PE20130149A1 - Derivados de la cromenona con actividad anti-tumoral - Google Patents
Derivados de la cromenona con actividad anti-tumoralInfo
- Publication number
- PE20130149A1 PE20130149A1 PE2012000578A PE2012000578A PE20130149A1 PE 20130149 A1 PE20130149 A1 PE 20130149A1 PE 2012000578 A PE2012000578 A PE 2012000578A PE 2012000578 A PE2012000578 A PE 2012000578A PE 20130149 A1 PE20130149 A1 PE 20130149A1
- Authority
- PE
- Peru
- Prior art keywords
- ethyl
- alkyl
- halogen
- chromenone
- alcoxy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE CROMENONA DE FORMULA (I) DONDE R1 ES H O ALQUILO(C1-C4) OPCIONALMENTE SUSTITUIDO CON HALOGENO, HIDROXI O ALCOXI(C1-C3); R2 ES ALQUILO(C1-C4) O ALCOXI(C1-C4) OPCIONALMENTE SUSTITUIDO CON HALOGENO, HIDROXI, ALQUENILO(C2-C3), ENTRE OTROS; R3 ES H O ALQUILO(C1-C3); R4 Y R5 SON CADA UNO H, HALOGENO, ALQUILO(C1-C3), ALQUENILO(C2-C3), CN, ENTRE OTROS; R6, R7 Y R8 SON CADA UNO H, HALOGENO, ALQUILO(C1-C3), ALCOXI(C1-C3), ENTRE OTROS; R9 ES ALQUILO(C1-C3); n ES DE 0 A 4. SON COMPUESTOS PREFERIDOS: N-(2-(DIMETILAMINO)ETIL)-8-(1-(4-FLUOROFENILAMINO)ETIL)-2-MORFOLINO-4-OXO-4H-CROMENO-6-CARBOXAMIDA; N-(2-(DIMETILAMINO)ETIL)-2-MORFOLINO-4-OXO-8-(1-(FENILAMINO)ETIL)-4H-CROMENO-6-CARBOXAMIDA; 8-(1-(3-CLORO-2-FLUOROFENILAMINO)ETIL)-N-(2-(DIMETILAMINO)ETIL)-2-MORFOLINO-4-OXO-4H-CROMENO-6-CARBOXAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE FOSFOINOSITIDA (PI) 3-QUINASA ? SIENDO UTILES EN EL TRATAMIENTO DE CANCER
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09306017 | 2009-10-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20130149A1 true PE20130149A1 (es) | 2013-03-10 |
Family
ID=43085922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2012000578A PE20130149A1 (es) | 2009-10-27 | 2010-10-25 | Derivados de la cromenona con actividad anti-tumoral |
Country Status (41)
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
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JP5599783B2 (ja) | 2008-05-30 | 2014-10-01 | アムジエン・インコーポレーテツド | Pi3キナーゼの阻害薬 |
US8399460B2 (en) * | 2009-10-27 | 2013-03-19 | Astrazeneca Ab | Chromenone derivatives |
UY34013A (es) * | 2011-04-13 | 2012-11-30 | Astrazeneca Ab | ?compuestos de cromenona con actividad anti-tumoral?. |
AU2014208964B2 (en) | 2013-01-23 | 2016-09-01 | Astrazeneca Ab | Chemical compounds |
ES2754034T3 (es) * | 2013-03-04 | 2020-04-15 | Astrazeneca Ab | Combinación para el tratamiento de cáncer |
EA201692249A1 (ru) | 2014-06-13 | 2017-05-31 | Джилид Сайэнс, Инк. | Ингибиторы фосфатидилинозитол-3-киназы |
EP3154960A1 (en) | 2014-06-13 | 2017-04-19 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
CN106660994A (zh) | 2014-06-13 | 2017-05-10 | 吉利德科学公司 | 磷脂酰肌醇3‑激酶抑制剂 |
AU2015274637B2 (en) | 2014-06-13 | 2018-04-19 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
ES2763104T3 (es) | 2014-06-13 | 2020-05-27 | Gilead Sciences Inc | Derivados de quinazolinona como inhibidores de fosfatidilinositol 3-quinasa |
CN104803921A (zh) * | 2015-03-14 | 2015-07-29 | 长沙深橙生物科技有限公司 | 一种苯取代嘧啶衍生物的制备方法 |
CN104744376A (zh) * | 2015-03-14 | 2015-07-01 | 长沙深橙生物科技有限公司 | 一种2-异丙基嘧啶衍生物的制备方法 |
KR101766731B1 (ko) | 2015-06-23 | 2017-08-10 | 충남대학교산학협력단 | 강심 활성을 갖는 크로메논 유도체 및 이를 포함하는 심부전의 예방 또는 치료용 약학 조성물 |
EA037401B1 (ru) * | 2015-10-09 | 2021-03-24 | Янссен Фармацевтика Нв | Производные хиноксалина и пиридопиразина в качестве ингибиторов pi3k |
TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
WO2018057808A1 (en) | 2016-09-23 | 2018-03-29 | Gilead Sciences, Inc. | Benzimidazole derivatives and their use as phosphatidylinositol 3-kinase inhibitors |
TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
AR121719A1 (es) | 2020-04-03 | 2022-06-29 | Petra Pharma Corp | Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades |
KR20210141214A (ko) * | 2020-05-15 | 2021-11-23 | 제이투에이치바이오텍 (주) | 3원환 화합물 및 이의 의약 용도 |
WO2022164812A1 (en) * | 2021-02-01 | 2022-08-04 | Geode Therapeutics Inc. | Phosphoinositide 3 kinase beta inhibitors and compositions and methods thereof |
IL307950A (en) * | 2021-05-03 | 2023-12-01 | Petra Pharma Corp | Allosteric chromanone inhibitors of PHOSPHOINOSITIDE 3-KINASE (PI3K) for the treatment of diseases |
AU2022269566A1 (en) * | 2021-05-03 | 2023-11-02 | Petra Pharma Corporation | Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of disease |
AU2022282380A1 (en) * | 2021-05-27 | 2023-12-07 | Petra Pharma Corporation | Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of cancer |
WO2023104111A1 (en) * | 2021-12-08 | 2023-06-15 | Nanjing Zenshine Pharmaceuticals Co., Ltd. | Fused heterocyclic compounds as pi3kalpha inhibitors |
WO2024003241A1 (en) | 2022-06-30 | 2024-01-04 | Astrazeneca Ab | Treatment for immuno-oncology resistant subjects with an anti pd-l1 antibody an antisense targeted to stat3 and an inhibitor of ctla-4 |
WO2024081904A1 (en) * | 2022-10-14 | 2024-04-18 | Genesis Therapeutics, Inc. | Methods for treating cancer |
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HUT58310A (en) | 1988-12-21 | 1992-02-28 | Upjohn Co | Anti-atherosclerotic and anti-thrombotic 1-benzopyran-4-one- and 2-amino-1,3-benzoxazin-4-one derivatives, process for producing them and pharmaceutical compositions containing them |
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DE4318756A1 (de) | 1993-06-05 | 1994-12-08 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
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CA2495661C (en) * | 2002-08-16 | 2011-06-14 | Kinacia Pty Ltd. | Inhibition of phosphoinositide 3-kinase beta |
AR053358A1 (es) * | 2005-04-15 | 2007-05-02 | Cancer Rec Tech Ltd | Inhibidores de adn - pk |
CA2620248A1 (en) | 2005-10-21 | 2007-04-26 | Merz Pharma Gmbh & Co. Kgaa | Chromenones and their use as modulators of metabotropic glutamate receptors |
SI2004654T1 (sl) * | 2006-04-04 | 2013-11-29 | The Regents Of The University Of California | Pirazolopirimidinski derivati za uporabo kot kinazni antagonisti |
WO2008064244A2 (en) | 2006-11-20 | 2008-05-29 | The Trustees Of Columbia University In The City Of New York | Phosphoinositide modulation for the treatment of neurodegenerative diseases |
EP2112145A1 (en) | 2008-04-24 | 2009-10-28 | AxoGlia Therapeutics S.A. | Chromenone derivatives useful for the treatment of neurodegenerative diseases |
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US8399460B2 (en) * | 2009-10-27 | 2013-03-19 | Astrazeneca Ab | Chromenone derivatives |
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2010
- 2010-10-22 US US12/909,968 patent/US8399460B2/en active Active
- 2010-10-25 UA UAA201206000A patent/UA107474C2/uk unknown
- 2010-10-25 MX MX2012005027A patent/MX2012005027A/es active IP Right Grant
- 2010-10-25 NZ NZ599457A patent/NZ599457A/en not_active IP Right Cessation
- 2010-10-25 ES ES10769052T patent/ES2530943T3/es active Active
- 2010-10-25 WO PCT/GB2010/051788 patent/WO2011051704A1/en active Application Filing
- 2010-10-25 RS RS20150090A patent/RS53813B1/en unknown
- 2010-10-25 AU AU2010311107A patent/AU2010311107B9/en active Active
- 2010-10-25 IN IN3328DEN2012 patent/IN2012DN03328A/en unknown
- 2010-10-25 DK DK10769052.1T patent/DK2493870T3/en active
- 2010-10-25 EP EP10769052.1A patent/EP2493870B1/en active Active
- 2010-10-25 CN CN201410654983.0A patent/CN104447657B/zh active Active
- 2010-10-25 PL PL10769052T patent/PL2493870T3/pl unknown
- 2010-10-25 ME MEP-2015-21A patent/ME02050B/me unknown
- 2010-10-25 MY MYPI2012001831A patent/MY179833A/en unknown
- 2010-10-25 SI SI201030875T patent/SI2493870T1/sl unknown
- 2010-10-25 PE PE2012000578A patent/PE20130149A1/es active IP Right Grant
- 2010-10-25 CN CN201080060262.7A patent/CN102712615B/zh active Active
- 2010-10-25 JP JP2012535931A patent/JP5657010B2/ja active Active
- 2010-10-25 CA CA2776994A patent/CA2776994C/en active Active
- 2010-10-25 KR KR1020127012933A patent/KR101738195B1/ko active IP Right Grant
- 2010-10-25 BR BR112012010124A patent/BR112012010124B8/pt active IP Right Grant
- 2010-10-25 EA EA201200618A patent/EA020523B9/ru not_active IP Right Cessation
- 2010-10-25 PT PT10769052T patent/PT2493870E/pt unknown
- 2010-10-26 AR ARP100103937 patent/AR078786A1/es active IP Right Grant
- 2010-10-27 UY UY32978A patent/UY32978A/es not_active Application Discontinuation
- 2010-10-27 TW TW099136762A patent/TWI483939B/zh active
- 2010-10-27 SA SA110310808A patent/SA110310808B1/ar unknown
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2012
- 2012-04-15 IL IL219191A patent/IL219191A0/en not_active IP Right Cessation
- 2012-04-25 CL CL2012001056A patent/CL2012001056A1/es unknown
- 2012-04-26 CO CO12068977A patent/CO6541528A2/es active IP Right Grant
- 2012-04-27 CR CR20120217A patent/CR20120217A/es unknown
- 2012-04-27 GT GT201200126A patent/GT201200126A/es unknown
- 2012-04-27 NI NI201200081A patent/NI201200081A/es unknown
- 2012-04-27 DO DO2012000124A patent/DOP2012000124A/es unknown
- 2012-04-27 EC ECSP12011838 patent/ECSP12011838A/es unknown
- 2012-04-27 HN HN2012000889A patent/HN2012000889A/es unknown
- 2012-04-27 CU CU2012000069A patent/CU20120069A7/es unknown
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2013
- 2013-01-22 HK HK13100967.4A patent/HK1174027A1/xx unknown
- 2013-02-13 US US13/765,850 patent/US8673906B2/en active Active
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2014
- 2014-01-24 US US14/163,105 patent/US9029374B2/en active Active
- 2014-11-20 JP JP2014235289A patent/JP5872016B2/ja active Active
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2015
- 2015-02-05 HR HRP20150146TT patent/HRP20150146T1/hr unknown
- 2015-02-12 SM SM201500036T patent/SMT201500036B/xx unknown
- 2015-02-13 CY CY20151100157T patent/CY1116143T1/el unknown
- 2015-04-08 US US14/681,244 patent/US20160060240A1/en not_active Abandoned
- 2015-07-20 HK HK15106851.8A patent/HK1206335A1/zh unknown
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2016
- 2016-03-24 US US15/079,633 patent/US9718800B2/en active Active
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