BG107513A - Кумаринови производни със сомт инхибираща активност - Google Patents

Кумаринови производни със сомт инхибираща активност Download PDF

Info

Publication number: BG107513A
Authority: BG; Bulgaria
Prior art keywords: alkyl; cooh; halogen; compound; substituents
Prior art date: 2000-07-03

Application number

BG107513A

Other languages

Bulgarian (bg)

English (en)

Inventor

Jarmo Pystynen

Martti Ovaska

Jukka Vidgren

Timo Lotta

Marjo Yliperttula-Ikonen

Original Assignee

Orion Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-03

Filing date

2003-01-31

Publication date

2003-06-30

2003-01-31 Application filed by Orion Corporation filed Critical Orion Corporation

2003-06-30 Publication of BG107513A publication Critical patent/BG107513A/bg

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans

BG107513A 2000-07-03 2003-01-31 Кумаринови производни със сомт инхибираща активност BG107513A (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FI20001593A FI20001593A (fi)	2000-07-03	2000-07-03	Comt-entsyymiõ inhiboivaa aktiivisuutta omaavia kumariinijohdannaisia
PCT/FI2001/000613 WO2002002548A1 (en)	2000-07-03	2001-06-28	Coumarin derivatives with comt inhibiting activity

Publications (1)

Publication Number	Publication Date
BG107513A true BG107513A (bg)	2003-06-30

Family

ID=8558717

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG107513A BG107513A (bg)	2000-07-03	2003-01-31	Кумаринови производни със сомт инхибираща активност

Country Status (27)

Country	Link
US (1)	US6951870B2 (fi)
EP (1)	EP1301503B1 (fi)
JP (1)	JP4851051B2 (fi)
KR (1)	KR20030040225A (fi)
CN (1)	CN1199963C (fi)
AT (1)	ATE260268T1 (fi)
AU (2)	AU2001272597B9 (fi)
BG (1)	BG107513A (fi)
BR (1)	BR0111969A (fi)
CA (1)	CA2414787C (fi)
DE (1)	DE60102161T2 (fi)
DK (1)	DK1301503T3 (fi)
EE (1)	EE200300008A (fi)
ES (1)	ES2215919T3 (fi)
FI (1)	FI20001593A (fi)
HU (1)	HUP0301706A3 (fi)
IL (2)	IL153352A0 (fi)
MX (1)	MXPA02012657A (fi)
NO (1)	NO328699B1 (fi)
NZ (1)	NZ523121A (fi)
PL (1)	PL359068A1 (fi)
PT (1)	PT1301503E (fi)
RU (1)	RU2282627C2 (fi)
SK (1)	SK18452002A3 (fi)
TR (1)	TR200400802T4 (fi)
WO (1)	WO2002002548A1 (fi)
ZA (1)	ZA200210161B (fi)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AUPR846401A0 (en) *	2001-10-25	2001-11-15	Novogen Research Pty Ltd	6-Hydroxy isoflavones, derivatives and medicaments involving same
AU2003265737B2 (en) *	2002-10-02	2008-10-16	Novogen Research Pty Ltd	Combination chemotherapy compositions and methods
AU2002951833A0 (en)	2002-10-02	2002-10-24	Novogen Research Pty Ltd	Compositions and therapeutic methods invloving platinum complexes
CN1506359A (zh)	2002-12-05	2004-06-23	�й�ҽѧ��ѧԺҩ��о��	新的香豆素酰胺衍生物及其制法和其药物组合物与用途
US8080675B2 (en)	2004-09-21	2011-12-20	Marshall Edwards, Inc.	Chroman derivatives, medicaments and use in therapy
AU2005287865B2 (en)	2004-09-21	2012-02-16	Marshall Edwards, Inc.	Substituted chroman derivatives, medicaments and use in therapy
MY148644A (en) *	2005-07-18	2013-05-15	Orion Corp	New pharmaceutical compounds
US8686002B2 (en)	2005-08-21	2014-04-01	AbbVie Deutschland GmbH & Co. KG	Heterocyclic compounds and their use as binding partners for 5-HT5 receptors
WO2007124617A1 (fr) *	2006-04-28	2007-11-08	Institute Of Mataria Medica, Chinese Academy Of Medical Sciences	Dérivés de coumarine, leurs procédés de préparation, compositions pharmaceutiques et utilisations
ES2343347B2 (es) *	2009-01-27	2011-12-07	Universidade De Santiago De Compostela	Uso de derivados de 3-fenilcumarinas 6-sustituidas y preparacion de nuevos derivados.
EP2635121B1 (en)	2010-11-01	2020-01-08	MEI Pharma, Inc.	Isoflavonoid compounds and methods for the treatment of cancer
TWI638802B (zh)	2012-05-24	2018-10-21	芬蘭商奧利安公司	兒茶酚ｏ－甲基轉移酶活性抑制化合物
PL3253208T3 (pl)	2015-02-02	2021-11-08	Mei Pharma, Inc.	Terapie kombinowane do zastosowania w leczeniu nowotworu piersi
WO2017103278A1 (en) *	2015-12-18	2017-06-22	Caprotec Bioanalytics Gmbh	Novel bicyclic-compounds for use as a medicament, in particular for treatment of parkinson's disease
CN107868069A (zh) *	2017-10-31	2018-04-03	山东新华制药股份有限公司	7‑羟基‑8‑甲基‑6‑硝基‑2‑氧‑2h‑苯并吡喃‑3‑羧酸的制备工艺

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5035393A (fi) *	1973-08-01	1975-04-04
US3973608A (en)	1973-08-01	1976-08-10	Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai	Microbial production of certain isoflavones
US5236952A (en) *	1986-03-11	1993-08-17	Hoffmann-La Roche Inc.	Catechol derivatives
US5283352A (en) *	1986-11-28	1994-02-01	Orion-Yhtyma Oy	Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same
GB8816519D0 (en)	1987-07-23	1988-08-17	Ici Plc	Antibiotic compounds
HUT63843A (en)	1992-02-13	1993-10-28	Biosignal Kutato Fejlesztoe Kf	Process for producing new kumarin derivatives and their analogs inhibiting mammal cell proliferation and tumour growth, as well as pharmaceutical comkpositions comprising such compounds
JP3166094B2 (ja) *	1993-09-08	2001-05-14	森永乳業株式会社	クマリン誘導体及びそれらの用途
JPH0892157A (ja)	1994-05-02	1996-04-09	F Hoffmann La Roche Ag	プルプロガリン誘導体
GB9626472D0 (en)	1996-12-20	1997-02-05	Aperia Anita C	New use of comt inhibitors

2000
- 2000-07-03 FI FI20001593A patent/FI20001593A/fi unknown
2001
- 2001-06-28 RU RU2003102894/04A patent/RU2282627C2/ru not_active IP Right Cessation
- 2001-06-28 JP JP2002507800A patent/JP4851051B2/ja not_active Expired - Fee Related
- 2001-06-28 ES ES01951741T patent/ES2215919T3/es not_active Expired - Lifetime
- 2001-06-28 AU AU2001272597A patent/AU2001272597B9/en not_active Ceased
- 2001-06-28 WO PCT/FI2001/000613 patent/WO2002002548A1/en active IP Right Grant
- 2001-06-28 DK DK01951741T patent/DK1301503T3/da active
- 2001-06-28 EE EEP200300008A patent/EE200300008A/xx unknown
- 2001-06-28 HU HU0301706A patent/HUP0301706A3/hu unknown
- 2001-06-28 KR KR1020027017767A patent/KR20030040225A/ko not_active Application Discontinuation
- 2001-06-28 SK SK1845-2002A patent/SK18452002A3/sk unknown
- 2001-06-28 DE DE60102161T patent/DE60102161T2/de not_active Expired - Lifetime
- 2001-06-28 BR BR0111969-9A patent/BR0111969A/pt not_active IP Right Cessation
- 2001-06-28 EP EP01951741A patent/EP1301503B1/en not_active Expired - Lifetime
- 2001-06-28 MX MXPA02012657A patent/MXPA02012657A/es active IP Right Grant
- 2001-06-28 TR TR2004/00802T patent/TR200400802T4/xx unknown
- 2001-06-28 CA CA2414787A patent/CA2414787C/en not_active Expired - Fee Related
- 2001-06-28 AT AT01951741T patent/ATE260268T1/de active
- 2001-06-28 NZ NZ523121A patent/NZ523121A/en not_active IP Right Cessation
- 2001-06-28 IL IL15335201A patent/IL153352A0/xx unknown
- 2001-06-28 PL PL01359068A patent/PL359068A1/xx not_active Application Discontinuation
- 2001-06-28 PT PT01951741T patent/PT1301503E/pt unknown
- 2001-06-28 AU AU7259701A patent/AU7259701A/xx active Pending
- 2001-06-28 CN CNB018121934A patent/CN1199963C/zh not_active Expired - Fee Related
- 2001-06-28 US US10/312,817 patent/US6951870B2/en not_active Expired - Fee Related
2002
- 2002-12-10 IL IL153352A patent/IL153352A/en not_active IP Right Cessation
- 2002-12-13 ZA ZA200210161A patent/ZA200210161B/en unknown
- 2002-12-18 NO NO20026095A patent/NO328699B1/no not_active IP Right Cessation
2003
- 2003-01-31 BG BG107513A patent/BG107513A/bg unknown

Also Published As

Publication number	Publication date
WO2002002548A1 (en)	2002-01-10
ES2215919T3 (es)	2004-10-16
ATE260268T1 (de)	2004-03-15
AU7259701A (en)	2002-01-14
HUP0301706A2 (hu)	2003-09-29
DE60102161D1 (de)	2004-04-01
JP4851051B2 (ja)	2012-01-11
HUP0301706A3 (en)	2005-12-28
CN1440399A (zh)	2003-09-03
EP1301503B1 (en)	2004-02-25
MXPA02012657A (es)	2003-05-14
SK18452002A3 (sk)	2004-04-06
CA2414787A1 (en)	2002-01-10
US6951870B2 (en)	2005-10-04
AU2001272597B9 (en)	2005-08-11
FI20001593A (fi)	2002-01-04
NO328699B1 (no)	2010-04-26
IL153352A (en)	2009-05-04
DE60102161T2 (de)	2004-09-16
EE200300008A (et)	2004-08-16
NO20026095L (no)	2003-03-03
US20030186975A1 (en)	2003-10-02
JP2004502684A (ja)	2004-01-29
ZA200210161B (en)	2004-03-15
FI20001593A0 (fi)	2000-07-03
AU2001272597B2 (en)	2005-07-21
TR200400802T4 (tr)	2004-07-21
IL153352A0 (en)	2003-07-06
NO20026095D0 (no)	2002-12-18
US20040110750A9 (en)	2004-06-10
BR0111969A (pt)	2003-07-01
EP1301503A1 (en)	2003-04-16
CA2414787C (en)	2010-12-14
PL359068A1 (en)	2004-08-23
DK1301503T3 (da)	2004-06-28
RU2282627C2 (ru)	2006-08-27
NZ523121A (en)	2004-08-27
PT1301503E (pt)	2004-06-30
KR20030040225A (ko)	2003-05-22
CN1199963C (zh)	2005-05-04

Publication	Publication Date	Title
BG107513A (bg)	2003-06-30	Кумаринови производни със сомт инхибираща активност
JPH09510704A (ja)	1997-10-28	Ｐａｒｐ（ａｄｐ−リボシルトランスフェラーゼ、ａｄｐｒｔ）および修復酵素として有用なベンズアミド類似体
EP2305246A1 (en)	2011-04-06	Tumor necrosis factor inhibitors
SK46599A3 (en)	2000-02-14	Use of condensated (hetaryl-substituted) 1-benzal-3-pyrazol derivates for treating special diseases of the cardiovascular and the central nervous systems
JPH11510154A (ja)	1999-09-07	ベンズイミダゾール化合物
AU2001272597A1 (en)	2002-04-11	Coumarin derivatives with COMT inhibiting activity
AU2012327209A8 (en)	2015-01-22	Compositions and methods for the modulation of specific amidases for N-acylethanolamines for use in the therapy of inflammatory diseases
KR20150103034A (ko)	2015-09-09	피리돈 유도체 및 바이러스 질환의 치료, 개선 또는 예방에서의 이의 용도
KR100545474B1 (ko)	2006-01-24	페닐아미노알킬카르복실산 유도체 및 그것을 함유하는의약조성물
JPWO2010032771A1 (ja)	2012-02-09	アミノ酸誘導体
JPH02124884A (ja)	1990-05-14	Ｎ―置換アミド誘導体
JP2001511799A (ja)	2001-08-14	オキシド−スクアレンシクラーゼ阻害剤として有用なヘテロ環式化合物
WO2013064714A1 (es)	2013-05-10	Fármacos inhibidores de p38 y aplicaciones
BG107219A (bg)	2003-05-30	Терапевтично приложими нови соли на сск инхибитори, методи за тяхното получаване и фармацевтични състави, които ги съдържат
EP0562796A1 (en)	1993-09-29	Phenoxyacetic acid compounds and medical preparations containing them
JP3166093B2 (ja)	2001-05-14	クマリン誘導体及びそれらの用途
EP1844775A1 (en)	2007-10-17	Therapeutic agent for herpes progenitalis
JP4976499B2 (ja)	2012-07-18	キマーゼ阻害剤としてのビニル酸誘導体
CN109824574B (zh)	2021-12-28	吲哚-3-甲酰胺类化合物及其应用
JPH11509533A (ja)	1999-08-24	Ｎｍｄａ受容体拮抗薬としての多環式アルカロイド誘導体
KR100832750B1 (ko)	2008-05-27	Ｎ-페닐아마이드 유도체를 함유하는 허혈성 질환의 예방또는 치료용 조성물
EP0395526A1 (fr)	1990-10-31	Nouveaux dérivés benzothiazolinoniques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
EP0623608B1 (en)	2001-05-30	Benzopyran derivative, production thereof, and pharmaceutical preparation containing the same as active ingredient
KR100832751B1 (ko)	2008-05-27	Ｎ-페닐아마이드 유도체 및 이의 제조방법
JP2006512378A (ja)	2006-04-13	３−置換−４−アリールキノリン−２−オン誘導体のアトロプ異性体