MX2009006730A - Derivados de n-(5, 6, 7, 8-tetrahidronaftalen-1-il) urea y compuestos relacionados como antagonistas de receptor vaniloide trpv1 par el tratamiento de dolor. - Google Patents
Derivados de n-(5, 6, 7, 8-tetrahidronaftalen-1-il) urea y compuestos relacionados como antagonistas de receptor vaniloide trpv1 par el tratamiento de dolor.Info
- Publication number
- MX2009006730A MX2009006730A MX2009006730A MX2009006730A MX2009006730A MX 2009006730 A MX2009006730 A MX 2009006730A MX 2009006730 A MX2009006730 A MX 2009006730A MX 2009006730 A MX2009006730 A MX 2009006730A MX 2009006730 A MX2009006730 A MX 2009006730A
- Authority
- MX
- Mexico
- Prior art keywords
- antagonists
- trpv1 receptor
- trpv1
- antagonictc
- exacerbated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente solicitud se dirige a compuestos que son antagonistas TRPV1 y que tienen la fórmula: (I); en donde las variables Ar1, L1, R1, R2, R3, R4, R5, Y1, Y2 y Y3 son tal como se definen en la descripción, las cuales son útiles para tratar transtornos originados o exacerbados por la actividad de receptor vaniloide.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87589006P | 2006-12-20 | 2006-12-20 | |
PCT/US2007/087163 WO2008079683A2 (en) | 2006-12-20 | 2007-12-12 | N- (5, 6, 7, 8-tetrahydronaphthalen-1-yl) urea derivatives and related compounds as trpv1 vanilloid receptor antagonists for the treatment of pain |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009006730A true MX2009006730A (es) | 2009-06-30 |
Family
ID=39102978
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009006730A MX2009006730A (es) | 2006-12-20 | 2007-12-12 | Derivados de n-(5, 6, 7, 8-tetrahidronaftalen-1-il) urea y compuestos relacionados como antagonistas de receptor vaniloide trpv1 par el tratamiento de dolor. |
Country Status (7)
Country | Link |
---|---|
US (3) | US8030504B2 (es) |
EP (2) | EP2134678A2 (es) |
JP (1) | JP2010513557A (es) |
CN (1) | CN101563318A (es) |
CA (1) | CA2672196A1 (es) |
MX (1) | MX2009006730A (es) |
WO (1) | WO2008079683A2 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101868443A (zh) | 2007-09-20 | 2010-10-20 | 特拉维夫大学拉莫特有限公司 | N-苯基邻氨基苯甲酸衍生物及其用途 |
WO2010023512A1 (en) * | 2008-08-28 | 2010-03-04 | Matrix Laboratories Ltd. | Novel vanilloid receptor modulators, process for their preparation and pharmaceutical compositions containing them |
MX2011004081A (es) * | 2008-10-17 | 2011-05-31 | Abbott Lab | Antagonistas trpv1. |
JP2012505908A (ja) * | 2008-10-17 | 2012-03-08 | アボット・ラボラトリーズ | Trpv1アンタゴニスト |
US9012651B2 (en) | 2011-03-24 | 2015-04-21 | Abbvie Inc. | TRPV3 modulators |
TW201302681A (zh) * | 2011-03-25 | 2013-01-16 | Abbott Lab | Trpv1拮抗劑 |
WO2013096223A1 (en) | 2011-12-19 | 2013-06-27 | Abbvie Inc. | Trpv1 antagonists |
WO2013096226A1 (en) | 2011-12-19 | 2013-06-27 | Abbvie Inc. | Trpv1 antagonists |
US8796328B2 (en) | 2012-06-20 | 2014-08-05 | Abbvie Inc. | TRPV1 antagonists |
EP2700431A1 (en) | 2012-08-24 | 2014-02-26 | AnalytiCon Discovery GmbH | Plant extracts for modulating TRPV1 function |
US11849727B2 (en) | 2013-11-13 | 2023-12-26 | Bedoukian Research, Inc. | Synergistic formulations for control and repellency of biting arthropods |
WO2018099570A1 (en) | 2016-12-02 | 2018-06-07 | Symrise Ag | Cosmetic blends |
EP3401307A1 (en) * | 2017-05-11 | 2018-11-14 | Antalgenics, S.L. | Trpv1 modulator compounds |
CN111548313A (zh) * | 2019-02-11 | 2020-08-18 | 绍兴从零医药科技有限公司 | 预防和治疗慢性疼痛药物的胍类化合物 |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1344579A (fr) | 1961-11-23 | 1963-11-29 | Sandoz Sa | Nouveaux dérivés de l'indole et leur préparation |
US3647819A (en) | 1969-09-19 | 1972-03-07 | Sterling Drug Inc | Indazolylphenylureas and indazolyl-phenylthioureas |
US3647910A (en) | 1970-03-20 | 1972-03-07 | Standard Oil Co Ohio | Dehydrogenation of hydrocarbons employing a catalyst of iron oxide-containing activated carbon |
US3711610A (en) | 1971-06-01 | 1973-01-16 | Sterling Drug Inc | Anticoccidiosis method and compositions involving indazolylphenylureas and indazolylphenylthioureas |
US3814711A (en) | 1971-07-26 | 1974-06-04 | Mallinckrodt Chemical Works | 10-acetamido-s-triazolo-(3,4-a)-isoquinolines |
NL7902993A (nl) | 1978-04-24 | 1979-10-26 | Rhone Poulenc Ind | Nieuwe isochinolinederivaten, de bereiding ervan en farmaceutische preparaten, die de nieuwe isochinoline- derivaten bevatten. |
DE3586123D1 (de) | 1984-08-15 | 1992-07-02 | Schering Ag | Neue dopamin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. |
WO1991004027A1 (en) | 1989-09-15 | 1991-04-04 | Pfizer Inc. | New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
WO1991013874A1 (fr) | 1990-03-07 | 1991-09-19 | Rhone-Poulenc Rorer S.A. | Derives de glycinamide, leur preparation et les medicaments les contenant |
JPH04178362A (ja) | 1990-11-13 | 1992-06-25 | Tosoh Corp | 尿素誘導体およびそれを含有する有害生物防除剤 |
JPH04178363A (ja) * | 1990-11-13 | 1992-06-25 | Tosoh Corp | 尿素誘導体及びそれを含有する有害生物防除剤 |
US5362878A (en) | 1991-03-21 | 1994-11-08 | Pfizer Inc. | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) |
US5444038A (en) | 1992-03-09 | 1995-08-22 | Zeneca Limited | Arylindazoles and their use as herbicides |
BR9306421A (pt) | 1992-05-28 | 1998-09-15 | Pfizer | Novos derivados n-aril e n-heteroariluréia como inbidores da acilcoenzima a:colesterol aciltransferase (acat) |
US5374643A (en) | 1992-09-11 | 1994-12-20 | E. R. Squibb & Sons, Inc. | Aryl urea (thiourea) and cyanoguanidine derivatives |
CA2107196A1 (en) | 1992-09-29 | 1994-03-30 | Mitsubishi Chemical Corporation | Carboxamide derivatives |
FI98337C (fi) * | 1992-11-30 | 1997-06-10 | Risto Juhani Ilmoniemi | Menetelmä ja laite aivojen herätevasteiden ja spontaanitoiminnan sekä sydämestä mitattujen signaalien eri komponenttien erottelemiseksi toisistaan |
GB9307833D0 (en) | 1993-04-15 | 1993-06-02 | Glaxo Inc | Modulators of cholecystokinin and gastrin |
EP0904262B1 (en) | 1996-01-16 | 2004-04-21 | Bristol-Myers Squibb Company | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
US5760246A (en) | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
AU7273598A (en) | 1997-05-05 | 1998-11-27 | Regents Of The University Of California, The | Naphthols useful in antiviral methods |
EP1150977B1 (en) * | 1999-02-12 | 2004-08-25 | SmithKline Beecham plc | Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists |
WO2000050387A1 (en) | 1999-02-22 | 2000-08-31 | Pacific Corporation | Vanilloid analogues containing resiniferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof |
DE60023128T2 (de) | 1999-05-12 | 2006-07-06 | Ortho-Mcneil Pharmaceutical, Inc. | Pyrazolcarboxamide zur behandlung von fettleibigkeit und anderen erkrankungen |
US6858577B1 (en) | 1999-06-29 | 2005-02-22 | Ortho-Mcneil Pharmaceutical, Inc. | Indole peptidomimetics as thrombin receptor antagonists |
YU54202A (sh) | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
US7217722B2 (en) | 2000-02-01 | 2007-05-15 | Kirin Beer Kabushiki Kaisha | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same |
CN1443170A (zh) | 2000-07-20 | 2003-09-17 | 神经原公司 | 辣椒素受体配体 |
JPWO2002100833A1 (ja) | 2001-06-12 | 2004-09-24 | 住友製薬株式会社 | Rhoキナーゼ阻害剤 |
AU2002325381A1 (en) | 2001-07-31 | 2003-02-24 | Bayer Healthcare Ag | Naphthylurea and naphthylacetamide derivatives as vanilloid receptor 1 (vr1) antagonists |
MY138086A (en) | 2001-09-13 | 2009-04-30 | Smithkline Beecham Plc | Novel urea derivative as vanilloid receptor-1 antagonist |
JP4178362B2 (ja) | 2001-09-27 | 2008-11-12 | 株式会社三洋物産 | 遊技機 |
SE0104250D0 (sv) | 2001-12-14 | 2001-12-14 | Astrazeneca Ab | Heterocyclic compounds |
SE0104248D0 (sv) | 2001-12-14 | 2001-12-14 | Astrazeneca Ab | Method of treatment |
DE10163439A1 (de) | 2001-12-21 | 2003-07-10 | Bosch Gmbh Robert | Koffer, insbesondere Werkzeugmaschinenkoffer |
JP2003192587A (ja) | 2001-12-26 | 2003-07-09 | Bayer Ag | 尿素誘導体 |
CA2469967A1 (en) | 2001-12-26 | 2003-07-10 | Bayer Healthcare Ag | Urea derivatives as vr1- antagonists |
CA2476936A1 (en) | 2002-02-20 | 2003-08-28 | Chih-Hung Lee | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor |
GB0206876D0 (en) | 2002-03-22 | 2002-05-01 | Merck Sharp & Dohme | Therapeutic agents |
CN1307150C (zh) * | 2002-05-08 | 2007-03-28 | 拜耳医药保健股份公司 | 羟基四氢-萘基脲衍生物 |
AU2003241453A1 (en) | 2002-05-17 | 2003-12-02 | Janssen Pharmaceutica N.V. | Aminotetralin-derived urea modulators of vanilloid vr1 receptor |
US7035841B2 (en) | 2002-07-18 | 2006-04-25 | Xerox Corporation | Method for automatic wrapper repair |
US7381840B2 (en) * | 2002-12-06 | 2008-06-03 | Xention Limited | Tetrahydro-naphthalene derivatives |
JP4440113B2 (ja) * | 2002-12-09 | 2010-03-24 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | バニロイド受容体アンタゴニストとしてのテトラヒドロ−ナフタレン誘導体 |
US6933311B2 (en) | 2003-02-11 | 2005-08-23 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
EP1493438A1 (en) | 2003-07-03 | 2005-01-05 | Bayer HealthCare AG | Vanilloid receptor (VR) inhibitors for treatment of Human Immunodeficiency Virus (HIV)-mediated pain states |
CA2542494A1 (en) * | 2003-10-15 | 2005-05-06 | Bayer Healthcare Ag | Tetrahydro-naphthalene and urea derivatives |
US7812019B2 (en) * | 2004-11-24 | 2010-10-12 | Abbott Laboratories | Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof |
JP2008532956A (ja) | 2005-03-05 | 2008-08-21 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | ヒドロキシテトラヒドロ−ナフタレン誘導体の使用 |
-
2007
- 2007-12-12 EP EP07855088A patent/EP2134678A2/en not_active Withdrawn
- 2007-12-12 CA CA002672196A patent/CA2672196A1/en not_active Abandoned
- 2007-12-12 CN CNA2007800471116A patent/CN101563318A/zh active Pending
- 2007-12-12 JP JP2009543075A patent/JP2010513557A/ja active Pending
- 2007-12-12 US US11/954,875 patent/US8030504B2/en not_active Expired - Fee Related
- 2007-12-12 MX MX2009006730A patent/MX2009006730A/es active IP Right Grant
- 2007-12-12 WO PCT/US2007/087163 patent/WO2008079683A2/en active Application Filing
- 2007-12-12 EP EP12152641A patent/EP2450346A1/en not_active Withdrawn
-
2011
- 2011-09-29 US US13/249,010 patent/US8350083B2/en active Active
-
2012
- 2012-12-06 US US13/706,468 patent/US20130165479A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2008079683A3 (en) | 2008-08-28 |
CA2672196A1 (en) | 2008-07-03 |
US8350083B2 (en) | 2013-01-08 |
US20080153871A1 (en) | 2008-06-26 |
US8030504B2 (en) | 2011-10-04 |
CN101563318A (zh) | 2009-10-21 |
US20130165479A1 (en) | 2013-06-27 |
EP2134678A2 (en) | 2009-12-23 |
JP2010513557A (ja) | 2010-04-30 |
WO2008079683A2 (en) | 2008-07-03 |
US20120022103A1 (en) | 2012-01-26 |
EP2450346A1 (en) | 2012-05-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2009006730A (es) | Derivados de n-(5, 6, 7, 8-tetrahidronaftalen-1-il) urea y compuestos relacionados como antagonistas de receptor vaniloide trpv1 par el tratamiento de dolor. | |
MX2009011205A (es) | Derivados de 2-iminoisotiazol como ligandos del receptor canabinoide. | |
EP1861399A4 (en) | CGRP RECEPTOR ANTAGONISTS | |
IL182317A0 (en) | Cgrp receptor antagonists | |
EP1804919A4 (en) | CGRP RECEPTOR ANTAGONISTS | |
DE602008005771D1 (de) | Disubstituierte alkyl-8-azabicycloä3.2.1üoktan-verbindungen als mu-opioid-rezeptorantagonisten | |
TW200716584A (en) | Dihydrobenzofuran derivatives and uses thereof | |
MX2007011023A (es) | 2-(4-oxo-4h-quinazolin-3-il) acetamidas y su uso como antagonistas de vasopresin v3. | |
JO2910B1 (en) | Organic compounds | |
ZA201102735B (en) | Antagonists of the vanilloid receptor subtype 1(vr1) and uses thereof | |
UA87856C2 (ru) | Алкильные производные как модуляторы метаботропных рецепторов глутамата | |
UA83311C2 (en) | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors | |
ATE553093T1 (de) | Indazolderivate zur hemmung von trpv1 und verwendungen davon | |
MX2009012374A (es) | Compuestos novedosos como ligandos del receptor de canabinoides. | |
MX2010004498A (es) | Derivados de ciclohexenoamida y su uso como antagonistas de trpv1. | |
RS20080246A (en) | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors | |
WO2008063781A3 (en) | Chemical compounds as cannabinoid receptor ligands | |
TW200800958A (en) | N-substituted-azacyclylamines as histamine-3 antagonists | |
GB0513886D0 (en) | Novel compounds | |
EP1802372A4 (en) | CGRP RECEPTOR ANTAGONISTS) | |
MX2010004495A (es) | Derivados de 2-aminooxazol como antagonistas de vanilloide-1 de receptor potencial transitorio (trpv1) utiles para tratar dolor. | |
ES2333026T3 (es) | Derivados de ciclohexil-1,4-diamina sustituidos. | |
MY149973A (en) | 3-carboxypropyl-aminotetralin derivatives as mu opioid receptor antagonists | |
NO20084698L (no) | Metode for fremstilling av indazolyl-ureaer som inhiberer vanilloidreseptor subtype 1(VR1) | |
DE602007004327D1 (de) | Einen azepin-kern enthaltende antagonisten des histaminrezeptors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
GB | Transfer or rights |