ATE496915T1 - Hetarylaniline als modulatoren für amyloid beta - Google Patents

Hetarylaniline als modulatoren für amyloid beta

Info

Publication number
ATE496915T1
ATE496915T1 AT08749887T AT08749887T ATE496915T1 AT E496915 T1 ATE496915 T1 AT E496915T1 AT 08749887 T AT08749887 T AT 08749887T AT 08749887 T AT08749887 T AT 08749887T AT E496915 T1 ATE496915 T1 AT E496915T1
Authority
AT
Austria
Prior art keywords
hetarylanilines
modulators
amyloid beta
amyloid
beta
Prior art date
Application number
AT08749887T
Other languages
English (en)
Inventor
Karlheinz Baumann
Alexander Flohr
Helmut Jacobsen
Synese Jolidon
Thomas Luebbers
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE496915T1 publication Critical patent/ATE496915T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT08749887T 2007-05-11 2008-04-30 Hetarylaniline als modulatoren für amyloid beta ATE496915T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07108004 2007-05-11
PCT/EP2008/055290 WO2008138753A1 (en) 2007-05-11 2008-04-30 Hetarylanilines as modulators for amyloid beta

Publications (1)

Publication Number Publication Date
ATE496915T1 true ATE496915T1 (de) 2011-02-15

Family

ID=39758855

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08749887T ATE496915T1 (de) 2007-05-11 2008-04-30 Hetarylaniline als modulatoren für amyloid beta

Country Status (20)

Country Link
US (1) US7910740B2 (de)
EP (1) EP2155740B1 (de)
JP (1) JP5264890B2 (de)
KR (1) KR101138045B1 (de)
CN (1) CN101675045B (de)
AR (1) AR066509A1 (de)
AT (1) ATE496915T1 (de)
AU (1) AU2008250436B2 (de)
BR (1) BRPI0811993A2 (de)
CA (1) CA2686754C (de)
CL (1) CL2008001347A1 (de)
DE (1) DE602008004769D1 (de)
ES (1) ES2358863T3 (de)
IL (1) IL201566A (de)
MX (1) MX2009012163A (de)
PE (1) PE20090248A1 (de)
RU (1) RU2009140182A (de)
TW (1) TW200904420A (de)
WO (1) WO2008138753A1 (de)
ZA (1) ZA200907585B (de)

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AU2006316005A1 (en) * 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. Process for production of cinnamamide derivative
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MY144960A (en) * 2005-11-24 2011-11-30 Eisai R&D Man Co Ltd Morpholine type cinnamide compound
TWI378091B (en) * 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
US7737141B2 (en) * 2006-07-28 2010-06-15 Eisai R&D Management Co., Ltd. Prodrug of cinnamide compound
RU2009123133A (ru) 2006-12-22 2011-01-27 Ф.Хоффманн-Ля Рош Аг (Ch) Производные спиро-пиперидина
US20080207900A1 (en) * 2007-02-28 2008-08-28 Teiji Kimura Two cyclic oxomorphorin derivatives
AU2008250119A1 (en) * 2007-05-16 2008-11-20 Eisai R & D Management Co., Ltd. One-pot production process for cinnamide derivative
US7935815B2 (en) * 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
EP2559693B1 (de) 2007-08-31 2014-11-26 Eisai R&D Management Co., Ltd. Polycyclische Verbindung
WO2009080533A1 (en) * 2007-12-21 2009-07-02 F. Hoffmann-La Roche Ag Heteroaryl derivatives as orexin receptor antagonists
BRPI0906799A2 (pt) 2008-01-11 2015-07-14 Hoffmann La Roche Moduladores para amiloide beta
US20100317860A1 (en) * 2008-01-28 2010-12-16 Ikuo Kushida Crystalline cinnamide compounds or salts thereof
JP5328816B2 (ja) 2008-02-22 2013-10-30 エフ．ホフマン−ラ ロシュ アーゲー アミロイドβの調節薬
MX2011003246A (es) 2008-10-09 2011-04-21 Hoffmann La Roche Moduladores de beta amiloide.
KR20110082189A (ko) * 2008-11-06 2011-07-18 아스트라제네카 아베 아밀로이드 베타의 조절제
WO2010052199A1 (en) * 2008-11-10 2010-05-14 F. Hoffmann-La Roche Ag Heterocyclic gamma secretase modulators
PA8854101A1 (es) * 2008-12-18 2010-07-27 Ortho Mcneil Janssen Pharm Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa
TW201030002A (en) 2009-01-16 2010-08-16 Bristol Myers Squibb Co Bicyclic compounds for the reduction of beta-amyloid production
NZ593951A (en) 2009-02-06 2013-01-25 Ortho Mcneil Janssen Pharm Novel substituted bicyclic heterocyclic compounds as gamma secretase modulators
TWI461425B (zh) * 2009-02-19 2014-11-21 Janssen Pharmaceuticals Inc 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類
US8835482B2 (en) * 2009-05-07 2014-09-16 Janssen Pharmaceuticals, Inc. Substituted indazole and aza-indazole derivatives as gamma secretase modulators
UY32622A (es) * 2009-05-12 2010-12-31 Astrazeneca Ab Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta)
CA2778517A1 (en) 2009-07-15 2011-01-20 Janssen Pharmaceuticals, Inc. Substituted triazole and imidazole derivatives as gamma secretase modulators
ES2512840T3 (es) 2010-01-15 2014-10-24 Janssen Pharmaceuticals, Inc. Derivados de triazol bicíclicos sustituidos novedosos como moduladores de gamma-secretasa
US20110190269A1 (en) * 2010-02-01 2011-08-04 Karlheinz Baumann Gamma secretase modulators
US8486967B2 (en) 2010-02-17 2013-07-16 Hoffmann-La Roche Inc. Heteroaryl substituted piperidines
MX2013010970A (es) 2011-03-24 2013-10-17 Cellzome Ltd Novedosos derivados de triazolil piperazina y triazolil piperidina sustituidos como moduladores de gamma-secretasa.
WO2012131539A1 (en) 2011-03-31 2012-10-04 Pfizer Inc. Novel bicyclic pyridinones
CA2841102C (en) 2011-07-15 2019-08-13 Janssen Pharmaceuticals, Inc. Novel substituted indole derivatives as gamma secretase modulators
AU2013261023B2 (en) 2012-05-16 2016-11-24 Cellzome Limited Substituted 3, 4 - dihydro - 2H - pyrido [1, 2 -a] pyrazine - 1, 6 - dione derivatives useful for the treatment of (inter alia) Alzheimer's disease
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
WO2014096212A1 (en) 2012-12-20 2014-06-26 Janssen Pharmaceutica Nv NOVEL TRICYCLIC 3,4-DIHYDRO-2H-PYRIDO[1,2-α]PYRAZINE-1,6-DIONE DERIVATIVES AS GAMMA SECRETASE MODULATORS
EP2945944B1 (de) 2013-01-17 2016-11-09 Janssen Pharmaceutica, N.V. Neuartige substituierte pyrido-piperazinon-derivate als gamma-sekretase-modulatoren
CN103664819A (zh) * 2013-12-16 2014-03-26 山东汇海医药化工有限公司 一种2-氨基-4-甲基噻唑-5-甲酸乙酯的制备方法
US10562897B2 (en) 2014-01-16 2020-02-18 Janssen Pharmaceutica Nv Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
PE20171318A1 (es) 2015-02-03 2017-09-07 Pfizer Ciclopropabenzofuranil-piridopirazindionas novedosas
AU2017231781C1 (en) * 2016-03-11 2021-12-16 Ac Immune Sa Bicyclic compounds for diagnosis and therapy
CN109476670B (zh) * 2016-10-04 2022-06-28 豪夫迈·罗氏有限公司 二环杂芳基衍生物
CN110194764B (zh) * 2018-02-26 2022-08-16 云南大学 酰胺类化合物、其制备方法及用途
CN114222732B (zh) * 2019-10-28 2023-04-04 南京明德新药研发有限公司 一种尿酸促排剂及其合成方法和其在医药上的应用

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ATE332896T1 (de) * 1997-10-27 2006-08-15 Agouron Pharma 4-aminothiazol derivate, deren herstellung und deren verwendung als inhibitoren cyclin- abhängiger kinasen
CA2332325A1 (en) * 1998-06-18 1999-12-23 Bristol-Myers Squibb Company Carbon substituted aminothiazole inhibitors of cyclin dependent kinases
US20030176454A1 (en) * 2000-05-15 2003-09-18 Akira Yamada N-coating heterocyclic compounds
US7244739B2 (en) * 2003-05-14 2007-07-17 Torreypines Therapeutics, Inc. Compounds and uses thereof in modulating amyloid beta
EP2261218B1 (de) 2004-05-26 2013-04-03 Eisai R&D Management Co., Ltd. Composé imidazole pour l'utilisation comme produit intermédiaire dans la production de composés cinnamide
BRPI0516915A (pt) 2004-12-01 2008-03-11 Devgen Nv derivados de tiazol substituìdos por 5-carboxamido que interagem com canais de ìons, particularmante com canais de ìons da famìlia kv
US20060241038A1 (en) 2005-04-20 2006-10-26 Eisai Co., Ltd. Therapeutic agent for Abeta related disorders
AU2006316005A1 (en) 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. Process for production of cinnamamide derivative
JPWO2007058304A1 (ja) 2005-11-18 2009-05-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 シンナミド化合物の塩またはそれらの溶媒和物
US20070117839A1 (en) 2005-11-24 2007-05-24 Eisai R&D Management Co., Ltd. Two cyclic cinnamide compound
MY144960A (en) 2005-11-24 2011-11-30 Eisai R&D Man Co Ltd Morpholine type cinnamide compound
CA2643796A1 (en) 2006-03-09 2007-09-13 Eisai R & D Management Co., Ltd. Polycyclic cinnamide derivatives
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives

Also Published As

Publication number Publication date
IL201566A0 (en) 2010-05-31
US7910740B2 (en) 2011-03-22
CN101675045B (zh) 2012-11-28
CN101675045A (zh) 2010-03-17
AR066509A1 (es) 2009-08-26
WO2008138753A1 (en) 2008-11-20
JP5264890B2 (ja) 2013-08-14
JP2010526847A (ja) 2010-08-05
MX2009012163A (es) 2009-12-01
TW200904420A (en) 2009-02-01
ES2358863T3 (es) 2011-05-16
EP2155740A1 (de) 2010-02-24
IL201566A (en) 2013-08-29
KR101138045B1 (ko) 2012-04-24
AU2008250436A1 (en) 2008-11-20
RU2009140182A (ru) 2011-06-20
PE20090248A1 (es) 2009-03-27
BRPI0811993A2 (pt) 2014-11-18
CL2008001347A1 (es) 2009-05-29
DE602008004769D1 (en) 2011-03-10
ZA200907585B (en) 2010-07-28
CA2686754C (en) 2014-10-28
CA2686754A1 (en) 2008-11-20
AU2008250436B2 (en) 2013-03-28
KR20100008791A (ko) 2010-01-26
EP2155740B1 (de) 2011-01-26
US20080280948A1 (en) 2008-11-13

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