ATE535527T1 - Verbindung mit affinität zu amyloid - Google Patents

Verbindung mit affinität zu amyloid

Info

Publication number
ATE535527T1
ATE535527T1 AT07743357T AT07743357T ATE535527T1 AT E535527 T1 ATE535527 T1 AT E535527T1 AT 07743357 T AT07743357 T AT 07743357T AT 07743357 T AT07743357 T AT 07743357T AT E535527 T1 ATE535527 T1 AT E535527T1
Authority
AT
Austria
Prior art keywords
carbon
halogen substituent
amyloid
affinity
salt
Prior art date
Application number
AT07743357T
Other languages
English (en)
Inventor
Shigeyuki Tanifuji
Daisaku Nakamura
Shinya Takasaki
Yuki Okumura
Original Assignee
Nihon Mediphysics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Mediphysics Co Ltd filed Critical Nihon Mediphysics Co Ltd
Application granted granted Critical
Publication of ATE535527T1 publication Critical patent/ATE535527T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT07743357T 2006-05-19 2007-05-15 Verbindung mit affinität zu amyloid ATE535527T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006140044 2006-05-19
JP2006324701 2006-11-30
PCT/JP2007/059922 WO2007135890A1 (ja) 2006-05-19 2007-05-15 新規アミロイド親和性化合物

Publications (1)

Publication Number Publication Date
ATE535527T1 true ATE535527T1 (de) 2011-12-15

Family

ID=38723203

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07743357T ATE535527T1 (de) 2006-05-19 2007-05-15 Verbindung mit affinität zu amyloid

Country Status (15)

Country Link
US (2) US8303935B2 (de)
EP (1) EP2019103B1 (de)
JP (1) JP5238496B2 (de)
KR (1) KR20090010987A (de)
AT (1) ATE535527T1 (de)
AU (1) AU2007252658B2 (de)
BR (1) BRPI0711818A2 (de)
CA (1) CA2653783A1 (de)
ES (1) ES2376491T3 (de)
IL (4) IL195378A0 (de)
NO (1) NO20085265L (de)
NZ (1) NZ573363A (de)
RU (1) RU2008150377A (de)
TW (1) TW200808795A (de)
WO (1) WO2007135890A1 (de)

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TW200803903A (en) * 2006-04-28 2008-01-16 Nihon Mediphysics Co Ltd Novel compound having affinity to amyloid
ATE535527T1 (de) 2006-05-19 2011-12-15 Nihon Mediphysics Co Ltd Verbindung mit affinität zu amyloid
EP2042501B1 (de) * 2006-06-21 2017-04-12 Nihon Medi-Physics Co., Ltd. Verbindung mit affinität zu amyloid
TW200811175A (en) * 2006-06-21 2008-03-01 Nihon Mediphysics Co Ltd Novel compound with affinity with amyloid
WO2008056481A1 (fr) * 2006-11-09 2008-05-15 Nihon Medi-Physics Co., Ltd. Agent d'imagerie de diagnostic radioactif
CN101535309A (zh) * 2006-11-17 2009-09-16 日本医事物理股份有限公司 对淀粉状蛋白具有亲和性的新化合物
NZ577511A (en) 2006-11-30 2012-04-27 Nihon Mediphysics Co Ltd 2-Phenyl-imidazo[1,2-a]pyridine derivatives substituted with a radioactive halogen substituent
TWI406674B (zh) 2007-02-13 2013-09-01 Nihon Mediphysics Co Ltd Method for manufacturing diagnostic radiographic diagnostic agents
CN101903381A (zh) * 2007-10-24 2010-12-01 日本医事物理股份有限公司 对淀粉样蛋白具有亲和性的新化合物
CN101903383A (zh) * 2007-10-26 2010-12-01 日本医事物理股份有限公司 对淀粉样蛋白具有亲和性的新化合物
CN101909659A (zh) * 2007-10-30 2010-12-08 日本医事物理股份有限公司 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法
EP2216052A4 (de) * 2007-10-30 2012-11-21 Nihon Mediphysics Co Ltd Verwendung einer neuen verbindung mit affinität für amyloid und verfahren zu ihrer herstellung
AU2008319985A1 (en) * 2007-10-30 2009-05-07 Nihon Medi-Physics Co., Ltd. Use of novel compound having affinity for amyloid, and process for production of the same
EP2218464A1 (de) * 2009-02-11 2010-08-18 Technische Universität München Verbindungen zur nichtinvasiven Messung von Aggregaten von Amyloidpeptiden
US8476449B2 (en) 2010-03-01 2013-07-02 Nihon Medi-Physics Co., Ltd. Radioactive iodine labeled organic compound or salt thereof
TWI528977B (zh) 2011-05-20 2016-04-11 Nihon Mediphysics Co Ltd New amyloid affinity products
EP2725027B1 (de) 2011-06-24 2017-03-01 Nihon Medi-Physics Co., Ltd. Neue verbindungen mit amyloidaffinität
MX2015015893A (es) 2013-05-23 2016-03-04 Hoffmann La Roche 2-fenilimidazo[1,2-a]pirimidinas como agentes formadores de imagen.
CA3055417A1 (en) 2017-03-07 2018-09-13 Nihon Medi-Physics Co., Ltd. Radioactive fluorine-labeling precursor compound and method for producing radioactive fluorine-labeled compound using same

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US4727145A (en) * 1986-09-22 1988-02-23 Ortho Pharmaceutical Corporation 2- Or 3- aryl substituted imidazo [1,2-a]pyridines
US4871745A (en) 1986-09-22 1989-10-03 Ortho Pharmaceutical Corporation 2- or 3-aryl substituted imidazo(1,2-A)pyridines and their use as antisecretory agents
US4791117A (en) 1986-09-22 1988-12-13 Ortho Pharmaceutical Corporation 2- or 3-aryl substituted imidazo[1,2-a]pyridines and their use as calcium channel blockers
DE4327027A1 (de) 1993-02-15 1994-08-18 Bayer Ag Imidazoazine
BR9611047A (pt) 1995-10-17 2000-03-08 Searle & Co Processo de deteção de ciclo oxigenase-2
US6812327B1 (en) 1996-10-25 2004-11-02 Human Genome Sciences, Inc. Neutrokine-alpha polypeptides
CA2340394A1 (en) 1998-08-20 2000-03-02 Jorge R. Barrio Methods for labeling .beta.-amyloid plaques and neurofibrillary tangles
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IL157359A0 (en) 2001-02-26 2004-02-19 Bristol Myers Squibb Pharma Co A radiopharmaceutical composition containing an ascorbic acid analog
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JP4317955B2 (ja) 2001-04-23 2009-08-19 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア アミロイド斑凝集阻害剤および診断用造影剤
US7186714B2 (en) 2001-06-21 2007-03-06 Smithkline Beecham Corporation Imidazo[1,2-α]pyridine derivatives for the prophylaxis and treatment of herpes viral infections
JP4436928B2 (ja) 2001-08-27 2010-03-24 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア スチルベン誘導体、およびアミロイド斑の結合および画像化のためのその使用
GB0205281D0 (en) 2002-03-06 2002-04-17 Novartis Ag Organic compounds
AU2003242233A1 (en) 2002-06-12 2003-12-31 Bf Research Institute, Inc. Probe compound for image diagnosis of disease with amyloid accumulation, compound for staining age spots/diffuse age spots, and remedy for disease with amyloid accumulation
JPWO2004035522A1 (ja) * 2002-08-30 2006-02-16 株式会社 ビーエフ研究所 プリオン蛋白蓄積性疾患の診断プローブおよび治療薬ならびにプリオン蛋白の染色剤
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EP1699799B1 (de) * 2003-12-31 2007-05-16 Schering-Plough Ltd. Bekämpfng von parasiten in tieren durch anwendung von imidazo[1,2-b]pyridazinderivaten
TW200803903A (en) 2006-04-28 2008-01-16 Nihon Mediphysics Co Ltd Novel compound having affinity to amyloid
ATE535527T1 (de) 2006-05-19 2011-12-15 Nihon Mediphysics Co Ltd Verbindung mit affinität zu amyloid
EP2042501B1 (de) * 2006-06-21 2017-04-12 Nihon Medi-Physics Co., Ltd. Verbindung mit affinität zu amyloid
CN101903381A (zh) 2007-10-24 2010-12-01 日本医事物理股份有限公司 对淀粉样蛋白具有亲和性的新化合物
CN101903383A (zh) 2007-10-26 2010-12-01 日本医事物理股份有限公司 对淀粉样蛋白具有亲和性的新化合物
CN101909659A (zh) 2007-10-30 2010-12-08 日本医事物理股份有限公司 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法

Also Published As

Publication number Publication date
CA2653783A1 (en) 2007-11-29
IL195378A0 (en) 2011-08-01
US8303935B2 (en) 2012-11-06
BRPI0711818A2 (pt) 2011-12-13
TW200808795A (en) 2008-02-16
EP2019103B1 (de) 2011-11-30
NO20085265L (no) 2009-02-18
RU2008150377A (ru) 2010-06-27
IL209650A0 (en) 2011-02-28
KR20090010987A (ko) 2009-01-30
JPWO2007135890A1 (ja) 2009-10-01
US20090252679A1 (en) 2009-10-08
IL209651A0 (en) 2011-02-28
JP5238496B2 (ja) 2013-07-17
WO2007135890A1 (ja) 2007-11-29
EP2019103A1 (de) 2009-01-28
IL209649A0 (en) 2011-02-28
AU2007252658B2 (en) 2012-03-29
ES2376491T3 (es) 2012-03-14
US8506930B2 (en) 2013-08-13
EP2019103A4 (de) 2010-05-05
AU2007252658A1 (en) 2007-11-29
US20120271053A1 (en) 2012-10-25
NZ573363A (en) 2012-01-12

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