AR054484A1 - Derivados de 2-azetidinonas como inhibidores de la absorcion de colesterol - Google Patents
Derivados de 2-azetidinonas como inhibidores de la absorcion de colesterolInfo
- Publication number
- AR054484A1 AR054484A1 ARP060102624A ARP060102624A AR054484A1 AR 054484 A1 AR054484 A1 AR 054484A1 AR P060102624 A ARP060102624 A AR P060102624A AR P060102624 A ARP060102624 A AR P060102624A AR 054484 A1 AR054484 A1 AR 054484A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- hydrogen
- amino
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Su uso como inhibidores de la absorcion del colesterol para el tratamiento de hiperlipidemia. También se describen procesos para su preparacion y composiciones farmacéuticas que los contienen. Reivindicacion 1: Un unico compuesto diastereoisomerico de la formula (1), donde: R1 es hidrogeno, alquilo 1-6, cicloalquilo C3-6 o arilo; donde dicho alquilo C1-6 puede estar opcionalmente sustituido con uno o varios hidroxi, amino, guanidino, carbamoilo, carboxi, alcoxi C1-6, N-(alquilC1-6)amino, N,N- (alquilC1-6)amino, alquilC1-6-carbonilamino, alquilC1-6-S(O)a, donde a es 0-2, cicloalquilo C3-6 o arilo; y donde cualquier grupo arilo puede estar opcionalmente sustituido con uno o dos sustituyentes seleccionados de halo, hidroxi, alquilo C1-6 o alcoxi C1-6; R2 es hidrogeno, un alquilo C1-6 ramificado o no ramificado, cicloalquilo C3-8 o arilo; donde dicho alquilo C1-6 puede estar opcionalmente sustituido con uno o varios hidroxi, amino, guanidino, carbamoilo, carboxi, alcoxi C1-6, (alquiloC1-4)3Si, N-(alquilC1-6)amino, N,N-(alquilC1-6)2amino, alquilC1-6S(O)a, donde a es 0-2, cicloalquilo C3-6 o arilo; y donde cualquier grupo arilo puede estar opcionalmente sustituido con uno o dos sustituyentes seleccionados de halo, hidroxi, alquilo C16 o alcoxi C1-6; R3 es hidrogeno, alquilo, halo o alcoxi C1-6; R4 es hidrogeno, halo o alcoxi C1-6; R5 es hidrogeno, alquilo C1-6, arilalquilo, o arilalquilo C1-6; R6 es hidrogeno, alquilo C1-6, o arilalquilo C1-6; donde R5 y R2 pueden formar un anillo con C2-7 y donde R6 y R2 pueden formar un anillo C3-6; o una de sus sales, solvatos, solvatos de tales sales o uno de sus profármacos farmacéuticamente aceptables.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0501425 | 2005-06-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR054484A1 true AR054484A1 (es) | 2007-06-27 |
Family
ID=37570721
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060102624A AR054484A1 (es) | 2005-06-20 | 2006-06-20 | Derivados de 2-azetidinonas como inhibidores de la absorcion de colesterol |
Country Status (18)
Country | Link |
---|---|
US (1) | US7863265B2 (es) |
EP (1) | EP1896407A4 (es) |
JP (1) | JP2008546766A (es) |
KR (1) | KR20080019710A (es) |
CN (1) | CN101228123A (es) |
AR (1) | AR054484A1 (es) |
AU (1) | AU2006259949A1 (es) |
BR (1) | BRPI0612254A2 (es) |
CA (1) | CA2610890A1 (es) |
EC (1) | ECSP088114A (es) |
IL (1) | IL187736A0 (es) |
MX (1) | MX2007016483A (es) |
NO (1) | NO20076137L (es) |
RU (1) | RU2007147338A (es) |
TW (1) | TW200730493A (es) |
UY (1) | UY29607A1 (es) |
WO (1) | WO2006137782A1 (es) |
ZA (1) | ZA200710415B (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE602004029715D1 (de) | 2003-12-23 | 2010-12-02 | Astrazeneca Ab | Diphenylazetidinonderivate mit die cholesterinabsorption hemmender wirkung |
UY29607A1 (es) | 2005-06-20 | 2007-01-31 | Astrazeneca Ab | Compuestos quimicos |
MY148538A (en) * | 2005-06-22 | 2013-04-30 | Astrazeneca Ab | Novel 2-azetidinone derivatives as cholesterol absorption inhibitors for the treatment of hyperlipidaemic conditions |
SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
TW200811098A (en) | 2006-04-27 | 2008-03-01 | Astrazeneca Ab | Chemical compounds |
AU2007283113A1 (en) | 2006-08-08 | 2008-02-14 | Sanofi-Aventis | Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
DE102007054497B3 (de) | 2007-11-13 | 2009-07-23 | Sanofi-Aventis Deutschland Gmbh | Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung |
UY31968A (es) | 2008-07-09 | 2010-01-29 | Sanofi Aventis | Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos |
WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
CA2754384A1 (en) | 2009-03-06 | 2010-09-10 | Lipideon Biotechnology Ag | Pharmaceutical hypocholesterolemic compositions |
KR20120060207A (ko) | 2009-08-26 | 2012-06-11 | 사노피 | 신규한 결정성 헤테로방향족 플루오로글리코시드 수화물, 이들 화합물을 포함하는 약제 및 이들의 용도 |
EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
EP2683700B1 (de) | 2011-03-08 | 2015-02-18 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
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-
2006
- 2006-06-16 UY UY29607A patent/UY29607A1/es unknown
- 2006-06-19 US US11/993,033 patent/US7863265B2/en not_active Expired - Fee Related
- 2006-06-19 MX MX2007016483A patent/MX2007016483A/es not_active Application Discontinuation
- 2006-06-19 WO PCT/SE2006/000741 patent/WO2006137782A1/en active Application Filing
- 2006-06-19 KR KR1020087001031A patent/KR20080019710A/ko not_active Application Discontinuation
- 2006-06-19 JP JP2008518077A patent/JP2008546766A/ja active Pending
- 2006-06-19 CA CA002610890A patent/CA2610890A1/en not_active Abandoned
- 2006-06-19 RU RU2007147338/04A patent/RU2007147338A/ru not_active Application Discontinuation
- 2006-06-19 EP EP06747933A patent/EP1896407A4/en not_active Withdrawn
- 2006-06-19 AU AU2006259949A patent/AU2006259949A1/en not_active Abandoned
- 2006-06-19 BR BRPI0612254A patent/BRPI0612254A2/pt not_active IP Right Cessation
- 2006-06-19 CN CNA2006800264766A patent/CN101228123A/zh active Pending
- 2006-06-20 AR ARP060102624A patent/AR054484A1/es unknown
- 2006-06-20 TW TW095122114A patent/TW200730493A/zh unknown
-
2007
- 2007-11-28 IL IL187736A patent/IL187736A0/en unknown
- 2007-11-28 NO NO20076137A patent/NO20076137L/no not_active Application Discontinuation
- 2007-11-30 ZA ZA200710415A patent/ZA200710415B/xx unknown
-
2008
- 2008-01-17 EC EC2008008114A patent/ECSP088114A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN101228123A (zh) | 2008-07-23 |
TW200730493A (en) | 2007-08-16 |
IL187736A0 (en) | 2008-08-07 |
AU2006259949A1 (en) | 2006-12-28 |
US20100216759A1 (en) | 2010-08-26 |
BRPI0612254A2 (pt) | 2016-09-06 |
KR20080019710A (ko) | 2008-03-04 |
RU2007147338A (ru) | 2009-07-27 |
ZA200710415B (en) | 2008-10-29 |
JP2008546766A (ja) | 2008-12-25 |
NO20076137L (no) | 2008-01-18 |
MX2007016483A (es) | 2008-03-10 |
WO2006137782A1 (en) | 2006-12-28 |
US7863265B2 (en) | 2011-01-04 |
ECSP088114A (es) | 2008-02-20 |
CA2610890A1 (en) | 2006-12-28 |
UY29607A1 (es) | 2007-01-31 |
EP1896407A4 (en) | 2010-06-16 |
EP1896407A1 (en) | 2008-03-12 |
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