AR061743A1 - Compuestos peptidicos para el tratamiento de trastornos de hiperexcitabilidad y trastornos asociados con disfuncion del canal de hierro - Google Patents
Compuestos peptidicos para el tratamiento de trastornos de hiperexcitabilidad y trastornos asociados con disfuncion del canal de hierroInfo
- Publication number
- AR061743A1 AR061743A1 ARP070102915A ARP070102915A AR061743A1 AR 061743 A1 AR061743 A1 AR 061743A1 AR P070102915 A ARP070102915 A AR P070102915A AR P070102915 A ARP070102915 A AR P070102915A AR 061743 A1 AR061743 A1 AR 061743A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- heterocyclic
- aryl
- group
- unsubstituted
- Prior art date
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
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- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/02—Drug screening
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2842—Pain, e.g. neuropathic pain, psychogenic pain
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2857—Seizure disorders; Epilepsy
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/30—Psychoses; Psychiatry
- G01N2800/302—Schizophrenia
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Uso de una clase de compuestos péptidos para tratar enfermedades asociadas con hiperexcitabilidad. Uso de una clase de compuestos péptidos para tratar enfermedades asociadas con disfuncion de un canal de hierro. Reivindicacion 1: Uso de un compuesto que tiene la formula (1) en donde, R es hidrogeno, alquilo, alquenilo, alquinilo, arilo, aril alquilo heterocíclico, heterocíclico alquilo, alquilo heterocíclico, cicloalquilo o cicloalquil alquilo, y R está insustituido o está sustituido con al menos un grupo aceptor de electrones, y/o al menos un grupo donante de electrones; R1 es hidrogeno o alquilo, alquenilo, alquinilo, aril alquilo, arilo, heterocíclico alquilo, alquilo heterocíclico, heterocíclico, cicloalquilo, cicloalquil alquilo, cada uno insustituido o sustituido con al menos un grupo donante de electrones y/o al menos un grupo aceptor de electrones; R2 y R3 son independientemente hidrogeno, alquilo, alquenilo, alquinilo, alcoxi, alcoxialquilo, aril alquilo, arilo, halo, heterocíclico, heterocíclico alquilo, alquilo heterocíclico, cicloalquilo, cicloalquil alquilo, o Z-Y en donde R2 y R3 pueden estar insustituidos o sustituidos con al menos un grupo aceptor de electrones y/o al menos un grupo donante de electrones; y en donde el heterocíclico en R2 y R3 es furilo, tienilo, pirazolilo, pirrolilo, metilpirrolilo, imidazolilo, indolilo, tiazolilo, oxazolilo, isotiazolilo, isoxazolilo, piperidilo, pirrolinilo, piperazinilo, quinolilo, triazolilo, tetrazolilo, isoquinolilo, benzofurilo, benzotienilo, morfolinilo, benzoxazolilo, tetrahidrofurilo, piranilo, indazolilo, purinilo, indolinilo, pirazolindinilo, imidazolinilo, imidazolindinilo, pirrolidinilo, furazanilo, N-metilindofilo, metilfurilo, piridazinilo, pirimidinilo, pirazinilo, piridilo, epoxi, aziridino, oxetanilo, azetidinilo, o cuando N está presente en el heterocíclico, un N-oxido del mismo; Z es O, S, S(O)a, NR4, NR'6, PR4 o un enlace químico; Y es hidrogeno, alquilo, arilo, aril alquilo, alquenilo, alquinilo, halo, heterocíclico, heterocíclico alquilo, alquil heterocíclico e Y puede estar insustituido o sustituido con al menos un grupo donante de electrones y/o al menos un grupo aceptor de electrones, con la condicion de que, cuando Y es halo, Z es un enlace químico, o ZY conjuntamente son NR4NR5R7, NR4OR5, ONR4R7, OPR4R5, PR4OR5, SNR4R7, NR4SR7, SPR4R5, PR4SR7, NR4PR5R6, PR4NR5R7, N+R5R6R7, NR4C(=O)R5, SC(=O)R5, NR4C(=O)OR5, SC(=O)OR5 o NR4NR5- C(=O)OR6; R'6 es hidrogeno, alquilo, alquenilo o alquinilo y que puede estar insustituido o sustituido con al menos un grupo aceptor de electrones y/o al menos un grupo donante de electrones; R4, R5 y R6 son independientemente hidrogeno, alquilo, arilo, aril alquilo, alquenilo, o alquinilo, en donde R4, R5 y R6 pueden estar independientemente insustituidos o sustituidos con al menos un grupo aceptor de electrones y/o al menos un grupo donante de electrones; R7 es R6 o COOR8 o COR8, en donde R7 puede estar insustituido o sustituido con al menos un grupo aceptor de electrones y/o al menos un grupo donante de electrones; R8 es hidrogeno o alquilo, o aril alquilo, y el grupo arilo o alquilo puede estar insustituido o sustituido con al menos un grupo aceptor de electrones y/o al menos un grupo donante de electrones; n es 1-4; y a es 1-3; o una sal farmacéuticamente aceptable del mismo, caracterizado porque es para la preparacion de una composicion farmacéutica para la prevencion, alivio y/o tratamiento de una enfermedad asociada con hiperexcitabilidad.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06013655A EP1873527A1 (en) | 2006-06-30 | 2006-06-30 | Method for identifying CRMP modulators |
EP06021469 | 2006-10-12 | ||
EP06021470A EP1920780A1 (en) | 2006-10-12 | 2006-10-12 | Peptide compounds for the treatment of hyperexcitability disorders |
EP06024241A EP1925314A1 (en) | 2006-11-22 | 2006-11-22 | Pharmaceutical composition with synergistic anticonvulsant effect |
Publications (1)
Publication Number | Publication Date |
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AR061743A1 true AR061743A1 (es) | 2008-09-17 |
Family
ID=38721381
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070102915A AR061743A1 (es) | 2006-06-30 | 2007-06-29 | Compuestos peptidicos para el tratamiento de trastornos de hiperexcitabilidad y trastornos asociados con disfuncion del canal de hierro |
ARP070102916A AR061744A1 (es) | 2006-06-30 | 2007-06-29 | Metodo para identificar proteinas mediadoras de respuesta a colapsina |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070102916A AR061744A1 (es) | 2006-06-30 | 2007-06-29 | Metodo para identificar proteinas mediadoras de respuesta a colapsina |
Country Status (14)
Country | Link |
---|---|
US (3) | US20090241205A1 (es) |
EP (3) | EP2345455B1 (es) |
JP (1) | JP2009541397A (es) |
KR (1) | KR20090030329A (es) |
CN (2) | CN101466390B (es) |
AR (2) | AR061743A1 (es) |
AU (1) | AU2007263936A1 (es) |
BR (1) | BRPI0713994A2 (es) |
CA (1) | CA2654652C (es) |
EA (1) | EA200900098A1 (es) |
ES (1) | ES2569333T3 (es) |
MX (1) | MX2009000249A (es) |
TW (2) | TW200819138A (es) |
WO (2) | WO2008000512A2 (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1243263E (pt) * | 2001-03-21 | 2003-03-31 | Sanol Arznei Schwarz Gmbh | Nova utilizacao de uma classe peptidica de composto para o tratamento de alodinia ou de outros tipos diferentes de dor cronica ou fantasma |
US20100256179A1 (en) * | 2004-03-26 | 2010-10-07 | Ucb Pharma Gmbh | Combination therapy for pain in painful diabetic neuropathy |
KR20070007931A (ko) * | 2004-04-16 | 2007-01-16 | 쉬바르츠파르마에이지 | 만성 두통의 예방 및 치료를 위한 펩티드 화합물의 용도 |
EP1604655A1 (en) | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating pain in trigeminal neuralgia |
JP2008510758A (ja) * | 2004-08-27 | 2008-04-10 | シュヴァルツ・ファーマ・アーゲー | 骨肉腫の痛み、化学療法誘発性及びヌクレオシド誘発性の痛みを治療するためのペプチド化合物の新規使用 |
EP1642889A1 (en) * | 2004-10-02 | 2006-04-05 | Schwarz Pharma Ag | Improved synthesis scheme for lacosamide |
EP1754476A1 (en) * | 2005-08-18 | 2007-02-21 | Schwarz Pharma Ag | Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia |
US20070043120A1 (en) * | 2005-08-18 | 2007-02-22 | Bettina Beyreuther | Therapeutic combination for painful medical conditions |
CN101466390B (zh) | 2006-06-15 | 2014-03-12 | 优时比制药有限公司 | 用于治疗难治性癫痫持续状态的肽类化合物 |
MX2008016000A (es) | 2006-06-15 | 2009-03-05 | Sanol Arznei Schwarz Gmbh | Composicion farmaceutica con efecto anticonvulsivante sinergistico. |
EP1873527A1 (en) * | 2006-06-30 | 2008-01-02 | Schwarz Pharma Ag | Method for identifying CRMP modulators |
WO2009053070A1 (en) * | 2007-10-23 | 2009-04-30 | Schwarz Pharma Ag | Compounds for treating demyelination conditions |
CA2774569A1 (en) | 2009-09-23 | 2011-03-31 | The University Of North Carolina At Chapel Hill | Novel n-benzylamide substituted derivatives of 2-(acylamido)acetic acid and 2-(acylamido)propionic acids: potent neurological agents |
CN102051408B (zh) * | 2009-11-04 | 2012-07-04 | 高新 | 用于***癌转移早期诊断的试剂盒 |
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2007
- 2007-06-15 CN CN200780022239.7A patent/CN101466390B/zh not_active Expired - Fee Related
- 2007-06-29 JP JP2009517011A patent/JP2009541397A/ja active Pending
- 2007-06-29 WO PCT/EP2007/005805 patent/WO2008000512A2/en active Application Filing
- 2007-06-29 CA CA2654652A patent/CA2654652C/en not_active Expired - Fee Related
- 2007-06-29 AU AU2007263936A patent/AU2007263936A1/en not_active Abandoned
- 2007-06-29 US US12/306,950 patent/US20090241205A1/en not_active Abandoned
- 2007-06-29 AR ARP070102915A patent/AR061743A1/es unknown
- 2007-06-29 EP EP11002768.7A patent/EP2345455B1/en not_active Revoked
- 2007-06-29 WO PCT/EP2007/005806 patent/WO2008000513A2/en active Application Filing
- 2007-06-29 EA EA200900098A patent/EA200900098A1/ru unknown
- 2007-06-29 EP EP07764966A patent/EP2038659A2/en not_active Withdrawn
- 2007-06-29 CN CN201310404840.XA patent/CN103494795A/zh active Pending
- 2007-06-29 MX MX2009000249A patent/MX2009000249A/es not_active Application Discontinuation
- 2007-06-29 US US12/306,953 patent/US9308183B2/en not_active Expired - Fee Related
- 2007-06-29 BR BRPI0713994-2A patent/BRPI0713994A2/pt not_active Application Discontinuation
- 2007-06-29 KR KR1020097001931A patent/KR20090030329A/ko not_active Application Discontinuation
- 2007-06-29 EP EP07764967.1A patent/EP2046386B1/en not_active Not-in-force
- 2007-06-29 AR ARP070102916A patent/AR061744A1/es unknown
- 2007-06-29 ES ES11002768.7T patent/ES2569333T3/es active Active
- 2007-07-02 TW TW096123999A patent/TW200819138A/zh unknown
- 2007-07-02 TW TW096123998A patent/TW200819744A/zh unknown
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2013
- 2013-09-10 US US14/022,342 patent/US20140066515A1/en not_active Abandoned
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CN101466390B (zh) | 2014-03-12 |
CN101466390A (zh) | 2009-06-24 |
US9308183B2 (en) | 2016-04-12 |
CA2654652A1 (en) | 2008-01-03 |
CN103494795A (zh) | 2014-01-08 |
EP2038659A2 (en) | 2009-03-25 |
US20090241205A1 (en) | 2009-09-24 |
WO2008000512A3 (en) | 2008-03-06 |
US20140066515A1 (en) | 2014-03-06 |
CA2654652C (en) | 2015-06-02 |
US20100324144A1 (en) | 2010-12-23 |
KR20090030329A (ko) | 2009-03-24 |
TW200819744A (en) | 2008-05-01 |
MX2009000249A (es) | 2009-01-23 |
EP2046386A2 (en) | 2009-04-15 |
JP2009541397A (ja) | 2009-11-26 |
TW200819138A (en) | 2008-05-01 |
WO2008000513A2 (en) | 2008-01-03 |
EP2046386B1 (en) | 2014-07-23 |
EA200900098A1 (ru) | 2009-06-30 |
AR061744A1 (es) | 2008-09-17 |
WO2008000512A2 (en) | 2008-01-03 |
ES2569333T3 (es) | 2016-05-10 |
WO2008000513A3 (en) | 2008-09-04 |
EP2345455A1 (en) | 2011-07-20 |
BRPI0713994A2 (pt) | 2012-11-20 |
EP2345455B1 (en) | 2016-03-16 |
AU2007263936A1 (en) | 2008-01-03 |
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