AR049551A1 - Derivados de amino-5, 5-difenilimidazolona para la inhibicion de la beta-secretasa - Google Patents
Derivados de amino-5, 5-difenilimidazolona para la inhibicion de la beta-secretasaInfo
- Publication number
- AR049551A1 AR049551A1 ARP050102449A ARP050102449A AR049551A1 AR 049551 A1 AR049551 A1 AR 049551A1 AR P050102449 A ARP050102449 A AR P050102449A AR P050102449 A ARP050102449 A AR P050102449A AR 049551 A1 AR049551 A1 AR 049551A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- alkyl
- independently
- haloalkyl
- alkynyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
La presente proporciona un compuesto de formula (1) y su uso para el tratamiento terapéutico, prevencion o alivio de una enfermedad o trastorno caracterizado por elevados depositos b-amiloides o elevados niveles b-amiloides en un paciente. Reivindicacion 1: Un compuesto de formula (1), en la que W es CO, CS o CH2; X es N, NO o CR10; Y es N, NO o CR11; Z es N, NO o CR19 con la condicion que no más de dos de X, Y, o Z puedan ser N o NO; R1 y R2 son cada uno independientemente H, COR20; CO2R21 o un grupo alquilo C1-4 opcionalmente sustituido; R3 es H, OR12, o un grupo alquilo C1-6, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-8 o arilalquilo C1-6, cada uno opcionalmente sustituido; R4 y R5 son cada uno independientemente H, halogeno, NO2, CN, OR13, NR14R15 o un grupo alquilo C1-6, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6 o cicloalquilo C3-8, cada uno opcionalmente sustituido o cuando se encuentra unido a átomos de carbono adyacentes, R4 y R5 pueden tomarse juntos con los átomos a los que se encuentran unidos para formar un anillo de 5 a 7 miembros opcionalmente sustituido y que contiene opcionalmente uno o dos heteroátomos seleccionados entre O, N o S; R6, R7, R8, R9, R10, R11 y R19 son cada uno independientemente H, halogeno, NO2, CN, OR16, NR17R18 o un grupo alquilo C1-6, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6 o cicloalquilo C3-8, cada uno opcionalmente sustituido; n es 0 o 1; la línea punteada es un enlace simple cuando n es 0 o un doble enlace cuando n es 1; R12, R13, R16, R20 y R21 son cada uno independientemente H o un grupo alquilo C1-6, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-8 o arilo, cada uno opcionalmente sustituido; y R14, R15, R17 y R18 son cada uno independientemente H o alquilo C1-4; o un tautomero de los mismos, un estereoisomero de los mismos o una sal farmacéuticamente aceptable de los mismos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58028604P | 2004-06-16 | 2004-06-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR049551A1 true AR049551A1 (es) | 2006-08-16 |
Family
ID=34978791
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050102449A AR049551A1 (es) | 2004-06-16 | 2005-06-15 | Derivados de amino-5, 5-difenilimidazolona para la inhibicion de la beta-secretasa |
Country Status (23)
Country | Link |
---|---|
US (2) | US7482349B2 (es) |
EP (1) | EP1756087B1 (es) |
JP (1) | JP2008503459A (es) |
CN (1) | CN1968945A (es) |
AR (1) | AR049551A1 (es) |
AT (1) | ATE444962T1 (es) |
AU (1) | AU2005264915A1 (es) |
BR (1) | BRPI0512213A (es) |
CA (1) | CA2579724A1 (es) |
DE (1) | DE602005017033D1 (es) |
EC (1) | ECSP067068A (es) |
ES (1) | ES2332659T3 (es) |
GT (1) | GT200500158A (es) |
IL (1) | IL180017A0 (es) |
MX (1) | MXPA06014793A (es) |
NO (1) | NO20070247L (es) |
NZ (1) | NZ552031A (es) |
PA (1) | PA8637301A1 (es) |
PE (1) | PE20060459A1 (es) |
RU (1) | RU2006142552A (es) |
TW (1) | TW200602045A (es) |
WO (1) | WO2006009653A1 (es) |
ZA (1) | ZA200610592B (es) |
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- 2005-06-14 BR BRPI0512213-9A patent/BRPI0512213A/pt not_active IP Right Cessation
- 2005-06-14 PE PE2005000679A patent/PE20060459A1/es not_active Application Discontinuation
- 2005-06-14 AT AT05760367T patent/ATE444962T1/de not_active IP Right Cessation
- 2005-06-14 CA CA002579724A patent/CA2579724A1/en not_active Abandoned
- 2005-06-14 EP EP05760367A patent/EP1756087B1/en active Active
- 2005-06-14 JP JP2007516599A patent/JP2008503459A/ja active Pending
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- 2005-06-14 MX MXPA06014793A patent/MXPA06014793A/es active IP Right Grant
- 2005-06-14 WO PCT/US2005/020720 patent/WO2006009653A1/en active Application Filing
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- 2005-06-14 CN CNA2005800194491A patent/CN1968945A/zh active Pending
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BRPI0512213A (pt) | 2008-02-19 |
PE20060459A1 (es) | 2006-05-30 |
MXPA06014793A (es) | 2007-02-16 |
EP1756087A1 (en) | 2007-02-28 |
US20050282825A1 (en) | 2005-12-22 |
JP2008503459A (ja) | 2008-02-07 |
ATE444962T1 (de) | 2009-10-15 |
NZ552031A (en) | 2009-06-26 |
ECSP067068A (es) | 2007-01-26 |
GT200500158A (es) | 2006-03-02 |
NO20070247L (no) | 2007-02-13 |
DE602005017033D1 (de) | 2009-11-19 |
CA2579724A1 (en) | 2006-01-26 |
US7482349B2 (en) | 2009-01-27 |
RU2006142552A (ru) | 2008-07-27 |
US20090093498A1 (en) | 2009-04-09 |
AU2005264915A1 (en) | 2006-01-26 |
ZA200610592B (en) | 2009-09-30 |
TW200602045A (en) | 2006-01-16 |
PA8637301A1 (es) | 2006-06-02 |
ES2332659T3 (es) | 2010-02-10 |
WO2006009653A1 (en) | 2006-01-26 |
IL180017A0 (en) | 2007-05-15 |
EP1756087B1 (en) | 2009-10-07 |
CN1968945A (zh) | 2007-05-23 |
US7700602B2 (en) | 2010-04-20 |
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