MX2009001203A - Muteinas de lipocalina lacrimosa y metodos para obtener las mismas. - Google Patents
Muteinas de lipocalina lacrimosa y metodos para obtener las mismas.Info
- Publication number
- MX2009001203A MX2009001203A MX2009001203A MX2009001203A MX2009001203A MX 2009001203 A MX2009001203 A MX 2009001203A MX 2009001203 A MX2009001203 A MX 2009001203A MX 2009001203 A MX2009001203 A MX 2009001203A MX 2009001203 A MX2009001203 A MX 2009001203A
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- Prior art keywords
- mutein
- muteins
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- same
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70521—CD28, CD152
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Pathology (AREA)
Abstract
La presente invención se relaciona con muteínas novedosas derivada de lipocalina de lágrimas humanas. La invención también se relaciona con la molécula de ácido nucleico correspondiente que codifica para esta muteína y con un método para su generación. La invención además se relaciona a un método para producir esta muteína. Por último, la invención se dirige a una composición farmacéutica que comprende esta muteína de lipocalina, así como también con los diversos usos de la muteína.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82107306P | 2006-08-01 | 2006-08-01 | |
US91201307P | 2007-04-16 | 2007-04-16 | |
PCT/EP2007/057971 WO2008015239A2 (en) | 2006-08-01 | 2007-08-01 | Muteins of tear lipocalin and methods for obtaining the same |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009001203A true MX2009001203A (es) | 2009-06-01 |
Family
ID=38997508
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009001203A MX2009001203A (es) | 2006-08-01 | 2007-08-01 | Muteinas de lipocalina lacrimosa y metodos para obtener las mismas. |
Country Status (14)
Country | Link |
---|---|
US (4) | US8313924B2 (es) |
EP (1) | EP2046820B1 (es) |
JP (1) | JP5608368B2 (es) |
KR (1) | KR101516023B1 (es) |
CN (2) | CN105112477A (es) |
AT (1) | ATE485304T1 (es) |
AU (1) | AU2007280398B2 (es) |
CA (1) | CA2659413C (es) |
DE (1) | DE602007009995D1 (es) |
DK (1) | DK2046820T3 (es) |
HK (1) | HK1131167A1 (es) |
MX (1) | MX2009001203A (es) |
SG (1) | SG173332A1 (es) |
WO (1) | WO2008015239A2 (es) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105112477A (zh) * | 2006-08-01 | 2015-12-02 | 皮里斯股份公司 | 泪液脂质运载蛋白的突变蛋白及其获得方法 |
US20090274623A1 (en) * | 2008-01-30 | 2009-11-05 | General Electric Company | In vivo imaging agents for met receptor tyrosine kinase |
US9212208B2 (en) * | 2008-01-30 | 2015-12-15 | Pieris Ag | Muteins with tear lipocalin having affinity to human c-Met receptor tyrosine kinase and methods for obtaining the same |
RU2012107812A (ru) * | 2009-08-05 | 2013-09-10 | Аллерган, Инк. | Препараты мутеинов липокалинов с контролируемым высвобождением |
SG10201408073XA (en) * | 2009-12-07 | 2015-01-29 | Pieris Ag | Muteins of human lipocalin 2 (lcn2, hngal) with affinity for a given target |
PL2580236T3 (pl) * | 2010-06-08 | 2019-09-30 | Pieris Pharmaceuticals Gmbh | Muteiny lipokaliny łez wiążące IL-4 R alfa |
CN103201293B (zh) * | 2010-09-08 | 2016-04-27 | 哈洛齐梅公司 | 评估和鉴定或发展条件活性治疗蛋白的方法 |
MX345245B (es) * | 2010-09-28 | 2017-01-23 | Amylin Pharmaceuticals Llc | Polipeptidos manipulados que tienen duracion de accion incrementada. |
WO2012136685A1 (en) | 2011-04-04 | 2012-10-11 | Pieris Ag | Methods and compositions for anti-vegf and anti-c-met therapy |
WO2012172054A1 (en) | 2011-06-16 | 2012-12-20 | Scil Proteins Gmbh | Modified multimeric ubiquitin proteins binding vegf-a |
WO2013068590A1 (en) * | 2011-11-11 | 2013-05-16 | Pieris Ag | Lipocalin muteins as vegf antagonists for use in treating diseases caused or promoted by increased vascularization |
CA2858962C (en) | 2011-12-13 | 2023-09-05 | Pieris Ag | Compositions of human tear lipocalin muteins and methods of use thereof |
DK2797622T3 (en) | 2011-12-30 | 2017-01-16 | Halozyme Inc | PH20 polypeptide variants, formulations and uses thereof |
US9522940B2 (en) | 2012-05-23 | 2016-12-20 | Pieris Pharmaceuticals Gmbh | Lipocalin muteins with binding-affinity for glypican-3 (GPC-3) and use of lipocalin muteins for target-specific delivery to cells expressing GPC-3 |
US10526384B2 (en) * | 2012-11-19 | 2020-01-07 | Pieris Pharmaceuticals Gmbh | Interleukin-17A-specific and interleukin-23-specific binding polypeptides and uses thereof |
US20140149578A1 (en) * | 2012-11-26 | 2014-05-29 | Go Daddy Operating Company, LLC | Method For Testing Methods of Accelerating Content Delivery |
US9255262B2 (en) * | 2013-03-06 | 2016-02-09 | Vision Global Holdings Ltd. | Albumin-binding arginine deminase and the use thereof |
USRE48805E1 (en) | 2013-03-06 | 2021-11-02 | Vision Global Holdings Ltd. | Method for cancer targeting treatment and detection of arginine using albumin-binding arginine deiminase fusion protein |
US9150629B2 (en) | 2013-03-14 | 2015-10-06 | Daiichi Sankyo Co., Ltd. | Human tear lipocalins which bind PCSK9 and methods of use thereof |
TW201534726A (zh) | 2013-07-03 | 2015-09-16 | Halozyme Inc | 熱穩定ph20玻尿酸酶變異體及其用途 |
US9388239B2 (en) * | 2014-05-01 | 2016-07-12 | Consejo Nacional De Investigation Cientifica | Anti-human VEGF antibodies with unusually strong binding affinity to human VEGF-A and cross reactivity to human VEGF-B |
CN106573964B (zh) * | 2014-05-22 | 2021-07-16 | 皮里斯制药有限公司 | 新型特异性结合多肽及其用途 |
US11382963B2 (en) | 2015-01-12 | 2022-07-12 | Pieris Pharmaceuticals Gmbh | Engineered T cells and uses therefor |
EP3064507A1 (en) | 2015-03-06 | 2016-09-07 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Fusion proteins comprising a binding protein and an interleukin-15 polypeptide having a reduced affinity for IL15ra and therapeutic uses thereof |
CN114573680A (zh) | 2015-05-04 | 2022-06-03 | 皮里斯制药有限公司 | Cd137特异性的蛋白 |
SG11201708334RA (en) * | 2015-05-04 | 2017-11-29 | Pieris Pharmaceuticals Gmbh | Anti-cancer fusion polypeptide |
CA2982034A1 (en) | 2015-05-18 | 2016-11-24 | Pieris Pharmaceuticals Gmbh | Muteins of human lipocalin 2 with affinity for glypican-3 (gpc3) |
MX2017014716A (es) * | 2015-05-18 | 2018-06-28 | Pieris Pharmaceuticals Gmbh | Polipeptido de fusion anti-cancer. |
US20190257832A1 (en) | 2016-07-18 | 2019-08-22 | Philippe Ulsemer | Natural microorganisms which are naturally capable of binding toxins and/or toxin receptors |
WO2018152326A1 (en) | 2017-02-17 | 2018-08-23 | Denali Therapeutics Inc. | Engineered transferrin receptor binding polypeptides |
EP3810642A1 (en) | 2018-06-21 | 2021-04-28 | Technische Universität München | Hepatitis b and/or hepatitis d-permissive cells and animals |
MX2021010039A (es) | 2019-02-26 | 2021-09-21 | Pieris Pharmaceuticals Gmbh | Novedosas proteinas de fusion especificas para cd137 y gpc3. |
CN113939307A (zh) | 2019-03-29 | 2022-01-14 | 皮里斯制药有限公司 | 脂质运载蛋白突变蛋白的吸入施用 |
KR20210146934A (ko) | 2019-03-29 | 2021-12-06 | 아스트라제네카 에이비이 | 천식 치료를 위한 리포칼린 뮤테인 |
KR20230121785A (ko) | 2020-12-18 | 2023-08-21 | 아스트라제네카 에이비이 | 천식 치료용 리포칼린 뮤테인 건조 분말 제형 |
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US6446467B1 (en) | 1997-07-29 | 2002-09-10 | Physical Optics Corporation | Monolithic glass light shaping diffuser and method for its production |
DE19742706B4 (de) * | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
DE19926068C1 (de) | 1999-06-08 | 2001-01-11 | Arne Skerra | Muteine des Bilin-Bindungsproteins |
JP4873818B2 (ja) * | 2000-05-16 | 2012-02-08 | ボルダー バイオテクノロジー, インコーポレイテッド | 遊離システイン残基を含有するタンパク質をリフォールディングする方法 |
WO2003029462A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
US7118915B2 (en) | 2001-09-27 | 2006-10-10 | Pieris Proteolab Ag | Muteins of apolipoprotein D |
EP1658308A1 (en) | 2003-08-25 | 2006-05-24 | Pieris ProteoLab AG | Muteins of a bilin-binding protein with affinity for a given target |
AU2003275958A1 (en) * | 2003-08-25 | 2005-03-10 | Pieris Proteolab Ag | Muteins of tear lipocalin |
EP1814988A2 (en) * | 2004-11-26 | 2007-08-08 | Pieris AG | Compound with affinity for the cytotoxic t lymphocyte-associated antigen (ctla-4) |
WO2007107563A2 (en) * | 2006-03-20 | 2007-09-27 | Technische Universität München | Muteins of tear lipocalin with affinity for the t-cell coreceptor cd4 |
CN105112477A (zh) * | 2006-08-01 | 2015-12-02 | 皮里斯股份公司 | 泪液脂质运载蛋白的突变蛋白及其获得方法 |
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2007
- 2007-08-01 CN CN201510431417.8A patent/CN105112477A/zh active Pending
- 2007-08-01 EP EP07788139A patent/EP2046820B1/en active Active
- 2007-08-01 DE DE602007009995T patent/DE602007009995D1/de active Active
- 2007-08-01 AT AT07788139T patent/ATE485304T1/de active
- 2007-08-01 CN CN201510013379.4A patent/CN104650213A/zh active Pending
- 2007-08-01 AU AU2007280398A patent/AU2007280398B2/en active Active
- 2007-08-01 CA CA2659413A patent/CA2659413C/en active Active
- 2007-08-01 US US12/309,820 patent/US8313924B2/en active Active
- 2007-08-01 JP JP2009522275A patent/JP5608368B2/ja active Active
- 2007-08-01 WO PCT/EP2007/057971 patent/WO2008015239A2/en active Application Filing
- 2007-08-01 KR KR1020097004449A patent/KR101516023B1/ko active IP Right Grant
- 2007-08-01 SG SG2011047883A patent/SG173332A1/en unknown
- 2007-08-01 MX MX2009001203A patent/MX2009001203A/es active IP Right Grant
- 2007-08-01 DK DK07788139.9T patent/DK2046820T3/da active
-
2009
- 2009-11-19 HK HK09110805.5A patent/HK1131167A1/zh unknown
-
2012
- 2012-09-14 US US13/616,815 patent/US9221887B2/en active Active
-
2015
- 2015-12-28 US US14/981,589 patent/US10046027B2/en active Active
-
2018
- 2018-07-10 US US16/031,663 patent/US20190015477A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2659413C (en) | 2016-06-14 |
US10046027B2 (en) | 2018-08-14 |
CA2659413A1 (en) | 2008-02-07 |
US20160256525A1 (en) | 2016-09-08 |
WO2008015239A3 (en) | 2008-08-21 |
HK1131167A1 (zh) | 2010-01-15 |
JP5608368B2 (ja) | 2014-10-15 |
KR20090090295A (ko) | 2009-08-25 |
EP2046820B1 (en) | 2010-10-20 |
CN105112477A (zh) | 2015-12-02 |
CN104650213A (zh) | 2015-05-27 |
JP2009545301A (ja) | 2009-12-24 |
WO2008015239A2 (en) | 2008-02-07 |
DE602007009995D1 (de) | 2010-12-02 |
US20090305982A1 (en) | 2009-12-10 |
AU2007280398A1 (en) | 2008-02-07 |
US20190015477A1 (en) | 2019-01-17 |
SG173332A1 (en) | 2011-08-29 |
AU2007280398B2 (en) | 2012-05-10 |
US20130017996A1 (en) | 2013-01-17 |
EP2046820A2 (en) | 2009-04-15 |
US9221887B2 (en) | 2015-12-29 |
DK2046820T3 (da) | 2011-02-07 |
ATE485304T1 (de) | 2010-11-15 |
KR101516023B1 (ko) | 2015-04-30 |
US8313924B2 (en) | 2012-11-20 |
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