AR066716A1 - Composiciones de fenilanina amoniaco liasa procarioticas y metodos de uso de las composiciones - Google Patents
Composiciones de fenilanina amoniaco liasa procarioticas y metodos de uso de las composicionesInfo
- Publication number
- AR066716A1 AR066716A1 ARP080102198A ARP080102198A AR066716A1 AR 066716 A1 AR066716 A1 AR 066716A1 AR P080102198 A ARP080102198 A AR P080102198A AR P080102198 A ARP080102198 A AR P080102198A AR 066716 A1 AR066716 A1 AR 066716A1
- Authority
- AR
- Argentina
- Prior art keywords
- compositions
- pal
- methods
- variant
- processories
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Fenilalanina amoníaco liasa (PAL) producida por procariontes, en donde dicha PAL procariotica donde la variante PAL tiene mayor actividad de conversion de la fenilalanina y/o una menor inmunogenicidad en comparacion con un PAL de tipo silvestre. Además composiciones de PAL bacteriana y sus fragmentos, mutantes, variantes y análogos biologicamente activos, así como métodos para la produccion, purificacion y uso de tales composiciones para fines terapéuticos e industriales. Reivindicacion 4: La variante de PAL de la reivindicacion 3, caracterizada porque la variante es PAL de Anabaena variabilis.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/807,227 US7534595B2 (en) | 2006-06-12 | 2007-05-25 | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
AR066716A1 true AR066716A1 (es) | 2009-09-09 |
Family
ID=39868905
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080102198A AR066716A1 (es) | 2007-05-25 | 2008-05-23 | Composiciones de fenilanina amoniaco liasa procarioticas y metodos de uso de las composiciones |
ARP180100106A AR110834A2 (es) | 2007-05-25 | 2018-01-17 | MOLÉCULA DE UNA VARIANTE AISLADA DE FENILALANINA AMONIACOLIASA DE ANABAENA VARIABILIS (AvPal) |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP180100106A AR110834A2 (es) | 2007-05-25 | 2018-01-17 | MOLÉCULA DE UNA VARIANTE AISLADA DE FENILALANINA AMONIACOLIASA DE ANABAENA VARIABILIS (AvPal) |
Country Status (30)
Country | Link |
---|---|
US (1) | US7534595B2 (es) |
EP (2) | EP2657335A1 (es) |
JP (1) | JP5670183B2 (es) |
KR (2) | KR101603796B1 (es) |
CN (1) | CN101842482B (es) |
AR (2) | AR066716A1 (es) |
AU (1) | AU2008263190B2 (es) |
BR (1) | BRPI0811267B8 (es) |
CA (1) | CA2687450C (es) |
CL (1) | CL2008001497A1 (es) |
CY (2) | CY1116894T1 (es) |
DK (1) | DK2152868T3 (es) |
EA (1) | EA018443B1 (es) |
ES (1) | ES2551315T3 (es) |
HK (1) | HK1135141A1 (es) |
HR (1) | HRP20151268T1 (es) |
HU (2) | HUE025784T2 (es) |
IL (1) | IL202132A (es) |
LT (1) | LTC2152868I2 (es) |
LU (1) | LUC00133I2 (es) |
MX (1) | MX2009012453A (es) |
MY (1) | MY151413A (es) |
NL (1) | NL301011I2 (es) |
NO (1) | NO2019037I1 (es) |
PE (1) | PE20090315A1 (es) |
PL (1) | PL2152868T3 (es) |
PT (1) | PT2152868E (es) |
SI (1) | SI2152868T1 (es) |
TW (1) | TWI418633B (es) |
WO (1) | WO2008153776A1 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7531341B1 (en) | 2006-06-12 | 2009-05-12 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
US7534595B2 (en) | 2006-06-12 | 2009-05-19 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
US7537923B2 (en) * | 2007-08-17 | 2009-05-26 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof |
WO2010014225A2 (en) | 2008-07-30 | 2010-02-04 | Biomarin Pharmaceutical Inc. | Assays for detection of phenylalanine ammonia-lyase and antibodies to phenylalanine ammonia-lyase |
PT3025728T (pt) * | 2010-02-04 | 2018-11-05 | Biomarin Pharm Inc | Método para purificar variantes procarióticas de fenilalanina amónia-liase |
AU2013295621A1 (en) * | 2012-07-27 | 2015-03-12 | University Of North Texas | Genetically modified probiotic for the treatment of phenylketonuria (PKU) disease |
DK2986722T3 (da) | 2013-04-18 | 2019-05-13 | Codexis Inc | Manipulerede phenylalaninammoniak-lyasepolypeptider |
CA2930665A1 (en) | 2013-11-18 | 2015-05-21 | Rubius Therapeutics, Inc. | Synthetic membrane-receiver complexes |
CN106456744A (zh) | 2014-04-01 | 2017-02-22 | 鲁比厄斯治疗法股份有限公司 | 用于免疫调节的方法和组合物 |
EP3928787A1 (en) * | 2014-04-16 | 2021-12-29 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
KR20220123342A (ko) | 2014-12-22 | 2022-09-06 | 코덱시스, 인코포레이티드 | 인간 알파-갈락토시다제 변이체 |
TWI797060B (zh) | 2015-08-04 | 2023-04-01 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
SG11201811603WA (en) | 2016-07-26 | 2019-02-27 | Biomarin Pharm Inc | Novel adeno-associated virus capsid proteins |
CN109844127B (zh) * | 2016-08-30 | 2023-09-19 | 三菱化学株式会社 | 突变型酶的制造方法及突变型醇酰基转移酶 |
CN106497905A (zh) * | 2016-12-14 | 2017-03-15 | 江南大学 | 一株鱼腥藻来源的苯丙氨酸脱氨酶的突变体 |
CN110573175A (zh) | 2017-02-13 | 2019-12-13 | 科德克希思公司 | 工程化苯丙氨酸氨裂合酶多肽 |
CN107653275A (zh) * | 2017-10-30 | 2018-02-02 | 安徽工程大学 | D‑苯丙氨酸的制备方法 |
CN108004225B (zh) * | 2017-12-19 | 2020-05-08 | 江南大学 | 一种成团泛菌来源的苯丙氨酸氨基变位酶的突变体 |
US11739345B2 (en) | 2018-05-09 | 2023-08-29 | Biomarin Pharmaceutical Inc. | Methods of treating phenylketonuria |
TW202005978A (zh) | 2018-05-14 | 2020-02-01 | 美商拜奧馬林製藥公司 | 新穎肝靶向腺相關病毒載體 |
CA3102968A1 (en) * | 2018-06-12 | 2019-12-19 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
WO2020013951A1 (en) * | 2018-07-12 | 2020-01-16 | Codexis, Inc. | Engineered phenylalanine ammonia lyase polypeptides |
WO2020123286A1 (en) | 2018-12-14 | 2020-06-18 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
CA3123598A1 (en) | 2018-12-20 | 2020-06-25 | Codexis, Inc. | Human alpha-galactosidase variants |
CN110456056A (zh) * | 2019-07-22 | 2019-11-15 | 浙江大学 | 一种新生儿苯丙酮尿症无创筛查试纸的制备方法 |
US11987823B2 (en) | 2019-08-30 | 2024-05-21 | Societe Des Produits Nestle S.A. | Engineered lipase variants |
IL294082A (en) | 2019-12-20 | 2022-08-01 | Codexis Inc | Transgenic variants of acid alpha-glycosidase |
AR122409A1 (es) | 2020-04-03 | 2022-09-07 | Biomarin Pharm Inc | Tratamiento de la fenilcetonuria con aav y formulaciones terapéuticas |
US11959108B2 (en) | 2020-08-28 | 2024-04-16 | Codexis, Inc. | Engineered protease variants |
BR112023003643A2 (pt) | 2020-08-28 | 2023-03-28 | Codexis Inc | Amilase recombinante, composição, sequência de polinucleotídeo recombinante, vetor de expressão, célula hospedeira, métodos para produzir uma amilase recombinante e para tratar e/ou prevenir os sintomas de insuficiência pancreática, composição farmacêutica para o tratamento de insuficiência pancreática, e, uso |
WO2022245924A1 (en) * | 2021-05-19 | 2022-11-24 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating adolescent subjects |
WO2023044381A1 (en) * | 2021-09-16 | 2023-03-23 | Arcturus Therapeutics, Inc. | Compositions and methods for treating phenylketonuria |
CN117417925A (zh) * | 2022-07-18 | 2024-01-19 | 浙江泽科塔生物医药有限公司 | Pal变体、包含该pal变体的药物组合物以及用于制备该pal变体的方法 |
CN116478975B (zh) * | 2023-06-16 | 2023-09-01 | 苏州优信合生技术有限公司 | 高活性苯丙氨酸解氨酶突变体及其表达菌株 |
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TWI227241B (en) * | 1998-06-20 | 2005-02-01 | United Biomedical Inc | IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate |
US6451986B1 (en) | 1998-06-22 | 2002-09-17 | Immunex Corporation | Site specific protein modification |
US6461849B1 (en) * | 1998-10-13 | 2002-10-08 | Novozymes, A/S | Modified polypeptide |
US6403312B1 (en) | 1998-10-16 | 2002-06-11 | Xencor | Protein design automatic for protein libraries |
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AU2001294774A1 (en) * | 2000-09-26 | 2002-04-08 | The Regents Of The University Of California | Characterization of phenylalanine ammonia-lyase (pal) gene in wounded lettuce |
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KR20060022261A (ko) * | 2003-06-11 | 2006-03-09 | 와이어쓰 | 혈소판 당단백질 ib 알파 변이체 융합 폴리펩티드 및이의 사용 방법 |
FR2868318B1 (fr) * | 2004-04-01 | 2012-11-16 | Commissariat Energie Atomique | Antigene tat stabilise et ses applications pour la vaccination anti-vih |
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CA2614769A1 (en) * | 2005-03-10 | 2006-09-21 | Verenium Corporation | Lyase enzymes, nucleic acids encoding them and methods for making and using them |
US7534595B2 (en) * | 2006-06-12 | 2009-05-19 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
US20090011400A1 (en) | 2006-12-01 | 2009-01-08 | The Salk Institute for Biological Studies and The Regents of the University of California | Substrate switched ammonia lyases and mutases |
US7537923B2 (en) * | 2007-08-17 | 2009-05-26 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof |
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2007
- 2007-05-25 US US11/807,227 patent/US7534595B2/en active Active
-
2008
- 2008-05-23 PE PE2008000889A patent/PE20090315A1/es active IP Right Grant
- 2008-05-23 PL PL08754717T patent/PL2152868T3/pl unknown
- 2008-05-23 TW TW097119178A patent/TWI418633B/zh active
- 2008-05-23 KR KR1020097027018A patent/KR101603796B1/ko active IP Right Grant
- 2008-05-23 WO PCT/US2008/006661 patent/WO2008153776A1/en active Application Filing
- 2008-05-23 MX MX2009012453A patent/MX2009012453A/es active IP Right Grant
- 2008-05-23 EP EP13169362.4A patent/EP2657335A1/en not_active Withdrawn
- 2008-05-23 EP EP08754717.0A patent/EP2152868B1/en active Active
- 2008-05-23 SI SI200831540T patent/SI2152868T1/sl unknown
- 2008-05-23 DK DK08754717.0T patent/DK2152868T3/en active
- 2008-05-23 AR ARP080102198A patent/AR066716A1/es active IP Right Grant
- 2008-05-23 EA EA200970980A patent/EA018443B1/ru unknown
- 2008-05-23 PT PT87547170T patent/PT2152868E/pt unknown
- 2008-05-23 BR BRPI0811267A patent/BRPI0811267B8/pt active IP Right Grant
- 2008-05-23 AU AU2008263190A patent/AU2008263190B2/en active Active
- 2008-05-23 JP JP2010509405A patent/JP5670183B2/ja active Active
- 2008-05-23 HU HUE08754717A patent/HUE025784T2/en unknown
- 2008-05-23 KR KR20157007821A patent/KR20150038753A/ko not_active Application Discontinuation
- 2008-05-23 CA CA2687450A patent/CA2687450C/en active Active
- 2008-05-23 ES ES08754717.0T patent/ES2551315T3/es active Active
- 2008-05-23 CL CL2008001497A patent/CL2008001497A1/es unknown
- 2008-05-23 MY MYPI20094868 patent/MY151413A/en unknown
- 2008-05-23 CN CN200880016898.4A patent/CN101842482B/zh active Active
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2009
- 2009-11-15 IL IL202132A patent/IL202132A/en active IP Right Grant
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2010
- 2010-04-01 HK HK10103366.8A patent/HK1135141A1/zh unknown
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2015
- 2015-11-06 CY CY20151100997T patent/CY1116894T1/el unknown
- 2015-11-24 HR HRP20151268TT patent/HRP20151268T1/hr unknown
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2018
- 2018-01-17 AR ARP180100106A patent/AR110834A2/es unknown
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2019
- 2019-10-09 NL NL301011C patent/NL301011I2/nl unknown
- 2019-10-10 LT LTPA2019517C patent/LTC2152868I2/lt unknown
- 2019-10-14 LU LU00133C patent/LUC00133I2/fr unknown
- 2019-10-16 NO NO2019037C patent/NO2019037I1/no unknown
- 2019-10-17 CY CY2019039C patent/CY2019039I1/el unknown
- 2019-10-18 HU HUS1900049C patent/HUS1900049I1/hu unknown
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