BG33294A3 - Method for obtaining the derivatives of 4- dezacetyl- vincaledcoblactine c- 3- carboxyhydrazid - Google Patents

Method for obtaining the derivatives of 4- dezacetyl- vincaledcoblactine c- 3- carboxyhydrazid

Info

Publication number: BG33294A3
Authority: BG; Bulgaria
Prior art keywords: obtaining; derivatives; vincaledcoblactine; dezacetyl; carboxyhydrazid
Prior art date: 1978-04-20

Application number

BG043323A

Other languages

Bulgarian (bg)

English (en)

Inventor

George Cullinan

Koert Gerzon

Original Assignee

Eli Lilly And Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-04-20

Filing date

1979-04-20

Publication date

1983-01-14

1979-04-20 Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company

1983-01-14 Publication of BG33294A3 publication Critical patent/BG33294A3/xx

Links

229960003048 vinblastine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

BG043323A 1978-04-20 1979-04-20 Method for obtaining the derivatives of 4- dezacetyl- vincaledcoblactine c- 3- carboxyhydrazid BG33294A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/899,032 US4166810A (en)	1978-04-20	1978-04-20	Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (1)

Publication Number	Publication Date
BG33294A3 true BG33294A3 (en)	1983-01-14

Family

ID=25410402

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
BG056469A BG33296A3 (en)	1978-04-20	1979-04-20	Method for obtaining the derivatives of 4- dezacetyl- vincalevcoblastine c- 3- carboxyhydrazid
BG056470A BG33297A3 (en)	1978-04-20	1979-04-20	Method for obtaining the derivatives of 4- dezacetyl- vinkalevcoblastine c- 3- carbrxyhydrazid
BG043323A BG33294A3 (en)	1978-04-20	1979-04-20	Method for obtaining the derivatives of 4- dezacetyl- vincaledcoblactine c- 3- carboxyhydrazid

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
BG056469A BG33296A3 (en)	1978-04-20	1979-04-20	Method for obtaining the derivatives of 4- dezacetyl- vincalevcoblastine c- 3- carboxyhydrazid
BG056470A BG33297A3 (en)	1978-04-20	1979-04-20	Method for obtaining the derivatives of 4- dezacetyl- vinkalevcoblastine c- 3- carbrxyhydrazid

Country Status (32)

Country	Link
US (1)	US4166810A (cs)
EP (1)	EP0005051B1 (cs)
JP (1)	JPS54141798A (cs)
AR (1)	AR228940A1 (cs)
AT (1)	AT369010B (cs)
AU (1)	AU527109B2 (cs)
BE (1)	BE875652A (cs)
BG (3)	BG33296A3 (cs)
CA (1)	CA1097629A (cs)
CH (1)	CH643269A5 (cs)
CS (3)	CS218583B2 (cs)
DD (1)	DD143075A5 (cs)
DE (1)	DE2964130D1 (cs)
DK (1)	DK147484C (cs)
EG (1)	EG14867A (cs)
ES (2)	ES479753A1 (cs)
FI (1)	FI791286A (cs)
FR (1)	FR2423495A1 (cs)
GB (1)	GB2019396B (cs)
GR (1)	GR69987B (cs)
HU (1)	HU181431B (cs)
IE (1)	IE48213B1 (cs)
IL (1)	IL57168A (cs)
LU (1)	LU81166A1 (cs)
NZ (1)	NZ190213A (cs)
PH (1)	PH14163A (cs)
PL (3)	PL215911A1 (cs)
PT (1)	PT69496A (cs)
RO (3)	RO81114A (cs)
SU (3)	SU1225490A3 (cs)
YU (1)	YU93179A (cs)
ZA (1)	ZA791856B (cs)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4322351A (en) *	1980-08-25	1982-03-30	Eli Lilly And Company	Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
EP0123441B1 (en) *	1983-03-30	1990-10-03	Lilly Industries Limited	Vincaleukoblastine derivatives
US4675400A (en) *	1985-06-17	1987-06-23	Eli Lilly And Company	Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) *	1985-06-17	1987-05-19	Eli Lilly And Company	Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4801688A (en) *	1986-05-27	1989-01-31	Eli Lilly And Company	Hydrazone immunoglobulin conjugates
US5043336A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5043340A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
WO2002085908A1 (en) *	2001-04-24	2002-10-31	Purdue Research Foundation	Folate mimetics and folate-receptor binding conjugates thereof
WO2003097647A1 (en) *	2002-05-15	2003-11-27	Endocyte, Inc.	Vitamin-mitomycin conjugates
CA2512867C (en)	2003-01-27	2014-08-26	Endocyte, Inc.	Vitamin receptor binding drug delivery conjugates
US8288557B2 (en) *	2004-07-23	2012-10-16	Endocyte, Inc.	Bivalent linkers and conjugates thereof
JP5289935B2 (ja) *	2005-03-16	2013-09-11	エンドサイト，インコーポレイテッド	プテロイン酸およびその結合体の合成と精製
KR101364912B1 (ko) *	2005-08-19	2014-02-21	엔도사이트, 인코포레이티드	복수-약제 리간드 공액체
EP2382995A3 (en)	2005-08-19	2013-09-25	Endocyte, Inc.	Ligand conjugates of Vinca alkaloids, analogs and derivatives
US20100087370A1 (en) *	2007-02-14	2010-04-08	The General Hospital Corporation	Modulation of nitric oxide signaling to normalize tumor vasculature
US20100104626A1 (en) *	2007-02-16	2010-04-29	Endocyte, Inc.	Methods and compositions for treating and diagnosing kidney disease
CN104127878A (zh) *	2007-03-14	2014-11-05	恩多塞特公司	结合配体连接的微管溶素递药缀合物
JP5690589B2 (ja) *	2007-06-25	2015-03-25	エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ，Ｉｎｃ．	親水性スペーサーリンカーを含有する結合体
US9877965B2 (en)	2007-06-25	2018-01-30	Endocyte, Inc.	Vitamin receptor drug delivery conjugates for treating inflammation
JP2011500835A (ja)	2007-10-25	2011-01-06	エンドサイト，インコーポレイテッド	チューブリシン類および調製プロセス
ES2574032T3 (es) *	2009-09-07	2016-06-14	Nipro Patch Co., Ltd.	Preparación absorbible por vía transdérmica
WO2013126797A1 (en)	2012-02-24	2013-08-29	Purdue Research Foundation	Cholecystokinin b receptor targeting for imaging and therapy
US20140080175A1 (en)	2012-03-29	2014-03-20	Endocyte, Inc.	Processes for preparing tubulysin derivatives and conjugates thereof
CN104869998A (zh)	2012-10-16	2015-08-26	恩多塞特公司	含有非天然氨基酸的药物递送缀合物以及其使用方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine
US3205220A (en) *	1961-10-26	1965-09-07	Lilly Co Eli	Leurosidine and leurocristine and their production
US3392173A (en) *	1964-03-09	1968-07-09	Lilly Co Eli	Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) *	1964-04-27	1968-02-20	Lilly Co Eli	Leurosine
US3387001A (en) *	1964-10-19	1968-06-04	Lilly Co Eli	Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) *	1974-05-06	1975-06-03	Lilly Co Eli	Vincadioline
US3890325A (en) *	1974-05-15	1975-06-17	Lilly Co Eli	Leurocolombine
US3954773A (en) *	1974-11-21	1976-05-04	Eli Lilly And Company	4-Desacetoxyvinblastine
IL48685A (en)	1975-01-09	1980-03-31	Lilly Co Eli	Amides of vincadioline and vinblastine
US3944554A (en) *	1975-01-09	1976-03-16	Eli Lilly And Company	4-Desacetoxy-3-hydroxyvinblastine
US4029663A (en) *	1975-07-10	1977-06-14	Eli Lilly And Company	Dimeric anhydro-vinca derivatives
US4115388A (en) *	1977-03-30	1978-09-19	Eli Lilly And Company	3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

1978
- 1978-04-20 US US05/899,032 patent/US4166810A/en not_active Expired - Lifetime
1979
- 1979-04-17 PH PH23391A patent/PH14163A/en unknown
- 1979-04-17 PT PT69496A patent/PT69496A/pt unknown
- 1979-04-17 JP JP4715279A patent/JPS54141798A/ja active Granted
- 1979-04-18 NZ NZ190213A patent/NZ190213A/xx unknown
- 1979-04-18 GR GR58950A patent/GR69987B/el unknown
- 1979-04-18 AT AT0291279A patent/AT369010B/de not_active IP Right Cessation
- 1979-04-18 YU YU00931/79A patent/YU93179A/xx unknown
- 1979-04-18 DE DE7979300638T patent/DE2964130D1/de not_active Expired
- 1979-04-18 RO RO79102376A patent/RO81114A/ro unknown
- 1979-04-18 EG EG238/79A patent/EG14867A/xx active
- 1979-04-18 AU AU46097/79A patent/AU527109B2/en not_active Ceased
- 1979-04-18 LU LU81166A patent/LU81166A1/xx unknown
- 1979-04-18 RO RO7997290A patent/RO80084A/ro unknown
- 1979-04-18 RO RO79102377A patent/RO81037A/ro unknown
- 1979-04-18 GB GB7913460A patent/GB2019396B/en not_active Expired
- 1979-04-18 BE BE1/9358A patent/BE875652A/xx unknown
- 1979-04-18 EP EP79300638A patent/EP0005051B1/en not_active Expired
- 1979-04-19 CA CA325,844A patent/CA1097629A/en not_active Expired
- 1979-04-19 ES ES479753A patent/ES479753A1/es not_active Expired
- 1979-04-19 PL PL21591179A patent/PL215911A1/xx unknown
- 1979-04-19 CH CH370779A patent/CH643269A5/fr not_active IP Right Cessation
- 1979-04-19 PL PL1979230538A patent/PL125470B1/pl unknown
- 1979-04-19 CS CS792678A patent/CS218583B2/cs unknown
- 1979-04-19 DK DK160679A patent/DK147484C/da not_active IP Right Cessation
- 1979-04-19 CS CS807545A patent/CS218584B2/cs unknown
- 1979-04-19 CS CS807546A patent/CS218585B2/cs unknown
- 1979-04-19 ZA ZA791856A patent/ZA791856B/xx unknown
- 1979-04-19 ES ES479754A patent/ES479754A1/es not_active Expired
- 1979-04-19 PL PL1979215011A patent/PL119416B1/pl unknown
- 1979-04-19 HU HU79EI850A patent/HU181431B/hu not_active IP Right Cessation
- 1979-04-19 FR FR7909874A patent/FR2423495A1/fr active Granted
- 1979-04-19 FI FI791286A patent/FI791286A/fi not_active Application Discontinuation
- 1979-04-20 BG BG056469A patent/BG33296A3/xx unknown
- 1979-04-20 DD DD79212369A patent/DD143075A5/de unknown
- 1979-04-20 BG BG056470A patent/BG33297A3/xx unknown
- 1979-04-20 SU SU792925606A patent/SU1225490A3/ru active
- 1979-04-20 SU SU792759650A patent/SU893135A3/ru active
- 1979-04-20 AR AR276248A patent/AR228940A1/es active
- 1979-04-20 BG BG043323A patent/BG33294A3/xx unknown
- 1979-04-29 IL IL57168A patent/IL57168A/xx unknown
- 1979-08-08 IE IE795/79A patent/IE48213B1/en unknown
1980
- 1980-05-26 SU SU802925605A patent/SU1061698A3/ru active

Also Published As

Publication number	Publication date
LU81166A1 (fr)	1979-09-07
FI791286A (fi)	1979-10-21
AU4609779A (en)	1979-10-25
IL57168A0 (en)	1979-07-25
PH14163A (en)	1981-03-19
ATA291279A (de)	1982-04-15
RO81114B (ro)	1983-01-30
ZA791856B (en)	1980-11-26
RO81037A (ro)	1983-02-01
RO80084B (ro)	1983-01-30
IL57168A (en)	1983-10-31
FR2423495A1 (fr)	1979-11-16
JPS54141798A (en)	1979-11-05
DD143075A5 (de)	1980-07-30
GB2019396A (en)	1979-10-31
RO80084A (ro)	1983-02-01
YU93179A (en)	1983-01-21
US4166810A (en)	1979-09-04
NZ190213A (en)	1982-12-21
BE875652A (fr)	1979-10-18
DK160679A (da)	1979-10-21
ES479754A1 (es)	1980-08-16
CS218584B2 (en)	1983-02-25
DE2964130D1 (en)	1983-01-05
GB2019396B (en)	1982-09-15
DK147484C (da)	1985-03-25
BG33296A3 (en)	1983-01-14
CS218585B2 (en)	1983-02-25
AU527109B2 (en)	1983-02-17
BG33297A3 (en)	1983-01-14
HU181431B (en)	1983-07-28
AR228940A1 (es)	1983-05-13
RO81114A (ro)	1983-02-01
SU1061698A3 (ru)	1983-12-15
EG14867A (en)	1986-09-30
SU893135A3 (ru)	1981-12-23
DK147484B (da)	1984-08-27
CA1097629A (en)	1981-03-17
FR2423495B1 (cs)	1983-02-11
IE790795L (en)	1979-10-20
CH643269A5 (fr)	1984-05-30
SU1225490A3 (ru)	1986-04-15
PL125470B1 (en)	1983-05-31
EP0005051B1 (en)	1982-12-01
AT369010B (de)	1982-11-25
IE48213B1 (en)	1984-10-31
PL215911A1 (cs)	1980-03-24
JPS6245873B2 (cs)	1987-09-29
RO81037B (ro)	1983-01-30
GR69987B (cs)	1982-07-22
PT69496A (en)	1979-05-01
ES479753A1 (es)	1980-08-16
PL119416B1 (en)	1981-12-31
CS218583B2 (en)	1983-02-25
EP0005051A1 (en)	1979-10-31

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