BG25090A3 - A method of obtaining 5,9-beta-substituted-2-tetrahydrofurfuryl-6,7-benzomorphanes and their salts - Google Patents

A method of obtaining 5,9-beta-substituted-2-tetrahydrofurfuryl-6,7-benzomorphanes and their salts

Info

Publication number: BG25090A3
Authority: BG; Bulgaria
Prior art keywords: benzomorphanes; tetrahydrofurfuryl; beta; salts; substituted
Prior art date: 1974-08-05

Application number

BG031843A

Other languages

Bulgarian (bg)

English (en)

Inventor

Herbert Merz

Adolf Langbein

Gerhard Walther

Klaus Stockhaus

Original Assignee

C.H.Boehringer Sohn

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-08-05

Filing date

1975-08-02

Publication date

1978-07-12

1975-08-02 Application filed by C.H.Boehringer Sohn filed Critical C.H.Boehringer Sohn

1978-07-12 Publication of BG25090A3 publication Critical patent/BG25090A3/xx

Links

150000003839 salts Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BG031843A 1974-08-05 1975-08-02 A method of obtaining 5,9-beta-substituted-2-tetrahydrofurfuryl-6,7-benzomorphanes and their salts BG25090A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2437610A DE2437610A1 (de)	1974-08-05	1974-08-05	Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung

Publications (1)

Publication Number	Publication Date
BG25090A3 true BG25090A3 (en)	1978-07-12

Family

ID=5922448

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
BG031843A BG25090A3 (en)	1974-08-05	1975-08-02	A method of obtaining 5,9-beta-substituted-2-tetrahydrofurfuryl-6,7-benzomorphanes and their salts
BG031842A BG25089A3 (en)	1974-08-05	1975-08-02	A method of obtaining 5,9-beta-substituted-2-tetrahydrofurfuryl-6,7-benzomorphanes and their salts
BG030726A BG25088A3 (en)	1974-08-05	1975-08-02	A method of obtaining 5,9-beta-substituted-2-tetrahydrofurfuryl-6,7-benzomorphanes and their salts

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
BG031842A BG25089A3 (en)	1974-08-05	1975-08-02	A method of obtaining 5,9-beta-substituted-2-tetrahydrofurfuryl-6,7-benzomorphanes and their salts
BG030726A BG25088A3 (en)	1974-08-05	1975-08-02	A method of obtaining 5,9-beta-substituted-2-tetrahydrofurfuryl-6,7-benzomorphanes and their salts

Country Status (27)

Country	Link
US (1)	US3982005A (fi)
JP (1)	JPS60358B2 (fi)
AT (1)	AT348140B (fi)
BE (1)	BE832099R (fi)
BG (3)	BG25090A3 (fi)
CA (1)	CA1049008A (fi)
CH (7)	CH613963A5 (fi)
CS (1)	CS189717B2 (fi)
DD (1)	DD122685A5 (fi)
DE (1)	DE2437610A1 (fi)
DK (1)	DK138992C (fi)
ES (6)	ES452765A1 (fi)
FI (1)	FI63229C (fi)
FR (1)	FR2320096A2 (fi)
GB (1)	GB1513950A (fi)
HU (1)	HU177952B (fi)
IE (1)	IE42216B1 (fi)
IL (1)	IL47860A (fi)
LU (1)	LU73138A1 (fi)
NL (1)	NL7509249A (fi)
NO (1)	NO143460C (fi)
PH (1)	PH13687A (fi)
PL (3)	PL99819B1 (fi)
RO (3)	RO67390A (fi)
SE (1)	SE425392B (fi)
SU (3)	SU591147A3 (fi)
ZA (1)	ZA754997B (fi)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4087532A (en) *	1974-03-09	1978-05-02	Boehringer Ingelheim Gmbh	Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
GB1575009A (en) *	1976-06-21	1980-09-17	Acf Chemiefarma Nv	6,7-benzomorphan derivatives
DE2716687A1 (de) *	1977-04-15	1978-10-19	Boehringer Sohn Ingelheim	2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
NL7804509A (nl) *	1978-04-26	1979-10-30	Acf Chemiefarma Nv	Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
DE2828039A1 (de) *	1978-06-26	1980-01-10	Boehringer Sohn Ingelheim	2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
JPS5636521A (en) *	1979-08-31	1981-04-09	Shin Etsu Chem Co Ltd	Production of alkenyloxy group-containing organopolysiloxane
ES2395081T3 (es)	2007-07-26	2013-02-08	Vitae Pharmaceuticals, Inc.	Síntesis de inhibidores de la 11beta-hidroxiesteroide deshidrogenasa de tipo 1
EP2220048B1 (en)	2007-11-16	2017-01-25	Boehringer Ingelheim International GmbH	Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
JP5490014B2 (ja)	2007-12-11	2014-05-14	ヴァイティーファーマシューティカルズ，インコーポレイテッド	１１β−ヒドロキシステロイドデヒドロゲナーゼ１型の環状尿素阻害剤
TW200934490A (en)	2008-01-07	2009-08-16	Vitae Pharmaceuticals Inc	Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
CA2712500A1 (en)	2008-01-24	2009-07-30	Vitae Pharmaceuticals, Inc.	Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2254872A2 (en)	2008-02-15	2010-12-01	Vitae Pharmaceuticals, Inc.	Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
CA2723034A1 (en)	2008-05-01	2009-11-05	Vitae Pharmaceuticals, Inc.	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CL2009001059A1 (es)	2008-05-01	2010-11-12	Boehringer Ingelheim Int	Compuestos derivados de 1,3-oxazin-2-ona-3,6 sustituidos, inhibidores de la actividad de la 11-beta-hidroxiesteroide deshidrogenasa i; composicion farmaceutica que los comprende; utiles en el tratamiento de enfermedades tales como diabetes mellitus, entre otras.
AR071236A1 (es)	2008-05-01	2010-06-02	Vitae Pharmaceuticals Inc	Inhibidores ciclicos de la 11beta-hidroxiesteroide deshidrogenasa 1
CL2009001151A1 (es)	2008-05-13	2010-08-13	Boehringer Ingelheim Int	Compuestos derivados de acidos carbociclicos aliciclicos de benzomorfanos, procedimiento de preparacion, composicion farmaceutica, utiles para tratar enfermedades influenciadas por la inhibicion de la enzima 11beta-hidroxiesteroide deshidrogenasa, como trastornos metabolicos.
WO2010010157A2 (en)	2008-07-25	2010-01-28	Boehringer Ingelheim International Gmbh	INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1
CN102119160B (zh)	2008-07-25	2014-11-05	贝林格尔·英格海姆国际有限公司	11β-羟基类固醇脱氢酶1的环状抑制剂
UA109255C2 (ru)	2009-04-30	2015-08-10	Берінгер Інгельхайм Інтернешнл Гмбх	Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
JP5656986B2 (ja)	2009-06-11	2015-01-21	ヴァイティーファーマシューティカルズ，インコーポレイテッド	１，３−オキサジナン−２−オン構造に基づく１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
TWI531571B (zh)	2009-11-06	2016-05-01	維它藥物公司	六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物
JP5860042B2 (ja)	2010-06-16	2016-02-16	ヴァイティーファーマシューティカルズ，インコーポレイテッド	置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
TWI537258B (zh)	2010-11-05	2016-06-11	百靈佳殷格翰國際股份有限公司	六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
JP2014524438A (ja)	2011-08-17	2014-09-22	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	インデノピリジン誘導体
US20240002606A1 (en)	2020-11-26	2024-01-04	Shin-Etsu Chemical Co., Ltd.	Room temperature curable organopolysiloxane composition, article, hydrolyzable organosilane compound and method for producing same
JPWO2023032745A1 (fi)	2021-09-03	2023-03-09

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE582575A (fi) *	1958-09-22
US3700734A (en) *	1969-01-23	1972-10-24	Merck & Co Inc	2{40 -hydroxy-2,3,5-trimethyl-6,7-benzomorphan
DE2105743C3 (de) *	1971-02-08	1979-11-29	Boehringer Sohn Ingelheim	2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung
CS166801B2 (fi) *	1971-02-08	1976-03-29	Boehringer Sohn Ingelheim
DE2200596A1 (de) *	1972-01-07	1973-07-12	Boehringer Sohn Ingelheim	N-(furyl-methyl)-2'-hydroxy-5-phenyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung
DE2217420C3 (de) *	1972-04-12	1981-03-12	C.H. Boehringer Sohn, 6507 Ingelheim	N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE2229695A1 (de) *	1972-06-19	1974-01-31	Boehringer Sohn Ingelheim	2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

1974
- 1974-08-05 DE DE2437610A patent/DE2437610A1/de not_active Ceased
1975
- 1975-07-08 AT AT523775A patent/AT348140B/de not_active IP Right Cessation
- 1975-07-25 SU SU752162235A patent/SU591147A3/ru active
- 1975-07-30 JP JP50092995A patent/JPS60358B2/ja not_active Expired
- 1975-07-30 US US05/600,374 patent/US3982005A/en not_active Expired - Lifetime
- 1975-07-30 RO RO7583017A patent/RO67390A/ro unknown
- 1975-07-31 CH CH1002475A patent/CH613963A5/xx not_active IP Right Cessation
- 1975-07-31 RO RO7593231A patent/RO72736A/ro unknown
- 1975-07-31 RO RO7593232A patent/RO72735A/ro unknown
- 1975-08-01 CA CA75232728A patent/CA1049008A/en not_active Expired
- 1975-08-02 BG BG031843A patent/BG25090A3/xx unknown
- 1975-08-02 BG BG031842A patent/BG25089A3/xx unknown
- 1975-08-02 BG BG030726A patent/BG25088A3/xx unknown
- 1975-08-04 BE BE158924A patent/BE832099R/xx not_active IP Right Cessation
- 1975-08-04 DD DD187666A patent/DD122685A5/xx unknown
- 1975-08-04 HU HU75BO1566A patent/HU177952B/hu unknown
- 1975-08-04 IL IL47860A patent/IL47860A/xx unknown
- 1975-08-04 SE SE7508789A patent/SE425392B/xx not_active IP Right Cessation
- 1975-08-04 ZA ZA754997A patent/ZA754997B/xx unknown
- 1975-08-04 PH PH17443A patent/PH13687A/en unknown
- 1975-08-04 NL NL7509249A patent/NL7509249A/xx not_active Application Discontinuation
- 1975-08-04 PL PL1975190658A patent/PL99819B1/pl unknown
- 1975-08-04 LU LU73138A patent/LU73138A1/xx unknown
- 1975-08-04 PL PL1975182528A patent/PL99838B1/pl unknown
- 1975-08-04 FI FI752211A patent/FI63229C/fi not_active IP Right Cessation
- 1975-08-04 DK DK352875A patent/DK138992C/da active
- 1975-08-04 PL PL1975190659A patent/PL99816B1/pl unknown
- 1975-08-04 CS CS755425A patent/CS189717B2/cs unknown
- 1975-08-04 GB GB32576/75A patent/GB1513950A/en not_active Expired
- 1975-08-04 NO NO752731A patent/NO143460C/no unknown
- 1975-08-05 IE IE1738/75A patent/IE42216B1/en unknown
- 1975-08-05 FR FR7524380A patent/FR2320096A2/fr active Granted
1976
- 1976-04-16 SU SU762346107A patent/SU587858A3/ru active
- 1976-04-16 SU SU762346108A patent/SU587859A3/ru active
- 1976-10-27 ES ES452765A patent/ES452765A1/es not_active Expired
- 1976-10-27 ES ES452766A patent/ES452766A1/es not_active Expired
- 1976-10-27 ES ES452767A patent/ES452767A1/es not_active Expired
- 1976-10-27 ES ES452763A patent/ES452763A1/es not_active Expired
- 1976-10-27 ES ES452768A patent/ES452768A1/es not_active Expired
- 1976-10-27 ES ES452764A patent/ES452764A1/es not_active Expired
1979
- 1979-04-26 CH CH393679A patent/CH615680A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393279A patent/CH615678A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393379A patent/CH616420A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393479A patent/CH615679A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393179A patent/CH615677A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393579A patent/CH616421A5/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
US3982005A (en)	1976-09-21
CH616421A5 (fi)	1980-03-31
AT348140B (de)	1979-01-25
IE42216L (en)	1976-02-05
ZA754997B (en)	1977-04-27
LU73138A1 (fi)	1977-04-13
SU587859A3 (ru)	1978-01-05
JPS60358B2 (ja)	1985-01-07
HU177952B (en)	1982-02-28
CS189717B2 (en)	1979-04-30
CA1049008A (en)	1979-02-20
DE2437610A1 (de)	1976-02-26
IE42216B1 (en)	1980-07-02
PH13687A (en)	1980-09-01
RO67390A (ro)	1981-06-30
AU8364675A (en)	1977-02-10
RO72736A (ro)	1982-09-09
SE425392B (sv)	1982-09-27
PL99816B1 (pl)	1978-08-31
NL7509249A (nl)	1976-02-09
IL47860A (en)	1979-01-31
CH615679A5 (fi)	1980-02-15
CH615677A5 (fi)	1980-02-15
ATA523775A (de)	1978-06-15
CH616420A5 (fi)	1980-03-31
NO143460C (no)	1981-02-18
DK352875A (da)	1976-02-06
BE832099R (fr)	1976-02-04
JPS5139673A (en)	1976-04-02
DD122685A5 (fi)	1976-10-20
NO143460B (no)	1980-11-10
NO752731L (fi)	1976-02-06
DK138992B (da)	1978-11-27
FR2320096B2 (fi)	1978-09-01
ES452764A1 (es)	1977-10-16
SU587858A3 (ru)	1978-01-05
DK138992C (da)	1979-04-30
SE7508789L (sv)	1976-02-10
BG25088A3 (en)	1978-07-12
ES452763A1 (es)	1977-10-01
FI63229C (fi)	1983-05-10
IL47860A0 (en)	1975-11-25
ES452767A1 (es)	1977-10-01
PL99819B1 (pl)	1978-08-31
CH615678A5 (fi)	1980-02-15
FI752211A (fi)	1976-02-06
ES452768A1 (es)	1977-10-01
ES452766A1 (es)	1977-10-01
RO72735A (ro)	1982-09-09
PL99838B1 (pl)	1978-08-31
ES452765A1 (es)	1977-10-16
GB1513950A (en)	1978-06-14
FI63229B (fi)	1983-01-31
CH615680A5 (fi)	1980-02-15
CH613963A5 (fi)	1979-10-31
FR2320096A2 (fr)	1977-03-04
BG25089A3 (en)	1978-07-12
SU591147A3 (ru)	1978-01-30

Publication	Publication Date	Title
BG25089A3 (en)	1978-07-12	A method of obtaining 5,9-beta-substituted-2-tetrahydrofurfuryl-6,7-benzomorphanes and their salts
BG25087A3 (en)	1978-07-12	A method of obtaining 2-tetrahydrofurfuryl-6,7-benzomorphanes and their salts
BG24950A3 (en)	1978-06-15	A method of obtaining 1,3,4-trisubstituted-4-arilpiperidines
BG25082A3 (en)	1978-07-12	A method of obtaining 1-aroyl-2-arylamine-2-imidazole derivatives
PH14732A (en)	1981-11-19	Phenylalkylamines and salts thereof
BG25221A3 (en)	1978-08-10	A method of obtaining 2,6-disubstituted-2-phenylimine-imidazolidines and their salts
PH13405A (en)	1980-03-28	11-aminoalkyl-pyridobenzodiazepinones and salts thereof
GR59201B (en)	1977-11-26	Preparation method of 8,8-disubstituted-6-methylergolines and related compounds
BG25518A3 (en)	1978-10-10	A method of obtaining xantain derivatives
BG23900A3 (en)	1977-11-10	Method of preparing 2-carbalcoxy-amino-benzimidazolyl-5(6)-sulfoacid phenylates
BG25199A3 (en)	1978-08-10	A method of obtaining derivatives of antibiotic a 204 i
BG25219A3 (en)	1978-08-10	A method of obtaining of substituted 2-phenylamineimidazolines-(2)and their additives with aciduous salts
JPS51125082A (en)	1976-11-01	Preparation method of 77 substitutedd88aminomethyll isoflavon derivatives
CS188251B2 (en)	1979-02-28	Method of producing 4-oxo-4h-pyrano-3,2-c-qunolin-2-carboxylic acids and salts thereof
BG25081A3 (en)	1978-07-12	A method of obtaining isohinolines
AU8208175A (en)	1976-12-16	Hexahydro-diazepino-indole derivatives and a process for their preparation
GB1523355A (en)	1978-08-31	19,20-dinorprostanoic acids and salts thereof
JPS51118711A (en)	1976-10-18	Dividing method and compound
BG25223A3 (en)	1978-08-10	A method of obtaining 2,6,6-threemethyl-2-cyanomethyl-tetrahydropiran
BG25075A3 (en)	1978-07-12	A method of obtaining 1,2,4-triazol derivatives
BG25073A3 (en)	1978-07-12	A method of obtaining 3,7-dimethyl-3-hydroxy-6-oktennitryl
BG25085A3 (en)	1978-07-12	A method of obtaining n-(1'-alyl-2'-pyrolydylmethyl)-2-methoxy-4,5-azimidobenzamide
GR58594B (en)	1977-11-10	Preparation method of 2-halogenmethyl-1,4,-benzodiazepine
ZA754921B (en)	1976-09-29	1-aryl-2-oxo-hexahydro-2,4,5,6,7,7a-indoles and acid addition salts thereof
HU173792B (hu)	1979-08-28	Sposob poluchenija novykh osnovnykh ehnol-ehfirov i ikh solej