MX2009001203A - Muteinas de lipocalina lacrimosa y metodos para obtener las mismas. - Google Patents

Muteinas de lipocalina lacrimosa y metodos para obtener las mismas.

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Publication number
MX2009001203A
MX2009001203A MX2009001203A MX2009001203A MX2009001203A MX 2009001203 A MX2009001203 A MX 2009001203A MX 2009001203 A MX2009001203 A MX 2009001203A MX 2009001203 A MX2009001203 A MX 2009001203A MX 2009001203 A MX2009001203 A MX 2009001203A
Authority
MX
Mexico
Prior art keywords
mutein
muteins
obtaining
methods
same
Prior art date
Application number
MX2009001203A
Other languages
English (en)
Inventor
Ian Kimber
Kristian Jensen
Martin Huelsmeyer
Steffen Schlehuber
Andreas Hohlbaum
Arne Skerra
Eric Boudreau
Richard C Jones
Rebecca Dearman
Original Assignee
Pieris Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pieris Ag filed Critical Pieris Ag
Publication of MX2009001203A publication Critical patent/MX2009001203A/es

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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P27/16—Otologicals
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P7/10—Antioedematous agents; Diuretics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C12N5/10—Cells modified by introduction of foreign genetic material
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
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    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
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  • Proteomics, Peptides & Aminoacids (AREA)
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Abstract

La presente invención se relaciona con muteínas novedosas derivada de lipocalina de lágrimas humanas. La invención también se relaciona con la molécula de ácido nucleico correspondiente que codifica para esta muteína y con un método para su generación. La invención además se relaciona a un método para producir esta muteína. Por último, la invención se dirige a una composición farmacéutica que comprende esta muteína de lipocalina, así como también con los diversos usos de la muteína.
MX2009001203A 2006-08-01 2007-08-01 Muteinas de lipocalina lacrimosa y metodos para obtener las mismas. MX2009001203A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82107306P 2006-08-01 2006-08-01
US91201307P 2007-04-16 2007-04-16
PCT/EP2007/057971 WO2008015239A2 (en) 2006-08-01 2007-08-01 Muteins of tear lipocalin and methods for obtaining the same

Publications (1)

Publication Number Publication Date
MX2009001203A true MX2009001203A (es) 2009-06-01

Family

ID=38997508

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009001203A MX2009001203A (es) 2006-08-01 2007-08-01 Muteinas de lipocalina lacrimosa y metodos para obtener las mismas.

Country Status (14)

Country Link
US (4) US8313924B2 (es)
EP (1) EP2046820B1 (es)
JP (1) JP5608368B2 (es)
KR (1) KR101516023B1 (es)
CN (2) CN105112477A (es)
AT (1) ATE485304T1 (es)
AU (1) AU2007280398B2 (es)
CA (1) CA2659413C (es)
DE (1) DE602007009995D1 (es)
DK (1) DK2046820T3 (es)
HK (1) HK1131167A1 (es)
MX (1) MX2009001203A (es)
SG (1) SG173332A1 (es)
WO (1) WO2008015239A2 (es)

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CN114573680A (zh) 2015-05-04 2022-06-03 皮里斯制药有限公司 Cd137特异性的蛋白
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CA2982034A1 (en) 2015-05-18 2016-11-24 Pieris Pharmaceuticals Gmbh Muteins of human lipocalin 2 with affinity for glypican-3 (gpc3)
MX2017014716A (es) * 2015-05-18 2018-06-28 Pieris Pharmaceuticals Gmbh Polipeptido de fusion anti-cancer.
US20190257832A1 (en) 2016-07-18 2019-08-22 Philippe Ulsemer Natural microorganisms which are naturally capable of binding toxins and/or toxin receptors
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CA2659413C (en) 2016-06-14
US10046027B2 (en) 2018-08-14
CA2659413A1 (en) 2008-02-07
US20160256525A1 (en) 2016-09-08
WO2008015239A3 (en) 2008-08-21
HK1131167A1 (zh) 2010-01-15
JP5608368B2 (ja) 2014-10-15
KR20090090295A (ko) 2009-08-25
EP2046820B1 (en) 2010-10-20
CN105112477A (zh) 2015-12-02
CN104650213A (zh) 2015-05-27
JP2009545301A (ja) 2009-12-24
WO2008015239A2 (en) 2008-02-07
DE602007009995D1 (de) 2010-12-02
US20090305982A1 (en) 2009-12-10
AU2007280398A1 (en) 2008-02-07
US20190015477A1 (en) 2019-01-17
SG173332A1 (en) 2011-08-29
AU2007280398B2 (en) 2012-05-10
US20130017996A1 (en) 2013-01-17
EP2046820A2 (en) 2009-04-15
US9221887B2 (en) 2015-12-29
DK2046820T3 (da) 2011-02-07
ATE485304T1 (de) 2010-11-15
KR101516023B1 (ko) 2015-04-30
US8313924B2 (en) 2012-11-20

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