AR036347A1 - Compuestos heterociclicos con actividades hipolipidemicas e hipocolesterolemicas, el proceso para su preparacion,las composiciones farmaceuticas que los contienen y su uso en medicina. - Google Patents

Compuestos heterociclicos con actividades hipolipidemicas e hipocolesterolemicas, el proceso para su preparacion,las composiciones farmaceuticas que los contienen y su uso en medicina.

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Publication number
AR036347A1
AR036347A1 ARP020102839A ARP020102839A AR036347A1 AR 036347 A1 AR036347 A1 AR 036347A1 AR P020102839 A ARP020102839 A AR P020102839A AR P020102839 A ARP020102839 A AR P020102839A AR 036347 A1 AR036347 A1 AR 036347A1
Authority
AR
Argentina
Prior art keywords
alkyl
substituted
alkylaminoinokylamino
unsubstituted
aralkyl
Prior art date
Application number
ARP020102839A
Other languages
English (en)
Inventor
Braj B Lohray
Vidya B Lohray
Saurin K Raval
Vijay K G Barot
Preeti S Raval
Sujay Basu
Original Assignee
Cadila Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd filed Critical Cadila Healthcare Ltd
Publication of AR036347A1 publication Critical patent/AR036347A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
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    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • G—PHYSICS
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    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F3/00—Input arrangements for transferring data to be processed into a form capable of being handled by the computer; Output arrangements for transferring data from processing unit to output unit, e.g. interface arrangements
    • G06F3/14—Digital output to display device ; Cooperation and interconnection of the display device with other functional units
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09G—ARRANGEMENTS OR CIRCUITS FOR CONTROL OF INDICATING DEVICES USING STATIC MEANS TO PRESENT VARIABLE INFORMATION
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    • G06F3/14—Digital output to display device ; Cooperation and interconnection of the display device with other functional units
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Abstract

Compuestos heterocíclicos con actividades hipolipidémicas e hipocolesterolémicas de fórmula (1) en donde sus derivados, sus análogos, sus formas tautoméricas, sus estereoisómeros, sus polimorfos, sus sales farmacéuticamente aceptables, sus solvatos farmacéuticamente aceptables, en donde: R1, R2, R3 y R4 pueden ser iguales o diferentes y representar hidrógeno, halógeno, haloalquilo, perhaloalquilo, haloalcoxi, perhaloalcoxi, hidroxi, tio, amino, nitro, ciano, formilo, amidino, guanidino o grupos sustituidos o no sustituidos seleccionados de alquilo C1-12 lineal o ramificado, alquenilo C1-12 lineal o ramificado, alquinilo C1-12 lineal o ramificado, cicloalquilo C3-7, cicloalquenilo C3-7, bicicloalquilo, bicicloalquenilo, alcoxi C1-12, alquenoxi C1-12, cicloalcoxi C3-7, arilo, ariloxi, aralquilo, aralcoxi C1-12, heterociclilo, heteroarilo, heterociclilo-alquilo C1-12, heteroaralquilo C1-12, heteroariloxi, heteroaralcoxi C1-12, heterocicloxi, heterociclilalquiloxi, acilo, aciloxi, acilamino, amino monosustituido o di-sustituido, arilamino, aralquilamino, ácido carboxílico y sus derivados tales como ésteres y amidas, hidroxialquilo, aminoalquilo; aminoalquilo mono-sustituido o di-sustituido, alcoxialquilo, ariloxialquilo, aralcoxialquilo, alquiltio C1-12, tio-alquilo C1-12, ariltio, alcoxicarbonilamino C1-12, ariloxicarbonilamino, aralquiloxicarbonilamino, aminocarbonilamino, alquilaminocarbonilamino, alquilamidino, alquilguanidino, dialquilguanidino, hidracino, alquil hidracino, alcoxiamino, hidroxil amino, derivados de los grupos sulfenilo y sulfonilo, ácido sulfónico y sus derivados, ácido fosfónico y sus derivados; n representa un número entero que varía entre 1 y 8; W representa O, S o NR9, en donde R9 representa hidrógeno, grupos alquilo C1-12 o arilo; Ar representa un grupo aromático, heteroaromático o heterocíclico divalente simple o fusionado, y sustituido o no sustituido; R5 y R6 representan ambos hidrógeno o juntos representan un enlace o pueden también representar un grupo hidroxi, alquilo C1-12, alcoxi C1-12, halógeno, acilo, aralquilo sustituido o no sustituido; X representa O ó S; R7 representa hidrógeno, perfluoroalquilo C1-12, grupos sustituidos o no sustituidos seleccionados de alquilo C1-12, cicloalquilo C1-12, arilo, aralquilo C1-12, heteroarilo, heteroaralquilo C1-12, heterociclilo, alcoxialquilo, ariloxialquilo, alcoxicarbonilo, ariloxicarbonilo, cicloalquiloxicarbonilo, alquilaminocarbonilo, arilaminocarbonilo, o acilo lineales o ramificados; Y representa O ó S; Z representa O, S ó NR10, en donde R10 representa hidrógeno o grupos sustituidos o no sustituidos seleccionados de grupos alquilo C1-12, arilo, aralquilo C1-12, hidroxi-alquilo C1-12, amino-alquilo C1-12, heteroarilo o heteroaralquilo C1-12; R8 representa hidrógeno, grupos sustituidos o no sustituidos seleccionados de grupos alquilo C1-12, arilo, aralquilo C1-12, heteroarilo, heteroaralquilo C1-12, heterociclilo, heterociclilalquilo, hidroxialquilo, alcoxialquilo o alquilaminoalquilo lineales o ramificados; R10 y R8 juntos pueden formar una estructura de anillo heterocíclico sustituida o no sustituida, de 5 ó 6 miembros, con uno o más heteroátomos seleccionados de O, N ó S. La presente también está relacionada al proceso para la preparación de tales compuestos, una composición que contiene tal compuesto, y el uso de tal compuesto y composición en medicina.
ARP020102839A 2001-07-26 2002-07-26 Compuestos heterociclicos con actividades hipolipidemicas e hipocolesterolemicas, el proceso para su preparacion,las composiciones farmaceuticas que los contienen y su uso en medicina. AR036347A1 (es)

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IN711MU2001 2001-07-26

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AR036347A1 true AR036347A1 (es) 2004-09-01

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