ATE523519T1 - Makrolidverbindungen mit biotin und fotoaffinitätsgruppe zur identifizierung eines makrolid-targets - Google Patents

Makrolidverbindungen mit biotin und fotoaffinitätsgruppe zur identifizierung eines makrolid-targets

Info

Publication number
ATE523519T1
ATE523519T1 AT06755941T AT06755941T ATE523519T1 AT E523519 T1 ATE523519 T1 AT E523519T1 AT 06755941 T AT06755941 T AT 06755941T AT 06755941 T AT06755941 T AT 06755941T AT E523519 T1 ATE523519 T1 AT E523519T1
Authority
AT
Austria
Prior art keywords
macrolide
biotin
affinity group
target
identifying
Prior art date
Application number
AT06755941T
Other languages
English (en)
Inventor
Ognjen Culic
Martina Bosnar
Nikola Marjanovic
Boris Mildner
Linda Tomaskovic
Sulejman Alihodzic
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE523519T1 publication Critical patent/ATE523519T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
AT06755941T 2005-01-14 2006-01-13 Makrolidverbindungen mit biotin und fotoaffinitätsgruppe zur identifizierung eines makrolid-targets ATE523519T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64433305P 2005-01-14 2005-01-14
PCT/IB2006/001484 WO2006106440A1 (en) 2005-01-14 2006-01-13 Macrolide compounds containing biotin and photo-affinity group for macrolide target identification

Publications (1)

Publication Number Publication Date
ATE523519T1 true ATE523519T1 (de) 2011-09-15

Family

ID=36808715

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06755941T ATE523519T1 (de) 2005-01-14 2006-01-13 Makrolidverbindungen mit biotin und fotoaffinitätsgruppe zur identifizierung eines makrolid-targets

Country Status (6)

Country Link
US (1) US7989600B2 (de)
EP (1) EP1836212B1 (de)
JP (1) JP5065910B2 (de)
AT (1) ATE523519T1 (de)
ES (1) ES2371931T3 (de)
WO (1) WO2006106440A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3738591A3 (de) 2003-03-10 2021-03-24 Merck Sharp & Dohme Corp. Neuartige antibakterielle wirkstoffe
US8080529B2 (en) 2005-01-13 2011-12-20 Glaxo Group Limited Macrolides with anti-inflammatory activity
CN103193840A (zh) 2006-05-01 2013-07-10 大正制药株式会社 大环内酯衍生物
JP5539864B2 (ja) * 2007-06-12 2014-07-02 アカオゲン，インコーポレーテッド 抗菌剤
AU2008316830B2 (en) 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
EP2362727B1 (de) 2008-10-24 2018-04-11 Cempra Pharmaceuticals, Inc. Verfahren zur behandlung von resistenten krankheiten mit traizolhaltigen makroliden
SG172782A1 (en) * 2009-01-30 2011-08-29 Glaxo Group Ltd Anti-inflammatory macrolide
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
CN102724874B (zh) 2009-09-10 2018-06-01 森普拉制药公司 治疗疟疾、结核病和mac疾病的方法
WO2012034058A1 (en) 2010-09-10 2012-03-15 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
JP6208742B2 (ja) 2012-03-27 2017-10-04 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライド抗生物質を投与するための非経口製剤
WO2014152326A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
US9751908B2 (en) 2013-03-15 2017-09-05 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
US11229657B2 (en) 2017-04-21 2022-01-25 Lunella Biotech, Inc. Targeting hypoxic cancer stem cells (CSCs) with doxycycline: implications for improving anti-angiogenic therapy
WO2018195434A1 (en) 2017-04-21 2018-10-25 Lisanti Michael P Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs)
CN111315400A (zh) 2017-05-19 2020-06-19 卢内拉生物技术有限公司 Antimitoscin：用于根除癌症干细胞的线粒体生物发生的靶向抑制剂
RU2020102908A (ru) 2017-06-26 2021-07-27 Лунелла Байотек, Инк. Митокетосцины: митохондриальная терапия, нацеленная на кетоновый метаболизм в раковых клетках

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005095014A (ja) 2003-09-22 2005-04-14 Science Univ Of Tokyo マクロライド系抗生物質結合ペプチド及びこれをコードする遺伝子

Also Published As

Publication number Publication date
US7989600B2 (en) 2011-08-02
JP5065910B2 (ja) 2012-11-07
US20080241959A1 (en) 2008-10-02
WO2006106440A1 (en) 2006-10-12
EP1836212A1 (de) 2007-09-26
EP1836212B1 (de) 2011-09-07
JP2008526952A (ja) 2008-07-24
ES2371931T3 (es) 2012-01-11

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