ATE92538T1 - Verstaerkung und nachweis von nukleinsaeuresequenzen. - Google Patents

Verstaerkung und nachweis von nukleinsaeuresequenzen.

Info

Publication number
ATE92538T1
ATE92538T1 AT89902420T AT89902420T ATE92538T1 AT E92538 T1 ATE92538 T1 AT E92538T1 AT 89902420 T AT89902420 T AT 89902420T AT 89902420 T AT89902420 T AT 89902420T AT E92538 T1 ATE92538 T1 AT E92538T1
Authority
AT
Austria
Prior art keywords
nucleic acid
detection
acid sequences
amplification
methods
Prior art date
Application number
AT89902420T
Other languages
English (en)
Inventor
Harvey I Miller
Sean Johnston
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22517472&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE92538(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE92538T1 publication Critical patent/ATE92538T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6865—Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Testing Of Optical Devices Or Fibers (AREA)
  • Light Guides In General And Applications Therefor (AREA)
AT89902420T 1988-01-21 1989-01-12 Verstaerkung und nachweis von nukleinsaeuresequenzen. ATE92538T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14646288A 1988-01-21 1988-01-21
PCT/US1989/000120 WO1989006700A1 (en) 1988-01-21 1989-01-12 Amplification and detection of nucleic acid sequences
EP89902420A EP0359789B1 (de) 1988-01-21 1989-01-12 Verstärkung und nachweis von nukleinsäuresequenzen

Publications (1)

Publication Number Publication Date
ATE92538T1 true ATE92538T1 (de) 1993-08-15

Family

ID=22517472

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89902420T ATE92538T1 (de) 1988-01-21 1989-01-12 Verstaerkung und nachweis von nukleinsaeuresequenzen.

Country Status (10)

Country Link
EP (1) EP0359789B1 (de)
JP (3) JP2846018B2 (de)
AT (1) ATE92538T1 (de)
AU (1) AU624601B2 (de)
DE (1) DE68908054T2 (de)
DK (1) DK175944B1 (de)
ES (1) ES2010094A6 (de)
NO (1) NO300782B1 (de)
NZ (1) NZ227688A (de)
WO (1) WO1989006700A1 (de)

Families Citing this family (214)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340807C (en) * 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
US5856092A (en) * 1989-02-13 1999-01-05 Geneco Pty Ltd Detection of a nucleic acid sequence or a change therein
SG50434A1 (en) * 1989-02-13 1998-07-20 Geneco Pty Ltd Detection of a nucleic acid sequence or a change therein
IE66597B1 (en) * 1989-05-10 1996-01-24 Akzo Nv Method for the synthesis of ribonucleic acid (RNA)
DE3929030A1 (de) * 1989-09-01 1991-03-07 Boehringer Mannheim Gmbh Verfahren zur vermehrung von nukleinsaeuren
US7049102B1 (en) * 1989-09-22 2006-05-23 Board Of Trustees Of Leland Stanford University Multi-gene expression profile
US5545522A (en) * 1989-09-22 1996-08-13 Van Gelder; Russell N. Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
US5629153A (en) * 1990-01-10 1997-05-13 Chiron Corporation Use of DNA-dependent RNA polymerase transcripts as reporter molecules for signal amplification in nucleic acid hybridization assays
EP0510085B1 (de) * 1990-01-10 1999-09-08 Chiron Diagnostics Corporation Dns-abhängige rns-polymerase-transkripte als reportermoleküle zur signalverstärkung in nukleinsäure-hybridisierungsuntersuchungen
US7585512B1 (en) 1990-05-08 2009-09-08 Thomas Jefferson University Composition and method of using tumor cells
US5518900A (en) * 1993-01-15 1996-05-21 Molecular Tool, Inc. Method for generating single-stranded DNA molecules
WO1992020820A1 (en) * 1991-05-15 1992-11-26 Vanderbilt University Method to determine metastatic potential of tumor cells
US5169766A (en) * 1991-06-14 1992-12-08 Life Technologies, Inc. Amplification of nucleic acid molecules
AU2663292A (en) * 1991-09-10 1993-04-05 Jack D. Love Dna/rna target and signal amplification
DE4213029A1 (de) * 1991-09-26 1993-04-01 Boehringer Mannheim Gmbh Verfahren zur spezifischen vervielfaeltigung von nukleins aeuresequenzen
US5981179A (en) * 1991-11-14 1999-11-09 Digene Diagnostics, Inc. Continuous amplification reaction
US5256555A (en) * 1991-12-20 1993-10-26 Ambion, Inc. Compositions and methods for increasing the yields of in vitro RNA transcription and other polynucleotide synthetic reactions
KR100249110B1 (ko) * 1992-05-06 2000-04-01 다니엘 엘. 캐시앙 핵산 서열 증폭 방법, 이에 이용되는 조성물 및 키트
US5834202A (en) * 1992-08-04 1998-11-10 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
US5733733A (en) * 1992-08-04 1998-03-31 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
US6261808B1 (en) 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US5614389A (en) * 1992-08-04 1997-03-25 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
DE4238699A1 (de) * 1992-11-17 1994-05-19 Boehringer Mannheim Gmbh Einfaches Nukleinsäurevermehrungsverfahren
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5863724A (en) * 1994-04-13 1999-01-26 Baylor College Of Medicine Methods of screening for persistent hyperinsulinemic hypoglycemia of infancy
US6593086B2 (en) 1996-05-20 2003-07-15 Mount Sinai School Of Medicine Of New York University Nucleic acid amplification methods
US5942391A (en) 1994-06-22 1999-08-24 Mount Sinai School Of Medicine Nucleic acid amplification method: ramification-extension amplification method (RAM)
FR2724934B1 (fr) * 1994-09-26 1997-01-24 Bio Merieux Oligonucleotide chimere et son utilisation dans l'obtention de transcrits d'un acide nucleique
US5789169A (en) * 1994-11-03 1998-08-04 Regents Of The University Of California Methods for the diagnosis of glaucoma
US5606043A (en) * 1994-11-03 1997-02-25 The Regents Of The University Of California Methods for the diagnosis of glaucoma
US5849879A (en) * 1994-11-03 1998-12-15 The Regents Of The University Of California Methods for the diagnosis of glaucoma
US5654141A (en) * 1994-11-18 1997-08-05 Thomas Jefferson University Amplification based detection of bacterial infection
JP3453746B2 (ja) * 1995-02-09 2003-10-06 横河電機株式会社 光ファイバ検査装置
DE754939T1 (de) * 1995-02-02 1997-07-10 Yokogawa Electric Corp., Musashino, Tokio/Tokyo Messvorrichtung für optische fasern
JP3453745B2 (ja) * 1995-02-02 2003-10-06 横河電機株式会社 光ファイバ検査装置
US5753787A (en) * 1995-04-10 1998-05-19 Yale University Nucleic acids encoding ancylostoma secreted protein
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
EP2369007B1 (de) 1996-05-29 2015-07-29 Cornell Research Foundation, Inc. Erkennung von Nukleinsäuresequenz-Unterschieden mittels der gleichzeitigen Ligaseerkennungs- und Polymerasekettenreaktion
US6132954A (en) * 1996-08-20 2000-10-17 Baylor College Of Medicine Methods of screening for agents that delay a cell cycle and compositions comprising era and an analogue of wild-type era
US6071493A (en) 1996-09-20 2000-06-06 Baylor College Of Medicine Method of screening for an agent that inhibits mononuclear phagocyte-plaque component complex formation
US6043283A (en) * 1996-09-20 2000-03-28 Baylor College Of Medicine Tyramine compounds and their neuronal effects
AU735416B2 (en) * 1996-11-06 2001-07-05 Sequenom, Inc. Dna diagnostics based on mass spectrometry
US6025133A (en) * 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
US7138511B1 (en) 1997-01-28 2006-11-21 The Regents Of The University Of California Nucleic acids, kits and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US6475724B1 (en) 1997-01-28 2002-11-05 The Regents Of The University Of California Nucleic acids, kits, and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US6171788B1 (en) 1997-01-28 2001-01-09 The Regents Of The University Of California Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US6262242B1 (en) 1997-01-30 2001-07-17 Board Of Regents, The University Of Texas System Tumor suppressor designated TS10Q23.3
US6482795B1 (en) 1997-01-30 2002-11-19 Myriad Genetics, Inc. Tumor suppressor designated TS10q23.3
US6713300B1 (en) 1997-02-27 2004-03-30 University Of Utah Research Foundation Nucleic acid and amino acid sequences for ATP-binding cassette transporter and methods of screening for agents that modify ATP-binding cassette transporter
US6117643A (en) 1997-11-25 2000-09-12 Ut Battelle, Llc Bioluminescent bioreporter integrated circuit
BR9814294B1 (pt) 1997-12-18 2011-10-18 polipeptìdeo cry3bb de b, thuringiensis modificado, composição compreendendo o mesmo, processo para a produção da referida composição, polinucleotìdeo, vetor, vìrus, microorganismo transgênico e métodos para matar e controlar uma população de insetos coleópteros e para preparar uma planta transgênica resistente a coleópteros e uma semente de planta resistente a coleópteros e uma semente de planta resistente a ataque por insetos coleópteros.
US6673914B1 (en) 1998-01-22 2004-01-06 John Wayne Cancer Institute Human tumor-associated gene
US20020147143A1 (en) 1998-03-18 2002-10-10 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US7029861B1 (en) 1998-09-15 2006-04-18 Board Of Regents, The University Of Texas System LPS-response gene compositions and methods
CA2350911A1 (en) 1998-11-16 2000-05-25 Board Of Regents, The University Of Texas System Hiv-specific t-cell induction
US6156515A (en) * 1999-02-09 2000-12-05 Urocor, Inc. Prostate-specific gene for diagnosis, prognosis and management of prostate cancer
US7037682B2 (en) 1999-03-13 2006-05-02 Government Of The Republic Of Singapore In vitro activity assay for human hepatitis B virus (HBV) DNA polymerase, and its use for screening for inhibitors of HBV DNA polymerase
CA2368194A1 (en) 1999-04-30 2000-11-09 University Of Florida Adeno-associated virus-delivered ribozyme compositions and methods of use
DK1471926T3 (da) 1999-06-01 2011-02-28 Baylor College Medicine Sammensætninger og fremgangsmåder til terapeutisk anvendelse af en atonal-associeret sekvens
CA2377707A1 (en) 1999-06-22 2000-12-28 Invitrogen Corporation Improved primers and methods for the detection and discrimination of nucleic acids
US6830902B1 (en) 1999-07-02 2004-12-14 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
US20040002068A1 (en) 2000-03-01 2004-01-01 Corixa Corporation Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
EP1278855B1 (de) 2000-04-21 2008-03-12 Corixa Corporation Verbindungen und verfahren zur behandlung und diagnose von chlamydia-infektionen
WO2002000174A2 (en) 2000-06-28 2002-01-03 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US20020164715A1 (en) 2000-07-10 2002-11-07 Lin Ji Chromosome 3p21.3 genes are tumor suppressors
JP2005503755A (ja) 2000-12-13 2005-02-10 ニューゲン テクノロジーズ， インコーポレイテッド 核酸配列の複数コピーを作製するための方法および組成物、ならびにそれらを検出する方法
JP3853161B2 (ja) * 2001-02-19 2006-12-06 独立行政法人科学技術振興機構 微量ｍＲＮＡ及びｃＤＮＡの増幅方法
AU2002252279B2 (en) 2001-03-09 2005-05-12 Nugen Technologies, Inc. Methods and compositions for amplification of RNA sequences
EP1988097A1 (de) 2001-05-09 2008-11-05 Corixa Corporation Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Prostatakrebs
AU2003303395A1 (en) 2001-05-22 2004-07-22 Dahl, Gary, A. Target-dependent transcription using deletion mutants of n4 rna polymerase
US8137911B2 (en) 2001-05-22 2012-03-20 Cellscript, Inc. Preparation and use of single-stranded transcription substrates for synthesis of transcription products corresponding to target sequences
EP1399541A4 (de) 2001-05-22 2005-04-13 Univ Chicago Einzelstrang-dna-abhängige rna polymerase des virions n4
WO2003012030A2 (en) 2001-08-01 2003-02-13 University Of Utah, Technology Transfer Office Isoform-selective inhibitors and activators of pde3 cyclic
EP2135960A1 (de) 2001-09-19 2009-12-23 Intergenetics Incorporated Genetische Analyse zur Stratifizierung eines Krebsrisikos mit Hilfe des Allelprofils der VDR-ApaI und CYP11b2 Gene
EP1908851A3 (de) 2001-09-19 2008-06-25 Intergenetics Incorporated Genetische Analyse zur Stratifizierung eines Krebsrisikos
US20030165859A1 (en) 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
ES2364037T3 (es) 2001-12-10 2011-08-23 Novartis Ag Métodos de tratamiento de psicosis y esquizofrenia basados en polimorfismos del gen del cntf.
WO2003053220A2 (en) 2001-12-17 2003-07-03 Corixa Corporation Compositions and methods for the therapy and diagnosis of inflammatory bowel disease
US6916474B2 (en) 2002-07-15 2005-07-12 Board Of Regents, The University Of Texas System Antibodies with increased affinities for anthrax antigens
CN101912421A (zh) 2002-08-12 2010-12-15 杰能斯有限公司 涉及痘病毒和癌的方法及组合物
AU2002951411A0 (en) 2002-09-16 2002-09-26 The University Of Sydney Genotype screen
EP1585824A4 (de) 2002-11-21 2008-01-02 Epict Technologies Herstellung und verwendung einzelsträngiger transkriptionssubstrate zur synthese von zielsequenzen entsprechenden transkriptionsprodukten
US7960522B2 (en) 2003-01-06 2011-06-14 Corixa Corporation Certain aminoalkyl glucosaminide phosphate compounds and their use
HUE026376T2 (en) 2003-01-06 2016-05-30 Corixa Corp Certain aminoalkyl glucosamide phosphate compounds and their use
EP2159285B1 (de) 2003-01-29 2012-09-26 454 Life Sciences Corporation Verfahren zur Verstärkung und Sequenzierung von Nukleinsäuren
JP4773338B2 (ja) 2003-03-07 2011-09-14 ルビコン ゲノミクス， インコーポレイテッド Ｄｎａ重合プロセスにより生成される全ゲノムおよび全トランスクリプトームライブラリーの増幅および分析
EP2390352A1 (de) 2003-03-18 2011-11-30 Quantum Genetics Ireland Limited Systeme und Methoden zur Erhöhung der Milchproduktion bei Tieren
JP2006523465A (ja) 2003-04-14 2006-10-19 ニューゲン テクノロジーズ， インコーポレイテッド ランダムにプライミングされる複合プライマーを用いる大規模増幅
EP2295569A1 (de) 2003-07-25 2011-03-16 Ambion, Inc. Verfahren und Zusammensetzungen zur Isolation von kleinen RNA-molekülen
US20050059024A1 (en) 2003-07-25 2005-03-17 Ambion, Inc. Methods and compositions for isolating small RNA molecules
CA2538222A1 (en) 2003-09-12 2005-03-24 Stephen Bryant Liggett Methods for risk assessment, survival prediction and treatment of heart failure and other conditions based on adrenergic receptor polymorphisms
EP1718770B1 (de) 2004-02-19 2011-05-25 The Governors of the University of Alberta Leptinpromotor-polymorphismen und verwendungen davon
EP2270034A3 (de) 2004-06-03 2011-06-01 Athlomics Pty Ltd Mittel und Methoden zur Diagnose von Stress
EP1802775B1 (de) 2004-09-14 2010-05-26 The Regents of the University of Colorado Auf genetischem targeting basierendes verfahren zur behandlung mit bucindolol
EP1874955A4 (de) 2005-02-28 2009-05-06 Bioquest Inc Verfahren zur durchführung direkter enzymatischer reaktionen unter beteiligung von nukleinsäuremolekülen
WO2006095941A1 (en) 2005-03-05 2006-09-14 Seegene, Inc. Processes using dual specificity oligonucleotide and dual specificity oligonucleotide
PL1856257T3 (pl) 2005-03-05 2012-03-30 Seegene Inc Procesy wykorzystujące oligonukleotyd o podwójnej specyficzności oraz oligonukleotyd o podwójnej specyficzności
EP1910565A4 (de) 2005-07-07 2009-10-28 Athlomics Pty Ltd Polynukleotidmarkergene und deren expression zur diagnose von endotoxämie
US7494788B2 (en) 2005-07-11 2009-02-24 Molecular Kinetics, Inc. Entropic bristle domain sequences and their use in recombinant protein production
US7838646B2 (en) 2005-08-18 2010-11-23 Quest Diagnostics Investments Incorporated Cystic fibrosis transmembrane conductance regulator gene mutations
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
CA2621267A1 (en) 2005-09-07 2007-03-15 Nugen Technologies, Inc. Improved nucleic acid amplification procedure
WO2007048074A1 (en) 2005-10-21 2007-04-26 Genenews Inc. Method and apparatus for correlating levels of biomarker products with disease
AU2006309096B2 (en) 2005-10-28 2013-07-04 Glaxosmithkline Llc Methods for identifying compounds of interest using encoded libraries
KR20080073748A (ko) 2005-11-16 2008-08-11 노파르티스 아게 척수 손상에서의 항-ｎｏｇｏ-ａ 항체 치료를 위한바이오마커
US8014957B2 (en) 2005-12-15 2011-09-06 Fred Hutchinson Cancer Research Center Genes associated with progression and response in chronic myeloid leukemia and uses thereof
WO2007106579A2 (en) 2006-03-15 2007-09-20 Micronics, Inc. Integrated nucleic acid assays
CA2909340C (en) 2006-05-25 2019-07-02 Monsanto Technology Llc A method to identify disease resistant quantitative trait loci in soybean and compositions thereof
CA2663034C (en) 2006-09-15 2016-05-03 Ottawa Health Research Institute Oncolytic rhabdovirus
KR100823642B1 (ko) * 2006-09-26 2008-04-21 고려대학교 산학협력단 큐티나아제 생산 균주, 그 선별 방법, 상기 균주에 의해생산된 큐티나아제 및 상기 큐티나아제를 포함하는 조성물
ATE555128T1 (de) 2006-11-30 2012-05-15 Res Dev Foundation Verbesserte immunglobulin-bibliotheken
AU2007336839C1 (en) * 2006-12-21 2013-12-19 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
US7794937B2 (en) 2006-12-22 2010-09-14 Quest Diagnostics Investments Incorporated Cystic fibrosis transmembrane conductance regulator gene mutations
HUE030719T2 (en) 2007-04-09 2017-05-29 Univ Florida RAAV vector formulations and methods comprising tyrosine-modified capsid proteins for their use
DK2155789T3 (da) 2007-05-01 2013-10-21 Res Dev Foundation Immunoglobulin-Fc-biblioteker
EP2173872B1 (de) 2007-06-29 2014-04-02 CellScript, Inc. Copy-dna und sense-rna
JP5250698B2 (ja) * 2008-08-29 2013-07-31 テレフオンアクチーボラゲット エル エム エリクソン（パブル） 光ネットワークにおけるファイバの監視方法
CN102458446B (zh) 2009-04-22 2017-06-13 印第安那大学科技研究公司 用于治疗慢性阻塞性肺病和哮喘的组合物和方法
EP2789689B1 (de) 2009-06-29 2016-04-27 Luminex Corporation Chimäre Primer mit Haarnadel-Konformationen und Verfahren zur Verwendung davon
WO2011003020A1 (en) 2009-07-01 2011-01-06 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
PL3042957T3 (pl) 2009-07-17 2018-03-30 Bioatla Llc Jednoczesna, zintegrowana selekcja i ewolucja wydajności ludzkiego białka i wyrażanie w gospodarzu do wytwarzania
US9409983B2 (en) 2009-07-23 2016-08-09 The Board Of Trustess Of The University Of Illinois Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases
US9512481B2 (en) 2009-09-11 2016-12-06 The Regents Of The University Of Colorado, A Body Corporate Polymorphisms in the PDE3A gene
CA2774144C (en) 2009-09-14 2018-02-13 Jennerex, Inc. Oncolytic vaccinia virus combination cancer therapy
KR20110050327A (ko) 2009-11-07 2011-05-13 주식회사 씨젠 Ｔｈｄ 프라이머 타겟 검출
CN102858959B (zh) 2009-12-10 2016-02-24 渥太华医院研究院 溶瘤弹状病毒
CN102762744B (zh) 2009-12-21 2017-07-25 Seegene株式会社 利用靶信号产生引物进行的靶检测
CA2822747A1 (en) 2009-12-23 2011-06-30 Arca Biopharma, Inc. Use of s-(6-nitro-oxi-hexahydro-furo[3,2-b]thioacetate in the treatment of cardiovascular disorders associated with oxide synthase dysfunction
CN102740976B (zh) 2010-01-29 2016-04-20 精密公司 取样-应答微流体盒
SI2558577T1 (sl) 2010-04-16 2019-05-31 Nuevolution A/S Bifunkcionalni kompleksi in metode za pripravo in uporabo takšnih kompleksov
CN105821079B (zh) 2010-04-23 2021-10-26 佛罗里达大学研究基金公司 用于治疗莱伯氏先天性黑蒙-1(lca1)的raav-鸟苷酸环化酶组合物及方法
KR101223660B1 (ko) 2010-05-20 2013-01-17 광주과학기술원 ＨＩＦ－２α 억제제를 유효성분으로 포함하는 관절염 예방 또는 치료용 약제학적 조성물
KR101176139B1 (ko) 2010-05-20 2012-08-22 광주과학기술원 관절염 동물모델로서 연골 특이적 ＨＩＦ?２α 형질전환 마우스 및 이의 용도
SG10201902596TA (en) 2010-07-16 2019-04-29 Bioatla Llc Novel methods of protein evolution
EP2580325A4 (de) 2010-07-16 2013-11-20 Tocagen Inc Retrovirenerkennung
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
CN104531812A (zh) 2010-10-01 2015-04-22 现代治疗公司 设计核酸及其使用方法
WO2012090073A2 (en) 2010-12-30 2012-07-05 The Netherlands Cancer Institute Methods and compositions for predicting chemotherapy sensitivity
BR112013017096A2 (pt) 2011-01-04 2020-09-01 Jennerex Inc. composição e métodos de indução de resposta citotóxica dependente de complemento mediado por anticorpo específico de tumor em animal tendo tumor, de geração de anticorpos in vivo, de inibição do crescimento ou morte de célula de câncer, para tratar indivíduo com câncer, para adaptar de terapia de câncer para indivíduo com câncer e para identificar antígeno específico de tumor
CA2826467C (en) 2011-02-07 2019-11-12 Research Development Foundation Engineered immunoglobulin fc polypeptides
US20140057295A1 (en) 2011-02-28 2014-02-27 Barbara J. Stegmann Anti-mullerian hormone changes in pregnancy and prediction of adverse pregnancy outcomes and gender
AU2012226530B2 (en) 2011-03-08 2016-12-01 King Abdullah University Of Science And Technology Molecular biomarker set for early detection of ovarian cancer
WO2012135805A2 (en) 2011-03-31 2012-10-04 modeRNA Therapeutics Delivery and formulation of engineered nucleic acids
AU2012240246A1 (en) 2011-04-04 2013-05-09 Netherlands Cancer Institute Methods and compositions for predicting resistance to anticancer treatment with protein kinase inhibitors
KR101291668B1 (ko) 2011-04-21 2013-08-01 서울대학교산학협력단 미코박테리아―대장균용 셔틀 벡터 및 이의 용도
KR102007444B1 (ko) 2011-04-25 2019-08-06 어드밴스드 바이오사이언스 라보라토리즈, 인코포레이티드 절단형 hiv 피막 단백질(env), 이와 관련된 방법 및 조성물
WO2012167382A1 (en) 2011-06-08 2012-12-13 Children's Hospital Of Eastern Ontario Research Institute Inc. Compositions and methods for glioblastoma treatment
US20150030586A1 (en) 2011-06-21 2015-01-29 Sarah Ellen Warren Compositions and methods for the therapy and diagnosis of cancer
US10040853B2 (en) 2011-09-09 2018-08-07 Fred Hutchinson Cancer Research Center Methods and compositions involving NKG2D inhibitors and cancer
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
WO2013045505A1 (en) 2011-09-28 2013-04-04 Novartis Ag Biomarkers for raas combination therapy
RU2707251C2 (ru) 2011-10-03 2019-11-25 Модерна Терапьютикс, Инк. Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
EP2780467B1 (de) 2011-11-14 2018-10-17 Alfasigma S.p.A. Assays und verfahren zur auswahl eines behandlungsplans für einen patienten mit depressionen und behandlungsverfahren dafür
KR20140102759A (ko) 2011-12-16 2014-08-22 모더나 세라퓨틱스, 인코포레이티드 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물
WO2013093629A2 (en) 2011-12-20 2013-06-27 Netherlands Cancer Institute Modular vaccines, methods and compositions related thereto
WO2013116698A2 (en) 2012-02-02 2013-08-08 Invenra, Inc. High throughput screen for biologically active polypeptides
EP2830621B1 (de) 2012-03-29 2020-10-21 Novartis AG Pharmazeutisches diagnostikum
EP2833892A4 (de) 2012-04-02 2016-07-20 Moderna Therapeutics Inc Modifizierte polynukleotide zur herstellung von in der onkologie nützlichen proteinen und peptiden
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
JP6144355B2 (ja) 2012-11-26 2017-06-07 モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． 化学修飾ｍＲＮＡ
EP2740805B1 (de) 2012-12-07 2019-02-20 SuppreMol GmbH Stratifizierung und Behandlung von Patienten, die an idiopathischer thrombozytopenischer Purpura leiden
EP3549674B1 (de) 2012-12-21 2020-08-12 PerkinElmer Health Sciences, Inc. Filme mit geringere elastizität zur mikrofluidischen verwendung
KR20150097764A (ko) 2012-12-21 2015-08-26 마이크로닉스 인코포레이티드. 휴대형 형광 검출 시스템 및 미량분석 카트리지
WO2014100732A1 (en) 2012-12-21 2014-06-26 Micronics, Inc. Fluidic circuits and related manufacturing methods
WO2014116721A1 (en) 2013-01-22 2014-07-31 The Arizona Board Of Regents For And On Behalf Of Arizona State University Geminiviral vector for expression of rituximab
RU2684211C2 (ru) 2013-02-21 2019-04-04 Тёрнстоун Лимитед Партнершип Композиция вакцины
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
KR101403507B1 (ko) 2013-03-21 2014-06-09 주식회사 현일바이오 결핵균 및 비결핵 마이코박테리아의 선택적 검출 방법, 그리고 이를 이용한 키트
KR101507505B1 (ko) 2013-04-18 2015-04-07 사회복지법인 삼성생명공익재단 제 1 형 근긴장성 이영양증의 진단 방법
US10386377B2 (en) 2013-05-07 2019-08-20 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
WO2014182831A1 (en) 2013-05-07 2014-11-13 Micronics, Inc. Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions
WO2014182847A1 (en) 2013-05-07 2014-11-13 Micronics, Inc. Device for preparation and analysis of nucleic acids
US20160186263A1 (en) 2013-05-09 2016-06-30 Trustees Of Boston University Using plexin-a4 as a biomarker and therapeutic target for alzheimer's disease
WO2015048744A2 (en) 2013-09-30 2015-04-02 Moderna Therapeutics, Inc. Polynucleotides encoding immune modulating polypeptides
BR112016007391A2 (pt) 2013-10-03 2017-08-01 Oklahoma Med Res Found biomarcadores da atividade, da intensidade e da fase aguda da doença lúpus eritematoso sistêmico
US10323076B2 (en) 2013-10-03 2019-06-18 Modernatx, Inc. Polynucleotides encoding low density lipoprotein receptor
AU2015204840B2 (en) 2014-01-07 2020-01-30 Bioatla, Llc Proteins targeting orthologs
WO2015191916A1 (en) 2014-06-11 2015-12-17 Micronics, Inc. Microfluidic cartridges and apparatus with integrated assay controls for analysis of nucleic acids
US20180057839A1 (en) 2014-11-26 2018-03-01 The Regents Of The University Of California Therapeutic compositions comprising transcription factors and methods of making and using the same
SG10202012249YA (en) 2014-12-08 2021-01-28 Berg Llc Use of markers including filamin a in the diagnosis and treatment of prostate cancer
KR101718800B1 (ko) 2015-01-21 2017-03-24 주식회사 디알나노 약물 및 ｓｉＲＮＡ의 공동―운반용 나노복합체 및 이의 용도
CA2976236A1 (en) 2015-02-09 2016-08-18 Research Development Foundation Engineered immunoglobulin fc polypeptides displaying improved complement activation
AU2016297510B2 (en) 2015-07-17 2021-09-09 President And Fellows Of Harvard College Methods of amplifying nucleic acid sequences
US9789087B2 (en) 2015-08-03 2017-10-17 Thomas Jefferson University PAR4 inhibitor therapy for patients with PAR4 polymorphism
US10526408B2 (en) 2015-08-28 2020-01-07 Research Development Foundation Engineered antibody FC variants
KR101651817B1 (ko) 2015-10-28 2016-08-29 대한민국 Ngs 라이브러리 제작용 프라이머 세트 및 이를 이용한 ngs 라이브러리 제작방법 및 키트
KR101845957B1 (ko) 2016-02-23 2018-04-05 전남대학교기술지주회사(주) 프로히비틴 유전자 타깃 백혈병 진단용 키트 및 이를 이용한 진단 방법
US20200185063A1 (en) 2016-06-05 2020-06-11 Berg Llc Systems and methods for patient stratification and identification of potential biomarkers
ES2972231T3 (es) 2016-12-29 2024-06-11 Seegene Inc Procedimiento para reducir la formación de dímeros de cebadores y aumentar la eficacia de la amplificación
KR101936799B1 (ko) 2017-01-09 2019-01-11 주식회사 엠이티라이프사이언스 구강전암의 치료용 약학 조성물 및 구강전암 또는 구강암의 예측 또는 진단 방법
US20190390278A1 (en) 2017-01-26 2019-12-26 Oklahoma Medical Research Foundation Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare
WO2019017680A2 (ko) 2017-07-19 2019-01-24 국민대학교 산학협력단 파킨슨병 바이오마커로서의 miRNA 및 이를 이용한 진단키트
KR101956315B1 (ko) 2017-07-19 2019-03-08 국민대학교 산학협력단 파킨슨병 바이오마커로서의 miR494 및 이를 이용한 진단키트
BR112020024083A2 (pt) 2018-05-25 2021-05-04 Arca Biopharma Inc. métodos e composições envolvendo bucindolol para o tratamento de fibrilação atrial
WO2020089841A1 (en) 2018-10-31 2020-05-07 Garcia Joe G N Biomarkers and methods of use for radiation-induced lung injury
EP3963099A1 (de) 2019-04-30 2022-03-09 Larimar Therapeutics, Inc. Frataxin-sensitive marker zur bestimmung der wirksamkeit einer frataxin ersatztherapie
CA3138015A1 (en) 2019-06-14 2020-12-17 Jong Yoon Chun Computer-implemented method for collaborative development of reagents for detection of target nucleic acids
WO2021246820A1 (ko) 2020-06-05 2021-12-09 주식회사 씨젠 호흡기 병원체 검출을 위한 검체수송 키트 및 이를 이용한 호흡기 병원체 검출방법
US20230266325A1 (en) 2020-06-30 2023-08-24 Lunglife Ai, Inc. Methods for detecting lung cancer
WO2022047359A1 (en) 2020-08-31 2022-03-03 Berg Llc Protein biomarkers for pancreatic cancer
CA3214833A1 (en) 2021-04-06 2022-10-13 Bpgbio, Inc. Protein markers for the prognosis of breast cancer progression
EP4320441A1 (de) 2021-04-06 2024-02-14 BPGbio, Inc. Proteinmarker für östrogenrezeptor (er)-positiv- und östrogenrezeptor (er)-negativ-ähnlichen brustkrebs
EP4320440A1 (de) 2021-04-06 2024-02-14 BPGbio, Inc. Proteinmarker für östrogenrezeptor (er)-positiven luminalen a(la)-ähnlichen und luminalen b1 (lb1)-ähnlichen brustkrebs
KR20240035874A (ko) 2021-07-21 2024-03-18 주식회사 씨젠 검수 수집 장치 및 검체 수집 방법
CA3232702A1 (en) * 2021-09-23 2023-03-30 Geert Meersseman Nucleic acid detection
KR20240056605A (ko) 2021-09-30 2024-04-30 주식회사 씨젠 분자진단 시스템의 샘플 처리 및 분석 방법
WO2023075394A1 (ko) 2021-10-29 2023-05-04 주식회사 씨젠 검체 채취 스왑 도구 및 호흡기 병원체의 검출 방법
WO2023196937A1 (en) 2022-04-06 2023-10-12 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring frataxin replacement therapy
WO2023230531A1 (en) 2022-05-24 2023-11-30 Lunglife Ai, Inc. Methods for detecting circulating genetically abnormal cells
WO2023240201A1 (en) 2022-06-08 2023-12-14 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring progression and treatment of leigh syndrome
WO2023239940A1 (en) 2022-06-10 2023-12-14 Research Development Foundation Engineered fcriib selective igg1 fc variants and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1339653C (en) * 1986-02-25 1998-02-03 Larry J. Johnson Appartus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
IL86724A (en) * 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
US4819269A (en) * 1987-07-21 1989-04-04 Hughes Aircraft Company Extended imaging split mode loudspeaker system
AU618965B2 (en) * 1987-07-31 1992-01-16 Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
CA1340843C (en) * 1987-07-31 1999-12-07 J. Lawrence Burg Selective amplification of target polynucleotide sequences

Also Published As

Publication number Publication date
EP0359789B1 (de) 1993-08-04
DK175944B1 (da) 2005-08-01
EP0359789A1 (de) 1990-03-28
NO893583D0 (no) 1989-09-06
AU624601B2 (en) 1992-06-18
ES2010094A6 (es) 1989-10-16
DE68908054T2 (de) 1994-03-10
AU3058589A (en) 1989-08-11
NO300782B1 (no) 1997-07-21
DK463089D0 (da) 1989-09-20
JPH02503054A (ja) 1990-09-27
WO1989006700A1 (en) 1989-07-27
DE68908054D1 (de) 1993-09-09
DK463089A (da) 1989-09-20
JP3514630B2 (ja) 2004-03-31
JPH1189600A (ja) 1999-04-06
JP2846018B2 (ja) 1999-01-13
NO893583L (no) 1989-09-06
JPH026724A (ja) 1990-01-10
NZ227688A (en) 1991-03-26

Similar Documents

Publication Publication Date Title
ATE92538T1 (de) Verstaerkung und nachweis von nukleinsaeuresequenzen.
ATE93896T1 (de) Nachweis und bestimmung der menge an rns und dns.
FI900602A0 (fi) Bestaemning.
ES2083955T3 (es) Determinacion de polinucleotidos con sitios de escision seleccionables.
ES8700270A1 (es) Un metodo para producir nucleotidos.
DE69231693D1 (de) Hbv amplifizierungssonden zur verwendung in hybridisierungssandwichassay in der lösungsphase
ES8605862A1 (es) Perfeccionamientos en las disposiciones para la deteccion desecuencias determinadas de nucleotidos, procedimiento de deteccion y de caracterizacion de una secuencia o de un fragmento de acido nucleico determinado y sonda clonad
DE68901285D1 (de) Verfahren zum nachweis von nukleotid-sequenzen.
NO870613L (no) Deteksjon av mikroorganismer i en prŸve inneholdende nukleinsyre.
DK163383C (da) Fremgangsmaade og reagenssystem til bestemmelse henholdsvis detektering af en bestemt polynucleotidsekvens i et testmedium indeholdende enkeltstrengede nucleinsyrer
DK0407789T3 (da) Fremgangsmåde til detektering af nukleinsyrer
DE3850468D1 (de) System zum Detektierung von ONS.
DE59606675D1 (de) Verfahren zum nachweis von telomerase-aktivität
SE8700821D0 (sv) Quantitative determination of nucleic acid molecules and the reagent kit used
DE69717840T2 (de) Nachweis und identifizierung von nicht-polio enteroviren
ATE309389T1 (de) Verfahren zum entdecken von telomerase-aktivität
ATE184055T1 (de) Verfahren zum sensitiven nachweis von reverser transcriptase
DE69125368D1 (de) Karakterisierung von hla-dqbeta-dns
ATE86672T1 (de) Nachweis und differenziierung von coxiella burnetit in biologischen fluessigkeiten.
DE68919387D1 (de) DNS- und RNS-Proben, Methoden und Testsätze zum Nachweis von Salmonella.
DE69632826D1 (de) Nukleinsaeure erkennung von hepatitis gb virus
JO1656B1 (en) New method of analysis
DE68925457D1 (de) Diagnoseverfahren für infektionskrankheiten sowie verfahren zum nachweis und identifizierung von mikroorganismen
DE3567908D1 (en) Photoimmune detection of dna and rna

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time