ATE377597T1 - Anilinochinazoline als protein-tyrosin- kinasehemmer - Google Patents

Anilinochinazoline als protein-tyrosin- kinasehemmer

Info

Publication number
ATE377597T1
ATE377597T1 AT00943348T AT00943348T ATE377597T1 AT E377597 T1 ATE377597 T1 AT E377597T1 AT 00943348 T AT00943348 T AT 00943348T AT 00943348 T AT00943348 T AT 00943348T AT E377597 T1 ATE377597 T1 AT E377597T1
Authority
AT
Austria
Prior art keywords
tyrosine kinase
protein tyrosine
anilinoquinazolines
kinase inhibitors
methods
Prior art date
Application number
AT00943348T
Other languages
English (en)
Inventor
George Stuart Cockerill
Karen Elizabeth Lackey
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9916218.2A external-priority patent/GB9916218D0/en
Priority claimed from GBGB9916213.3A external-priority patent/GB9916213D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE377597T1 publication Critical patent/ATE377597T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
AT00943348T 1999-07-09 2000-06-30 Anilinochinazoline als protein-tyrosin- kinasehemmer ATE377597T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9916218.2A GB9916218D0 (en) 1999-07-09 1999-07-09 Heterocyclic compounds
GBGB9916213.3A GB9916213D0 (en) 1999-07-09 1999-07-09 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
ATE377597T1 true ATE377597T1 (de) 2007-11-15

Family

ID=26315754

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00943348T ATE377597T1 (de) 1999-07-09 2000-06-30 Anilinochinazoline als protein-tyrosin- kinasehemmer

Country Status (8)

Country Link
US (4) US7084147B2 (de)
EP (1) EP1192151B1 (de)
JP (1) JP2003504363A (de)
AT (1) ATE377597T1 (de)
AU (1) AU5783300A (de)
DE (1) DE60037020T2 (de)
ES (1) ES2295035T3 (de)
WO (1) WO2001004111A1 (de)

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CN104109152A (zh) * 2013-04-19 2014-10-22 上海医药工业研究院 一种制备拉帕替尼的方法
WO2016033296A1 (en) * 2014-08-28 2016-03-03 Codexis, Inc. N-substituted 4-aminoquinazoline derivatives and methods of use
CN105801565B (zh) * 2014-12-30 2020-04-03 天津法莫西医药科技有限公司 N-[3-氯-4-[(3-氟苯基)甲氧基]苯基]-6-[(5-甲酰基)呋喃-2-基]-4-喹唑啉胺制备方法
CN105085496B (zh) * 2015-09-12 2018-02-23 重庆医科大学 一种制备拉帕替尼的方法和中间体
CN108472298B (zh) 2015-11-24 2021-04-20 深圳阿拉丁医疗科技有限公司 选择性激酶抑制剂
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CN108558854A (zh) * 2017-06-10 2018-09-21 曹艳 一种治疗革兰氏阳性菌引起的感染的药物及其合成方法
CN107033138B (zh) * 2017-06-10 2018-06-08 徐晓东 一种治疗恶性肿瘤的药物
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Also Published As

Publication number Publication date
US7084147B2 (en) 2006-08-01
US20050143401A1 (en) 2005-06-30
DE60037020D1 (en) 2007-12-20
US20080004294A1 (en) 2008-01-03
WO2001004111A1 (en) 2001-01-18
US7507741B2 (en) 2009-03-24
ES2295035T3 (es) 2008-04-16
US20070093512A1 (en) 2007-04-26
US20060189637A1 (en) 2006-08-24
US7189734B2 (en) 2007-03-13
JP2003504363A (ja) 2003-02-04
US7265123B2 (en) 2007-09-04
EP1192151A1 (de) 2002-04-03
DE60037020T2 (de) 2008-08-21
AU5783300A (en) 2001-01-30
EP1192151B1 (de) 2007-11-07

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