AR069978A1 - Metodos y agentes para mejorar el reconocimiento de celulas de tumor que expresan cd 138 - Google Patents
Metodos y agentes para mejorar el reconocimiento de celulas de tumor que expresan cd 138Info
- Publication number
- AR069978A1 AR069978A1 ARP080105721A ARP080105721A AR069978A1 AR 069978 A1 AR069978 A1 AR 069978A1 AR P080105721 A ARP080105721 A AR P080105721A AR P080105721 A ARP080105721 A AR P080105721A AR 069978 A1 AR069978 A1 AR 069978A1
- Authority
- AR
- Argentina
- Prior art keywords
- tumor cells
- cells
- carcinoma
- cytotoxic agent
- immunoconjugate
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 12
- 210000004881 tumor cell Anatomy 0.000 title abstract 8
- 229940127089 cytotoxic agent Drugs 0.000 abstract 5
- 239000002254 cytotoxic agent Substances 0.000 abstract 5
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 5
- 239000012636 effector Substances 0.000 abstract 4
- 229940127121 immunoconjugate Drugs 0.000 abstract 4
- 239000011230 binding agent Substances 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 230000008685 targeting Effects 0.000 abstract 3
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 abstract 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 abstract 2
- 206010009944 Colon cancer Diseases 0.000 abstract 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 210000002536 stromal cell Anatomy 0.000 abstract 2
- 229960003433 thalidomide Drugs 0.000 abstract 2
- JSHOVKSMJRQOGY-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4-(pyridin-2-yldisulfanyl)butanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCCSSC1=CC=CC=N1 JSHOVKSMJRQOGY-UHFFFAOYSA-N 0.000 abstract 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 abstract 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 abstract 1
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 abstract 1
- 206010059866 Drug resistance Diseases 0.000 abstract 1
- 208000017604 Hodgkin disease Diseases 0.000 abstract 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 abstract 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 abstract 1
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 abstract 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 208000034578 Multiple myelomas Diseases 0.000 abstract 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 abstract 1
- 206010033128 Ovarian cancer Diseases 0.000 abstract 1
- 206010035226 Plasma cell myeloma Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 206010038389 Renal cancer Diseases 0.000 abstract 1
- 208000006265 Renal cell carcinoma Diseases 0.000 abstract 1
- 206010039491 Sarcoma Diseases 0.000 abstract 1
- 229940123237 Taxane Drugs 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 abstract 1
- 229960001467 bortezomib Drugs 0.000 abstract 1
- 201000008275 breast carcinoma Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000021164 cell adhesion Effects 0.000 abstract 1
- 230000011712 cell development Effects 0.000 abstract 1
- 229960004316 cisplatin Drugs 0.000 abstract 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 abstract 1
- 229960004397 cyclophosphamide Drugs 0.000 abstract 1
- 229960000684 cytarabine Drugs 0.000 abstract 1
- 230000018109 developmental process Effects 0.000 abstract 1
- 229960003957 dexamethasone Drugs 0.000 abstract 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 abstract 1
- 229960004679 doxorubicin Drugs 0.000 abstract 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 abstract 1
- 229960005420 etoposide Drugs 0.000 abstract 1
- 201000010175 gallbladder cancer Diseases 0.000 abstract 1
- 201000007487 gallbladder carcinoma Diseases 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 229960004618 prednisone Drugs 0.000 abstract 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 abstract 1
- 201000010174 renal carcinoma Diseases 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 abstract 1
- 229960004528 vincristine Drugs 0.000 abstract 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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Landscapes
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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- Molecular Biology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Hematology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Reivindicacion 1: Un método para reducir la adhesion de las células del estroma a células tumorales que expresan CD138 en las células tumorales de un sujeto que lo necesita, que comprende: administrara dichas células tumorales un inmunoconjugado que toma como blanco a dichas células tumorales con expresion de CD138 en una cantidad efectiva para reducir la adhesion de las células del estroma a las células tumorales con expresion de CD138, optativamente administrar a dichas células tumorales otro agente citotoxico en una cantidad suficiente para inhibir, retardar y/o prevenir el desarrollo de las células tumorales. Reivindicacion 2: El método de acuerdo con la reivindicacion 1, donde dicho inmunoconjugado comprende una molécula efectora y un agente de direccionamiento al blanco, en el cual dicha molécula efectora y dicho agente de direccionamiento al blanco están acoplados entre sí por medio de un ligante escindible. Reivindicacion 3: El método de acuerdo con la reivindicacion 2, en el cual el ligante escindible contiene un enlace de disulfuro. Reivindicacion 4: El método de acuerdo con la reivindicacion 3, en el cual el ligante es SPP o SPDB. Reivindicacion 7: El método de acuerdo con la reivindicacion 6, en el cual se reduce la fármaco-resistencia mediada por la adhesion celular contra otro agente citotoxico que no es dicho inmunoconjugado y donde dicho agente citotoxico adicional se administra en una cantidad suficiente para inhibir, retardar y/o prevenir el desarrollo de las células tumorales. Reivindicacion 8: El método de acuerdo con la reivindicacion 7, en el cual dicho agente citotoxico es mefalan, vincristina, doxorubicina, dexametasona, ciclofosfamida, etoposido, citarabina, cisplatino, talidomida, prednisona, talidomida, bortezomib, lenalidomida, sorafenib, romidepsina o combinaciones de los mismos. Reivindicacion 9: El método de acuerdo con la reivindicacion 7, en el cual el agente citotoxico se basa en anticuerpos. Reivindicacion 11: El método de acuerdo con la reivindicacion 1 o 2, en el cual la molécula efectora es por lo menos un maitansinoide, taxano o un a CC1065, o un análogo de los mismos. Reivindicacion 12: El método de acuerdo con la reivindicacion 11, en el cual la molécula efectora es por lo menos un maitansinoide tal como DM1, DM3 o DM4. Reivindicacion 14: El método de acuerdo con cualquiera de las reivindicaciones 1 a 4, en el cual dicho agente de direccionamiento al blanco del inmunoconjugado comprende: una secuencia de aminoácidos de la cadena pesada de una inmunoglobulina o parte de la misma, en la cual dicha cadena pesada de inmunoglobulina o parte de la misma tiene por lo menos 70%, por lo menos 80%, por lo menos 90%, por lo menos 95% o por lo menos 98% de identidad de secuencia con SEC ID NO:1. Reivindicacion 17: El método de acuerdo con cualquiera de las reivindicaciones 1 a 4 y 7 a 9, en el cual dicho sujeto es un paciente con cáncer que sufre una de las siguientes: mieloma multiple, carcinoma de ovario, carcinoma renal, carcinoma de vesícula biliar, carcinoma de mama, cáncer de prostata, cáncer de pulmon, células de carcinoma de colon y células de linfomas de Hodgkin y no de Hodgkin, leucemia linfocítica cronica (CLL), leucemia linfoblástica aguda (ALL), leucemia mieloblástica aguda (AML), sarcomas de tejido solido o carcinoma de colon.
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JP (2) | JP2011508738A (es) |
KR (1) | KR101579218B1 (es) |
CN (1) | CN101945892B (es) |
AR (1) | AR069978A1 (es) |
AU (1) | AU2008339913B2 (es) |
BR (1) | BRPI0821417A2 (es) |
CA (1) | CA2710483C (es) |
ES (1) | ES2543201T3 (es) |
HK (1) | HK1149032A1 (es) |
IL (1) | IL206552A (es) |
MX (1) | MX2010007101A (es) |
PL (1) | PL2240516T3 (es) |
RU (1) | RU2486203C2 (es) |
TW (1) | TWI450726B (es) |
WO (1) | WO2009080832A1 (es) |
ZA (1) | ZA201004326B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004224925C1 (en) * | 2004-08-30 | 2011-07-21 | Biotest Ag | Immunoconjugates targeting syndecan-1 expressing cells and use thereof |
EP2238168B8 (en) * | 2007-12-26 | 2014-07-23 | Biotest AG | Agents targeting cd138 and uses thereof |
JP5817034B2 (ja) * | 2007-12-26 | 2015-11-18 | バイオテスト・アクチエンゲゼルシヤフト | Cd138を標的とする免疫複合体及びその使用 |
AR069978A1 (es) | 2007-12-26 | 2010-03-03 | Dana Farber Cancer Inst Inc | Metodos y agentes para mejorar el reconocimiento de celulas de tumor que expresan cd 138 |
BRPI1013990A2 (pt) | 2009-05-06 | 2019-04-30 | Biotest Ag | método para tratar uma doença , e, combinação anticâncer |
AU2013201618B2 (en) * | 2009-05-06 | 2016-06-02 | Biotest Ag | Uses of immunoconjugates targeting CD138 |
EP2547693B1 (en) | 2010-03-19 | 2015-03-11 | H. Lee Moffitt Cancer Center & Research Institute | Integrin interaction inhibitors for the treatment of cancer |
EP3559049A4 (en) | 2011-10-28 | 2019-12-04 | Teva Pharmaceuticals Australia Pty Ltd | POLYPEPTIDE CONSTRUCTS AND APPLICATIONS THEREOF |
KR20140100571A (ko) | 2011-12-08 | 2014-08-14 | 바이오테스트 아게 | Cd138을 타겟팅하는 면역접합체의 용도 |
CA2866881A1 (en) * | 2012-03-09 | 2013-09-12 | Lankenau Institute For Medical Research | Compositions and methods for treating cancer |
CN112587671A (zh) * | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
WO2014089354A1 (en) * | 2012-12-07 | 2014-06-12 | The Regents Of The University Of California | Cd138-targeted interferon demonstrates potent apoptotic and anti-tumor activities |
WO2014194100A1 (en) | 2013-05-29 | 2014-12-04 | The Regents Of The University Of California | Anti-cspg4 fusions with interferon for the treatment of malignancy |
WO2015048477A1 (en) | 2013-09-27 | 2015-04-02 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Cyclic peptide conjugates and methods of use |
ES2785551T3 (es) | 2014-06-30 | 2020-10-07 | Glykos Finland Oy | Derivado de sacárido de una carga útil tóxica y sus conjugados con anticuerpos |
RU2611685C2 (ru) | 2015-07-20 | 2017-02-28 | Илья Владимирович Духовлинов | Гуманизированное моноклональное антитело, специфичное к синдекану-1 |
US10918627B2 (en) | 2016-05-11 | 2021-02-16 | Massachusetts Institute Of Technology | Convergent and enantioselective total synthesis of Communesin analogs |
US11242403B2 (en) * | 2017-04-26 | 2022-02-08 | Mitsubishi Tanabe Pharma Corporation | Syndecan-1 (CD138) binding agents and uses thereof |
US11932650B2 (en) | 2017-05-11 | 2024-03-19 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
BR112020005419A2 (pt) * | 2017-10-02 | 2020-09-29 | Visterra, Inc. | moléculas de anticorpo para cd138 e seus usos |
US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
SG11202109066RA (en) | 2019-03-19 | 2021-09-29 | Fundacio Privada Inst Dinvestigacio Oncològica De Vall Hebron | Combination therapy with omomyc and an antibody binding pd-1 or ctla-4 for the treatment of cancer |
EP3947440A1 (en) | 2019-03-29 | 2022-02-09 | F. Hoffmann-La Roche AG | Method for generating avid-binding multispecific antibodies |
WO2020247054A1 (en) | 2019-06-05 | 2020-12-10 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
WO2024089013A1 (en) | 2022-10-25 | 2024-05-02 | Peptomyc, S.L. | Combination therapy for the treatment of cancer |
WO2024102954A1 (en) | 2022-11-10 | 2024-05-16 | Massachusetts Institute Of Technology | Activation induced clipping system (aics) |
Family Cites Families (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3896111A (en) | 1973-02-20 | 1975-07-22 | Research Corp | Ansa macrolides |
US4151042A (en) | 1977-03-31 | 1979-04-24 | Takeda Chemical Industries, Ltd. | Method for producing maytansinol and its derivatives |
US4169888A (en) | 1977-10-17 | 1979-10-02 | The Upjohn Company | Composition of matter and process |
US4137230A (en) | 1977-11-14 | 1979-01-30 | Takeda Chemical Industries, Ltd. | Method for the production of maytansinoids |
US4307016A (en) | 1978-03-24 | 1981-12-22 | Takeda Chemical Industries, Ltd. | Demethyl maytansinoids |
US4265814A (en) | 1978-03-24 | 1981-05-05 | Takeda Chemical Industries | Matansinol 3-n-hexadecanoate |
JPS5562090A (en) | 1978-10-27 | 1980-05-10 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
JPS5566585A (en) | 1978-11-14 | 1980-05-20 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
JPS55164687A (en) | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
US4256746A (en) | 1978-11-14 | 1981-03-17 | Takeda Chemical Industries | Dechloromaytansinoids, their pharmaceutical compositions and method of use |
JPS55102583A (en) | 1979-01-31 | 1980-08-05 | Takeda Chem Ind Ltd | 20-acyloxy-20-demethylmaytansinoid compound |
JPS55162791A (en) | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
JPS55164685A (en) | 1979-06-08 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
JPS55164686A (en) | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
US4309428A (en) | 1979-07-30 | 1982-01-05 | Takeda Chemical Industries, Ltd. | Maytansinoids |
JPS5645483A (en) | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
EP0028683A1 (en) | 1979-09-21 | 1981-05-20 | Takeda Chemical Industries, Ltd. | Antibiotic C-15003 PHO and production thereof |
JPS5645485A (en) | 1979-09-21 | 1981-04-25 | Takeda Chem Ind Ltd | Production of c-15003pnd |
US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
WO1982001188A1 (en) | 1980-10-08 | 1982-04-15 | Takeda Chemical Industries Ltd | 4,5-deoxymaytansinoide compounds and process for preparing same |
US4313946A (en) | 1981-01-27 | 1982-02-02 | The United States Of America As Represented By The Secretary Of Agriculture | Chemotherapeutically active maytansinoids from Trewia nudiflora |
US4315929A (en) | 1981-01-27 | 1982-02-16 | The United States Of America As Represented By The Secretary Of Agriculture | Method of controlling the European corn borer with trewiasine |
JPS57192389A (en) | 1981-05-20 | 1982-11-26 | Takeda Chem Ind Ltd | Novel maytansinoid |
US4761111A (en) | 1981-09-18 | 1988-08-02 | Brown Andrew M | Automobile lifting and towing equipment |
US4418064A (en) | 1982-09-29 | 1983-11-29 | The United States Of America As Represented By The Secretary Of Agriculture | Chemotherapeutically active maytansinoids: treflorine, trenudine, and N-methyltrenudone |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
JPH01501476A (ja) | 1986-10-09 | 1989-05-25 | ネオルックス コーポレイション | 抗体、抗体断片、ホルモン並びに他の標的剤、およびそれらの配合体を標的とする改良方法 |
US5053394A (en) | 1988-09-21 | 1991-10-01 | American Cyanamid Company | Targeted forms of methyltrithio antitumor agents |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
CA2078118C (en) | 1990-04-25 | 1999-11-16 | Paul A. Aristoff | Cc-1065 analogs |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
US5998656A (en) | 1991-09-23 | 1999-12-07 | Florida State University | C10 tricyclic taxanes |
US6080777A (en) | 1992-01-31 | 2000-06-27 | The Trustees Of Columbia University In The City Of New York | Taxol as a radiation sensitizer |
US5200534A (en) | 1992-03-13 | 1993-04-06 | University Of Florida | Process for the preparation of taxol and 10-deacetyltaxol |
CA2076465C (en) | 1992-03-25 | 2002-11-26 | Ravi V. J. Chari | Cell binding agent conjugates of analogues and derivatives of cc-1065 |
US6005079A (en) | 1992-08-21 | 1999-12-21 | Vrije Universiteit Brussels | Immunoglobulins devoid of light chains |
US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
US5703247A (en) | 1993-03-11 | 1997-12-30 | Virginia Tech Intellectual Properties, Inc. | 2-Debenzoyl-2-acyl taxol derivatives and methods for making same |
US5475011A (en) | 1993-03-26 | 1995-12-12 | The Research Foundation Of State University Of New York | Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment |
SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
US6740734B1 (en) | 1994-01-14 | 2004-05-25 | Biovitrum Ab | Bacterial receptor structures |
US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
US5763477A (en) | 1994-07-22 | 1998-06-09 | Dr. Reddy's Research Foundation | Taxane derivatives from 14-β-hydroxy-10 deacetylbaccatin III |
EP0815096A4 (en) | 1995-03-10 | 1998-07-08 | Hauser Chemical Res Inc | EPOXIDE OF CEPHALOMANNIN, ITS ANALOGS, AND PROCESS FOR PREPARING THE SAME |
KR100654645B1 (ko) | 1995-04-27 | 2007-04-04 | 아브게닉스, 인크. | 면역화된 제노마우스 유래의 인간 항체 |
CA2219486A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
US5712374A (en) | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
ES2263178T3 (es) * | 1996-06-27 | 2006-12-01 | Chugai Seiyaku Kabushiki Kaisha | Remedios para mieloma para ser utilizados junto con agentes antitumorales de mostaza nitrogenada. |
US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
KR20080059467A (ko) | 1996-12-03 | 2008-06-27 | 아브게닉스, 인크. | 복수의 vh 및 vk 부위를 함유하는 사람 면역글로불린유전자좌를 갖는 형질전환된 포유류 및 이로부터 생성된항체 |
KR100663319B1 (ko) | 1997-04-14 | 2007-01-02 | 마이크로메트 에이지 | 인간 17-1에이항원에 대해 특이성을 갖는 인간항체 및 그용도 |
US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
US6962702B2 (en) | 1998-06-22 | 2005-11-08 | Immunomedics Inc. | Production and use of novel peptide-based agents for use with bi-specific antibodies |
US6087362A (en) | 1999-03-16 | 2000-07-11 | Pentech Pharmaceuticals, Inc. | Apomorphine and sildenafil composition |
AU765588C (en) | 1999-11-24 | 2004-12-16 | Immunogen, Inc. | Cytotoxic agents comprising taxanes and their therapeutic use |
US20030203451A1 (en) | 2000-08-24 | 2003-10-30 | Genentech, Inc. | IL-17 homologous polypeptides and therapeutic uses thereof |
US6333410B1 (en) | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
WO2002016602A2 (en) | 2000-08-24 | 2002-02-28 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
ATE412009T1 (de) | 2000-08-24 | 2008-11-15 | Genentech Inc | Methode zur inhibierung von il-22 induziertem pap1 |
US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
MXPA04001072A (es) * | 2001-08-03 | 2005-02-17 | Glycart Biotechnology Ag | Variantes de glicosilacion de anticuerpos que tienen citotoxicidad celulares dependiente de anticuerpos incrementada. |
US6716821B2 (en) | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
US6756397B2 (en) | 2002-04-05 | 2004-06-29 | Immunogen, Inc. | Prodrugs of CC-1065 analogs |
US6534660B1 (en) | 2002-04-05 | 2003-03-18 | Immunogen, Inc. | CC-1065 analog synthesis |
SG187991A1 (en) | 2002-05-02 | 2013-03-28 | Wyeth Corp | Calicheamicin derivative-carrier conjugates |
US6596757B1 (en) | 2002-05-14 | 2003-07-22 | Immunogen Inc. | Cytotoxic agents comprising polyethylene glycol-containing taxanes and their therapeutic use |
US7390898B2 (en) | 2002-08-02 | 2008-06-24 | Immunogen Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
US20040126379A1 (en) | 2002-08-21 | 2004-07-01 | Boehringer Ingelheim International Gmbh | Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and chemotherapeutic agents |
US7534427B2 (en) * | 2002-12-31 | 2009-05-19 | Immunomedics, Inc. | Immunotherapy of B cell malignancies and autoimmune diseases using unconjugated antibodies and conjugated antibodies and antibody combinations and fusion proteins |
EP2264151B1 (en) | 2003-01-22 | 2016-04-20 | Roche Glycart AG | Fusion constructs and use of same to produce antibodies with increased FC receptor binding affinity and effector function |
CA2525029A1 (en) * | 2003-05-02 | 2004-11-18 | Health Research, Inc. | Use of jag2 expression in diagnosis of plasma cell disorders |
US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
KR20060006975A (ko) * | 2003-05-30 | 2006-01-20 | 제넨테크, 인크. | 항-vegf 항체를 사용한 치료 |
EA014640B1 (ru) | 2003-07-21 | 2010-12-30 | Иммьюноджен, Инк. | Антитело или его эпитоп-связывающий фрагмент, которые связываются с гликотопом са6, и способы их применения |
US7271245B2 (en) | 2004-02-13 | 2007-09-18 | The Scripps Research Institute | Methods and compositions for inhibition of metastasis |
AU2005249490B2 (en) | 2004-06-01 | 2010-07-29 | Genentech, Inc. | Antibody drug conjugates and methods |
KR101151957B1 (ko) | 2004-07-22 | 2012-06-01 | 로저 킹돈 크레이그 | 결합 분자 |
AU2004224925C1 (en) | 2004-08-30 | 2011-07-21 | Biotest Ag | Immunoconjugates targeting syndecan-1 expressing cells and use thereof |
EP2535355B1 (en) * | 2005-03-23 | 2019-01-02 | Genmab A/S | Antibodies against CD38 for treatment of multiple myeloma |
JP2008535491A (ja) | 2005-04-07 | 2008-09-04 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド | 癌に関連した遺伝子(PTPε) |
EA200702239A1 (ru) | 2005-04-15 | 2008-10-30 | Иммьюноджен, Инк. | Уничтожение гетерогенной или смешанной клеточной популяции в опухолях |
KR20080090414A (ko) | 2005-12-06 | 2008-10-08 | 도만티스 리미티드 | 세포 표면 표적에 대한 결합 특이성이 있는 이중 특이성리간드 및 이의 사용방법 |
JP2009532027A (ja) * | 2006-03-28 | 2009-09-10 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 抗igf−1r抗体およびその使用 |
EP4342995A3 (en) | 2006-03-31 | 2024-05-15 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
US20100291105A1 (en) | 2006-05-03 | 2010-11-18 | Elke Pogge Von Strandmann | Agent for the treatment of malignant diseases |
CA2701664A1 (en) | 2007-10-04 | 2009-04-09 | Nestec S.A. | Integrated heater for a beverage preparation device |
JP5817034B2 (ja) | 2007-12-26 | 2015-11-18 | バイオテスト・アクチエンゲゼルシヤフト | Cd138を標的とする免疫複合体及びその使用 |
AR069978A1 (es) | 2007-12-26 | 2010-03-03 | Dana Farber Cancer Inst Inc | Metodos y agentes para mejorar el reconocimiento de celulas de tumor que expresan cd 138 |
EP2238168B8 (en) | 2007-12-26 | 2014-07-23 | Biotest AG | Agents targeting cd138 and uses thereof |
JP2011507933A (ja) | 2007-12-26 | 2011-03-10 | バイオテスト・アクチエンゲゼルシヤフト | 免疫複合体の細胞傷害性副作用の低減及び有効性の改善方法 |
BRPI1013990A2 (pt) | 2009-05-06 | 2019-04-30 | Biotest Ag | método para tratar uma doença , e, combinação anticâncer |
-
2008
- 2008-12-23 AR ARP080105721A patent/AR069978A1/es unknown
- 2008-12-23 PL PL08865592T patent/PL2240516T3/pl unknown
- 2008-12-23 EP EP08865592.3A patent/EP2240516B1/en not_active Not-in-force
- 2008-12-23 ES ES08865592.3T patent/ES2543201T3/es active Active
- 2008-12-23 CA CA2710483A patent/CA2710483C/en not_active Expired - Fee Related
- 2008-12-23 WO PCT/EP2008/068270 patent/WO2009080832A1/en active Application Filing
- 2008-12-23 BR BRPI0821417-4A patent/BRPI0821417A2/pt not_active Application Discontinuation
- 2008-12-23 CN CN200880126958.8A patent/CN101945892B/zh not_active Expired - Fee Related
- 2008-12-23 AU AU2008339913A patent/AU2008339913B2/en not_active Ceased
- 2008-12-23 RU RU2010130993/10A patent/RU2486203C2/ru not_active IP Right Cessation
- 2008-12-23 JP JP2010540132A patent/JP2011508738A/ja active Pending
- 2008-12-23 US US12/342,815 patent/US9446146B2/en not_active Expired - Fee Related
- 2008-12-23 MX MX2010007101A patent/MX2010007101A/es active IP Right Grant
- 2008-12-23 KR KR1020107016664A patent/KR101579218B1/ko active IP Right Grant
- 2008-12-24 TW TW097150431A patent/TWI450726B/zh not_active IP Right Cessation
-
2010
- 2010-06-18 ZA ZA2010/04326A patent/ZA201004326B/en unknown
- 2010-06-22 IL IL206552A patent/IL206552A/en active IP Right Grant
-
2011
- 2011-03-31 HK HK11103272.0A patent/HK1149032A1/xx not_active IP Right Cessation
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2015
- 2015-03-04 JP JP2015042307A patent/JP2015127331A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
HK1149032A1 (en) | 2011-09-23 |
WO2009080832A1 (en) | 2009-07-02 |
US9446146B2 (en) | 2016-09-20 |
JP2015127331A (ja) | 2015-07-09 |
ES2543201T3 (es) | 2015-08-17 |
ZA201004326B (en) | 2011-04-28 |
TW200936163A (en) | 2009-09-01 |
CN101945892A (zh) | 2011-01-12 |
JP2011508738A (ja) | 2011-03-17 |
CA2710483C (en) | 2018-05-08 |
CA2710483A1 (en) | 2009-07-02 |
BRPI0821417A2 (pt) | 2015-06-16 |
EP2240516B1 (en) | 2015-07-08 |
TWI450726B (zh) | 2014-09-01 |
MX2010007101A (es) | 2011-07-01 |
US20090169570A1 (en) | 2009-07-02 |
EP2240516A1 (en) | 2010-10-20 |
IL206552A0 (en) | 2010-12-30 |
KR20100098717A (ko) | 2010-09-08 |
IL206552A (en) | 2016-04-21 |
RU2010130993A (ru) | 2012-02-10 |
CN101945892B (zh) | 2017-11-24 |
RU2486203C2 (ru) | 2013-06-27 |
AU2008339913A1 (en) | 2009-07-02 |
PL2240516T3 (pl) | 2015-12-31 |
KR101579218B1 (ko) | 2015-12-21 |
AU2008339913B2 (en) | 2014-03-20 |
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