AR049170A1 - Derivados de pirimidina para el tratamiento del crecimiento celular anormal - Google Patents
Derivados de pirimidina para el tratamiento del crecimiento celular anormalInfo
- Publication number
- AR049170A1 AR049170A1 ARP050101939A ARP050101939A AR049170A1 AR 049170 A1 AR049170 A1 AR 049170A1 AR P050101939 A ARP050101939 A AR P050101939A AR P050101939 A ARP050101939 A AR P050101939A AR 049170 A1 AR049170 A1 AR 049170A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- heterocyclyl
- cycloalkyl
- hydrogen
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Abstract
La presente se refiere a composiciones farmacéuticas que contienen dichos compuestos. Reivindicacion 1: Un compuesto descrito por la formula (1), o una sal, solvato, hidrato o profármaco suyo farmacéuticamente aceptable, en el que Ar es seleccionado entre un grupo de formula (2), y el anillo B es una formula (3), en el que m es un numero entero entre 0 y 2; Ra representa sustituyentes seleccionados de forma independiente del grupo que consiste en hidrogeno, halogeno, hidroxi, -CF3, -CN, -NR1R2, -OR1, -R1, -CO2R1 y -CONR1R2; Rb representa un sustituyente seleccionado del grupo que consiste en hidrogeno, alquilo-C1-6, cicloalquilo-C3-7, heterociclilo-C2-9, -CO2R1, -CONR1R2; cada Rc representa de forma independiente un sustituyente seleccionado del grupo que consiste en hidrogeno, halogeno, hidroxi, -CF3, -CN, alquilo-C1-6, -NR1R2, -OR1, cicloalquilo-C3-7, heterociclilo-C2-9, -CO2R1 y -CONR1R2 o se pueden considerar dos sustituyentes Rc en conjunto con el átomo(s) al que están unidos para formar un grupo cíclico, cicloalquilo-C3-10 o heterociclilo-C2-9; A es un resto cíclico adecuadamente sustituido seleccionado del grupo que consiste en: a) un grupo heterociclilo-C2-9 incluyendo el átomo de nitrogeno del anillo de la union entre el resto cíclico A y la posicion C-4 del anillo de pirimidina de formula (1); y b) un grupo heterociclilo-C2-7 en el que dos carbonos metilénicos adyacentes de dicho grupo heterociclilo-C2-7 están unidos a un grupo fenilo o heteroarilo-C2-6; en el que A está sustituido opcionalmente por de 1 a 3 sustituyentes seleccionados de forma independiente del grupo que consiste en halogeno, hidroxilo, ciano, -R1, -NR1R2, -NH(CO)R1, -NR2(CO)R1, alquilo-C1-6-NR1R2, alquilo-C1-6- NH(CO)R1, alquilo-C1-6-NR2(CO)R1, -NHSO2R1, -N(R2)(SO2)(R1), alquilo-C1-6-(SO2)(R1), alquilo-C1-6(NHSO2)(R1), alquilo-C1-6(NR2(SO2)(R1), -OR1, alquilo-C1-6-OR1, alquilo-C1-6-OSOR1, -O-SO2R1, -SO2R1, SO2NH2, SO2NHR1 y -SO2NR1R2; y dicho grupo cíclico A está opcionalmente interrumpido por de uno a tres elementos seleccionados del grupo que consiste en -(C=O), -SO2, -S-, -O-, -N-, -NH- y -NR3; R1 y R2 son cada uno sustituyentes seleccionados de forma independiente del grupo que consiste en hidrogeno, alquilo-C1-6, cicloalquilo-C3-7, heterociclilo-C2-9, arilo-C6-10, y heteroarilo-C1-9; en el que dichos sustituyentes de R1 y R2, alquilo-C1-6, cicloalquilo-C3-7, heterociclilo-C2-9, arilo-C6-10, y heteroarilo-C1-9, están sustituidos opcionalmente por de uno a tres restos seleccionados de forma independiente del grupo que consiste en hidrogeno, halogeno, -CF3, -CN, alquilo-C1-6, -NH-alquilo-C1-6, -NH-cicloalquilo-C3-7, -NH-heterociclilo-C2-9, -NH-arilo-C6-10,-NH-heteroarilo-C1- 9, -N-(alquilo-C1-6)2, -N-(cicloalquilo-C3-7)2, -N(heterociclilo-C2-9)2, -N-(arilo-C6-10)2, -N-(heteroarilo-C1-9)2, -O-(alquilo-C1-6, O-cicloalquilo-C3-7, -O-heterociclilo-C2-9, -O-arilo-C6-10, -O-heteroarilo-C1-9, cicloalquilo-C3-7 y heterociclilo- C2-9; o R1 y R2 pueden ser considerados en conjunto con el átomo(s) a los que están unidos para formar un cicloalquilo-C3-10 o un heterociclilo-C2-9, en el que dicho cicloalquilo-C3-10 o heterociclilo-C2-9 está sustituido opcionalmente por de uno a tres elementos seleccionados del grupo que consiste en hidrogeno, halogeno, e hidroxi, y dicho grupo cíclico está interrumpido opcionalmente por de uno a tres elementos seleccionados del grupo que consiste en -(C=O), -SO2, -S-, -O-, -N-, -NH- y - NR3; R3 es un sustituyentes seleccionado del grupo que consiste en hidrogeno, alquilo-C1-6, cicloalquilo-C3-7, heterociclilo-C2-9, arilo-C6-10, heteroarilo-C1-9, -COR1, y -SO2R1; en el que dichos radicales de R3, alquilo-C1-6, cicloalquilo-C3-7, heterociclilo-C2-9, arilo-C6-10, heteroarilo-C1-9, -COR1, y SO2R1 están sustituidos opcionalmente por de uno a tres restos seleccionados de forma independiente del grupo que consiste en hidrogeno, halogeno, hidroxi, -CN, alquilo-C1-6, -NH2, -NHR4, - NR42, -OR4, cicloalquilo-C3-7, heterociclilo-C2-9, -COR5, -CONH2, -CONHR5, y -CONR5R6, en el que R5 y R6 en -CONR5R6 pueden ser considerados en conjunto con los átomos a los que están unidos para formar un heterociclilo-C2-9; R4 y R5 son cada uno un alquilo-C1-6; y R6 es un hidrogeno o un alquilo-C1-6.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57121004P | 2004-05-14 | 2004-05-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR049170A1 true AR049170A1 (es) | 2006-07-05 |
Family
ID=34967615
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050101939A AR049170A1 (es) | 2004-05-14 | 2005-05-12 | Derivados de pirimidina para el tratamiento del crecimiento celular anormal |
Country Status (10)
Country | Link |
---|---|
US (1) | US7208499B2 (es) |
EP (1) | EP1756090A1 (es) |
JP (1) | JP2007537235A (es) |
AR (1) | AR049170A1 (es) |
BR (1) | BRPI0511132A (es) |
CA (1) | CA2566477A1 (es) |
HN (1) | HN2005000212A (es) |
MX (1) | MXPA06011658A (es) |
TW (1) | TW200607801A (es) |
WO (1) | WO2005111024A1 (es) |
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-
2005
- 2005-05-02 WO PCT/IB2005/001239 patent/WO2005111024A1/en active Application Filing
- 2005-05-02 CA CA002566477A patent/CA2566477A1/en not_active Abandoned
- 2005-05-02 MX MXPA06011658A patent/MXPA06011658A/es not_active Application Discontinuation
- 2005-05-02 BR BRPI0511132-3A patent/BRPI0511132A/pt not_active IP Right Cessation
- 2005-05-02 EP EP05739736A patent/EP1756090A1/en not_active Withdrawn
- 2005-05-02 JP JP2007512568A patent/JP2007537235A/ja active Pending
- 2005-05-06 US US11/124,006 patent/US7208499B2/en not_active Expired - Fee Related
- 2005-05-12 AR ARP050101939A patent/AR049170A1/es unknown
- 2005-05-12 HN HN2005000212A patent/HN2005000212A/es unknown
- 2005-05-13 TW TW094115478A patent/TW200607801A/zh unknown
Also Published As
Publication number | Publication date |
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HN2005000212A (es) | 2009-06-01 |
MXPA06011658A (es) | 2006-12-14 |
CA2566477A1 (en) | 2005-11-24 |
JP2007537235A (ja) | 2007-12-20 |
WO2005111024A1 (en) | 2005-11-24 |
EP1756090A1 (en) | 2007-02-28 |
BRPI0511132A (pt) | 2007-11-27 |
US20050256144A1 (en) | 2005-11-17 |
US7208499B2 (en) | 2007-04-24 |
TW200607801A (en) | 2006-03-01 |
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