UY32622A - Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta) - Google Patents

Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta)

Info

Publication number
UY32622A
UY32622A UY0001032622A UY32622A UY32622A UY 32622 A UY32622 A UY 32622A UY 0001032622 A UY0001032622 A UY 0001032622A UY 32622 A UY32622 A UY 32622A UY 32622 A UY32622 A UY 32622A
Authority
UY
Uruguay
Prior art keywords
beta
treatment
new compounds
pathologies related
relates
Prior art date
Application number
UY0001032622A
Other languages
English (en)
Inventor
Lo-Alfredsson Yvonne
Rakos Laszlo
Paulsen Kim
Waldman Magnus
Rotticci Didier
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of UY32622A publication Critical patent/UY32622A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Abstract

La presente invención se refiere a novedosos compuestos de fórmula I y II y sales terapéuticamente aceptables de los mismos, sus composiciones farmacéuticas, procesos para prepararlos y su uso en métodos terapéuticos para el tratamiento y/o la prevención de distintas enfermedades. En particular, la invención se refiere a compuestos que interfieren con la y-secretasa y/o su sustrato y, por consiguiente, modulan la formación de péptidos AB(beta).
UY0001032622A 2009-05-12 2010-05-10 Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta) UY32622A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17730509P 2009-05-12 2009-05-12
US28960009P 2009-12-23 2009-12-23

Publications (1)

Publication Number Publication Date
UY32622A true UY32622A (es) 2010-12-31

Family

ID=43069012

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001032622A UY32622A (es) 2009-05-12 2010-05-10 Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta)

Country Status (5)

Country Link
US (1) US20100292210A1 (es)
AR (1) AR076760A1 (es)
TW (1) TW201043635A (es)
UY (1) UY32622A (es)
WO (1) WO2010132015A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012507512A (ja) 2008-11-06 2012-03-29 アストラゼネカ・アクチエボラーグ アミロイドβのモジュレーター
US8637525B2 (en) 2009-07-31 2014-01-28 Bristol-Myers Squibb Company Compounds for the reduction of beta-amyloid production
TWI468402B (zh) 2009-07-31 2015-01-11 必治妥美雅史谷比公司 降低β-類澱粉生成之化合物
US20120122843A1 (en) * 2010-11-11 2012-05-17 Astrazeneca Ab Compounds and Their Use for Treatment of Amyloid Beta-Related Diseases
US9006226B2 (en) 2012-02-23 2015-04-14 Boehringer Ingelheim International Gmbh Dihydropteridinones I
US8865716B2 (en) 2012-02-23 2014-10-21 Boehringer Ingelheim International Gmbh Dihydropteridinones II
JP6072308B2 (ja) 2013-02-21 2017-02-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ジヒドロプテリジノンii
JP6052527B2 (ja) * 2013-02-21 2016-12-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ジヒドロプテリジノンi
CN105308037B (zh) 2013-06-04 2017-09-19 阿克图拉姆生命科学股份公司 ***化合物及其作为γ分泌酶调节剂的用途
US9718805B2 (en) 2013-06-04 2017-08-01 Acturum Life Science AB Triazole compounds and their use as gamma secretase modulators
PL3004079T3 (pl) 2013-06-04 2018-07-31 Acturum Real Estate Ab Związki pirymidyny i ich zastosowanie jako modulatorów sekretazy gamma
WO2017026538A1 (en) 2015-08-07 2017-02-16 Takeda Pharmaceutical Company Limited Production method of pyrazine
KR20190024876A (ko) * 2016-05-06 2019-03-08 에스테베 파마슈티칼스 에스에이 통증 및 통증 관련 질환을 치료하기 위한 테트라하이드로피리미도디아제핀 및 테트라하이드로피리도디아제핀 화합물
CA3048376A1 (en) 2016-12-27 2018-07-05 Riken Bmp-signal-inhibiting compound
JP7300460B2 (ja) 2018-03-09 2023-06-29 リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー 置換1,2-ジヒドロ-3H-ピラゾロ[3,4-d]ピリミジン-3-オン
WO2022055168A1 (ko) * 2020-09-09 2022-03-17 서울대학교산학협력단 신규 피리미도디아제핀 유도체 및 이의 용도
WO2022231928A1 (en) * 2021-04-27 2022-11-03 Merck Sharp & Dohme Llc Ripk1 inhibitors and methods of use
EP4329765A1 (en) * 2021-04-27 2024-03-06 Merck Sharp & Dohme LLC Phenyl azepines as ripk1 inhibitors and methods of use thereof
CN115368363B (zh) * 2021-05-17 2024-02-20 中山大学 一种手性或消旋的嘧啶并二氮杂环庚酮类化合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2531232A1 (en) * 2003-07-16 2005-02-10 Janssen Pharmaceutica N.V. Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors
TWI301760B (en) * 2004-02-27 2008-10-11 Merz Pharma Gmbh & Co Kgaa Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors
TWI335816B (en) * 2004-05-26 2011-01-11 Eisai R&D Man Co Ltd Cinnamide compound
KR20090018963A (ko) * 2006-05-19 2009-02-24 에자이 알앤드디 매니지먼트 가부시키가이샤 우레아계 신나미드 유도체
CA2652484A1 (en) * 2006-05-19 2007-11-29 Eisai R & D Management Co., Ltd. Heterocyclic type cinnamide derivative
US20090099195A1 (en) * 2007-05-08 2009-04-16 Astrazeneca Ab Therapeutic Compounds 570
RU2009140182A (ru) * 2007-05-11 2011-06-20 Ф. Хоффманн-Ля Рош Аг (Ch) Гетариланилины в качестве модуляторов для бета-амилоида
CA2695543A1 (en) * 2007-08-06 2009-02-12 Schering Corporation Gamma secretase modulators
JP2012507512A (ja) * 2008-11-06 2012-03-29 アストラゼネカ・アクチエボラーグ アミロイドβのモジュレーター

Also Published As

Publication number Publication date
AR076760A1 (es) 2011-07-06
US20100292210A1 (en) 2010-11-18
TW201043635A (en) 2010-12-16
WO2010132015A1 (en) 2010-11-18

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Legal Events

Date Code Title Description
DESI Application deemed to be withdrawn

Effective date: 20130123