AR095266A1 - Inhibidores de bromodominios tetraciclicos - Google Patents
Inhibidores de bromodominios tetraciclicosInfo
- Publication number
- AR095266A1 AR095266A1 ARP140100878A AR095266A1 AR 095266 A1 AR095266 A1 AR 095266A1 AR P140100878 A ARP140100878 A AR P140100878A AR 095266 A1 AR095266 A1 AR 095266A1
- Authority
- AR
- Argentina
- Prior art keywords
- tetraciclic
- bromodomines
- inhibitors
- tetraciclic bromodomines
- bromodomines inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361777797P | 2013-03-12 | 2013-03-12 | |
| US201461928779P | 2014-01-17 | 2014-01-17 | |
| PCT/CN2014/000258 WO2014139324A1 (en) | 2013-03-12 | 2014-03-12 | Tetracyclic bromodomain inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR095266A1 true AR095266A1 (es) | 2015-09-30 |
Family
ID=51535867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140100878 AR095266A1 (es) | 2013-03-12 | 2014-03-12 | Inhibidores de bromodominios tetraciclicos |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US10035800B2 (es) |
| EP (2) | EP2970330B1 (es) |
| JP (2) | JP6419735B2 (es) |
| KR (1) | KR102224992B1 (es) |
| CN (2) | CN108440528A (es) |
| AR (1) | AR095266A1 (es) |
| AU (2) | AU2014231563A1 (es) |
| CA (1) | CA2903910C (es) |
| CR (1) | CR20150474A (es) |
| DO (1) | DOP2015000216A (es) |
| HK (1) | HK1217102A1 (es) |
| IL (1) | IL241010B (es) |
| MX (1) | MX363913B (es) |
| PE (1) | PE20151788A1 (es) |
| PH (1) | PH12015502004A1 (es) |
| RU (1) | RU2015143192A (es) |
| SG (1) | SG11201507402WA (es) |
| TW (1) | TWI635087B (es) |
| UY (1) | UY35395A (es) |
| WO (1) | WO2014139324A1 (es) |
| ZA (1) | ZA201506477B (es) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013276617B9 (en) | 2012-06-13 | 2018-03-29 | F. Hoffmann-La Roche Ag | New diazaspirocycloalkane and azaspirocycloalkane |
| LT2900669T (lt) | 2012-09-25 | 2019-11-11 | Hoffmann La Roche | Heksahidropirol[3,4-c]pirolo dariniai ir susiję junginai kaip autotaksino (atx) inhibitoriai ir kaip lizofosfatidinės rūgšties (lpa) gamybos inhibitoriai, skirti gydyti pvz., inkstų ligas |
| EP2970330B1 (en) * | 2013-03-12 | 2019-04-17 | AbbVie Inc. | Tetracyclic bromodomain inhibitors |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| EA035469B1 (ru) | 2013-03-15 | 2020-06-22 | Инсайт Холдингс Корпорейшн | Трициклические гетероциклы как ингибиторы белков бэт |
| US9290514B2 (en) | 2013-07-08 | 2016-03-22 | Incyte Holdings Corporation | Tricyclic heterocycles as BET protein inhibitors |
| EP3024327B1 (en) | 2013-07-25 | 2019-09-04 | Dana-Farber Cancer Institute, Inc. | Inhibitors of transcription factors and uses thereof |
| US9315501B2 (en) | 2013-11-26 | 2016-04-19 | Incyte Corporation | Bicyclic heterocycles as BET protein inhibitors |
| MX2016005186A (es) | 2013-11-26 | 2016-07-08 | Hoffmann La Roche | Nuevo octahidro-ciclobuta[1,2-c;3,4-c']dipirrol-2-ilo. |
| WO2015081203A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
| US9309246B2 (en) | 2013-12-19 | 2016-04-12 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
| US10793571B2 (en) | 2014-01-31 | 2020-10-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
| CA2936865A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
| RS59477B1 (sr) | 2014-03-26 | 2019-12-31 | Hoffmann La Roche | Biciklička jedinjenja kao inhibitori proizvodnje autotaksina (atx) i lizofosfatidne kiseline (lpa) |
| EA032357B1 (ru) | 2014-03-26 | 2019-05-31 | Ф. Хоффманн-Ля Рош Аг | Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa) |
| MX2016013851A (es) | 2014-04-23 | 2017-07-14 | Incyte Corp | 1h-pirrolo[2,3-c]piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7(6h) -onas como inhibidores de proteinas de bromodominio y extra terminal (bet). |
| KR20170032474A (ko) | 2014-08-08 | 2017-03-22 | 다나-파버 캔서 인스티튜트 인크. | 디히드로프테리디논 유도체 및 그의 용도 |
| WO2016022902A1 (en) | 2014-08-08 | 2016-02-11 | Dana-Farber Cancer Institute, Inc. | Diazepane derivatives and uses thereof |
| WO2016044130A1 (en) | 2014-09-15 | 2016-03-24 | Incyte Corporation | Tricyclic heterocycles for use as bet protein inhibitors |
| MA40943A (fr) | 2014-11-10 | 2017-09-19 | Constellation Pharmaceuticals Inc | Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines |
| EP3218376B1 (en) | 2014-11-10 | 2019-12-25 | Genentech, Inc. | Bromodomain inhibitors and uses thereof |
| MA40940A (fr) * | 2014-11-10 | 2017-09-19 | Constellation Pharmaceuticals Inc | Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines |
| WO2016123391A1 (en) | 2015-01-29 | 2016-08-04 | Genentech, Inc. | Therapeutic compounds and uses thereof |
| GB201504694D0 (en) | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Covalent conjugates |
| EP3277683B1 (en) | 2015-03-30 | 2022-03-09 | Jubilant Biosys Limited | Tricyclic fused derivatives of 1-(cyclo)alkyl pyridin-2-one useful for the treatment of cancer |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| US10702527B2 (en) | 2015-06-12 | 2020-07-07 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| EP3344619B1 (en) | 2015-09-04 | 2020-10-28 | H. Hoffnabb-La Roche Ag | Phenoxymethyl derivatives |
| US10689395B2 (en) | 2015-09-09 | 2020-06-23 | Jubilant Biosys Limited | Tricyclic fused pyridin-2-one derivatives and their use as BRD4 inhibitors |
| BR112018004618A2 (pt) | 2015-09-11 | 2018-09-25 | Dana-Farber Cancer Institute, Inc. | ciano tienotriazoldiazepinas e usos das mesmas |
| PE20181086A1 (es) | 2015-09-11 | 2018-07-05 | Dana Farber Cancer Inst Inc | Acetamida tienotrizolodiazepinas y usos de las mismas |
| JP6846414B2 (ja) | 2015-09-24 | 2021-03-24 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ａｔｘ阻害剤としての二環式化合物 |
| KR20180053408A (ko) | 2015-09-24 | 2018-05-21 | 에프. 호프만-라 로슈 아게 | 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서의 신규한 이환형 화합물 |
| JP6876685B2 (ja) | 2015-09-24 | 2021-05-26 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ａｔｘ阻害剤としての二環式化合物 |
| CR20180057A (es) | 2015-09-24 | 2018-04-02 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores duales de atx/ca. |
| AR106520A1 (es) | 2015-10-29 | 2018-01-24 | Incyte Corp | Forma sólida amorfa de un inhibidor de proteína bet |
| BR112018009798A8 (pt) * | 2015-11-25 | 2019-02-26 | Dana Farber Cancer Inst Inc | inibidores de bromodomínio bivalentes e usos dos mesmos |
| JP6978424B2 (ja) | 2016-04-15 | 2021-12-08 | アッヴィ・インコーポレイテッド | ブロモドメイン阻害剤 |
| IL263824B2 (en) | 2016-06-20 | 2023-10-01 | Incyte Corp | Crystals in solid form in the presence of an inhibitor |
| RU2019117356A (ru) | 2016-11-10 | 2020-12-10 | Лосинь Фармасьютикал (Шанхай) Ко., Лтд. | Азотсодержащее макроциклическое соединение, способ его получения, фармацевтическая композиция и применение |
| WO2018130174A1 (zh) * | 2017-01-11 | 2018-07-19 | 江苏豪森药业集团有限公司 | 吡咯并[2,3-c]吡啶类衍生物、其制备方法及其在医药上的应用 |
| EP3596060B1 (en) | 2017-03-16 | 2023-09-20 | F. Hoffmann-La Roche AG | New bicyclic compounds as atx inhibitors |
| KR20190129924A (ko) | 2017-03-16 | 2019-11-20 | 에프. 호프만-라 로슈 아게 | 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 유용한 헤테로환형 화합물 |
| US20210130346A1 (en) * | 2017-04-14 | 2021-05-06 | Abbvie Inc. | Bromodomain Inhibitors |
| CN110305123B (zh) * | 2018-03-27 | 2021-12-10 | 海创药业股份有限公司 | 一种含有金刚烷的化合物及其在治疗癌症中的用途 |
| CN110865130B (zh) * | 2018-08-27 | 2023-08-22 | 北京海晶生物医药科技有限公司 | 一种盐酸奥洛他定及其有关物质的检测方法 |
| CN113056287A (zh) | 2018-10-24 | 2021-06-29 | 豪夫迈·罗氏有限公司 | 缀合的化学降解诱导剂及使用方法 |
| CA3116931A1 (en) | 2018-10-30 | 2020-05-07 | Nuvation Bio Inc. | Heterocyclic compounds as bet inhibitors |
| CN109394768B (zh) * | 2018-12-10 | 2019-08-23 | 牡丹江医学院 | 一种治疗湿疹的药物及其制备方法 |
| CN111377934B (zh) * | 2018-12-29 | 2023-01-24 | 中国科学院上海药物研究所 | 一类杂环化合物，其制备及用途 |
| EP3967690A4 (en) * | 2019-03-17 | 2023-04-12 | Shanghai Ringene BioPharma Co., Ltd. | PYRROLE AMIDOPYRIDONE COMPOUND, METHOD FOR PREPARING IT AND ITS USE |
| WO2021003310A1 (en) | 2019-07-02 | 2021-01-07 | Nuvation Bio Inc. | Heterocyclic compounds as bet inhibitors |
| WO2021121276A1 (zh) * | 2019-12-17 | 2021-06-24 | 江苏恒瑞医药股份有限公司 | 稠合四环类衍生物、其制备方法及其在医药上的应用 |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
| UY39610A (es) | 2021-01-20 | 2022-08-31 | Abbvie Inc | Conjugados anticuerpo-fármaco anti-egfr |
| EP4319748A1 (en) * | 2021-04-09 | 2024-02-14 | Tachyon Therapeutics, Inc. | Treatment of cancer with kdm4 inhibitors |
| GB2621505A (en) * | 2021-06-29 | 2024-02-14 | Tay Therapeutics Ltd | Pyrrolopyridone derivatives useful in the treatment of cancer |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1887008B1 (en) | 2005-05-30 | 2021-04-21 | Mitsubishi Tanabe Pharma Corporation | Thienotriazolodiazepine compound and a medicinal use thereof |
| CA2668159A1 (en) * | 2006-11-01 | 2008-07-03 | Vertex Pharmaceuticals Incorporated | Tricyclic heteroaryl compounds useful as inhibitors of janus kinase |
| US9102677B2 (en) * | 2009-11-05 | 2015-08-11 | Glaxosmithkline Llc | Benzodiazepine bromodomain inhibitor |
| GB0919426D0 (en) * | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| ES2526671T3 (es) * | 2010-06-22 | 2015-01-14 | Glaxosmithkline Llc | Compuestos de benzotriazoldiazepina inhibidores de bromodominios |
| AR084070A1 (es) * | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| US9422292B2 (en) * | 2011-05-04 | 2016-08-23 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| EP2970330B1 (en) * | 2013-03-12 | 2019-04-17 | AbbVie Inc. | Tetracyclic bromodomain inhibitors |
-
2014
- 2014-03-12 EP EP14762617.0A patent/EP2970330B1/en active Active
- 2014-03-12 CN CN201810419623.0A patent/CN108440528A/zh active Pending
- 2014-03-12 AR ARP140100878 patent/AR095266A1/es unknown
- 2014-03-12 TW TW103108954A patent/TWI635087B/zh active
- 2014-03-12 SG SG11201507402WA patent/SG11201507402WA/en unknown
- 2014-03-12 JP JP2015561913A patent/JP6419735B2/ja active Active
- 2014-03-12 MX MX2015012006A patent/MX363913B/es active IP Right Grant
- 2014-03-12 WO PCT/CN2014/000258 patent/WO2014139324A1/en active Application Filing
- 2014-03-12 CN CN201480015201.7A patent/CN105026403B/zh active Active
- 2014-03-12 RU RU2015143192A patent/RU2015143192A/ru not_active Application Discontinuation
- 2014-03-12 US US14/774,866 patent/US10035800B2/en active Active
- 2014-03-12 PE PE2015001915A patent/PE20151788A1/es not_active Application Discontinuation
- 2014-03-12 KR KR1020157028346A patent/KR102224992B1/ko active IP Right Grant
- 2014-03-12 AU AU2014231563A patent/AU2014231563A1/en not_active Abandoned
- 2014-03-12 UY UY0001035395A patent/UY35395A/es not_active Application Discontinuation
- 2014-03-12 EP EP19156935.9A patent/EP3539962A1/en not_active Withdrawn
- 2014-03-12 CA CA2903910A patent/CA2903910C/en active Active
-
2015
- 2015-09-01 IL IL241010A patent/IL241010B/en active IP Right Grant
- 2015-09-03 ZA ZA2015/06477A patent/ZA201506477B/en unknown
- 2015-09-04 DO DO2015000216A patent/DOP2015000216A/es unknown
- 2015-09-08 PH PH12015502004A patent/PH12015502004A1/en unknown
- 2015-09-11 CR CR20150474A patent/CR20150474A/es unknown
-
2016
- 2016-05-04 HK HK16105095.5A patent/HK1217102A1/zh unknown
-
2018
- 2018-05-31 AU AU2018203833A patent/AU2018203833A1/en not_active Abandoned
- 2018-06-26 US US16/018,357 patent/US20180298003A1/en not_active Abandoned
- 2018-10-09 JP JP2018190645A patent/JP2019014748A/ja active Pending
-
2019
- 2019-01-22 US US16/254,124 patent/US20190389861A1/en not_active Abandoned
-
2020
- 2020-03-23 US US16/827,026 patent/US20200291027A1/en not_active Abandoned
- 2020-11-16 US US17/099,133 patent/US20210070756A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |