BRPI0309631A8 - vacina tetravalente da dengue contendo uma trivial deleção de 30 nucleotídeos na utr-31' dos tipos de dengue 1,2,3 e 4, ou de vírus antigênicos quiméricos da dengue 1,2,3 e 4 - Google Patents
vacina tetravalente da dengue contendo uma trivial deleção de 30 nucleotídeos na utr-31' dos tipos de dengue 1,2,3 e 4, ou de vírus antigênicos quiméricos da dengue 1,2,3 e 4 Download PDFInfo
- Publication number
- BRPI0309631A8 BRPI0309631A8 BRPI0309631A BRPI0309631A BRPI0309631A8 BR PI0309631 A8 BRPI0309631 A8 BR PI0309631A8 BR PI0309631 A BRPI0309631 A BR PI0309631A BR PI0309631 A BRPI0309631 A BR PI0309631A BR PI0309631 A8 BRPI0309631 A8 BR PI0309631A8
- Authority
- BR
- Brazil
- Prior art keywords
- dengue
- deletion
- utr
- trivial
- nucleotides
- Prior art date
Links
- 230000000890 antigenic effect Effects 0.000 title abstract 2
- 230000037430 deletion Effects 0.000 title abstract 2
- 238000012217 deletion Methods 0.000 title abstract 2
- 239000002773 nucleotide Substances 0.000 title abstract 2
- 125000003729 nucleotide group Chemical group 0.000 title abstract 2
- 208000001490 Dengue Diseases 0.000 title 3
- 206010012310 Dengue fever Diseases 0.000 title 3
- 208000025729 dengue disease Diseases 0.000 title 3
- 241000700605 Viruses Species 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 241000725619 Dengue virus Species 0.000 abstract 2
- 241000710829 Dengue virus group Species 0.000 abstract 1
- 108091036066 Three prime untranslated region Proteins 0.000 abstract 1
- 229940031351 tetravalent vaccine Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24161—Methods of inactivation or attenuation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37786002P | 2002-05-03 | 2002-05-03 | |
US60/377,860 | 2002-05-03 | ||
US43650002P | 2002-12-23 | 2002-12-23 | |
US60/436,500 | 2002-12-23 | ||
PCT/US2003/013279 WO2003092592A2 (en) | 2002-05-03 | 2003-04-25 | Dengue tetravalent vaccine containing a common 30 nucleotide deletion in the 3'-utr of dengue types 1,2,3, and 4, or antigenic chimeric dengue viruses 1,2,3, and 4 |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0309631A2 BRPI0309631A2 (pt) | 2016-11-01 |
BRPI0309631A8 true BRPI0309631A8 (pt) | 2018-09-25 |
BRPI0309631B1 BRPI0309631B1 (pt) | 2021-07-20 |
Family
ID=29406814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0309631-9A BRPI0309631B1 (pt) | 2002-05-03 | 2003-04-25 | Composição imunogênica tetravalente compreendendo vírus atenuado contra dengue e vacina tetravalente compreendendo a dita composição |
Country Status (15)
Country | Link |
---|---|
US (7) | US7517531B2 (pt) |
EP (5) | EP2338508B1 (pt) |
JP (1) | JP4977811B2 (pt) |
AT (1) | ATE481982T1 (pt) |
BR (1) | BRPI0309631B1 (pt) |
CA (1) | CA2483653C (pt) |
CY (1) | CY1120558T1 (pt) |
DE (1) | DE60334310D1 (pt) |
DK (2) | DK1554301T3 (pt) |
ES (2) | ES2355719T3 (pt) |
HU (1) | HUE037330T2 (pt) |
PT (2) | PT1554301E (pt) |
SI (2) | SI1554301T1 (pt) |
TR (1) | TR201806655T4 (pt) |
WO (1) | WO2003092592A2 (pt) |
Families Citing this family (53)
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ES2355719T3 (es) | 2002-05-03 | 2011-03-30 | The United States Government As Represented By The Department Of Health And Human Services | Vacuna contra el dengue que contiene una deleción común de 30 nucleótidos en la utr en 3' del dengue tipos 1 y 2. |
RU2465326C2 (ru) | 2005-04-24 | 2012-10-27 | Санофи Пастер Байолоджикс Ко | Рекомбинантные флавивирусные вакцины |
JP4549224B2 (ja) * | 2005-04-25 | 2010-09-22 | 出光ユニテック株式会社 | 透明ポリプロピレン系樹脂シートの製造方法、透明ポリプロピレン系樹脂シート、及び成形品、並びに透明ポリプロピレン系樹脂シートからなる成形品の白化防止方法、及び温度判別方法 |
EP1893637B1 (en) * | 2005-06-17 | 2016-01-06 | Sanofi Pasteur | Dengue serotype 1 attenuated strain |
CA2611954C (en) | 2005-06-17 | 2014-01-28 | Sanofi Pasteur | Dengue serotype 2 attenuated strain |
CA2616026A1 (en) * | 2005-07-22 | 2007-02-08 | Research Development Foundation | Attenuated strains of flaviviruses , and uses thereof |
US8337860B2 (en) | 2006-08-15 | 2012-12-25 | The United States Of America, As Represented By The Secretary Of The Department Of Health & Human Services | Development of dengue virus vaccine components |
AU2013263788B2 (en) * | 2006-08-15 | 2016-05-26 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The | Development of dengue virus vaccine components |
AU2016219680B2 (en) * | 2006-08-15 | 2018-08-09 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The | Development of dengue virus vaccine components |
TWI472639B (zh) | 2009-05-22 | 2015-02-11 | Samsung Display Co Ltd | 薄膜沉積設備 |
JP5623786B2 (ja) | 2009-05-22 | 2014-11-12 | 三星ディスプレイ株式會社Samsung Display Co.,Ltd. | 薄膜蒸着装置 |
KR101117719B1 (ko) * | 2009-06-24 | 2012-03-08 | 삼성모바일디스플레이주식회사 | 박막 증착 장치 |
JP5328726B2 (ja) | 2009-08-25 | 2013-10-30 | 三星ディスプレイ株式會社 | 薄膜蒸着装置及びこれを利用した有機発光ディスプレイ装置の製造方法 |
JP5677785B2 (ja) | 2009-08-27 | 2015-02-25 | 三星ディスプレイ株式會社Samsung Display Co.,Ltd. | 薄膜蒸着装置及びこれを利用した有機発光表示装置の製造方法 |
EP2473624B1 (en) * | 2009-08-31 | 2019-05-01 | Gen-Probe Incorporated | Dengue virus assay |
US8876975B2 (en) | 2009-10-19 | 2014-11-04 | Samsung Display Co., Ltd. | Thin film deposition apparatus |
KR101084184B1 (ko) | 2010-01-11 | 2011-11-17 | 삼성모바일디스플레이주식회사 | 박막 증착 장치 |
KR101174875B1 (ko) | 2010-01-14 | 2012-08-17 | 삼성디스플레이 주식회사 | 박막 증착 장치, 이를 이용한 유기 발광 디스플레이 장치의 제조방법 및 이에 따라 제조된 유기 발광 디스플레이 장치 |
KR101193186B1 (ko) | 2010-02-01 | 2012-10-19 | 삼성디스플레이 주식회사 | 박막 증착 장치, 이를 이용한 유기 발광 디스플레이 장치의 제조방법 및 이에 따라 제조된 유기 발광 디스플레이 장치 |
KR101156441B1 (ko) | 2010-03-11 | 2012-06-18 | 삼성모바일디스플레이주식회사 | 박막 증착 장치 |
KR101202348B1 (ko) | 2010-04-06 | 2012-11-16 | 삼성디스플레이 주식회사 | 박막 증착 장치 및 이를 이용한 유기 발광 표시 장치의 제조 방법 |
US8894458B2 (en) | 2010-04-28 | 2014-11-25 | Samsung Display Co., Ltd. | Thin film deposition apparatus, method of manufacturing organic light-emitting display device by using the apparatus, and organic light-emitting display device manufactured by using the method |
IT1400574B1 (it) | 2010-05-06 | 2013-06-14 | Freni Brembo Spa | Dispositivo di frenatura a disco per veicoli |
US8685649B2 (en) | 2010-06-10 | 2014-04-01 | The United States Of America As Represented By The Secretary Of The Navy | RT-LAMP assay for the detection of pan-serotype dengue virus |
KR101223723B1 (ko) | 2010-07-07 | 2013-01-18 | 삼성디스플레이 주식회사 | 박막 증착 장치, 이를 이용한 유기 발광 디스플레이 장치의 제조방법 및 이에 따라 제조된 유기 발광 디스플레이 장치 |
WO2012045063A2 (en) * | 2010-10-01 | 2012-04-05 | University Of Rochester | Flavivirus domain iii vaccine |
KR101738531B1 (ko) | 2010-10-22 | 2017-05-23 | 삼성디스플레이 주식회사 | 유기 발광 디스플레이 장치의 제조 방법 및 이에 따라 제조된 유기 발광 디스플레이 장치 |
KR101723506B1 (ko) | 2010-10-22 | 2017-04-19 | 삼성디스플레이 주식회사 | 유기층 증착 장치 및 이를 이용한 유기 발광 디스플레이 장치의 제조 방법 |
KR20120045865A (ko) | 2010-11-01 | 2012-05-09 | 삼성모바일디스플레이주식회사 | 유기층 증착 장치 |
WO2012065105A2 (en) * | 2010-11-12 | 2012-05-18 | Thomas Monath | Chimeric flavivirus vaccines |
KR20120065789A (ko) | 2010-12-13 | 2012-06-21 | 삼성모바일디스플레이주식회사 | 유기층 증착 장치 |
KR101760897B1 (ko) | 2011-01-12 | 2017-07-25 | 삼성디스플레이 주식회사 | 증착원 및 이를 구비하는 유기막 증착 장치 |
KR101840654B1 (ko) | 2011-05-25 | 2018-03-22 | 삼성디스플레이 주식회사 | 유기층 증착 장치 및 이를 이용한 유기 발광 디스플레이 장치의 제조 방법 |
KR101852517B1 (ko) | 2011-05-25 | 2018-04-27 | 삼성디스플레이 주식회사 | 유기층 증착 장치 및 이를 이용한 유기 발광 디스플레이 장치의 제조 방법 |
KR101857249B1 (ko) | 2011-05-27 | 2018-05-14 | 삼성디스플레이 주식회사 | 패터닝 슬릿 시트 어셈블리, 유기막 증착 장치, 유기 발광 표시장치제조 방법 및 유기 발광 표시 장치 |
KR20130004830A (ko) | 2011-07-04 | 2013-01-14 | 삼성디스플레이 주식회사 | 유기층 증착 장치 및 이를 이용한 유기 발광 표시 장치의 제조 방법 |
KR101826068B1 (ko) | 2011-07-04 | 2018-02-07 | 삼성디스플레이 주식회사 | 유기층 증착 장치 |
KR102015872B1 (ko) | 2012-06-22 | 2019-10-22 | 삼성디스플레이 주식회사 | 유기층 증착 장치, 이를 이용한 유기 발광 디스플레이 장치의 제조 방법 및 이에 따라 제조된 유기 발광 디스플레이 장치 |
US8895028B2 (en) | 2012-07-20 | 2014-11-25 | Arbovax, Inc. | Methods and compositions for dengue virus 3 (DV3) infectious clone |
US20150265695A1 (en) * | 2012-07-24 | 2015-09-24 | Sanofi Pasteur | Vaccine compositions for prevention against dengue virus infection |
KR102081284B1 (ko) | 2013-04-18 | 2020-02-26 | 삼성디스플레이 주식회사 | 증착장치, 이를 이용한 유기발광 디스플레이 장치 제조 방법 및 유기발광 디스플레이 장치 |
KR20160023683A (ko) * | 2013-06-21 | 2016-03-03 | 머크 샤프 앤드 돔 코포레이션 | 뎅기 바이러스 백신 조성물 및 그의 사용 방법 |
NO340722B1 (no) * | 2014-06-27 | 2017-06-06 | Norwegian Institute For Agricultural & Environmental Res | Transgene planter som uttrykker et rekombinant tetravalent kimært denguevirusantigen for å fremstille effektive vaksiner avledet derfra, samt transgent plastid, plantecelle og frø, rekombinant DNA molekyl, vektor, fremgangsmåter for fremstilling og anvendelse derav |
SG11201704942QA (en) | 2014-12-22 | 2017-07-28 | Merck Sharp & Dohme | Dengue virus vaccine compositions and methods of use thereof |
US10004795B2 (en) * | 2015-09-08 | 2018-06-26 | Fundacao Butantan | Process for preparing an attenuated tetravalent dengue vaccine |
US11285202B2 (en) * | 2016-01-26 | 2022-03-29 | University Of South Carolina | Polymer-protein core-shell particles as effective vaccine delivery vehicles and treatments methods using the same |
EP3426292A1 (en) | 2016-03-11 | 2019-01-16 | THE UNITED STATES OF AMERICA, represented by the S | Live attenuated zika virus vaccine |
SG10201913383RA (en) * | 2016-04-13 | 2020-03-30 | Takeda Vaccines Inc | Compositions and methods of vaccination against dengue virus in children and young adults |
WO2018129160A1 (en) | 2017-01-06 | 2018-07-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Live attenuated flavivirus vaccines and methods of using and making same |
KR102494651B1 (ko) | 2017-12-07 | 2023-01-31 | 머크 샤프 앤드 돔 엘엘씨 | 뎅기 바이러스 백신 조성물의 제제 |
EP3846848A4 (en) * | 2018-09-04 | 2022-07-06 | The Board of Regents of the University of Texas System | DNA PLASMID INITIATED LIVE VACCINES FOR PLUS-POLARITY SINGLE STRAND RNA VIRUS |
WO2021173597A1 (en) * | 2020-02-28 | 2021-09-02 | Merck Sharp & Dohme Corp. | Dengue serotype specific rt-pcr multiplex assay |
WO2023161715A1 (en) * | 2022-02-22 | 2023-08-31 | Futr Bio Ltda. | Next generation mrna vaccines |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000058444A2 (en) * | 1999-03-26 | 2000-10-05 | Walter Reed Army Institute Of Research | Adaptation of virus to vertebrate cells |
EP1159969A1 (fr) * | 2000-05-30 | 2001-12-05 | Aventis Pasteur | Vaccine composition |
DK2290109T3 (da) * | 2001-05-22 | 2014-11-10 | Us Gov Health & Human Serv | Udvikling af mutationer, der er anvendelige til svækkelse af dengue-vira samt kimære dengue-vira |
ES2355719T3 (es) * | 2002-05-03 | 2011-03-30 | The United States Government As Represented By The Department Of Health And Human Services | Vacuna contra el dengue que contiene una deleción común de 30 nucleótidos en la utr en 3' del dengue tipos 1 y 2. |
US8337860B2 (en) * | 2006-08-15 | 2012-12-25 | The United States Of America, As Represented By The Secretary Of The Department Of Health & Human Services | Development of dengue virus vaccine components |
-
2003
- 2003-04-25 ES ES03724319T patent/ES2355719T3/es not_active Expired - Lifetime
- 2003-04-25 PT PT03724319T patent/PT1554301E/pt unknown
- 2003-04-25 PT PT101777357T patent/PT2338508T/pt unknown
- 2003-04-25 AT AT03724319T patent/ATE481982T1/de active
- 2003-04-25 EP EP10177735.7A patent/EP2338508B1/en not_active Expired - Lifetime
- 2003-04-25 DE DE60334310T patent/DE60334310D1/de not_active Expired - Lifetime
- 2003-04-25 SI SI200331929T patent/SI1554301T1/sl unknown
- 2003-04-25 CA CA2483653A patent/CA2483653C/en not_active Expired - Lifetime
- 2003-04-25 TR TR2018/06655T patent/TR201806655T4/tr unknown
- 2003-04-25 SI SI200332569T patent/SI2338508T1/en unknown
- 2003-04-25 EP EP10177740A patent/EP2319532A1/en not_active Ceased
- 2003-04-25 EP EP03724319A patent/EP1554301B1/en not_active Expired - Lifetime
- 2003-04-25 WO PCT/US2003/013279 patent/WO2003092592A2/en active Application Filing
- 2003-04-25 DK DK03724319.3T patent/DK1554301T3/da active
- 2003-04-25 JP JP2004500777A patent/JP4977811B2/ja not_active Expired - Lifetime
- 2003-04-25 ES ES10177735.7T patent/ES2677348T3/es not_active Expired - Lifetime
- 2003-04-25 DK DK10177735.7T patent/DK2338508T3/en active
- 2003-04-25 EP EP17155603.8A patent/EP3205352A1/en not_active Withdrawn
- 2003-04-25 EP EP20153909.5A patent/EP3763382A1/en active Pending
- 2003-04-25 BR BRPI0309631-9A patent/BRPI0309631B1/pt not_active IP Right Cessation
- 2003-04-25 HU HUE10177735A patent/HUE037330T2/hu unknown
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2004
- 2004-10-21 US US10/970,640 patent/US7517531B2/en not_active Ceased
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2009
- 2009-03-04 US US12/398,043 patent/US8075903B2/en not_active Ceased
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2011
- 2011-11-28 US US13/305,639 patent/US9783787B2/en not_active Expired - Lifetime
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2013
- 2013-05-17 US US13/896,388 patent/USRE46641E1/en not_active Expired - Lifetime
- 2013-05-17 US US13/896,384 patent/USRE46631E1/en active Active
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2017
- 2017-09-20 US US15/710,672 patent/US10837003B2/en not_active Expired - Lifetime
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2018
- 2018-05-14 CY CY20181100488T patent/CY1120558T1/el unknown
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2020
- 2020-09-01 US US17/009,448 patent/US11753627B2/en active Active
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