzheimer, síndrome do intestino irritável, síndrome da dificuldade respiratória do adulto, e doença pulmonar obstrutiva crónica.
BR0113628-3A 2000-08-31 2001-08-22 7-oxo-piridopirimidinas como inibidores de uma proliferação celular BR0113628A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22958400P 2000-08-31 2000-08-31
PCT/EP2001/009689 WO2002018380A1 (en) 2000-08-31 2001-08-22 7-oxo pyridopyrimidines as inhibitors of a cellular proliferation

Publications (1)

Publication Number Publication Date
BR0113628A true BR0113628A (pt) 2003-07-01

Family

ID=22861859

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0113628-3A BR0113628A (pt) 2000-08-31 2001-08-22 7-oxo-piridopirimidinas como inibidores de uma proliferação celular

Country Status (15)

Country Link
EP (1) EP1315726A1 (pt)
JP (1) JP4141830B2 (pt)
KR (1) KR100571339B1 (pt)
CN (1) CN1275964C (pt)
AR (1) AR033681A1 (pt)
AU (2) AU9378401A (pt)
BR (1) BR0113628A (pt)
CA (1) CA2420286A1 (pt)
GT (1) GT200100191A (pt)
MX (1) MXPA03001821A (pt)
PA (1) PA8527301A1 (pt)
PE (1) PE20020406A1 (pt)
UY (1) UY26918A1 (pt)
WO (1) WO2002018380A1 (pt)
ZA (1) ZA200301079B (pt)

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US6518276B2 (en) 2000-08-31 2003-02-11 Syntex (U.S.A.) Llc 7-oxo-pyridopyrimidines (II)
BR0113590A (pt) * 2000-08-31 2003-07-22 Hoffmann La Roche 7-oxo-piridopirimidinas
AU2003215675B2 (en) * 2002-04-03 2007-07-12 F. Hoffmann-La Roche Ag Imidazo fused compounds
PL373339A1 (en) * 2002-04-19 2005-08-22 Smithkline Beecham Corporation Novel compounds
US7084270B2 (en) 2002-08-14 2006-08-01 Hoffman-La Roche Inc. Pyrimido compounds having antiproliferative activity
UY27939A1 (es) 2002-08-21 2004-03-31 Glaxo Group Ltd Compuestos
US7129351B2 (en) 2002-11-04 2006-10-31 Hoffmann-La Roche Inc. Pyrimido compounds having antiproliferative activity
DE60327097D1 (de) * 2002-11-18 2009-05-20 Hoffmann La Roche Diazinopyrimidine und ihre verwendung als proteinkinaseinhibitoren
US7098332B2 (en) 2002-12-20 2006-08-29 Hoffmann-La Roche Inc. 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones
BRPI0409366A (pt) 2003-04-10 2006-04-25 Hoffmann La Roche compostos de pirimido
CA2539190A1 (en) * 2003-07-07 2005-01-27 George F. Vande Woude Inhibition of tumor angiogenesis by combination of thrombospondin-1 and inhibitors of vascular endothelial growth factor
NZ546634A (en) * 2003-11-13 2010-01-29 Hoffmann La Roche Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones
WO2005105097A2 (en) * 2004-04-28 2005-11-10 Gpc Biotech Ag Pyridopyrimidines for treating inflammatory and other diseases
US20070054916A1 (en) * 2004-10-01 2007-03-08 Amgen Inc. Aryl nitrogen-containing bicyclic compounds and methods of use
WO2006056863A1 (en) * 2004-11-23 2006-06-01 Ranbaxy Laboratories Limited Pyrido’2, 3-d!pyrimidines as anti-inflammatory agents
WO2006082492A1 (en) * 2005-02-02 2006-08-10 Ranbaxy Laboratories Limited Azabicyclo derivatives as anti-inflammatory agents
EP1931667A1 (en) * 2005-09-28 2008-06-18 Ranbaxy Laboratories Limited Pyrido-pyridimidine derivatives useful as antiinflammatory agents
DE602007001952D1 (de) 2006-01-31 2009-09-24 Hoffmann La Roche 7h-pyridoä3,4-düpyrimidin-8-one, ihre herstellung und ihre verwendung als proteinkinaseinhibitoren
KR100661523B1 (ko) * 2006-06-09 2006-12-26 주식회사 청용산기 포장박스 제조장치에 장착되는 개선된 비틀림 교정 장치
EP1914234A1 (en) 2006-10-16 2008-04-23 GPC Biotech Inc. Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors
CN101535308A (zh) 2006-11-09 2009-09-16 霍夫曼-拉罗奇有限公司 作为激酶抑制剂的取代的6-苯基-吡啶并[2，3-d]嘧啶-7-酮衍生物及其使用方法
WO2008078249A1 (en) * 2006-12-21 2008-07-03 Ranbaxy Laboratories Limited Anti-inflammatory agents
EP2112150B1 (en) 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Improved raf inhibitors
KR101106162B1 (ko) * 2010-04-20 2012-01-20 주식회사 청용산기 포장박스 제조장치용 스티칭 장치에 있어서의 하역가이드 지지유닛
TR201816480T4 (tr) * 2012-03-22 2018-11-21 Oscotec Inc İkame edi̇lmi̇ş pi̇ri̇dopi̇ri̇mi̇di̇n bi̇leşi̇kleri̇ ve flt3 i̇nhi̇bi̇törleri̇ olarak kullanimlari.
CN105307657B (zh) 2013-03-15 2020-07-10 西建卡尔有限责任公司 杂芳基化合物和其用途
AR095464A1 (es) 2013-03-15 2015-10-21 Celgene Avilomics Res Inc Compuestos de heteroarilo y usos de los mismos
EP3943087A1 (en) 2013-03-15 2022-01-26 Celgene CAR LLC Heteroaryl compounds and uses thereof
HUE040387T2 (hu) 2014-09-12 2019-03-28 Biolab Sanus Farmaceutica Ltda Piridopirimidin-származékok
WO2019071144A1 (en) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. USE OF P38 INHIBITORS TO REDUCE DUX4 EXPRESSION
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
CN113508115A (zh) 2019-01-03 2021-10-15 基因泰克公司 吡啶并嘧啶酮和蝶啶酮化合物作为需要酶i(ire i α)的内切核糖核酸酶肌醇的抑制剂用于治疗癌症疾病
TW202110841A (zh) * 2019-05-31 2021-03-16 美商阿吉歐斯製藥公司 Ｍａｔ２ａ之雜雙環抑制劑及用於治療癌症之使用方法
CN115960098A (zh) * 2020-09-11 2023-04-14 上海凌达生物医药有限公司 一类含氮稠环类化合物的制备方法和用途

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0790997B1 (en) * 1994-11-14 2000-03-22 Warner-Lambert Company 6-ARYL PYRIDO[2,3-d]PYRIMIDINES AND NAPHTHYRIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION
IL117923A (en) * 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
ES2310039T3 (es) * 1998-05-26 2008-12-16 Warner-Lambert Company Llc Pirimidinas biciclicas y 3,4-dihidropirimidinas biciclicas como inhibidores de la proliferacion celular.

Also Published As

Publication number Publication date
PE20020406A1 (es) 2002-05-17
KR20030022422A (ko) 2003-03-15
PA8527301A1 (es) 2002-07-30
AR033681A1 (es) 2004-01-07
ZA200301079B (en) 2004-05-07
WO2002018380A1 (en) 2002-03-07
EP1315726A1 (en) 2003-06-04
CN1275964C (zh) 2006-09-20
GT200100191A (es) 2002-05-16
JP2004507541A (ja) 2004-03-11
CA2420286A1 (en) 2002-03-07
KR100571339B1 (ko) 2006-04-17
MXPA03001821A (es) 2003-06-04
UY26918A1 (es) 2002-02-28
JP4141830B2 (ja) 2008-08-27
CN1451005A (zh) 2003-10-22
AU9378401A (en) 2002-03-13
AU2001293784B2 (en) 2007-08-30

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Legal Events

Date Code Title Description
B07A Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.