CY1105035T1 - Συγχωνευμενα με αρυλιο ή ετεροαρυλιο παραγωγα της ιμιδαζολης ως αντιφλεγμονωδεις και αναλγητικοι παραγοντες - Google Patents

Συγχωνευμενα με αρυλιο ή ετεροαρυλιο παραγωγα της ιμιδαζολης ως αντιφλεγμονωδεις και αναλγητικοι παραγοντες

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Publication number
CY1105035T1
CY1105035T1 CY20061100447T CY061100447T CY1105035T1 CY 1105035 T1 CY1105035 T1 CY 1105035T1 CY 20061100447 T CY20061100447 T CY 20061100447T CY 061100447 T CY061100447 T CY 061100447T CY 1105035 T1 CY1105035 T1 CY 1105035T1
Authority
CY
Cyprus
Prior art keywords
alkyl
aromatic ring
membered monocyclic
optionally containing
ring optionally
Prior art date
Application number
CY20061100447T
Other languages
English (en)
Inventor
Kazunari Nakao
Yoshiyuki Okumura
Miyako Matsumizu
Naomi Uneo
Yoshinobu Hashizume
Tomoki Kato
Akiyoshi Kawai
Yoriko Miyake
Seiji Nukui
Katsuhiro Shinjyo
Kana Taniguchi
Original Assignee
Pfizer Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Pharmaceuticals Inc. filed Critical Pfizer Pharmaceuticals Inc.
Publication of CY1105035T1 publication Critical patent/CY1105035T1/el

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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Abstract

Η παρούσα εφεύρεση παρέχει μία ένωση τύπου (I) ή τα φαρμακευτικά αποδεκτά άλατά της, στην οποία τα Υ1, Υ2, Υ3 και Υ4 επιλέγονται ανεξάρτητα από Ν, CH, κλπ.· το R1 είναι Η, αλκύλιο με C1-8, κλπ.· το Q1 είναι ένας μονοκυκλικός ή δικυκλικός αρωματικός δακτύλιος με 5-12 μέλη προαιρετικά περιέχων έως 4 ετεροάτομα επιλεγόμενα από Ο, Ν και S, κλπ.· το Α είναι ένας μονοκυκλικός αρωματικός δακτύλιος με 5-6 μέλη προαιρετικά περιέχων έως 3 ετεροάτομα επιλεγόμενα από Ο, Ν και S, κλπ.· το Β είναι αλκυλένιο με C1-6 προαιρετικά υποκατασταθέν με μία οξοομάδα κλπ.· το W είναι ΝΗ, Ο, κλπ.· το R2 είναι Η, αλκύλιο με C1-4, κλπ.· το Ζ είναι μονοκυκλικός ή δικυκλικός αρωματικός δακτύλιος με 5-12 μέλη περιέχων προαιρετικά έως 3 ετεροάτομα επιλεγόμενα από Ο, Ν και S, κλπ.· το L είναι αλογόνο, αλκύλιο με C1-4, κλπ.· το m είναι 0, 1 ή 2· τα R3 και R4 επιλέγονται ανεξάρτητα από Η και αλκύλιο με C1-4· το R5 είναι Η, αλκύλιο με C1-4, κλπ.· το Q2 είναι ένας μονοκυκλικός ή δικυκλικός αρωματικός δακτύλιος με 5-12 μέλη προαιρετικά περιέχων έως 3 ετεροάτομα επιλεγόμενα από Ο, Ν και S, κλπ. Αυτές οι ενώσεις είναι χρήσιμες για την αγωγή ιατρικών καταστάσεων στις οποίες μεσολαβεί η προσταγλανδίνη όπως ο πόνος, ο πυρετός ή η φλεγμονή, κλπ. Η παρούσα εφεύρεση παρέχει επίσης μία φαρμακευτική σύνθεση περιλαμβάνουσα την ανωτέρω ένωση.
CY20061100447T 2000-10-19 2006-03-30 Συγχωνευμενα με αρυλιο ή ετεροαρυλιο παραγωγα της ιμιδαζολης ως αντιφλεγμονωδεις και αναλγητικοι παραγοντες CY1105035T1 (el)

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