BG33888A3 - Method for producing crystal hydrate of sin- isomer of natrium salt of 3- acetoxymethyl ester of 7- making open mean bracket 2- (2- amino- 4- thiazolyl)- 2- methoxyimino- acetamido closing mean bracket- cef- 3- em- 4- carbonic acid - Google Patents

Method for producing crystal hydrate of sin- isomer of natrium salt of 3- acetoxymethyl ester of 7- making open mean bracket 2- (2- amino- 4- thiazolyl)- 2- methoxyimino- acetamido closing mean bracket- cef- 3- em- 4- carbonic acid

Info

Publication number: BG33888A3
Authority: BG; Bulgaria
Prior art keywords: bracket; mean; cef; methoxyimino; acetamido
Prior art date: 1977-08-17

Application number

BG042035A

Other languages

Bulgarian (bg)

English (en)

Inventor

Gaston Amiard

Dieter Bormann

Walter Duerckheimer

Jean Jolly

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-08-17

Filing date

1978-08-15

Publication date

1983-05-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9194564&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG33888(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1978-08-15 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1983-05-16 Publication of BG33888A3 publication Critical patent/BG33888A3/xx

Links

-1 2- (2- amino- 4- thiazolyl)- 2- methoxyimino- acetamido Chemical group 0.000 title 1
KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 title 1
239000013078 crystal Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
150000002148 esters Chemical class 0.000 abstract 1
159000000000 sodium salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BG042035A 1977-08-17 1978-08-15 Method for producing crystal hydrate of sin- isomer of natrium salt of 3- acetoxymethyl ester of 7- making open mean bracket 2- (2- amino- 4- thiazolyl)- 2- methoxyimino- acetamido closing mean bracket- cef- 3- em- 4- carbonic acid BG33888A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR7725142A FR2400519A1 (fr)	1977-08-17	1977-08-17	Forme cristalline du sel de sodium d'un derive oximine de l'acide 7-amino-thiazolyl acetamido cephalosporanique, son procede de preparation et son application comme medicament

Publications (1)

Publication Number	Publication Date
BG33888A3 true BG33888A3 (en)	1983-05-16

Family

ID=9194564

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
BG042035A BG33888A3 (en)	1977-08-17	1978-08-15	Method for producing crystal hydrate of sin- isomer of natrium salt of 3- acetoxymethyl ester of 7- making open mean bracket 2- (2- amino- 4- thiazolyl)- 2- methoxyimino- acetamido closing mean bracket- cef- 3- em- 4- carbonic acid
BG040671A BG33887A3 (en)	1977-08-17	1978-08-15	Method for producing crystal hydrate of sin- isomer of natrium salt of 3- acetoxymethyl ester of 7- making open mean bracket 2- (2- amino- 4- thiazolyl)- 2- methoxyimino- acetamido closing mean bracket- cef- 3- em- 4- carbonic acid

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
BG040671A BG33887A3 (en)	1977-08-17	1978-08-15	Method for producing crystal hydrate of sin- isomer of natrium salt of 3- acetoxymethyl ester of 7- making open mean bracket 2- (2- amino- 4- thiazolyl)- 2- methoxyimino- acetamido closing mean bracket- cef- 3- em- 4- carbonic acid

Country Status (34)

Country	Link
US (1)	US4224371A (da)
EP (1)	EP0001024B1 (da)
JP (1)	JPS5441890A (da)
AT (2)	AT366049B (da)
AU (1)	AU520898B2 (da)
BG (2)	BG33888A3 (da)
CA (1)	CA1121343A (da)
CS (2)	CS207646B2 (da)
DD (1)	DD137588A5 (da)
DE (1)	DE2860358D1 (da)
DK (2)	DK152213C (da)
EG (1)	EG13520A (da)
ES (1)	ES472381A1 (da)
FI (1)	FI65433C (da)
FR (1)	FR2400519A1 (da)
GE (2)	GEP19960475B (da)
GR (1)	GR73661B (da)
HR (1)	HRP931395B1 (da)
HU (1)	HU181497B (da)
IE (1)	IE47230B1 (da)
IL (1)	IL55186A (da)
IT (1)	IT1107961B (da)
MD (2)	MD247C2 (da)
MX (2)	MX155976A (da)
NO (1)	NO156168C (da)
NZ (1)	NZ188163A (da)
OA (1)	OA06016A (da)
PL (1)	PL126619B1 (da)
PT (1)	PT68431A (da)
RO (1)	RO79999A (da)
SI (1)	SI7811917A8 (da)
SU (2)	SU799666A3 (da)
YU (1)	YU42166B (da)
ZA (1)	ZA784187B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60120886A (ja) *	1983-12-02	1985-06-28	Takeda Chem Ind Ltd	セフェムカルボン酸のナトリウム塩の結晶
JPS60142987A (ja) *	1983-12-29	1985-07-29	Mochida Pharmaceut Co Ltd	セフアロスポリン誘導体
DE150507T1 (de) *	1983-12-29	1987-02-26	Mochida Pharmaceutical Co., Ltd., Tokio/Tokyo	Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
US4840945A (en) *	1985-04-01	1989-06-20	Mochida Pharmaceutical Co., Ltd.	Cephalosporin derivatives
DE3650526T2 (de) *	1985-08-12	1996-10-31	Upjohn Co	Umwandlung des cephalosporin-hydrohalid-salzes zu einem alkalimetallsalz
JPS63132893A (ja) *	1986-11-25	1988-06-04	Mochida Pharmaceut Co Ltd	新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤
US4880798A (en) *	1986-11-25	1989-11-14	Mochida Pharmaceutical Co., Ltd.	Cephalosporin derivatives
RU2021274C1 (ru)	1991-05-17	1994-10-15	Польска Акадэмия Наук Институт Хэмии Органичнэй	Способ получения аминотиазолильных производных цефалоспорина
US5318781A (en) *	1993-04-06	1994-06-07	Hoffmann-La Roche Inc.	Absorption enhancement of antibiotics
US5574154A (en) *	1994-09-29	1996-11-12	Alnejma Bulk Pharmaceutical Co. A.B.P.C.	Process for the preparation of cephalosporanic compounds
GB9423459D0 (en) *	1994-11-21	1995-01-11	Biochemie Gmbh	Silylation process
AT402928B (de) *	1994-12-23	1997-09-25	Biochemie Gmbh	Neues verfahren zur herstellung von cefotaxim
AU690482B2 (en) *	1996-03-18	1998-04-23	Ranbaxy Laboratories Limited	Process for producing cephalosporin antibiotics
GB9717629D0 (en) *	1997-08-21	1997-10-22	Johnson Matthey Plc	Removal of residual organic solvents
WO2001092254A1 (fr) *	2000-05-30	2001-12-06	Fujisawa Pharmaceutical Co., Ltd.	Procede permettant de remplacer des solvants contenus dans des cristaux de type clathrates
WO2004063203A1 (en) *	2003-01-10	2004-07-29	Orchid Chemicals & Pharmaceuticals Ltd	Process for the preparation of cefotaxime sodium
CN100361995C (zh) *	2004-10-27	2008-01-16	山东瑞阳制药有限公司	注射级无菌头孢噻肟钠的一步法制备工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3970651A (en) *	1974-01-07	1976-07-20	Bristol-Myers Company	Crystalline cephalosporin derivative
US3985747A (en) *	1974-05-24	1976-10-12	Bristol-Myers Company	Crystalline sesquihydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
DK154939C (da) *	1974-12-19	1989-06-12	Takeda Chemical Industries Ltd	Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
US4006138A (en) *	1975-04-11	1977-02-01	Eli Lilly And Company	Crystalline form of sodium O-formylcefamandole
DE2760123C2 (de) *	1976-01-23	1986-04-30	Roussel-Uclaf, Paris	7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
SE440655B (sv) *	1976-01-23	1985-08-12	Roussel Uclaf	Sett att framstella nya oximderivat av 7-amino-tiazolyl-acetamido-cefalosporansyra

1977
- 1977-08-17 FR FR7725142A patent/FR2400519A1/fr active Granted
1978
- 1978-07-20 IL IL55186A patent/IL55186A/xx active IP Right Grant
- 1978-07-22 OA OA56566A patent/OA06016A/xx unknown
- 1978-07-24 ZA ZA00784187A patent/ZA784187B/xx unknown
- 1978-08-02 DD DD78207090A patent/DD137588A5/xx unknown
- 1978-08-03 EP EP78400072A patent/EP0001024B1/fr not_active Expired
- 1978-08-03 AT AT0563578A patent/AT366049B/de not_active IP Right Cessation
- 1978-08-03 DE DE7878400072T patent/DE2860358D1/de not_active Expired
- 1978-08-04 ES ES472381A patent/ES472381A1/es not_active Expired
- 1978-08-08 CS CS785183A patent/CS207646B2/cs unknown
- 1978-08-08 IT IT50648/78A patent/IT1107961B/it active Protection Beyond IP Right Term
- 1978-08-09 SU SU782645701A patent/SU799666A3/ru active
- 1978-08-10 SI SI7811917A patent/SI7811917A8/sl unknown
- 1978-08-10 US US05/932,437 patent/US4224371A/en not_active Expired - Lifetime
- 1978-08-10 YU YU1917/78A patent/YU42166B/xx unknown
- 1978-08-11 MX MX7926A patent/MX155976A/es unknown
- 1978-08-11 GR GR56985A patent/GR73661B/el unknown
- 1978-08-11 MX MX787309U patent/MX5448E/es unknown
- 1978-08-15 BG BG042035A patent/BG33888A3/xx unknown
- 1978-08-15 BG BG040671A patent/BG33887A3/xx unknown
- 1978-08-16 EG EG510/78A patent/EG13520A/xx active
- 1978-08-16 NO NO782782A patent/NO156168C/no unknown
- 1978-08-16 AU AU38965/78A patent/AU520898B2/en not_active Expired
- 1978-08-16 DK DK361078A patent/DK152213C/da not_active IP Right Cessation
- 1978-08-16 RO RO78101982A patent/RO79999A/ro unknown
- 1978-08-16 PT PT68431A patent/PT68431A/pt unknown
- 1978-08-16 FI FI782494A patent/FI65433C/fi not_active IP Right Cessation
- 1978-08-16 HU HU78RO993A patent/HU181497B/hu unknown
- 1978-08-16 NZ NZ188163A patent/NZ188163A/xx unknown
- 1978-08-16 CA CA000309454A patent/CA1121343A/fr not_active Expired
- 1978-08-16 PL PL1978209080A patent/PL126619B1/pl unknown
- 1978-08-17 JP JP9958078A patent/JPS5441890A/ja active Granted
- 1978-08-17 IE IE1669/78A patent/IE47230B1/en not_active IP Right Cessation
1979
- 1979-06-27 CS CS794439A patent/CS207647B2/cs unknown
1980
- 1980-01-31 AT AT0052280A patent/AT366050B/de not_active IP Right Cessation
- 1980-03-12 SU SU802891755A patent/SU852175A3/ru active
1986
- 1986-04-09 DK DK159786A patent/DK163514C/da not_active IP Right Cessation
1993
- 1993-07-31 GE GEAP19931371A patent/GEP19960475B/en unknown
- 1993-07-31 GE GEAP19931355A patent/GEP19960476B/en unknown
- 1993-11-11 HR HRP-1917/78A patent/HRP931395B1/xx not_active IP Right Cessation
1994
- 1994-09-08 MD MD94-0275A patent/MD247C2/ro unknown
- 1994-09-08 MD MD94-0267A patent/MD225C2/ro unknown

Also Published As

Publication number	Publication date
MD247B1 (ro)	1995-07-31
EP0001024A1 (fr)	1979-03-07
BG33887A3 (en)	1983-05-16
EG13520A (en)	1982-03-31
DK159786D0 (da)	1986-04-09
ATA52280A (de)	1981-07-15
IE781669L (en)	1979-02-17
DK152213B (da)	1988-02-08
HRP931395B1 (en)	1996-04-30
PL209080A1 (pl)	1979-06-04
PL126619B1 (en)	1983-08-31
NO156168B (no)	1987-04-27
DK361078A (da)	1979-02-18
GEP19960476B (en)	1996-07-22
AU520898B2 (en)	1982-03-04
AU3896578A (en)	1980-02-21
SI7811917A8 (en)	1997-12-31
US4224371A (en)	1980-09-23
DK163514B (da)	1992-03-09
IL55186A0 (en)	1978-09-29
MD225C2 (ro)	1995-12-31
JPS5441890A (en)	1979-04-03
FI65433B (fi)	1984-01-31
EP0001024B1 (fr)	1981-01-21
IL55186A (en)	1981-07-31
GEP19960475B (en)	1996-07-22
SU852175A3 (ru)	1981-07-30
CS207647B2 (en)	1981-08-31
MX5448E (es)	1983-08-09
DK163514C (da)	1992-07-27
GR73661B (da)	1984-03-28
ZA784187B (en)	1979-09-26
MD247C2 (ro)	1995-12-31
ATA563578A (de)	1981-07-15
AT366049B (de)	1982-03-10
IT1107961B (it)	1985-12-02
FI782494A (fi)	1979-02-18
FR2400519A1 (fr)	1979-03-16
HU181497B (en)	1983-07-28
DD137588A5 (de)	1979-09-12
DE2860358D1 (en)	1981-03-12
AT366050B (de)	1982-03-10
DK152213C (da)	1988-07-11
JPS6145626B2 (da)	1986-10-08
IT7850648A0 (it)	1978-08-08
FI65433C (fi)	1984-05-10
DK159786A (da)	1986-04-09
YU42166B (en)	1988-06-30
NO156168C (no)	1987-08-19
ES472381A1 (es)	1979-03-16
IE47230B1 (en)	1984-01-25
CS207646B2 (en)	1981-08-31
OA06016A (fr)	1981-06-30
CA1121343A (fr)	1982-04-06
MD225B1 (ro)	1995-06-30
FR2400519B1 (da)	1980-05-16
YU191778A (en)	1983-02-28
NO782782L (no)	1979-02-20
RO79999A (ro)	1982-10-11
MX155976A (es)	1988-06-06
PT68431A (fr)	1978-09-01
NZ188163A (en)	1981-10-19
SU799666A3 (ru)	1981-01-23

Publication	Publication Date	Title
BG33888A3 (en)	1983-05-16	Method for producing crystal hydrate of sin- isomer of natrium salt of 3- acetoxymethyl ester of 7- making open mean bracket 2- (2- amino- 4- thiazolyl)- 2- methoxyimino- acetamido closing mean bracket- cef- 3- em- 4- carbonic acid
PT66353A (fr)	1977-04-01	Procede de preparation de nouvelles alcoyloximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique
JPS5430194A (en)	1979-03-06	Cephalosporin derivative and its preparation
ES8503339A1 (es)	1985-02-16	Procedimiento para la obtencion de tetrahidropiridazinonas
NL7801779A (nl)	1978-09-27	Werkwijze voor het bereiden van kristallen van natriumcarbonaatmonohydraat.
ES412859A1 (es)	1976-06-01	Un procedimiento para la preparacion de un derivado de 7- (alfa hidroxi-alfa-fenil) acetamido - 3 - (1 - metil - 1h - tetrazol - 5 - iltiometil) cefalosporina.
LU79313A1 (fr)	1978-11-03	Procede de preparation de nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique
RO80298A (ro)	1982-12-06	Procedeu pentru prepararea unor derivati triazolil-alchenici
MA20109A1 (fr)	1984-12-31	Procede de preparation de composes de cepheme
LU79080A1 (fr)	1978-09-28	Procede de preparation de nouvelles oximes derivees de 1'acide 3-thiadiazolyl thiomethyl 7-amino thiazolyl acetamido cephalosporanique
YU297976A (en)	1983-04-30	Process for preparing the crystalline from of the cefacetrial sodium salt
BG34904A3 (en)	1983-12-15	Method for preparing d- sesquisodium salt of oxa- beta- lactam
JPS5515454A (en)	1980-02-02	Novel cephalosporin derivative
IT1078470B (it)	1985-05-08	Procedimento per la produzione di derivati di acido cefalosporanico
JPS5315395A (en)	1978-02-13	Cephalosporin derivatives and their preparation
GB1508314A (en)	1978-04-19	7-alpha-methoxy-7-beta-(substituted-acetamido)-cephalosporins and methods for their preparation
ES443372A1 (es)	1977-12-01	Un procedimiento para la preparacion de derivados del acido 3-cefem-4-carboxilico.
IT1011242B (it)	1977-01-20	Procedimento per produrre sali di zinco di 2 mercapto benzotiazolo o 2 mercapto benzimidazolo
JPS5414968A (en)	1979-02-03	Production of biganite derivative heterocyclic five membered calboxylic acid salt
ES438894A1 (es)	1977-08-16	Procedimiento de obtencion de los esteres de hidroxibencil- cefalosporinas y sus sales.