AR047682A1 - Derivados tetrahidroisoquinolinilo de quinazolina e isoquinolina - Google Patents

Derivados tetrahidroisoquinolinilo de quinazolina e isoquinolina

Info

Publication number
AR047682A1
AR047682A1 ARP050100564A ARP050100564A AR047682A1 AR 047682 A1 AR047682 A1 AR 047682A1 AR P050100564 A ARP050100564 A AR P050100564A AR P050100564 A ARP050100564 A AR P050100564A AR 047682 A1 AR047682 A1 AR 047682A1
Authority
AR
Argentina
Prior art keywords
alkyl
alkenyl
independently
substituted
halogens
Prior art date
Application number
ARP050100564A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR047682A1 publication Critical patent/AR047682A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Abstract

Productos intermedios para la preparacion de dichos compuestos; composiciones farmacéuticas que comprenden dichos compuestos y al uso de dichos compuestos en un procedimiento para tratar ciertos trastornos del sistema nervioso central (SNC) u otros. Reivindicacion 1: Un compuesto de la formula (1), o una sal, solvato o profármaco del mismo farmacéuticamente aceptable; donde Q es N o CH; donde R1, R2 y R3 son cada uno de forma independiente hidrogeno, halogeno, alquilo C1-9, alquenilo C2- 9, alquinilo C2-9, cicloalquilo C3-8, -O-alquilo C1-9, -O-alquenilo C2-9, alquil C1-8-O-alquilo C1-6, C:::N,-NO2, -COOR4, -CONR4R5, -NR4R5, -COR5 o -COOH, donde dichos alquilo, alquenilo y alquinilo están opcionalmente sustituidos con de 1 a 3 halogenos; donde R4 y R5 son de forma independiente H, alquilo C1-6 o alquenilo C2-8, donde dichos alquilo y alquenilo están opcionalmente sustituidos con de 1 a 3 átomos de halogeno; y, cuando R1, R2 y R3 son de forma independiente -O-alquilo, -O- alquenilo, o alquilo, alquenilo o alquinilo, R2 y R1, o R1 y R3, pueden estar opcionalmente conectados para formar un anillo de 5 a 6 miembros; R6 y R7 son de forma independiente hidrogeno; -C(=O)-X; -S(=O)2-X, -N(Y)-S(=O)2-X o -N(Y)-C(=O)-X, donde X es un grupo alquilo C1-6 insustituido o sustituido con uno o más halogenos, O-alquilo C1-6 insustituido o sustituido con uno o más halogenos, un grupo arilo C6-14 insustituido o sustituido con uno o dos sustituyentes, un grupo -NR8R9 o una formula (2), donde dichos sustituyentes del grupo arilo C6-14 se seleccionan de forma independiente de alquilo C1-6, -O-alquilo C1-6, halogeno, -C:::N, -NO2, -COOR4, -CONR4R5, -NR4R5, -COR4 y -COOH, y alquilo C1-6 sustituido con de 1 a 3 halogenos; Y es hidrogeno o alquilo C1-6; n es 0 o 1; R8 y R9 son cada uno de forma independiente alquilo C1-6 o hidrogeno; Z es oxígeno o NR10, donde R10 es hidrogeno o alquilo C1-6; donde R11 y R12 son de forma independiente H, halogeno, C:::N, -COOH, -COOR4, - CONR4R5, COR4, -NR4R5, -OH, arilo C6-14, heteroarilo de 5 a 12 miembros, alquilo C1-6, alquenilo C2-6, alquinilo C2-6 o cicloalquilo C3-8, donde dichos alquilo, alquenilo y alquinilo están opcionalmente sustituidos de forma independiente con de 1 a 3 halogenos.
ARP050100564A 2004-02-18 2005-02-17 Derivados tetrahidroisoquinolinilo de quinazolina e isoquinolina AR047682A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54556504P 2004-02-18 2004-02-18

Publications (1)

Publication Number Publication Date
AR047682A1 true AR047682A1 (es) 2006-02-01

Family

ID=34910729

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050100564A AR047682A1 (es) 2004-02-18 2005-02-17 Derivados tetrahidroisoquinolinilo de quinazolina e isoquinolina

Country Status (14)

Country Link
US (1) US7268142B2 (es)
EP (1) EP1723134A2 (es)
JP (1) JP2007523152A (es)
AR (1) AR047682A1 (es)
BR (1) BRPI0507839A (es)
CA (1) CA2556413A1 (es)
DO (1) DOP2005000022A (es)
GT (1) GT200500027A (es)
NL (1) NL1028321C2 (es)
PA (1) PA8624101A1 (es)
PE (1) PE20050694A1 (es)
TW (1) TW200528446A (es)
UY (1) UY28750A1 (es)
WO (1) WO2005082883A2 (es)

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ZA200701232B (en) 2004-07-15 2008-08-27 Amr Technology Inc Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
US20070093515A1 (en) * 2005-08-16 2007-04-26 Arrington Mark P Phosphodiesterase 10 inhibitors
US20090023756A1 (en) * 2006-02-23 2009-01-22 Pfizer Inc Substituted quinazolines as pde10 inhibitors
US20070287707A1 (en) * 2006-02-28 2007-12-13 Arrington Mark P Phosphodiesterase 10 inhibitors
US20090099175A1 (en) * 2006-03-01 2009-04-16 Arrington Mark P Phosphodiesterase 10 inhibitors
US20070265258A1 (en) * 2006-03-06 2007-11-15 Ruiping Liu Quinazoline derivatives as phosphodiesterase 10 inhibitors
CA2644850A1 (en) * 2006-03-08 2007-09-13 Amgen Inc. Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors
PT2057153E (pt) * 2006-07-10 2012-11-14 Lundbeck & Co As H Derivados (3-aril-piperazin-1-il) de 6,7- dialcoxiquinazolina, 6,7-dialcoxiftalazina e 6,7-dialcoxiisoquinolina
US7786139B2 (en) 2006-11-21 2010-08-31 Omeros Corporation PDE10 inhibitors and related compositions and methods
MX2009012474A (es) * 2007-05-18 2009-12-18 Wyeth Corp Compuestos de quinazolina.
US7858620B2 (en) 2007-09-19 2010-12-28 H. Lundbeck A/S Cyanoisoquinoline
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
UA102693C2 (ru) * 2008-06-20 2013-08-12 Х. Луннбек А/С Производные фенилимидазола как ингибиторы фермента pde10a
US8133897B2 (en) 2008-06-20 2012-03-13 H. Lundbeck A/S Phenylimidazole derivatives as PDE10A enzyme inhibitors
TWI501965B (zh) * 2008-06-20 2015-10-01 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物
JP5739415B2 (ja) 2009-05-12 2015-06-24 ブリストル−マイヤーズ スクウィブ カンパニー （Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用
CA2760837C (en) * 2009-05-12 2018-04-03 Albany Molecular Research, Inc. 7-([1,2,4]triazolo[1,5-.alpha.]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
WO2010132437A1 (en) 2009-05-12 2010-11-18 Albany Molecular Research, Inc. Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
TWI487705B (zh) 2009-12-17 2015-06-11 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族芳基***衍生物
TWI481607B (zh) 2009-12-17 2015-04-21 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物
TW201200516A (en) 2009-12-17 2012-01-01 Lundbeck & Co As H Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors
TWI485151B (zh) 2009-12-17 2015-05-21 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物
ES2540867T3 (es) 2010-02-26 2015-07-14 Mitsubishi Tanabe Pharma Corporation Compuestos de pirazolopirimidina y su uso como inhibidores de PDE10
TW201215607A (en) 2010-07-02 2012-04-16 Lundbeck & Co As H Aryl-and heteroarylamid derivatives as PDE10A enzyme inhibitor
TW201206935A (en) 2010-07-16 2012-02-16 Lundbeck & Co As H Triazolo-and pyrazoloquinazoline derivatives as PDE10A enzyme inhibitor
DE102010042833B4 (de) 2010-10-22 2018-11-08 Helmholtz-Zentrum Dresden - Rossendorf E.V. Neue Halogenalkoxychinazoline, deren Herstellung und Verwendung
JO3089B1 (ar) 2010-11-19 2017-03-15 H Lundbeck As مشتقات ايميدازول كمثبطات لانزيمات pde10a
US8772316B2 (en) 2011-02-18 2014-07-08 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (PDE10A)
WO2013045607A1 (en) 2011-09-30 2013-04-04 H. Lundbeck A/S Quinazoline linked heteroaromatic tricycle derivatives as pde10a enzyme inhibitors
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CA2965336A1 (en) * 2014-10-22 2016-04-28 The Board Of Regents Of The University Of Texas System Small-molecule inhibitors targeting discoidin domain receptor 1 and uses thereof
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Also Published As

Publication number Publication date
WO2005082883A3 (en) 2007-04-26
GT200500027A (es) 2005-10-24
CA2556413A1 (en) 2005-09-09
PE20050694A1 (es) 2005-10-04
TW200528446A (en) 2005-09-01
PA8624101A1 (es) 2005-11-25
BRPI0507839A (pt) 2007-05-08
UY28750A1 (es) 2005-09-30
US20050182079A1 (en) 2005-08-18
NL1028321C2 (nl) 2006-05-23
NL1028321A1 (nl) 2005-08-19
DOP2005000022A (es) 2005-08-30
WO2005082883A2 (en) 2005-09-09
US7268142B2 (en) 2007-09-11
EP1723134A2 (en) 2006-11-22
JP2007523152A (ja) 2007-08-16

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