SG11202013177WA - Polymorphic forms of rad 1901-2hcl - Google Patents

Polymorphic forms of rad 1901-2hcl

Info

Publication number
SG11202013177WA
SG11202013177WA SG11202013177WA SG11202013177WA SG11202013177WA SG 11202013177W A SG11202013177W A SG 11202013177WA SG 11202013177W A SG11202013177W A SG 11202013177WA SG 11202013177W A SG11202013177W A SG 11202013177WA SG 11202013177W A SG11202013177W A SG 11202013177WA
Authority
SG
Singapore
Prior art keywords
2hcl
rad
polymorphic forms
polymorphic
forms
Prior art date
Application number
SG11202013177WA
Inventor
Michael Cruskie
Joshua Bolger
Jonathan Mckenzie
Pratik Sheth
Richard Edwards
Alex Eberlin
Michael Markey
Original Assignee
Radius Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Radius Pharmaceuticals Inc filed Critical Radius Pharmaceuticals Inc
Publication of SG11202013177WA publication Critical patent/SG11202013177WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
SG11202013177WA 2018-07-04 2019-07-03 Polymorphic forms of rad 1901-2hcl SG11202013177WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862694003P 2018-07-04 2018-07-04
PCT/US2019/040527 WO2020010216A1 (en) 2018-07-04 2019-07-03 Polymorphic forms of rad 1901-2hcl

Publications (1)

Publication Number Publication Date
SG11202013177WA true SG11202013177WA (en) 2021-01-28

Family

ID=67470668

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202013177WA SG11202013177WA (en) 2018-07-04 2019-07-03 Polymorphic forms of rad 1901-2hcl

Country Status (11)

Country Link
US (1) US11643385B2 (en)
EP (1) EP3817821A1 (en)
JP (1) JP7473486B2 (en)
KR (1) KR20210030393A (en)
CN (1) CN112423844A (en)
AU (1) AU2019297421A1 (en)
CA (1) CA3104395A1 (en)
IL (1) IL279853A (en)
MX (1) MX2020013713A (en)
SG (1) SG11202013177WA (en)
WO (1) WO2020010216A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023064519A1 (en) 2021-10-14 2023-04-20 Teva Pharmaceuticals International Gmbh Solid state forms of elacestrant and processes for preparation thereof
WO2023227029A1 (en) * 2022-05-25 2023-11-30 苏州科睿思制药有限公司 Crystal form of elacestrant dihydrochloride, preparation method therefor, and use thereof

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