ATE239011T1 - Neuartige form von s-omeprazol - Google Patents

Neuartige form von s-omeprazol

Info

Publication number
ATE239011T1
ATE239011T1 AT98926005T AT98926005T ATE239011T1 AT E239011 T1 ATE239011 T1 AT E239011T1 AT 98926005 T AT98926005 T AT 98926005T AT 98926005 T AT98926005 T AT 98926005T AT E239011 T1 ATE239011 T1 AT E239011T1
Authority
AT
Austria
Prior art keywords
omeprazole
novel form
novel
Prior art date
Application number
AT98926005T
Other languages
English (en)
Inventor
Hanna Cotton
Anders Kronstroem
Anders Mattson
Eva Moeller
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20407186&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE239011(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE239011T1 publication Critical patent/ATE239011T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Glass Compositions (AREA)
AT98926005T 1997-05-30 1998-05-25 Neuartige form von s-omeprazol ATE239011T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9702065A SE510650C2 (sv) 1997-05-30 1997-05-30 Ny förening
PCT/SE1998/000974 WO1998054171A1 (en) 1997-05-30 1998-05-25 Novel form of s-omeprazole

Publications (1)

Publication Number Publication Date
ATE239011T1 true ATE239011T1 (de) 2003-05-15

Family

ID=20407186

Family Applications (2)

Application Number Title Priority Date Filing Date
AT98926005T ATE239011T1 (de) 1997-05-30 1998-05-25 Neuartige form von s-omeprazol
AT02019642T ATE291574T1 (de) 1997-05-30 1998-05-25 Neuer prozess zur herstellung von s-omeprazol- magnesiumsalz-trihydrat

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT02019642T ATE291574T1 (de) 1997-05-30 1998-05-25 Neuer prozess zur herstellung von s-omeprazol- magnesiumsalz-trihydrat

Country Status (44)

Country Link
US (6) US6369085B1 (de)
EP (2) EP0984957B3 (de)
JP (2) JP4002303B2 (de)
KR (2) KR100527804B1 (de)
CN (1) CN1161351C (de)
AR (2) AR012717A1 (de)
AT (2) ATE239011T1 (de)
AU (1) AU722839B2 (de)
BR (1) BR9809509A (de)
CA (2) CA2290963C (de)
CY (1) CY2012029I2 (de)
CZ (1) CZ297585B6 (de)
DE (3) DE69829511T2 (de)
DK (2) DK0984957T3 (de)
DZ (1) DZ2495A1 (de)
EE (1) EE03875B1 (de)
EG (1) EG24291A (de)
ES (2) ES2236407T3 (de)
HK (2) HK1051681A1 (de)
HR (1) HRP980263B1 (de)
HU (1) HU225987B1 (de)
ID (1) ID29306A (de)
IL (1) IL132947A0 (de)
IS (2) IS2142B (de)
LU (2) LU91871I2 (de)
MA (1) MA26500A1 (de)
ME (3) ME00198B (de)
MY (2) MY120745A (de)
NO (3) NO317518B1 (de)
NZ (1) NZ500991A (de)
PL (1) PL193546B1 (de)
PT (2) PT984957E (de)
RS (2) RS50005B (de)
RU (1) RU2184115C2 (de)
SA (2) SA05260296B1 (de)
SE (1) SE510650C2 (de)
SI (2) SI0984957T1 (de)
SK (2) SK284837B6 (de)
TN (1) TNSN98074A1 (de)
TR (1) TR199902934T2 (de)
TW (1) TW538040B (de)
UA (1) UA60334C2 (de)
WO (1) WO1998054171A1 (de)
ZA (1) ZA984179B (de)

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
US6875872B1 (en) * 1993-05-28 2005-04-05 Astrazeneca Compounds
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
EP0909323B1 (de) 1996-01-04 2007-02-28 Novartis Vaccines and Diagnostics, Inc. Bakterioferritin aus helicobacter pylori
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6699885B2 (en) * 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
SE510650C2 (sv) * 1997-05-30 1999-06-14 Astra Ab Ny förening
SE9900274D0 (sv) * 1999-01-28 1999-01-28 Astra Ab New compound
US6369087B1 (en) * 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
ES2286408T3 (es) 2002-03-05 2007-12-01 Astrazeneca Ab Sales de alquilamonio de omeprazol e esomeprazol.
AU2003262375A1 (en) * 2002-04-22 2003-11-03 Sun Pharmaceutical Industries Limited Optically active substituted pyridinylmethyl-sulphinyl-benzimidazole and salts
US7169793B2 (en) 2002-06-27 2007-01-30 Dr. Reddy's Laboratories Limited Process for preparation of optically pure or optically enriched sulfoxide compounds, including amorphous esomeprazole and salts thereof
ATE353887T1 (de) * 2002-06-27 2007-03-15 Reddys Lab Ltd Dr Verfahren zur herstellung optisch reiner oder optisch angereicherter sulfoxidverbindungen einschliesslich amorphen esomeprazols und dessen salze
TW200410955A (en) 2002-07-29 2004-07-01 Altana Pharma Ag Novel salt of (S)-PANTOPRAZOLE
US7612098B2 (en) * 2002-08-30 2009-11-03 Dr. Reddy's Laboratories Limited Amorphous hydrous esomeprazole magnesium
ES2534713T3 (es) * 2002-10-16 2015-04-27 Takeda Pharmaceutical Company Limited Preparaciones sólidas estables
US20040235903A1 (en) * 2002-10-22 2004-11-25 Khanna Mahavir Singh Amorphous form of esomeprazole salts
US20040242642A1 (en) * 2002-11-18 2004-12-02 Dr. Reddy's Laboratories Limited Crystalline esomeprazole compounds and process for the preparation thereof
EP1583507A2 (de) * 2003-01-07 2005-10-12 Ranbaxy Laboratories Limited Magnesiumsalz eines imidazol-derivats
AU2003238671A1 (en) * 2003-04-10 2004-11-01 Hetero Drugs Limitd Novel crystalline forms of s-omeprazole magnesium
EP1633736A1 (de) 2003-05-05 2006-03-15 Ranbaxy Laboratories Limited Barium salz eines benzimidazol-derivats
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
CA2532774A1 (en) * 2003-07-23 2005-02-10 Altana Pharma Ag Alkaline salts of proton pump inhibitors
CN100457104C (zh) * 2003-07-23 2009-02-04 尼科梅德有限责任公司 质子泵抑制剂的碱性盐
SE0302381D0 (sv) 2003-09-04 2003-09-04 Astrazeneca Ab New salts I
SE0302382D0 (sv) 2003-09-04 2003-09-04 Astrazeneca Ab New salts II
US20050075371A1 (en) * 2003-10-03 2005-04-07 Allergan, Inc. Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
BRPI0507837A (pt) * 2004-02-18 2007-07-10 Allergan Inc métodos e composições para a administração intravenosa de compostos relacionados a inibidores de bomba de prótons
US20070060621A1 (en) * 2004-02-18 2007-03-15 Hughes Patrick M Methods and compositions for the administration of prodrugs of proton pump inhibitors
US20050239845A1 (en) * 2004-04-16 2005-10-27 Santarus, Inc. Combination of proton pump inhibitor, buffering agent, and prokinetic agent
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US20050267159A1 (en) * 2004-05-28 2005-12-01 Aaipharma, Inc. Magnesium complexes of S-omeprazole
US20050267157A1 (en) * 2004-05-28 2005-12-01 David White Magnesium-S-omeprazole
AU2005264864B2 (en) 2004-06-16 2011-08-11 Takeda Pharmaceutical Company Limited Multiple PPI dosage form
KR20130038949A (ko) * 2004-06-24 2013-04-18 아스트라제네카 아베 에소메프라졸 나트륨염의 제조에서 사용하기 위한 결정 변형의 제조를 위한 신규한 방법
ES2246149B1 (es) * 2004-07-02 2007-06-01 Esteve Quimica, S.A. Formas solidas de la sal magnesica de s-omeprazol y procedimientos para su preparacion.
US20060024362A1 (en) * 2004-07-29 2006-02-02 Pawan Seth Composition comprising a benzimidazole and process for its manufacture
US20060160783A1 (en) * 2004-12-30 2006-07-20 Transform Pharmaceuticals, Inc. Novel omeprazole forms and related methods
ES2259269B1 (es) 2005-03-03 2007-11-01 Esteve Quimica, S.A. Procedimiento para la preparacion de derivados de 2-(2-piridilmetilsulfinil)-bencimidazol opticamente activos.
US20060210637A1 (en) * 2005-03-17 2006-09-21 Qpharma, Llc Stable tablet dosage forms of proton pump inhibitors
KR20080007508A (ko) * 2005-05-06 2008-01-21 그렌마크 파머수티칼스 엘티디. 에소메프라졸 스트론튬염, 그것의 제조방법 및 그것을함유하는 약제학적 조성물
US7563812B2 (en) * 2005-06-15 2009-07-21 Hetero Drugs Limited Amorphous esomeprazole hydrate
WO2007008588A2 (en) * 2005-07-07 2007-01-18 Dr. Reddy's Laboratories Ltd. Omeprazole form b
KR100641534B1 (ko) 2005-07-28 2006-11-01 한미약품 주식회사 에스오메프라졸 및 그의 염의 제조방법
US20070026071A1 (en) * 2005-07-28 2007-02-01 Qpharma, Llc Magnesium salt proton pump inhibitor dosage forms
WO2007031845A2 (en) * 2005-09-14 2007-03-22 Glenmark Pharmaceuticals Limited Polymorphic forms of (s)-omeprazole magnesium salts and processes for their preparation
WO2007041630A1 (en) * 2005-10-06 2007-04-12 Auspex Pharmaceuticals, Inc. Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties
US7576219B2 (en) 2005-10-26 2009-08-18 Hanmi Pharm. Co., Ltd Crystalline S-omeprazole strontium hydrate, method for preparing same, and pharmaceutical composition containing same
AU2006306906B2 (en) * 2005-10-26 2010-02-04 Hanmi Science Co., Ltd. S-omeprazole strontium or hydrate thereof, method for preparing same, and pharmaceutical composition comprising same
EP1801110A1 (de) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Argininsalz des Esomeprazols
US7553857B2 (en) * 2005-12-23 2009-06-30 Lek Pharmaceuticals D.D. S-omeprazole magnesium
CN100384839C (zh) * 2006-02-17 2008-04-30 中国科学院上海有机化学研究所 [(取代的吡啶基)甲基]亚磺酰基-1h-苯并咪唑类化合物及其对映体的锌盐的制备方法
US7579476B2 (en) * 2006-02-24 2009-08-25 Praktikatalyst Pharma, Llc Transition metal mediated oxidation of hetero atoms in organic molecules coordinated to transition metals
US8063074B2 (en) 2006-05-04 2011-11-22 Dr. Reddy's Laboratories Limited Polymorphic forms of esomeprazole sodium
US20100286208A1 (en) * 2006-06-21 2010-11-11 Bobba Venkata Siva Kumar Novel polymorph of esomeprazole potassium and process for its preparation
GB2444593B (en) 2006-10-05 2010-06-09 Santarus Inc Novel formulations for immediate release of proton pump inhibitors and methods of using these formulations
EP2486910A3 (de) 2006-10-27 2012-08-22 The Curators Of The University Of Missouri Vorrichtung mit mehreren Kammern und Dispenser
EP1947099A1 (de) * 2007-01-18 2008-07-23 LEK Pharmaceuticals D.D. Verfahren zur Entfernung von Lösungsmitteln in Omeprazol-Salzen
WO2008092939A2 (en) 2007-01-31 2008-08-07 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically pure omeprazole via salt formation with a chiral amine or treatment with an entiomer converting enzyme and chromatographic separation
NZ579136A (en) * 2007-02-21 2012-05-25 Cipla Ltd Process for the preparation of esomeprazole magnesium dihydrate
KR101303813B1 (ko) * 2007-04-16 2013-09-04 에스케이케미칼주식회사 라세믹 오메프라졸로부터 에스오메프라졸의 개선된제조방법
EP2000468A1 (de) 2007-05-09 2008-12-10 Dr. Reddy's Laboratories Ltd. Esomeprazolsalze und Verfahren zur Herstellung davon
WO2008149204A1 (en) * 2007-06-07 2008-12-11 Aurobindo Pharma Limited An improved process for preparing an optically active proton pump inhibitor
FR2920428B1 (fr) 2007-08-29 2012-06-15 Univ Rouen Procede de dedoublement de sels de l'omeprazole
WO2009047775A2 (en) * 2007-10-08 2009-04-16 Hetero Drugs Limited Polymorphs of esomeprazole salts
JP5629581B2 (ja) 2007-10-12 2014-11-19 タケダ ファーマシューティカルズ ユー．エス．エー． インコーポレイティド 食物の摂取から独立した消化器疾患の治療方法
WO2009074997A2 (en) * 2007-12-10 2009-06-18 Lee Pharma Ltd. A novel process for the preparation of crystalline magnesium salt of (s)-omeprazole di hydrate
EP2240496A4 (de) * 2008-02-01 2011-05-11 Reddys Lab Ltd Dr Herstellung von esomeprazol-magnesium und hydraten davon
US20090280175A1 (en) * 2008-05-09 2009-11-12 Ishwar Chauhan Multilayer Proton Pump Inhibitor Tablets
US20090280173A1 (en) * 2008-05-09 2009-11-12 Ishwar Chauhan Multilayer Omeprazole Tablets
EP2143722A1 (de) 2008-07-09 2010-01-13 Lek Pharmaceuticals D.D. Verfahren zur Herstellung von Esomeprazol-Natrium von hoher chemischer Reinheit und neue Formen von Esomeprazol-Natrium
EP2147918A1 (de) * 2008-07-21 2010-01-27 LEK Pharmaceuticals D.D. Verfahren zur Herstellung von S-Omeprazol-Magnesium in einer stabilen Form
MX2011002515A (es) 2008-09-09 2011-04-07 Astrazeneca Ab Metodo de administracion de una composicion farmaceutica a un paciente que lo necesita.
CN101391993B (zh) * 2008-10-28 2012-07-04 安徽美诺华药物化学有限公司 通过与(s)-(-)-1,1'-联萘-2,2'-二酚形成包合配合物制备s-奥美拉唑及其盐的方法
WO2010097583A1 (en) 2009-02-24 2010-09-02 Cipla Limited Esomeprazole potassium polymorph and its preparation
US20100267959A1 (en) * 2009-04-15 2010-10-21 Glenmark Generics Limited Process for the preparation of esomeprazole magnesium dihydrate
WO2010122583A2 (en) 2009-04-24 2010-10-28 Rubicon Research Private Limited Oral pharmaceutical compositions of acid labile substances
EP2438057A4 (de) * 2009-06-02 2013-12-25 Sun Pharmaceutical Ind Ltd Verfahren zur herstellung von sulfoxidverbindungen
MX2011013467A (es) 2009-06-25 2012-02-13 Astrazeneca Ab Metodo para tratar un paciente que corre el riesgo de desarollar una ulcera asociada a antiinflamatorio no esteroide (aine).
EA021112B1 (ru) * 2009-06-25 2015-04-30 Поузен Инк. Способ лечения боли и/или воспаления у пациента, нуждающегося в аспириновой терапии
WO2011012957A1 (en) * 2009-07-29 2011-02-03 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of esomeprazole magnesium dihydrate
EP2499125B1 (de) 2009-11-12 2016-01-27 Hetero Research Foundation Verfahren zur racematspaltung von omeprazol
SI2510089T1 (sl) 2009-12-08 2015-12-31 Codexis, Inc. Sinteza prazolnih spojin
US20110207779A1 (en) * 2010-02-25 2011-08-25 Glenmark Generics Ltd Process for the preparation of esomeprazole magnesium
FR2959509B1 (fr) 2010-05-03 2012-07-13 Prod Chim Auxiliaires Et De Synthese Phase precurseur et son utilisation pour preparer le sel de magnesium tetrahydrate d'un enantiomere d'omeprazole
CN102241668B (zh) * 2010-05-11 2015-11-25 中国科学院成都有机化学有限公司 S-奥美拉唑盐
DK2649187T3 (da) 2010-12-08 2018-01-29 Codexis Inc Biokatalysatorer og fremgangsmåder til syntesen af armodafinil
CN102757421A (zh) * 2011-04-29 2012-10-31 江苏正大天晴药业股份有限公司 埃索美拉唑的纯化方法
CN102911158B (zh) * 2011-07-31 2015-07-22 连云港润众制药有限公司 埃索美拉唑镁的晶型
CN102936238B (zh) * 2011-11-25 2015-02-18 成都自豪药业有限公司 S-奥美拉唑镁盐的晶型及其制备方法
WO2013088272A1 (en) * 2011-12-14 2013-06-20 Wockhardt Limited Pharmaceutical composition comprising esomeprazole magnesium dihydrate
BR112014016085A8 (pt) 2011-12-28 2017-07-04 Pozen Inc composições aprimoradas e métodos para distribuição de omeprazol mais ácido acetilsalicílico
CN102584792B (zh) * 2012-01-06 2014-06-11 南京优科生物医药研究有限公司 制备高纯度的埃索美拉唑盐的方法
CN102993184A (zh) * 2013-01-08 2013-03-27 湖南方盛制药股份有限公司 一种埃索美拉唑及其镁盐三水合物的制备方法
CN104250243B (zh) * 2013-06-27 2016-12-28 四川国为制药有限公司 一种埃索美拉唑镁二水合物a晶型的制备方法
CN103570686B (zh) * 2013-10-14 2015-04-01 哈药集团技术中心 一种埃索美拉唑钠的合成及精制工艺
CN104725357A (zh) * 2013-12-24 2015-06-24 苏州联友制药技术有限公司 一种埃索美拉唑镁二水合物晶型b的制备方法
FR3018812A1 (fr) * 2014-03-21 2015-09-25 Minakem Nouvelle phase intermediaire de la forme a du sel de magnesium dihydrate d'un enantiomere de l'omeprazole
CN104447699A (zh) * 2014-12-10 2015-03-25 哈药集团技术中心 一种埃索美拉唑镁三水合物的制备方法
CN105111188B (zh) * 2015-08-19 2018-01-19 扬子江药业集团有限公司 一种埃索美拉唑镁三水合物晶型的制备方法
US10736855B2 (en) 2016-02-25 2020-08-11 Dexcel Pharma Technologies Ltd. Compositions comprising proton pump inhibitors
CN106397402B (zh) * 2016-08-30 2019-05-03 山东罗欣药业集团股份有限公司 一种埃索美拉唑镁晶型化合物及其制备方法
KR102006777B1 (ko) 2018-01-29 2019-10-08 주식회사 종근당 에스오메프라졸 및 탄산수소나트륨을 포함하는 약제학적 제제
KR102080023B1 (ko) 2018-01-29 2020-02-21 주식회사 종근당 에스오메프라졸 및 탄산수소나트륨을 포함하는 안정한 약제학적 조성물
KR102432084B1 (ko) 2021-11-16 2022-08-12 알리코제약(주) S-오메프라졸을 함유하는 안정성이 개선되고 소형화된 정제
WO2024075017A1 (en) 2022-10-04 2024-04-11 Zabirnyk Arsenii Inhibition of aortic valve calcification

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
SE8301182D0 (sv) 1983-03-04 1983-03-04 Haessle Ab Novel compounds
US5244891A (en) * 1985-08-05 1993-09-14 Bristol-Myers Squibb Company Injectable compositions of cefepime dihydrochloride hydrate
GB2189698A (en) 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
US5204118A (en) 1989-11-02 1993-04-20 Mcneil-Ppc, Inc. Pharmaceutical compositions and methods for treating the symptoms of overindulgence
DE4035455A1 (de) 1990-11-08 1992-05-14 Byk Gulden Lomberg Chem Fab Enantiomerentrennung
US5360582A (en) 1991-07-15 1994-11-01 Minnesota Mining And Manufacturing Company Nonlinear optical materials containing polar disulfone-functionalized molecules
US5877192A (en) 1993-05-28 1999-03-02 Astra Aktiebolag Method for the treatment of gastric acid-related diseases and production of medication using (-) enantiomer of omeprazole
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
SE9302396D0 (sv) * 1993-07-09 1993-07-09 Ab Astra A novel compound form
SE9302395D0 (sv) * 1993-07-09 1993-07-09 Ab Astra New pharmaceutical formulation
FR2719045B1 (fr) * 1994-04-20 1996-05-31 Rhone Poulenc Chimie Procédé de préparation d'acide L-aspartique à partir d'aspartate d'ammonium.
BR9506018A (pt) 1994-07-08 1997-09-02 Astra Ab Forma farmacêutica oral de múltipla dosagem unitária em tablete processos para a preparação da mesma para a inibição da secreção de ácido gástrico em mamiferos e no homem e para o tratamento das doenças inflamatórias gastrointestinais em mamiferos e no homem e embalagem de ampola de pressão transversal
FR2722191B1 (fr) * 1994-07-08 1996-08-23 Rhone Poulenc Rorer Sa Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle
SE504459C2 (sv) 1994-07-15 1997-02-17 Astra Ab Förfarande för framställning av substituerade sulfoxider
RU2152941C1 (ru) * 1994-11-14 2000-07-20 Дайити Фармасьютикал Ко., Лтд. Кристаллический дигидрохлорид 3-[2-[4-(3-хлор-2-метилфенил)-1-пиперазинил]этил]-5,6-диметокси-1- (4-имидазолилметил)-1н-индазола и его 3,5-гидрат, способы их получения
GB9423970D0 (en) * 1994-11-28 1995-01-11 Astra Ab Oxidation
SE9500422D0 (sv) 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
CN1042423C (zh) 1995-05-25 1999-03-10 常州市第四制药厂 奥美拉唑盐水合物及其制备方法
SE9600072D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral formulation of two active ingredients II
SE9600071D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral formulation of two active ingredients I
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
SE510650C2 (sv) * 1997-05-30 1999-06-14 Astra Ab Ny förening
US6747155B2 (en) * 1997-05-30 2004-06-08 Astrazeneca Ab Process
AR057181A1 (es) 2005-11-30 2007-11-21 Astra Ab Nueva forma de dosificacion de combinacion

Also Published As

Publication number Publication date
MY127793A (en) 2006-12-29
EP0984957B3 (de) 2013-09-18
IS2774B (is) 2012-03-15
SK284837B6 (sk) 2005-12-01
DK0984957T3 (da) 2003-06-30
HUP0001849A2 (hu) 2002-05-29
SK162599A3 (en) 2000-06-12
HUP0001849A3 (en) 2003-02-28
IL132947A0 (en) 2001-03-19
PT1273581E (pt) 2005-06-30
DE122012000017I1 (de) 2012-08-16
US20120252847A1 (en) 2012-10-04
US7745466B2 (en) 2010-06-29
ZA984179B (en) 1998-11-30
CA2521391A1 (en) 1998-12-03
EG24291A (en) 2009-01-08
HK1025962A1 (en) 2000-12-01
IS2142B (is) 2006-09-15
MEP24908A (en) 2010-10-10
TW538040B (en) 2003-06-21
CA2521391C (en) 2009-09-29
HRP980263A2 (en) 1999-02-28
LU92017I2 (fr) 2012-08-06
YU60999A (sh) 2002-03-18
US8076361B2 (en) 2011-12-13
JP4002303B2 (ja) 2007-10-31
HU225987B1 (en) 2008-02-28
NO995852D0 (no) 1999-11-29
RU2184115C2 (ru) 2002-06-27
DE69829511D1 (de) 2005-04-28
DE69814069T3 (de) 2014-03-27
RS50005B (sr) 2008-09-29
US20020198239A1 (en) 2002-12-26
SE510650C2 (sv) 1999-06-14
DE69829511T2 (de) 2006-02-16
WO1998054171A8 (en) 1999-12-23
PL193546B1 (pl) 2007-02-28
EP0984957A1 (de) 2000-03-15
SI0984957T1 (en) 2003-10-31
HRP980263B1 (en) 2002-02-28
US20050075369A1 (en) 2005-04-07
EP1273581A1 (de) 2003-01-08
SE9702065L (sv) 1998-12-01
UA60334C2 (uk) 2003-10-15
KR20010013126A (ko) 2001-02-26
US20080255363A1 (en) 2008-10-16
JP2002501529A (ja) 2002-01-15
ME00198B (me) 2011-02-10
DZ2495A1 (fr) 2003-01-25
DE69814069D1 (de) 2003-06-05
JP2007161734A (ja) 2007-06-28
CZ297585B6 (cs) 2007-01-10
EE9900550A (et) 2000-06-15
ES2195345T7 (es) 2014-01-15
MY120745A (en) 2005-11-30
NO995852L (no) 2000-01-31
US20110130570A1 (en) 2011-06-02
TNSN98074A1 (fr) 2005-03-15
IS5272A (is) 1999-11-25
TR199902934T2 (xx) 2000-04-21
NO2011010I1 (no) 2011-06-20
BR9809509A (pt) 2000-06-20
NO2012011I1 (no) 2012-06-18
NZ500991A (en) 2001-05-25
CA2290963A1 (en) 1998-12-03
KR100540720B1 (ko) 2006-01-12
AU7793598A (en) 1998-12-30
ES2195345T3 (es) 2003-12-01
MA26500A1 (fr) 2004-12-20
MEP18008A (en) 2010-10-10
CN1258295A (zh) 2000-06-28
EP0984957B1 (de) 2003-05-02
AR059589A2 (es) 2008-04-16
SI1273581T1 (de) 2005-08-31
SK285137B6 (sk) 2006-07-07
US6677455B2 (en) 2004-01-13
DE69814069T2 (de) 2004-04-01
CY2012029I1 (el) 2015-08-05
SA05260296B1 (ar) 2008-04-16
SE9702065D0 (sv) 1997-05-30
EE03875B1 (et) 2002-10-15
AU722839B2 (en) 2000-08-10
IS8368A (is) 2006-03-22
LU91871I2 (fr) 2011-11-21
CA2290963C (en) 2006-03-28
HK1051681A1 (en) 2003-08-15
WO1998054171A1 (en) 1998-12-03
PL337180A1 (en) 2000-08-14
ATE291574T1 (de) 2005-04-15
CN1161351C (zh) 2004-08-11
ES2236407T3 (es) 2005-07-16
RS20070459A (en) 2008-06-05
DK1273581T3 (da) 2005-06-06
KR20050042827A (ko) 2005-05-10
ID29306A (id) 2001-08-16
US8466175B2 (en) 2013-06-18
NO317518B1 (no) 2004-11-08
RS50067B (sr) 2009-01-22
CY2012029I2 (el) 2015-08-05
US7411070B2 (en) 2008-08-12
AR012717A1 (es) 2000-11-08
EP1273581B1 (de) 2005-03-23
KR100527804B1 (ko) 2005-11-15
US6369085B1 (en) 2002-04-09
HU0001849D0 (de) 2002-05-29
PT984957E (pt) 2003-07-31
SA98190280B1 (ar) 2006-07-04

Similar Documents

Publication Publication Date Title
ATE239011T1 (de) Neuartige form von s-omeprazol
DE69928195D1 (de) Komplettierung von Untrerdruck-Bohrlöchern
DE69837906D1 (de) Insektizides proteintoxin von xenorhabus
DE69941116D1 (de) G von gdf-8
ID24481A (id) Gastrokinetik monosiklik benzamida dari derivat-3-atau-tersubstitusi 4-(aminometil)-piperidin
DE60136181D1 (de) 3'-prodrugs von 2'-deoxy-beta-l-nukleosiden
DE19882125T1 (de) Direkte Abscheidung von Palladium
MX209959B (es) 4-(3-heterociclil-1-benzoil)pirazoles
DE69833228D1 (de) Brückenzünder
ID24458A (id) Modifikasi rheologi in-sito poliolefin
DE69907146T2 (de) Direkte oxidation von cycloalkanen
EE04154B1 (et) Omeprasooli valmistamise meetod
ATE259825T1 (de) Hemihydrat von 16.alpha.-bromoepiandrosterone
PT964867E (pt) Antagonistas da taquicinima
DE60006799D1 (de) Oralverabreichbare lösung von prucaloprid
DE69927626D1 (de) Ausführung von Permutationen
DE60007360T2 (de) Amorphe modifikation von torasemid
DE59804303D1 (de) Herstellung von Polyenaldehyden
ATE232199T1 (de) Polymorphe modifikationen von dofetilid
DE69811864T2 (de) Herstellung von bandförmigen werkstücken
DE69809562T2 (de) Herstellung von verbrückte hafnocene
DE69803309D1 (de) Rückgewinnung von gipsmaterialien
DE29718782U1 (de) Oberfläche von Keramik-Gegenständen
DE29720614U1 (de) Begrenzungen von Ställen
DE29710141U1 (de) Aufhängevorrichtung von Schürzen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0984957

Country of ref document: EP