ATE553093T1 - Indazolderivate zur hemmung von trpv1 und verwendungen davon - Google Patents
Indazolderivate zur hemmung von trpv1 und verwendungen davonInfo
- Publication number
- ATE553093T1 ATE553093T1 AT07814410T AT07814410T ATE553093T1 AT E553093 T1 ATE553093 T1 AT E553093T1 AT 07814410 T AT07814410 T AT 07814410T AT 07814410 T AT07814410 T AT 07814410T AT E553093 T1 ATE553093 T1 AT E553093T1
- Authority
- AT
- Austria
- Prior art keywords
- indazole derivatives
- compounds
- inhibiting trpv1
- compositions
- trpv1
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84025406P | 2006-08-25 | 2006-08-25 | |
PCT/US2007/076696 WO2008024945A1 (en) | 2006-08-25 | 2007-08-24 | Indazole derivatives that inhibit trpv1 and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE553093T1 true ATE553093T1 (de) | 2012-04-15 |
Family
ID=38739912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07814410T ATE553093T1 (de) | 2006-08-25 | 2007-08-24 | Indazolderivate zur hemmung von trpv1 und verwendungen davon |
Country Status (9)
Country | Link |
---|---|
US (2) | US7767705B2 (de) |
EP (1) | EP2054390B1 (de) |
JP (1) | JP2010501592A (de) |
CN (1) | CN101541758A (de) |
AT (1) | ATE553093T1 (de) |
CA (1) | CA2661898A1 (de) |
MX (1) | MX2009002018A (de) |
TW (1) | TW200824687A (de) |
WO (1) | WO2008024945A1 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2009002018A (es) * | 2006-08-25 | 2009-03-05 | Abbott Lab | Derivados de indazol que inhiben vanilloide-1 potencial de receptor pasajero (trpv1) y usos de los mismos. |
EP2323989A4 (de) | 2008-03-20 | 2011-06-22 | Abbott Lab | Verfahren zur herstellung von auf das zentrale nervensystem wirkenden mitteln, bei denen es sich um trpv1-antagonisten handelt |
EP2288922B1 (de) * | 2008-05-08 | 2016-08-17 | University of Utah Research Foundation | Sensorische rezeptoren für chronische müdigkeit und schmerzen und verwendungen dafür |
ES2566339T3 (es) * | 2008-06-05 | 2016-04-12 | Glaxo Group Limited | Derivados de 4-carboxamida indazol útiles como inhibidores de PI3-quinasas |
EP2300437B1 (de) | 2008-06-05 | 2013-11-20 | Glaxo Group Limited | Benzpyrazolderivate als inhibitoren von pi3-kinasen |
JP5502077B2 (ja) * | 2008-06-05 | 2014-05-28 | グラクソ グループ リミテッド | 新規な化合物 |
WO2009147189A1 (en) * | 2008-06-05 | 2009-12-10 | Glaxo Group Limited | Novel compounds |
JP5656880B2 (ja) | 2009-03-09 | 2015-01-21 | グラクソ グループ リミテッドGlaxo Group Limited | Pi3キナーゼの阻害剤としての4−オキサジアゾール−2−イル−インダゾール |
DK2899191T3 (da) | 2009-04-30 | 2017-11-13 | Glaxo Group Ltd | Oxazol-substituerede indazoler som pi3-kinaseinhibitorer |
JP2013512879A (ja) * | 2009-12-03 | 2013-04-18 | グラクソ グループ リミテッド | Pi3キナーゼの阻害剤としてのベンズピラゾール誘導体 |
US8680110B2 (en) * | 2010-08-03 | 2014-03-25 | Nippon Chemiphar Co., Ltd. | P2X4 receptor antagonist |
GB201018124D0 (en) | 2010-10-27 | 2010-12-08 | Glaxo Group Ltd | Polymorphs and salts |
ES2673301T3 (es) | 2010-11-03 | 2018-06-21 | University Of Hawaii | Métodos y composiciones para la prevención y el tratamiento de la hipertrofia cardíaca |
BR112014001714A2 (pt) * | 2011-07-26 | 2017-02-14 | Gruenenthal Gmbh | derivados de carboxamida e ureia aromáticos bicíclicos substituídos como ligantes de receptor vaniloide |
WO2015044759A1 (en) | 2013-09-24 | 2015-04-02 | Purdue Pharma L.P. | Treatment of burn pain by trpv1 modulators |
US10696638B2 (en) * | 2017-12-26 | 2020-06-30 | Industrial Technology Research Institute | Compounds for inhibiting AGC kinase and pharmaceutical compositions comprising the same |
CN117247339B (zh) * | 2023-11-16 | 2024-03-12 | 潍坊富邦药业有限公司 | 一种烷基胺衍生物的制备方法 |
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US3043694A (en) * | 1960-05-23 | 1962-07-10 | Eastman Kodak Co | Novel class of 3-indazolinone developing agent |
FR1344579A (fr) | 1961-11-23 | 1963-11-29 | Sandoz Sa | Nouveaux dérivés de l'indole et leur préparation |
US3647819A (en) * | 1969-09-19 | 1972-03-07 | Sterling Drug Inc | Indazolylphenylureas and indazolyl-phenylthioureas |
US3711610A (en) * | 1971-06-01 | 1973-01-16 | Sterling Drug Inc | Anticoccidiosis method and compositions involving indazolylphenylureas and indazolylphenylthioureas |
US3814711A (en) * | 1971-07-26 | 1974-06-04 | Mallinckrodt Chemical Works | 10-acetamido-s-triazolo-(3,4-a)-isoquinolines |
NL7902993A (nl) | 1978-04-24 | 1979-10-26 | Rhone Poulenc Ind | Nieuwe isochinolinederivaten, de bereiding ervan en farmaceutische preparaten, die de nieuwe isochinoline- derivaten bevatten. |
JPS5587771A (en) | 1978-12-27 | 1980-07-02 | Teikoku Hormone Mfg Co Ltd | 1-phenylisoquinoline derivative |
DE3430310A1 (de) | 1984-08-15 | 1986-02-27 | Schering AG, Berlin und Bergkamen, 1000 Berlin | Neue dopamin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
EP0189473B1 (de) * | 1984-08-15 | 1992-05-27 | Schering Aktiengesellschaft | Neue dopamin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
US4569779A (en) | 1985-01-03 | 1986-02-11 | Jabalee Walter J | Solution for cleansing a cooling system |
JPS62116559A (ja) | 1985-11-18 | 1987-05-28 | Sagami Chem Res Center | 4−アシルメチリデン−4,5,6,7−テトラヒドロインド−ル誘導体及びその製造方法 |
US4788206A (en) | 1987-07-10 | 1988-11-29 | Hoffmann-La Roche Inc. | Pentadieneamides |
JPS6487629A (en) | 1987-09-28 | 1989-03-31 | Mitsubishi Petrochemical Co | Production of aromatic poly(thio)ether amide |
MX22406A (es) | 1989-09-15 | 1994-01-31 | Pfizer | Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat). |
JPH05504968A (ja) | 1990-03-07 | 1993-07-29 | ローン―プーラン・ロレ・ソシエテ・アノニム | グリシンアミド誘導体、その製造及びそれを含む医薬品 |
US5362878A (en) * | 1991-03-21 | 1994-11-08 | Pfizer Inc. | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) |
US5444038A (en) * | 1992-03-09 | 1995-08-22 | Zeneca Limited | Arylindazoles and their use as herbicides |
CA2134359C (en) * | 1992-05-28 | 1997-07-01 | Ernest S. Hamanaka | New n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
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US5760246A (en) * | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
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TWI239942B (en) * | 2001-06-11 | 2005-09-21 | Dainippon Pharmaceutical Co | N-arylphenylacetamide derivative and pharmaceutical composition containing the same |
EP1403255A4 (de) | 2001-06-12 | 2005-04-06 | Sumitomo Pharma | Rho-kinase-inhibitoren |
CA2455754A1 (en) | 2001-07-31 | 2003-02-20 | Bayer Healthcare Ag | Amine derivatives |
PE20030417A1 (es) | 2001-09-13 | 2003-08-06 | Smithkline Beecham Plc | Derivados de urea como antagonistas del receptor vainilloide |
WO2003029199A1 (fr) | 2001-09-28 | 2003-04-10 | Takeda Chemical Industries, Ltd. | Derives de benzene et procede de preparation et d'utilisation associe |
PL373484A1 (en) | 2001-12-10 | 2005-09-05 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
GB0130550D0 (en) | 2001-12-20 | 2002-02-06 | Smithkline Beecham Plc | Novel compounds |
US20050154230A1 (en) | 2001-12-26 | 2005-07-14 | Bayer Healthcare Ag | Urea derivatives |
JP2003192587A (ja) | 2001-12-26 | 2003-07-09 | Bayer Ag | 尿素誘導体 |
DE60325834D1 (de) | 2002-02-20 | 2009-03-05 | Abbott Lab | Kondensierte azabicyclischeverbindungen als inhibitoren des vanilloid-rezeptors 1 (vr1) |
GB0206876D0 (en) | 2002-03-22 | 2002-05-01 | Merck Sharp & Dohme | Therapeutic agents |
AU2003241453A1 (en) | 2002-05-17 | 2003-12-02 | Janssen Pharmaceutica N.V. | Aminotetralin-derived urea modulators of vanilloid vr1 receptor |
US6933311B2 (en) * | 2003-02-11 | 2005-08-23 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
JP2005036929A (ja) * | 2003-07-17 | 2005-02-10 | Advics:Kk | 電磁弁の弁軸付可動鉄心及びその製造方法 |
GB0322016D0 (en) * | 2003-09-19 | 2003-10-22 | Merck Sharp & Dohme | New compounds |
MX2009002018A (es) * | 2006-08-25 | 2009-03-05 | Abbott Lab | Derivados de indazol que inhiben vanilloide-1 potencial de receptor pasajero (trpv1) y usos de los mismos. |
-
2007
- 2007-08-24 MX MX2009002018A patent/MX2009002018A/es active IP Right Grant
- 2007-08-24 EP EP07814410A patent/EP2054390B1/de active Active
- 2007-08-24 US US11/844,712 patent/US7767705B2/en not_active Expired - Fee Related
- 2007-08-24 WO PCT/US2007/076696 patent/WO2008024945A1/en active Application Filing
- 2007-08-24 CN CNA2007800317363A patent/CN101541758A/zh active Pending
- 2007-08-24 JP JP2009525788A patent/JP2010501592A/ja active Pending
- 2007-08-24 CA CA002661898A patent/CA2661898A1/en not_active Abandoned
- 2007-08-24 TW TW096131540A patent/TW200824687A/zh unknown
- 2007-08-24 AT AT07814410T patent/ATE553093T1/de active
-
2010
- 2010-06-14 US US12/815,259 patent/US8815930B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US8815930B2 (en) | 2014-08-26 |
US20080058401A1 (en) | 2008-03-06 |
US20100249203A1 (en) | 2010-09-30 |
TW200824687A (en) | 2008-06-16 |
EP2054390A1 (de) | 2009-05-06 |
JP2010501592A (ja) | 2010-01-21 |
US7767705B2 (en) | 2010-08-03 |
CA2661898A1 (en) | 2008-02-28 |
MX2009002018A (es) | 2009-03-05 |
WO2008024945A1 (en) | 2008-02-28 |
EP2054390B1 (de) | 2012-04-11 |
CN101541758A (zh) | 2009-09-23 |
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