AR033681A1 - Un compuesto derivado de 7-oxo-piridopirimidinas, un proceso para su obtencion, una composicion que lo contiene y un metodo de fabricacion de un medicamento - Google Patents
Un compuesto derivado de 7-oxo-piridopirimidinas, un proceso para su obtencion, una composicion que lo contiene y un metodo de fabricacion de un medicamentoInfo
- Publication number
- AR033681A1 AR033681A1 ARP010104132A ARP010104132A AR033681A1 AR 033681 A1 AR033681 A1 AR 033681A1 AR P010104132 A ARP010104132 A AR P010104132A AR P010104132 A ARP010104132 A AR P010104132A AR 033681 A1 AR033681 A1 AR 033681A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkyl
- hydrogen
- oxo
- compound derived
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- AIDS & HIV (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un compuesto derivado de 7-oxo-piridopirimidina de fórmula (1) en la cual R1 es hidrógeno o alquilo; R2 es cicloalquilo sustituido, cicloalquilo heterosustituido, cicloalquilo heteroalquilsustituido, cicloalquilalquilo, heterosustituido, heterociclilo, heterociclilo- espiro-cicloalquilo, aralcoxi, alcoxi, alquil-S(O)n-alquileno-(en el que n es el número 1 o 2) o -SO2-Ar2;; R3 es hidrogeno, amino, monoalquilamino, dialquilamino, acilamino, -NRa-C(=O)-Rb (en el que Ra es hidrógeno o alquilo y Rb es heterociclilo o heteroalquilo), alquilo, cicloalquilo, arilo, aralquilo, haloalquilo, heteroalquilo, cianoalquilo, -alquileno-C(O)-R (en el que R es hidrógeno, alquilo, hidroxi, alcoxi, amino, monoalquilamino o dialquilamino), acilo o ftalimidoalquilo; y Ar1 y Ar2 con independencia entre sí son en cada caso arilo; o sales farmacéuticamente aceptables o profármacos del mismo. Un proceso para su obtención, una composición que lo contiene y un método para la fabricación de un medicamento. El compuesto derivado de 7-oxo-piridopirimidina es útil para los trastornos causados por p38, en el que el trastorno causado por p38 se selecciona entre la artritis, la enfermedad de Crohn, la enfermedad de Alzheimer, el síndrome de intestino irritable, el síndrome de la deficiencia respiratoria adulta y la enfermedad pulmonar obstructiva crónica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22958400P | 2000-08-31 | 2000-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR033681A1 true AR033681A1 (es) | 2004-01-07 |
Family
ID=22861859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010104132A AR033681A1 (es) | 2000-08-31 | 2001-08-30 | Un compuesto derivado de 7-oxo-piridopirimidinas, un proceso para su obtencion, una composicion que lo contiene y un metodo de fabricacion de un medicamento |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1315726A1 (es) |
| JP (1) | JP4141830B2 (es) |
| KR (1) | KR100571339B1 (es) |
| CN (1) | CN1275964C (es) |
| AR (1) | AR033681A1 (es) |
| AU (2) | AU9378401A (es) |
| BR (1) | BR0113628A (es) |
| CA (1) | CA2420286A1 (es) |
| GT (1) | GT200100191A (es) |
| MX (1) | MXPA03001821A (es) |
| PA (1) | PA8527301A1 (es) |
| PE (1) | PE20020406A1 (es) |
| UY (1) | UY26918A1 (es) |
| WO (1) | WO2002018380A1 (es) |
| ZA (1) | ZA200301079B (es) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6518276B2 (en) | 2000-08-31 | 2003-02-11 | Syntex (U.S.A.) Llc | 7-oxo-pyridopyrimidines (II) |
| ES2243568T3 (es) * | 2000-08-31 | 2005-12-01 | F. Hoffmann-La Roche Ag | 7-oxo-piridopirimidinas. |
| MXPA04009585A (es) * | 2002-04-03 | 2005-01-11 | Hoffmann La Roche | Compuestos imidazo fusionados. |
| WO2003088972A1 (en) * | 2002-04-19 | 2003-10-30 | Smithkline Beecham Corporation | Novel compounds |
| US7084270B2 (en) | 2002-08-14 | 2006-08-01 | Hoffman-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
| UY27939A1 (es) | 2002-08-21 | 2004-03-31 | Glaxo Group Ltd | Compuestos |
| US7112676B2 (en) | 2002-11-04 | 2006-09-26 | Hoffmann-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
| ATE427951T1 (de) * | 2002-11-18 | 2009-04-15 | Hoffmann La Roche | Diazinopyrimidine und ihre verwendung als proteinkinaseinhibitoren |
| US7098332B2 (en) | 2002-12-20 | 2006-08-29 | Hoffmann-La Roche Inc. | 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones |
| KR20050111636A (ko) | 2003-04-10 | 2005-11-25 | 에프. 호프만-라 로슈 아게 | 피리미도 화합물 |
| DE602004024536D1 (de) * | 2003-07-07 | 2010-01-21 | Van Andel Res Inst | Hemmung der tumor-angiogenese durch eine kombination von thrombospondin-1 und hemmern des vaskulären endothel-wachstumsfaktors |
| DE602004005238T2 (de) * | 2003-11-13 | 2007-11-08 | F. Hoffmann-La Roche Ag | Hydroxyalkylsubstituierte pyrido-7-pyrimidin-7-one |
| WO2005105097A2 (en) * | 2004-04-28 | 2005-11-10 | Gpc Biotech Ag | Pyridopyrimidines for treating inflammatory and other diseases |
| US20070054916A1 (en) * | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| US20090131430A1 (en) * | 2004-11-23 | 2009-05-21 | Palle Venkata P | Pyrido'2,3-dipyrimidines as anti-inflammatory agents |
| WO2006082492A1 (en) * | 2005-02-02 | 2006-08-10 | Ranbaxy Laboratories Limited | Azabicyclo derivatives as anti-inflammatory agents |
| EP1931667A1 (en) * | 2005-09-28 | 2008-06-18 | Ranbaxy Laboratories Limited | Pyrido-pyridimidine derivatives useful as antiinflammatory agents |
| CA2636981A1 (en) | 2006-01-31 | 2007-08-09 | F. Hoffmann-La Roche Ag | 7h-pyrido[3,4-d]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors |
| KR100661523B1 (ko) * | 2006-06-09 | 2006-12-26 | 주식회사 청용산기 | 포장박스 제조장치에 장착되는 개선된 비틀림 교정 장치 |
| EP1914234A1 (en) | 2006-10-16 | 2008-04-23 | GPC Biotech Inc. | Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors |
| WO2008055842A1 (en) | 2006-11-09 | 2008-05-15 | F. Hoffmann-La Roche Ag | Substituted 6-phenyl-pyrido [2,3-d] pyrimidin-7-one derivatives as kinase inhibitors and methods for using the same |
| WO2008078249A1 (en) * | 2006-12-21 | 2008-07-03 | Ranbaxy Laboratories Limited | Anti-inflammatory agents |
| EP2112150B1 (en) | 2008-04-22 | 2013-10-16 | Forma Therapeutics, Inc. | Improved raf inhibitors |
| KR101106162B1 (ko) * | 2010-04-20 | 2012-01-20 | 주식회사 청용산기 | 포장박스 제조장치용 스티칭 장치에 있어서의 하역가이드 지지유닛 |
| MX360912B (es) * | 2012-03-22 | 2018-11-22 | Oscotec Inc | Compuestos de piridopirimidina sustituida y su uso como inhibidores de tirosina cinasa 3 similar a fms. |
| JP6576325B2 (ja) | 2013-03-15 | 2019-09-18 | セルジーン シーエーアール エルエルシー | ヘテロアリール化合物およびそれらの使用 |
| MY181020A (en) | 2013-03-15 | 2020-12-16 | Sanofi Sa | Heteroaryl compounds and uses thereof |
| AR095464A1 (es) | 2013-03-15 | 2015-10-21 | Celgene Avilomics Res Inc | Compuestos de heteroarilo y usos de los mismos |
| AU2015316120B2 (en) | 2014-09-12 | 2018-05-17 | Biolab Sanus Farmaceutica Ltda. | New pyridopyrimidines derivatives compounds |
| BR112020006169A2 (pt) | 2017-10-05 | 2020-10-20 | Fulcrum Therapeutics, Inc. | inibidores de quinase p38 que reduzem dux4 e expressão de gene a jusante para o tratamento de fshd |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| EP3941919A1 (en) * | 2019-01-03 | 2022-01-26 | Genentech, Inc. | Pyrido-pyrimidinone and pteridinone compounds as inhibitors of endoribonuclease inositol requiring enzyme i (ire i alpha) for the treatment of cancer diseases |
| AU2020284018A1 (en) * | 2019-05-31 | 2022-01-27 | Les Laboratoires Servier | Heterobicyclic inhibitors of MAT2A and methods of use for treating cancer |
| CN115960098A (zh) * | 2020-09-11 | 2023-04-14 | 上海凌达生物医药有限公司 | 一类含氮稠环类化合物的制备方法和用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GEP20012444B (en) * | 1994-11-14 | 2001-05-25 | Warner Lambert Company Us | 6-Aryl Pyrido[2,3-d]Pyrimidines and Naphthyridines, Pharmaceutical Composition on Their Basis and Application for Inhibiting Cellular Proliferation |
| IL117923A (en) * | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| BR9911590A (pt) * | 1998-05-26 | 2001-02-13 | Warner Lambert Co | Pirimidinas bicìclicas e 3,4-diidropirimidinas bicìclicas como inibidores da proliferação celular |
-
2001
- 2001-08-22 EP EP01974206A patent/EP1315726A1/en not_active Withdrawn
- 2001-08-22 BR BR0113628-3A patent/BR0113628A/pt not_active Application Discontinuation
- 2001-08-22 CA CA002420286A patent/CA2420286A1/en not_active Abandoned
- 2001-08-22 JP JP2002523895A patent/JP4141830B2/ja not_active Expired - Fee Related
- 2001-08-22 WO PCT/EP2001/009689 patent/WO2002018380A1/en not_active Application Discontinuation
- 2001-08-22 KR KR1020037002936A patent/KR100571339B1/ko not_active IP Right Cessation
- 2001-08-22 CN CNB018150306A patent/CN1275964C/zh not_active Expired - Fee Related
- 2001-08-22 AU AU9378401A patent/AU9378401A/xx active Pending
- 2001-08-22 MX MXPA03001821A patent/MXPA03001821A/es active IP Right Grant
- 2001-08-22 AU AU2001293784A patent/AU2001293784B2/en not_active Ceased
- 2001-08-28 PE PE2001000860A patent/PE20020406A1/es not_active Application Discontinuation
- 2001-08-28 PA PA20018527301A patent/PA8527301A1/es unknown
- 2001-08-30 AR ARP010104132A patent/AR033681A1/es unknown
- 2001-08-30 UY UY26918A patent/UY26918A1/es not_active Application Discontinuation
- 2001-09-18 GT GT200100191A patent/GT200100191A/es unknown
-
2003
- 2003-02-07 ZA ZA200301079A patent/ZA200301079B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU9378401A (en) | 2002-03-13 |
| JP2004507541A (ja) | 2004-03-11 |
| AU2001293784B2 (en) | 2007-08-30 |
| JP4141830B2 (ja) | 2008-08-27 |
| ZA200301079B (en) | 2004-05-07 |
| CA2420286A1 (en) | 2002-03-07 |
| EP1315726A1 (en) | 2003-06-04 |
| KR100571339B1 (ko) | 2006-04-17 |
| PE20020406A1 (es) | 2002-05-17 |
| BR0113628A (pt) | 2003-07-01 |
| MXPA03001821A (es) | 2003-06-04 |
| WO2002018380A1 (en) | 2002-03-07 |
| KR20030022422A (ko) | 2003-03-15 |
| GT200100191A (es) | 2002-05-16 |
| CN1451005A (zh) | 2003-10-22 |
| UY26918A1 (es) | 2002-02-28 |
| CN1275964C (zh) | 2006-09-20 |
| PA8527301A1 (es) | 2002-07-30 |
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| Date | Code | Title | Description |
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| FB | Suspension of granting procedure |