ATE297754T1 - Heilung von bruchverletzungen unter verwendung von pthrp analogen - Google Patents

Heilung von bruchverletzungen unter verwendung von pthrp analogen

Info

Publication number
ATE297754T1
ATE297754T1 AT98951341T AT98951341T ATE297754T1 AT E297754 T1 ATE297754 T1 AT E297754T1 AT 98951341 T AT98951341 T AT 98951341T AT 98951341 T AT98951341 T AT 98951341T AT E297754 T1 ATE297754 T1 AT E297754T1
Authority
AT
Austria
Prior art keywords
healing
pthrp analogue
fracture injuries
injuries
fracture
Prior art date
Application number
AT98951341T
Other languages
English (en)
Inventor
Brian Henry Vickery
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE297754T1 publication Critical patent/ATE297754T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT98951341T 1997-09-09 1998-09-02 Heilung von bruchverletzungen unter verwendung von pthrp analogen ATE297754T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5832497P 1997-09-09 1997-09-09
PCT/EP1998/005550 WO1999012561A2 (en) 1997-09-09 1998-09-02 FRACTURE HEALING USING PTHrP ANALOGS

Publications (1)

Publication Number Publication Date
ATE297754T1 true ATE297754T1 (de) 2005-07-15

Family

ID=22016113

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98951341T ATE297754T1 (de) 1997-09-09 1998-09-02 Heilung von bruchverletzungen unter verwendung von pthrp analogen

Country Status (32)

Country Link
US (1) US6583114B2 (de)
EP (1) EP1005359B1 (de)
JP (1) JP2002509854A (de)
KR (1) KR100679778B1 (de)
CN (1) CN1210059C (de)
AR (1) AR015435A1 (de)
AT (1) ATE297754T1 (de)
AU (1) AU752925B2 (de)
BR (1) BR9812068A (de)
CA (1) CA2302255C (de)
CO (1) CO4890856A1 (de)
CZ (1) CZ298701B6 (de)
DE (1) DE69830591T2 (de)
ES (1) ES2244090T3 (de)
HK (1) HK1030753A1 (de)
HR (1) HRP20000109A2 (de)
HU (1) HU226866B1 (de)
IL (2) IL134719A0 (de)
MA (1) MA26545A1 (de)
MY (1) MY121291A (de)
NO (1) NO323740B1 (de)
NZ (1) NZ502970A (de)
PE (1) PE117399A1 (de)
PL (1) PL195703B1 (de)
RS (1) RS49707B (de)
RU (1) RU2224539C2 (de)
SA (1) SA98190565B1 (de)
TR (1) TR200000649T2 (de)
TW (1) TW552139B (de)
UY (1) UY25172A1 (de)
WO (1) WO1999012561A2 (de)
ZA (1) ZA988030B (de)

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SI1059933T1 (en) * 1998-08-19 2003-04-30 Eli Lilly & Company Use of parathyroide hormone consisting of aminoacid sequence 1-34 of human parathyroid hormone for reducing the risk of both vertebral and non vertebral bone fracture
AR033639A1 (es) * 1998-08-19 2004-01-07 Lilly Co Eli Uso de hormonas paratiroideas para preparar medicamentos para reducir el riesgo de fracturas oseas vertebrales o no vertebrales en seres humanos con riesgo de padecer o que padecen osteoporosis
US20040033950A1 (en) 2000-09-26 2004-02-19 Hock Janet M. Method of increasing bone toughness and stiffness and reducing fractures
EP1769804B1 (de) * 1998-08-19 2012-09-19 Eli Lilly And Company hPTH(1-34) zur Verwendung in der Vorbeugung und Reduzierung des Auftretens oder der Schwere von Knochenbrüchen bei Männern
CA2245903A1 (en) * 1998-09-28 2000-03-28 Mcgill University Use of pex in the treatment of metabolic bone diseases
HUP0200258A2 (hu) 1999-03-05 2002-05-29 The Procter & Gamble Co. C16-telítetlen FP-szelektív prosztaglandin analógok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US6560487B1 (en) 2000-05-08 2003-05-06 International Rehabilitative Sciences, Inc. Electro-medical device for use with biologics
US6393328B1 (en) * 2000-05-08 2002-05-21 International Rehabilitative Sciences, Inc. Multi-functional portable electro-medical device
US6675048B2 (en) * 2000-05-08 2004-01-06 International Rehabilitative Sciences, Inc. Electro-medical device for use with biologics
EP1531855A4 (de) * 2002-01-10 2009-07-22 Osteotrophin Llc Behandlung von knochenerkrankungen mit skelettalen anabolika
WO2005041998A1 (en) 2003-10-02 2005-05-12 Ali Sadat M Peptide for promoting healing of fractures
AU2005294125A1 (en) * 2004-10-08 2006-04-20 Transition Therapeutics Inc. Vasoactive intestinal polypeptide pharmaceuticals
JP2009515535A (ja) * 2005-11-10 2009-04-16 ボード オブ コントロール オブ ミシガン テクノロジカル ユニヴァーシティー クロクマの副甲状腺ホルモン及びクロクマの副甲状腺ホルモンを使用する方法
WO2007133580A2 (en) * 2006-05-09 2007-11-22 Zelos Therapeutics, Inc. Use of pth (1-31) and optionally g-csf for hematopoietic stimulation
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
US7803770B2 (en) 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
UA98776C2 (ru) 2006-10-03 2012-06-25 Радиус Хелс, Инк. СПОСОБ ДОСТАВКИ лекарственного ПРЕПАРАТА ДЛЯ УСИЛЕНИЯ СИНТЕЗА БЕЛКА В КОСТЯХ
EP1961765A1 (de) * 2006-12-08 2008-08-27 Zealand Pharma A/S Verkürzte PTH-Peptide mit zyklischer Konformation
JP5564167B2 (ja) * 2008-05-22 2014-07-30 日本たばこ産業株式会社 苦味マスキング剤及び苦味低減方法
US8870876B2 (en) 2009-02-13 2014-10-28 Tarsus Medical Inc. Methods and devices for treating hallux valgus
CN102448482A (zh) 2009-03-27 2012-05-09 范安德尔研究所 甲状旁腺素肽和甲状旁腺素相关蛋白肽及使用方法
US8277459B2 (en) 2009-09-25 2012-10-02 Tarsus Medical Inc. Methods and devices for treating a structural bone and joint deformity
EP2509996A1 (de) 2009-12-07 2012-10-17 Michigan Technological University Schwarzbär-parathyroid-hormon und verfahren zur verwendung des schwarzbär-parathyroid-hormons
US8652141B2 (en) 2010-01-21 2014-02-18 Tarsus Medical Inc. Methods and devices for treating hallux valgus
US8696719B2 (en) 2010-06-03 2014-04-15 Tarsus Medical Inc. Methods and devices for treating hallux valgus
CN104146961B (zh) * 2014-07-04 2018-02-27 深圳职业技术学院 一种薄膜蒸发法制备载细胞因子和骨蛋白微球的方法
MX2017013802A (es) 2015-04-29 2018-08-15 Radius Pharmaceuticals Inc Métodos para tratar el cáncer.
WO2017007777A2 (en) * 2015-07-06 2017-01-12 Zhengxin Dong NOVEL FORMULATIONS OF PTHrP ANALOGUE
CA3020333A1 (en) 2016-04-18 2017-10-26 Radius Health, Inc. Formulations of abaloparatide, transdermal patches thereof, and uses thereof
MX2019007748A (es) 2017-01-05 2019-09-09 Radius Pharmaceuticals Inc Formas polimorficas de rad1901-2hcl.
US10996208B2 (en) 2017-04-28 2021-05-04 Radius Health, Inc. Abaloparatide formulations and methods of testing, storing, modifying, and using same
SG11202013177WA (en) 2018-07-04 2021-01-28 Radius Pharmaceuticals Inc Polymorphic forms of rad 1901-2hcl
EP4027899A4 (de) * 2019-09-12 2023-08-16 Radius Health, Inc. Verfahren zur verbesserung der wirbelsäulenfusion mit abaloparatid
CN112646042A (zh) * 2019-10-10 2021-04-13 陕西麦科奥特科技有限公司 活性多肽化合物
AU2022205801A1 (en) * 2021-01-05 2023-07-13 Radius Health, Inc. Treatment of long bone fractures with abaloparatide

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3935738A1 (de) * 1989-10-27 1991-05-08 Forssmann Wolf Georg Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff
US5977070A (en) * 1992-07-14 1999-11-02 Piazza; Christin Teresa Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
US5821225A (en) * 1992-07-14 1998-10-13 Syntex (U.S.A.) Inc. Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
AU672790B2 (en) * 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
WO1995002610A1 (en) * 1993-07-13 1995-01-26 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
WO1995011697A1 (fr) * 1993-10-27 1995-05-04 Chugai Seiyaku Kabushiki Kaisha Accelerateur de guerison utilise en chondroplastie
JPH08310965A (ja) * 1995-05-16 1996-11-26 Chugai Pharmaceut Co Ltd 骨癒合促進剤
US5717062A (en) * 1995-06-07 1998-02-10 Beth Israel Hospital Association Cyclic analogs of PTH and PTHrP
US5723577A (en) * 1995-07-13 1998-03-03 Biomeasure Inc. Analogs of parathyroid hormone
US5955574A (en) * 1995-07-13 1999-09-21 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Analogs of parathyroid hormone

Also Published As

Publication number Publication date
AU752925B2 (en) 2002-10-03
KR100679778B1 (ko) 2007-02-07
NO323740B1 (no) 2007-07-02
PE117399A1 (es) 1999-11-20
MY121291A (en) 2006-01-28
EP1005359B1 (de) 2005-06-15
CO4890856A1 (es) 2000-02-28
AR015435A1 (es) 2001-05-02
HRP20000109A2 (en) 2001-02-28
BR9812068A (pt) 2000-09-26
MA26545A1 (fr) 2004-12-20
HUP0004560A2 (hu) 2001-04-28
WO1999012561A3 (en) 1999-05-14
US6583114B2 (en) 2003-06-24
NO20001195L (no) 2000-03-08
IL134719A (en) 2010-04-29
CZ298701B6 (cs) 2007-12-27
PL339449A1 (en) 2000-12-18
WO1999012561A9 (en) 2000-03-16
SA98190565B1 (ar) 2006-07-30
HU226866B1 (en) 2009-12-28
US20020077281A1 (en) 2002-06-20
AU9740698A (en) 1999-03-29
RS49707B (sr) 2007-12-31
WO1999012561A2 (en) 1999-03-18
CN1269726A (zh) 2000-10-11
CZ2000862A3 (cs) 2000-09-13
EP1005359A2 (de) 2000-06-07
PL195703B1 (pl) 2007-10-31
HK1030753A1 (en) 2001-05-18
ZA988030B (en) 1999-03-09
NO20001195D0 (no) 2000-03-08
ES2244090T3 (es) 2005-12-01
HUP0004560A3 (en) 2005-11-28
DE69830591T2 (de) 2006-05-04
TR200000649T2 (tr) 2000-09-21
RU2224539C2 (ru) 2004-02-27
IL134719A0 (en) 2001-04-30
JP2002509854A (ja) 2002-04-02
TW552139B (en) 2003-09-11
UY25172A1 (es) 2001-01-31
CA2302255A1 (en) 1999-03-18
CA2302255C (en) 2011-11-08
CN1210059C (zh) 2005-07-13
DE69830591D1 (de) 2005-07-21
KR20010023795A (ko) 2001-03-26
YU12700A (sh) 2004-09-03
NZ502970A (en) 2002-03-01

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