IL153352A0 - Coumarin derivatives with comt inhibiting activity - Google Patents

Coumarin derivatives with comt inhibiting activity

Info

Publication number: IL153352A0
Authority: IL; Israel
Prior art keywords: sub; inhibiting activity; coumarin derivatives; comt; comt inhibiting
Prior art date: 2000-07-03

Application number

IL15335201A

Other languages

English (en)

Original Assignee

Orion Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-03

Filing date

2001-06-28

Publication date

2003-07-06

2001-06-28 Application filed by Orion Corp filed Critical Orion Corp

2003-07-06 Publication of IL153352A0 publication Critical patent/IL153352A0/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans

IL15335201A 2000-07-03 2001-06-28 Coumarin derivatives with comt inhibiting activity IL153352A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FI20001593A FI20001593A (fi)	2000-07-03	2000-07-03	Comt-entsyymiõ inhiboivaa aktiivisuutta omaavia kumariinijohdannaisia
PCT/FI2001/000613 WO2002002548A1 (en)	2000-07-03	2001-06-28	Coumarin derivatives with comt inhibiting activity

Publications (1)

Publication Number	Publication Date
IL153352A0 true IL153352A0 (en)	2003-07-06

Family

ID=8558717

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL15335201A IL153352A0 (en)	2000-07-03	2001-06-28	Coumarin derivatives with comt inhibiting activity
IL153352A IL153352A (en)	2000-07-03	2002-12-10	History of coumarin with inhibitory COMT action

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL153352A IL153352A (en)	2000-07-03	2002-12-10	History of coumarin with inhibitory COMT action

Country Status (27)

Country	Link
US (1)	US6951870B2 (xx)
EP (1)	EP1301503B1 (xx)
JP (1)	JP4851051B2 (xx)
KR (1)	KR20030040225A (xx)
CN (1)	CN1199963C (xx)
AT (1)	ATE260268T1 (xx)
AU (2)	AU2001272597B9 (xx)
BG (1)	BG107513A (xx)
BR (1)	BR0111969A (xx)
CA (1)	CA2414787C (xx)
DE (1)	DE60102161T2 (xx)
DK (1)	DK1301503T3 (xx)
EE (1)	EE200300008A (xx)
ES (1)	ES2215919T3 (xx)
FI (1)	FI20001593A (xx)
HU (1)	HUP0301706A3 (xx)
IL (2)	IL153352A0 (xx)
MX (1)	MXPA02012657A (xx)
NO (1)	NO328699B1 (xx)
NZ (1)	NZ523121A (xx)
PL (1)	PL359068A1 (xx)
PT (1)	PT1301503E (xx)
RU (1)	RU2282627C2 (xx)
SK (1)	SK18452002A3 (xx)
TR (1)	TR200400802T4 (xx)
WO (1)	WO2002002548A1 (xx)
ZA (1)	ZA200210161B (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AUPR846401A0 (en) *	2001-10-25	2001-11-15	Novogen Research Pty Ltd	6-Hydroxy isoflavones, derivatives and medicaments involving same
AU2003265737B2 (en) *	2002-10-02	2008-10-16	Novogen Research Pty Ltd	Combination chemotherapy compositions and methods
AU2002951833A0 (en)	2002-10-02	2002-10-24	Novogen Research Pty Ltd	Compositions and therapeutic methods invloving platinum complexes
CN1506359A (zh)	2002-12-05	2004-06-23	�й�ҽѧ��ѧԺҩ��о��	新的香豆素酰胺衍生物及其制法和其药物组合物与用途
US8080675B2 (en)	2004-09-21	2011-12-20	Marshall Edwards, Inc.	Chroman derivatives, medicaments and use in therapy
AU2005287865B2 (en)	2004-09-21	2012-02-16	Marshall Edwards, Inc.	Substituted chroman derivatives, medicaments and use in therapy
MY148644A (en) *	2005-07-18	2013-05-15	Orion Corp	New pharmaceutical compounds
US8686002B2 (en)	2005-08-21	2014-04-01	AbbVie Deutschland GmbH & Co. KG	Heterocyclic compounds and their use as binding partners for 5-HT5 receptors
WO2007124617A1 (fr) *	2006-04-28	2007-11-08	Institute Of Mataria Medica, Chinese Academy Of Medical Sciences	Dérivés de coumarine, leurs procédés de préparation, compositions pharmaceutiques et utilisations
ES2343347B2 (es) *	2009-01-27	2011-12-07	Universidade De Santiago De Compostela	Uso de derivados de 3-fenilcumarinas 6-sustituidas y preparacion de nuevos derivados.
EP2635121B1 (en)	2010-11-01	2020-01-08	MEI Pharma, Inc.	Isoflavonoid compounds and methods for the treatment of cancer
TWI638802B (zh)	2012-05-24	2018-10-21	芬蘭商奧利安公司	兒茶酚ｏ－甲基轉移酶活性抑制化合物
PL3253208T3 (pl)	2015-02-02	2021-11-08	Mei Pharma, Inc.	Terapie kombinowane do zastosowania w leczeniu nowotworu piersi
WO2017103278A1 (en) *	2015-12-18	2017-06-22	Caprotec Bioanalytics Gmbh	Novel bicyclic-compounds for use as a medicament, in particular for treatment of parkinson's disease
CN107868069A (zh) *	2017-10-31	2018-04-03	山东新华制药股份有限公司	7‑羟基‑8‑甲基‑6‑硝基‑2‑氧‑2h‑苯并吡喃‑3‑羧酸的制备工艺

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5035393A (xx) *	1973-08-01	1975-04-04
US3973608A (en)	1973-08-01	1976-08-10	Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai	Microbial production of certain isoflavones
US5236952A (en) *	1986-03-11	1993-08-17	Hoffmann-La Roche Inc.	Catechol derivatives
US5283352A (en) *	1986-11-28	1994-02-01	Orion-Yhtyma Oy	Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same
GB8816519D0 (en)	1987-07-23	1988-08-17	Ici Plc	Antibiotic compounds
HUT63843A (en)	1992-02-13	1993-10-28	Biosignal Kutato Fejlesztoe Kf	Process for producing new kumarin derivatives and their analogs inhibiting mammal cell proliferation and tumour growth, as well as pharmaceutical comkpositions comprising such compounds
JP3166094B2 (ja) *	1993-09-08	2001-05-14	森永乳業株式会社	クマリン誘導体及びそれらの用途
JPH0892157A (ja)	1994-05-02	1996-04-09	F Hoffmann La Roche Ag	プルプロガリン誘導体
GB9626472D0 (en)	1996-12-20	1997-02-05	Aperia Anita C	New use of comt inhibitors

2000
- 2000-07-03 FI FI20001593A patent/FI20001593A/fi unknown
2001
- 2001-06-28 RU RU2003102894/04A patent/RU2282627C2/ru not_active IP Right Cessation
- 2001-06-28 JP JP2002507800A patent/JP4851051B2/ja not_active Expired - Fee Related
- 2001-06-28 ES ES01951741T patent/ES2215919T3/es not_active Expired - Lifetime
- 2001-06-28 AU AU2001272597A patent/AU2001272597B9/en not_active Ceased
- 2001-06-28 WO PCT/FI2001/000613 patent/WO2002002548A1/en active IP Right Grant
- 2001-06-28 DK DK01951741T patent/DK1301503T3/da active
- 2001-06-28 EE EEP200300008A patent/EE200300008A/xx unknown
- 2001-06-28 HU HU0301706A patent/HUP0301706A3/hu unknown
- 2001-06-28 KR KR1020027017767A patent/KR20030040225A/ko not_active Application Discontinuation
- 2001-06-28 SK SK1845-2002A patent/SK18452002A3/sk unknown
- 2001-06-28 DE DE60102161T patent/DE60102161T2/de not_active Expired - Lifetime
- 2001-06-28 BR BR0111969-9A patent/BR0111969A/pt not_active IP Right Cessation
- 2001-06-28 EP EP01951741A patent/EP1301503B1/en not_active Expired - Lifetime
- 2001-06-28 MX MXPA02012657A patent/MXPA02012657A/es active IP Right Grant
- 2001-06-28 TR TR2004/00802T patent/TR200400802T4/xx unknown
- 2001-06-28 CA CA2414787A patent/CA2414787C/en not_active Expired - Fee Related
- 2001-06-28 AT AT01951741T patent/ATE260268T1/de active
- 2001-06-28 NZ NZ523121A patent/NZ523121A/en not_active IP Right Cessation
- 2001-06-28 IL IL15335201A patent/IL153352A0/xx unknown
- 2001-06-28 PL PL01359068A patent/PL359068A1/xx not_active Application Discontinuation
- 2001-06-28 PT PT01951741T patent/PT1301503E/pt unknown
- 2001-06-28 AU AU7259701A patent/AU7259701A/xx active Pending
- 2001-06-28 CN CNB018121934A patent/CN1199963C/zh not_active Expired - Fee Related
- 2001-06-28 US US10/312,817 patent/US6951870B2/en not_active Expired - Fee Related
2002
- 2002-12-10 IL IL153352A patent/IL153352A/en not_active IP Right Cessation
- 2002-12-13 ZA ZA200210161A patent/ZA200210161B/en unknown
- 2002-12-18 NO NO20026095A patent/NO328699B1/no not_active IP Right Cessation
2003
- 2003-01-31 BG BG107513A patent/BG107513A/bg unknown

Also Published As

Publication number	Publication date
WO2002002548A1 (en)	2002-01-10
ES2215919T3 (es)	2004-10-16
ATE260268T1 (de)	2004-03-15
AU7259701A (en)	2002-01-14
HUP0301706A2 (hu)	2003-09-29
BG107513A (bg)	2003-06-30
DE60102161D1 (de)	2004-04-01
JP4851051B2 (ja)	2012-01-11
HUP0301706A3 (en)	2005-12-28
CN1440399A (zh)	2003-09-03
EP1301503B1 (en)	2004-02-25
MXPA02012657A (es)	2003-05-14
SK18452002A3 (sk)	2004-04-06
CA2414787A1 (en)	2002-01-10
US6951870B2 (en)	2005-10-04
AU2001272597B9 (en)	2005-08-11
FI20001593A (fi)	2002-01-04
NO328699B1 (no)	2010-04-26
IL153352A (en)	2009-05-04
DE60102161T2 (de)	2004-09-16
EE200300008A (et)	2004-08-16
NO20026095L (no)	2003-03-03
US20030186975A1 (en)	2003-10-02
JP2004502684A (ja)	2004-01-29
ZA200210161B (en)	2004-03-15
FI20001593A0 (fi)	2000-07-03
AU2001272597B2 (en)	2005-07-21
TR200400802T4 (tr)	2004-07-21
NO20026095D0 (no)	2002-12-18
US20040110750A9 (en)	2004-06-10
BR0111969A (pt)	2003-07-01
EP1301503A1 (en)	2003-04-16
CA2414787C (en)	2010-12-14
PL359068A1 (en)	2004-08-23
DK1301503T3 (da)	2004-06-28
RU2282627C2 (ru)	2006-08-27
NZ523121A (en)	2004-08-27
PT1301503E (pt)	2004-06-30
KR20030040225A (ko)	2003-05-22
CN1199963C (zh)	2005-05-04

Publication	Publication Date	Title
AU7259701A (en)	2002-01-14	Coumarin derivatives with comt inhibiting activity
DK0931788T3 (da)	2002-11-25	Metalloproteasehæmmere
ATE302001T1 (de)	2005-09-15	Stabilisierte askorbinsäurederivate
NO20025590D0 (no)	2002-11-21	Fenylglycin-derivater
SE0004245D0 (sv)	2000-11-20	Novel compounds and their use
BR0001569A (pt)	2001-08-21	Inibidores da uroquinase do tipo 2-piridinilguanidina
AP2001002175A0 (en)	2001-06-21	Combination chemotherapy.
WO2000005214A3 (en)	2001-05-31	Isoquinolines as urokinase inhibitors
WO2005046672A3 (fr)	2005-09-15	Utilisation d’inhibiteurs de glucosidase pour une therapie de la mucoviscidose
PL341239A1 (en)	2001-03-26	Dihydrobenzofuranes
HK1096548A1 (en)	2007-06-01	Imidazopyridine-derivatives as inductible no-synthase inhibitors
ATE233264T1 (de)	2003-03-15	Polynalbuphinderivat
WO2004099130A3 (en)	2005-01-27	1,2-diarylimidazoles useful as inhibitors of cox
HRP20010885B1 (en)	2010-07-31	Ethanesulfonyl-piperidine derivatives
BG105966A (en)	2002-07-31	C7 carbonate substituted taxanes and their application as antitumor agents
ES2159489A1 (es)	2001-10-01	Nuevos derivados de imidazol con actividad antiinflamatoria.
BG105965A (en)	2002-07-31	C10 ester substituted taxanes and their application as antitumor agents
AU5846901A (en)	2001-11-20	New polycyclic indanylimidazoles with alpha2 adrenergic activity
BG105252A (en)	2001-12-29	Isoquinolines as urokinase inhibitors
MXPA06004299A (es)	2006-06-05	Derivados de arilespirofuropiridina.
ES2166710A1 (es)	2003-12-01	Nuevos compuestos heterociclicos con actividad antiinflamatoria.
WO2002033216A3 (en)	2002-08-01	Corrosion inhibitor-drag reducer combinations
ATE367377T1 (de)	2007-08-15	Bis(5-aryl-2-pyridyl)derivate
EP1300395A4 (en)	2003-05-28	4-SUBSTITUTED PIPERIDINE CONNECTION
MXPA05008839A (es)	2005-10-05	Derivados de imidazo[4,5-b]quinolina y su uso como inhibidores de no-sintasa.