AR045462A1 - DERIVADOS DE INDOLES SUSTITUIDOS eTILES COMO COMPUESTOS FARMACEUTICOS PARA EL TRATAMIENTO DE ENFERMEDADES RESPIRATORIAS - Google Patents
DERIVADOS DE INDOLES SUSTITUIDOS eTILES COMO COMPUESTOS FARMACEUTICOS PARA EL TRATAMIENTO DE ENFERMEDADES RESPIRATORIASInfo
- Publication number
- AR045462A1 AR045462A1 ARP040102959A ARP040102959A AR045462A1 AR 045462 A1 AR045462 A1 AR 045462A1 AR P040102959 A ARP040102959 A AR P040102959A AR P040102959 A ARP040102959 A AR P040102959A AR 045462 A1 AR045462 A1 AR 045462A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- halogen
- aryl
- heteroaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Reivindicación 1: Un compuesto caracterizado porque es de la fórmula (1), o una sal o solvato aceptables para uso farmacéutico del mismo, en donde: R1 es uno o más sustituyentes seleccionados entre hidrógeno, halógeno, CN, nitro, SO2R4, OH, OR4, S(O)xR4, SO2NR5R6, CONR5R6, NR5R6, NR9SO2R4, NR9SO2NR5R6, NR9CO2R4, NR9COR4, arilo, heteroarilo, C2-6 alquenilo, C2-6 alquinilo o C1-6 alquilo, donde los últimos cinco sustituyentes están opcionalmente sustituidos con uno o más sustituyentes seleccionados en forma independiente entre halógeno, CN, NR9SO2R4, NR9CO2R4, NR9COR4, OR8 y NR5R6, S(O)xR7 donde x es 0, 1 ó 2; R2 es hidrógeno, halógeno, CN, SO2R4 o CONR5R6, CH2OH, CH2OR4 o C1-7 alquilo, donde el último grupo están opcionalmente sustituido con uno o más sustituyentes seleccionados en forma independiente entre átomos de halógeno, OR8, y NR5R6, S(O)xR7 donde es 0, 1 ó 2; R3 es arilo o heteroarilo donde cada uno de los cuales está opcionalmente sustituido con uno o más sustituyentes seleccionados en forma independiente entre hidrógeno, halógeno, CN, nitro, OH, SO2R4,OR4, SR4, SOR4, SO2NR5R6, CONR5R6, NR5R6, NHSO2R4, NHCO2R4, NHCOR4, NR7SO2R4, NR7CO2R4, NR7COR4, NH(C1-6)alquilNR5R6, C2-6 alquenilo, C2-6 alquinilo, C1-6 alquilo, donde los últimos tres grupos están opcionalmente sustituidos con uno o más sustituyentes seleccionados en forma independiente entre átomos de halógeno, CN, OR8 y NR5R6, S(O)xR7 donde x es 0, 1 ó 2; R4 representa arilo, heteroarilo, o C1-6 alquilo donde todos pueden estar opcionalmente sustituidos con uno o más sustituyentes seleccionados en forma independiente entre átomos de halógeno, arilo, heteroarilo, OR10, OH, NR11R12, S(O)xR13 (donde x = 0, 1 ó 2), CONR14R15, NR14COR15, SO2NR14R15, NR14SO2R15, CN, nitro; R5 y R6 representan en forma independiente un átomo de hidrógeno, un grupo C1-6 alquilo, o un arilo, o un heteroarilo, donde los últimos tres pueden estar opcionalmente sustituidos con uno o más sustituyentes seleccionados en forma independiente entre átomos de halógeno, arilo, OR8 y R14R15, CONR14R15, NR14COR15, SO2NR14R15, NR14SO2R15, CN, nitro, o R5 y R6 junto con el átomo de nitrógeno al cual está unidos pueden formar un anillo heterocíclico saturado de entre 3 y 8 miembros que contiene opcionalmente uno o más átomos seleccionados entre O, S(O)x donde x = 0, 1 ó 2, NR16 y a su vez está opcionalmente sustituido con C1-3 alquilo; R7 y R13 representan en forma independiente un grupo C1-6 alquilo, arilo o heteroarilo, donde todos pueden estar opcionalmente sustituidos con átomos de halógeno; R8 representa un átomo de hidrógeno, C(O)R9, C1-6 alquilo (sustituido opcionalmente con átomos de halógeno o arilo) un grupo arilo o heteroarilo (sustituido opcionalmente con halógeno); cada uno de R9, R10, R11, R12, R14, R15, representa en forma independiente un átomo de hidrógeno, C1-6 alquilo, un grupo arilo o heteroarilo (donde todos pueden estar opcionalmente sustituidos con átomos de halógeno); y R16 es hidrógeno, C1-4 alquilo, -CO(C1-4 alquilo), COY(C1-4 alquilo) donde Y es O o NR7.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0302232A SE0302232D0 (sv) | 2003-08-18 | 2003-08-18 | Novel Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR045462A1 true AR045462A1 (es) | 2005-10-26 |
Family
ID=28450248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040102959A AR045462A1 (es) | 2003-08-18 | 2004-08-18 | DERIVADOS DE INDOLES SUSTITUIDOS eTILES COMO COMPUESTOS FARMACEUTICOS PARA EL TRATAMIENTO DE ENFERMEDADES RESPIRATORIAS |
Country Status (18)
Country | Link |
---|---|
US (1) | US7709521B2 (es) |
EP (1) | EP1656347B1 (es) |
JP (1) | JP4709758B2 (es) |
AR (1) | AR045462A1 (es) |
AT (1) | ATE484494T1 (es) |
CY (1) | CY1110977T1 (es) |
DE (1) | DE602004029580D1 (es) |
DK (1) | DK1656347T3 (es) |
ES (1) | ES2352201T3 (es) |
MY (1) | MY143367A (es) |
PL (1) | PL1656347T3 (es) |
PT (1) | PT1656347E (es) |
SA (1) | SA04250255B1 (es) |
SE (1) | SE0302232D0 (es) |
SI (1) | SI1656347T1 (es) |
TW (1) | TW200510303A (es) |
UY (1) | UY28473A1 (es) |
WO (1) | WO2005019171A1 (es) |
Families Citing this family (46)
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SE0201635D0 (sv) | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
TW200307542A (en) | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
SE0202241D0 (sv) * | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
SE0301569D0 (sv) * | 2003-05-27 | 2003-05-27 | Astrazeneca Ab | Novel compounds |
SE0302232D0 (sv) | 2003-08-18 | 2003-08-18 | Astrazeneca Ab | Novel Compounds |
SE0303180D0 (sv) * | 2003-11-26 | 2003-11-26 | Astrazeneca Ab | Novel compounds |
CN1930162B (zh) | 2004-03-11 | 2010-06-16 | 埃科特莱茵药品有限公司 | 四氢吡啶并吲哚衍生物 |
CA2594280C (en) | 2004-12-27 | 2013-04-23 | Anja Fecher | 2,3,4,9-tetrahydro-1h-carbazole derivatives as crth2 receptor antagonists |
GB0500604D0 (en) | 2005-01-13 | 2005-02-16 | Astrazeneca Ab | Novel process |
GB0505048D0 (en) * | 2005-03-11 | 2005-04-20 | Oxagen Ltd | Compounds with PGD antagonist activity |
US7842692B2 (en) | 2005-07-22 | 2010-11-30 | Shionogi & Co., Ltd. | Azaindole derivative having PGD2 receptor antagonistic activity |
WO2007010964A1 (ja) | 2005-07-22 | 2007-01-25 | Shionogi & Co., Ltd. | Pgd2受容体アンタゴニスト活性を有するインドール誘導体 |
GB0521275D0 (en) * | 2005-10-19 | 2005-11-30 | Argenta Discovery Ltd | 3-Aminoindole compounds |
JP2009538289A (ja) | 2006-05-26 | 2009-11-05 | アストラゼネカ・アクチエボラーグ | ビアリールまたはヘテロアリール置換インドール |
US20150072963A1 (en) * | 2006-06-16 | 2015-03-12 | The Trustees Of The University Of Pennsylvania | Compositions and methods for regulating hair growth |
EP2037967B1 (en) | 2006-06-16 | 2016-12-07 | The Trustees Of The University Of Pennsylvania | Prostaglandin d2 receptor antagonists for treating androgenetic alopecia |
DK2046740T3 (da) | 2006-07-22 | 2012-08-20 | Oxagen Ltd | Forbindelser med CRTH2-antagonistisk virkning |
SI2051962T1 (sl) | 2006-08-07 | 2012-02-29 | Actelion Pharmaceuticals Ltd | Derivati (3-amino-1,2,3,4-tetrahidro-9h-karbazol-9-il)-ocetne kisline |
DK2133332T3 (da) | 2007-04-11 | 2013-09-30 | Kissei Pharmaceutical | (aza)indolderivat og anvendelse deraf til medicinske formål |
US7960567B2 (en) * | 2007-05-02 | 2011-06-14 | Amgen Inc. | Compounds and methods useful for treating asthma and allergic inflammation |
PT2327693E (pt) | 2007-12-14 | 2012-07-24 | Pulmagen Therapeutics Asthma Ltd | Indoles e sua utilização terapêutica |
WO2009090414A1 (en) | 2008-01-18 | 2009-07-23 | Oxagen Limited | Compounds having crth2 antagonist activity |
US7750027B2 (en) * | 2008-01-18 | 2010-07-06 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
EP2240444A1 (en) | 2008-01-22 | 2010-10-20 | Oxagen Limited | Compounds having crth2 antagonist activity |
JP2011509990A (ja) | 2008-01-22 | 2011-03-31 | オキサジェン リミテッド | Crth2アンタゴニスト活性を有する化合物 |
WO2009151910A2 (en) * | 2008-05-25 | 2009-12-17 | Wyeth | Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer |
EP2377851A4 (en) * | 2008-12-25 | 2012-06-20 | Taisho Pharmaceutical Co Ltd | isoquinoline |
TWI546537B (zh) * | 2009-05-19 | 2016-08-21 | 維維亞生技公司 | 提供針對血液腫瘤之體外個人化藥物測試之方法 |
BR112012000353B1 (pt) * | 2009-07-06 | 2020-06-02 | Astrazeneca Ab | Composto de fórmula markush, uso do composto, processos de reação com agente de acetilação e processo para preparação de um composto |
CA2789427A1 (en) * | 2010-02-11 | 2011-08-18 | Vanderbilt University | Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
KR101444572B1 (ko) | 2010-03-22 | 2014-09-24 | 액테리온 파마슈티칼 리미티드 | 3-(헤테로아릴-아미노)-1,2,3,4-테트라히드로-9h-카르바졸 유도체 및 이의 프로스타글란딘 d2 수용체 조절제로서의 용도 |
TW201212916A (en) | 2010-06-23 | 2012-04-01 | Taisho Pharmaceutical Co Ltd | Isoquinoline derivative |
EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
ES2596581T3 (es) | 2011-04-14 | 2017-01-10 | Actelion Pharmaceuticals Ltd. | Derivados de ácido 7-(heteroaril-amino)-6,7,8,9-tetrahidropirido[1,2-a]indol acético y su uso como moduladores del receptor de prostaglandina D2 |
EP2526945A1 (en) | 2011-05-25 | 2012-11-28 | Almirall, S.A. | New CRTH2 Antagonists |
EP2548863A1 (en) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists. |
EP2548876A1 (en) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists |
US20140328861A1 (en) | 2011-12-16 | 2014-11-06 | Atopix Therapeutics Limited | Combination of CRTH2 Antagonist and a Proton Pump Inhibitor for the Treatment of Eosinophilic Esophagitis |
CA2867901A1 (en) * | 2012-03-21 | 2013-09-26 | The Trustees Of The University Of Pennsylvania | Compositions and methods for regulating hair growth |
MY179356A (en) | 2014-03-17 | 2020-11-05 | Idorsia Pharmaceuticals Ltd | Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators |
CA2938107A1 (en) | 2014-03-18 | 2015-09-24 | Actelion Pharmaceuticals Ltd | Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators |
GB201407807D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
GB201407820D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
TWI695831B (zh) | 2014-09-13 | 2020-06-11 | 香港商南北兄弟藥業投資有限公司 | Crth2拮抗劑化合物及其用途 |
KR20180031019A (ko) | 2015-07-30 | 2018-03-27 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | Pgd2에 의한 모발 성장 억제에 대한 민감성의 검출을 위한 인간 dp―2 유전자의 단일 뉴클레오티드 다형성 대립유전자 |
TWI711616B (zh) | 2015-09-15 | 2020-12-01 | 瑞士商愛杜西亞製藥有限公司 | 結晶型式 |
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SE0200411D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
SE0200356D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
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TW200307542A (en) * | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
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SE0202241D0 (sv) * | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
SE0202463D0 (sv) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel compounds |
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SE0303180D0 (sv) | 2003-11-26 | 2003-11-26 | Astrazeneca Ab | Novel compounds |
GB0500604D0 (en) | 2005-01-13 | 2005-02-16 | Astrazeneca Ab | Novel process |
GB2422831A (en) | 2005-02-04 | 2006-08-09 | Oxagen Ltd | Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor |
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-
2003
- 2003-08-18 SE SE0302232A patent/SE0302232D0/xx unknown
-
2004
- 2004-08-06 TW TW093123728A patent/TW200510303A/zh unknown
- 2004-08-16 PT PT04768065T patent/PT1656347E/pt unknown
- 2004-08-16 DE DE602004029580T patent/DE602004029580D1/de active Active
- 2004-08-16 EP EP04768065A patent/EP1656347B1/en not_active Not-in-force
- 2004-08-16 JP JP2006523677A patent/JP4709758B2/ja not_active Expired - Fee Related
- 2004-08-16 AT AT04768065T patent/ATE484494T1/de active
- 2004-08-16 US US10/568,889 patent/US7709521B2/en not_active Expired - Fee Related
- 2004-08-16 MY MYPI20043328A patent/MY143367A/en unknown
- 2004-08-16 DK DK04768065.7T patent/DK1656347T3/da active
- 2004-08-16 SI SI200431554T patent/SI1656347T1/sl unknown
- 2004-08-16 PL PL04768065T patent/PL1656347T3/pl unknown
- 2004-08-16 WO PCT/GB2004/003502 patent/WO2005019171A1/en active Search and Examination
- 2004-08-16 SA SA04250255A patent/SA04250255B1/ar unknown
- 2004-08-16 ES ES04768065T patent/ES2352201T3/es active Active
- 2004-08-17 UY UY28473A patent/UY28473A1/es unknown
- 2004-08-18 AR ARP040102959A patent/AR045462A1/es not_active Application Discontinuation
-
2010
- 2010-12-09 CY CY20101101133T patent/CY1110977T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
DK1656347T3 (da) | 2011-01-10 |
WO2005019171A1 (en) | 2005-03-03 |
ATE484494T1 (de) | 2010-10-15 |
JP2007502804A (ja) | 2007-02-15 |
DE602004029580D1 (de) | 2010-11-25 |
SI1656347T1 (sl) | 2011-01-31 |
PT1656347E (pt) | 2010-12-09 |
UY28473A1 (es) | 2005-03-31 |
CY1110977T1 (el) | 2015-06-11 |
PL1656347T3 (pl) | 2011-02-28 |
MY143367A (en) | 2011-04-29 |
US20060264444A1 (en) | 2006-11-23 |
SE0302232D0 (sv) | 2003-08-18 |
ES2352201T3 (es) | 2011-02-16 |
SA04250255B1 (ar) | 2009-02-25 |
TW200510303A (en) | 2005-03-16 |
JP4709758B2 (ja) | 2011-06-22 |
EP1656347B1 (en) | 2010-10-13 |
EP1656347A1 (en) | 2006-05-17 |
US7709521B2 (en) | 2010-05-04 |
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