AR030055A1 - Proceso para la preparacion de derivados de resorcinol y compuestos intermediarios - Google Patents

Proceso para la preparacion de derivados de resorcinol y compuestos intermediarios

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Publication number
AR030055A1
AR030055A1 ARP010101165A ARP010101165A AR030055A1 AR 030055 A1 AR030055 A1 AR 030055A1 AR P010101165 A ARP010101165 A AR P010101165A AR P010101165 A ARP010101165 A AR P010101165A AR 030055 A1 AR030055 A1 AR 030055A1
Authority
AR
Argentina
Prior art keywords
alkyl
formula
compound
aryl
alkoxy
Prior art date
Application number
ARP010101165A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR030055A1 publication Critical patent/AR030055A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/06—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by conversion of non-aromatic six-membered rings or of such rings formed in situ into aromatic six-membered rings, e.g. by dehydrogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/06—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by conversion of non-aromatic six-membered rings or of such rings formed in situ into aromatic six-membered rings, e.g. by dehydrogenation
    • C07C37/07—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by conversion of non-aromatic six-membered rings or of such rings formed in situ into aromatic six-membered rings, e.g. by dehydrogenation with simultaneous reduction of C=O group in that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/926—Topical chemical, e.g. cosmetic or sunscreen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un proceso mejorado para preparar derivados de resorcinol 4-sustituidos, y de compuestos intermediarios utiles en la preparacion de dichos derivados de resorcinol de formula (1) en la cual X e Y se seleccionan cada uno independientemente entre hidrogeno, alquilo (C1-12), alquenilo (C2-12), alquinilo (C2-12), o X e Y se toman conjuntamente con el carbono al cual están unidos para formar un anillo cicloalquilo (C4-8) o un anillo cicloalquenilo (C5-8), con la condicion de que el anillo cicloalquilo (C4-8) o un anillo cicloalquenilo (C5-8) no sean aromáticos; y en la cual el alquilo (C1-12), alquenilo (C2-12), alquinilo (C2-12), el anillo cicloalquilo (C4-8) o el anillo cicloalquenilo (C5-8) están opcionalmente sustituidos con uno a tres grupos Z seleccionados independientemente, y Z se selecciona del grupo formado por ciano; halo, alquilo (C1-6); arilo, heterocicloalquilo (C2-9); heteroarilo (C2-9); aril-(alquilo C1-6)-, =O, =CHO(alquilo C1-6); amino; hidroxi, alcoxi (C1-6); aril(alcoxi C1-6); acilo (C1-6); alquilamino-(C1-6)-; arilo(alquilamino C1-6)-; aminoalquilo (C1-6)-; alcoxi (C1-6)-CO-NH-; alquilamino (C1-6)-CO-; alquenilo (C2-6); alquinilo (C2-6); hidroxialquilo (C1-6)-; (alcoxi C1-6)-(alquilo C1-6)-; (aciloxi C1-6)(alquilo C1-6)-; nitro; cianoalquilo (C1-6)-; haloalquilo (C1-6)-; nitroalquilo (C1-6)-; trifluorometilo; trifluorometil (alquilo C1-6)-; acilamino (C1-6)-; (acilamino C1-6) (alquilo C1-6)-; (alcoxi C1-6)(acilamino C1-6)-; aminoacilo (C1-6)-; (aminoacilo C1-6)(alquilo C1-6)-; (alquilamino C1-6)(acilo C1-6); (alquilo C1-6)2 aminoacilo (C1-6)-; -CO2R2; -alquilo (C1-6)-CO2R2; -C(O)N(R2)2; -alquilo(C1-6)-C(O)N(R2)2; R2ON=; R2ON=alquilo(C1-6)-; R2ON=CR2(alquilo C1-6)-; -NR2(OR2); -alquilo(C1-6)-NR2(OR2); -alquilo(C1-6)-NR2(OR2); -C(O)(NR2OR2); -alquilo (C1-6)-C(O)(NR2OR2); -S(O)mR2; y cada R2 se selecciona independientemente entre hidrogeno, alquilo (C1-6), arilo, o arilo(alquilo C1-6)-; R3C(O)O-, y R3 es alquilo (C1-6), arilo o arilo(alquilo C1-6)-; R3C(O)O-alquilo(C1-6)-; R4R5N-C(O)-O-; R4R5NS(O)2-; R4R5NS(O)2(alquiloC1-6)-; R4S(O)2R5N-, R4S(O)2R5N(alquiloC1-6)-; y m es 0, 1 o 2, y R4 y R5 se seleccionan cada uno independientemente entre hidrogeno o alquilo (C1-6); -C(=NR6)(N(R4)2); -alquilo(C1-6)-C(=NR6)-(N(R4)2), y R6 representa OR2 o R2, y R2 es como se define anteriormente; -OC(O)arilo(alquilo C1-6); -NH(alquilo C1-6); arilo(alquilo C1-6)-NH-; y un cetal; que comprende (a) hacer reaccionar un compuesto de formula (5) o (5') en las cuales Q es halogeno, W es hidrogeno o un grupo protector, y X e Y son como se define anteriormente, con una base para formar el compuesto de formula (6) o formula (7) en la cual X, Y y W son como se definio anteriormente; y (b) cuando W es H, y el producto de la etapa (a) es un compuesto de formula (6), reducir el compuesto de formula (6) formado de esta manera, para formar el compuesto de formula 1; o (c) cuando W es un grupo protector y el producto de la etapa (a) es un compuesto de formula (6) , reducir el compuesto de formula (6) formado de esta manera y eliminar el grupo protector, para formar el compuesto de formula 1; (d) donde W es H y el producto de la etapa (a) es un compuesto de formula (7), hidrogenar el compuesto de formula (7) así formado para formar el compuesto de formula 1; o (e) donde W es un grupo protector, hidrogenar el compuesto de formula (7) así formado y remover el grupo protector para formar el compuesto de formula 1; Los derivados de resorcinol han tenido usos muy diversos como ser cosmética, como agentes antimicrobianos, en alimentacion o en fotografía.
ARP010101165A 2000-03-15 2001-03-13 Proceso para la preparacion de derivados de resorcinol y compuestos intermediarios AR030055A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18970400P 2000-03-15 2000-03-15

Publications (1)

Publication Number Publication Date
AR030055A1 true AR030055A1 (es) 2003-08-13

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ID=22698426

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010101165A AR030055A1 (es) 2000-03-15 2001-03-13 Proceso para la preparacion de derivados de resorcinol y compuestos intermediarios

Country Status (18)

Country Link
US (3) US6504037B2 (es)
EP (1) EP1134207A1 (es)
JP (1) JP2001294549A (es)
KR (1) KR100432303B1 (es)
CN (1) CN1325838A (es)
AR (1) AR030055A1 (es)
AU (1) AU782397B2 (es)
BR (1) BR0100982A (es)
CA (1) CA2340486A1 (es)
CZ (1) CZ2001930A3 (es)
HK (1) HK1040987A1 (es)
ID (1) ID29673A (es)
IL (1) IL141915A0 (es)
IN (1) IN192530B (es)
PL (1) PL346463A1 (es)
RU (1) RU2213087C2 (es)
YU (1) YU18601A (es)
ZA (1) ZA200102070B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6828460B2 (en) * 1999-03-22 2004-12-07 Pfizer Inc. Resorcinol derivatives
US6863897B2 (en) * 2002-03-22 2005-03-08 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Stabilization of resorcinol derivatives in cosmetic compositions
JP4228605B2 (ja) 2002-07-02 2009-02-25 住友化学株式会社 改変型還元酵素、その遺伝子及びそれらの利用
JP4228606B2 (ja) 2002-07-03 2009-02-25 住友化学株式会社 改変型還元酵素、その遺伝子及びそれらの利用
US6852310B2 (en) 2002-08-23 2005-02-08 Unilever Home & Personal Care Usa Division Of Conopco, Inc. Skin lightening agents, compositions and methods
US7163327B2 (en) * 2002-12-02 2007-01-16 3M Innovative Properties Company Illumination system using a plurality of light sources
US6875425B2 (en) 2002-12-12 2005-04-05 Unilever Home & Personal Care Usa Skin lightening agents, compositions and methods
US7524485B2 (en) 2002-12-12 2009-04-28 Unilever Home & Personal Care, Usa, Division Of Conopco, Inc. Skin lightening agents, compositions and methods
US7338979B2 (en) 2003-02-11 2008-03-04 Warner-Lambert Company Depigmentation agents
US7300646B2 (en) * 2004-02-27 2007-11-27 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Skin lightening agents, compositions and methods
US20060062865A1 (en) * 2004-09-17 2006-03-23 Nebojsa Ilic Tyrosinase inhibitor and method for preparation
US20060210498A1 (en) 2005-03-18 2006-09-21 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Novel resorcinol derivatives for skin
US20060210497A1 (en) * 2005-03-18 2006-09-21 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Novel resorcinol derivatives
US7270805B1 (en) 2006-03-30 2007-09-18 Conopco, Inc. Skin lightening agents, compositions and methods
US7250158B1 (en) 2006-03-30 2007-07-31 Conopco, Inc. Skin lightening agents, compositions and methods
US7247294B1 (en) 2006-03-30 2007-07-24 Conopco, Inc. Skin lightening agents, compositions and methods
MX355430B (es) 2013-03-08 2018-04-18 Unilever Nv Compuestos de resorcinol para uso dermatologico.
EP3471692B1 (en) 2016-06-15 2019-10-30 Unilever N.V. Method and cosmetic composition for enhanced transdermal delivery of alkyl substituted resorcinol
CN111909012B (zh) * 2020-08-24 2022-10-21 浙江工业大学台州研究院 一种高选择性、高转化制备1,3-环己二酮的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8469601A1 (es) * 1998-04-10 2000-09-29 Pfizer Prod Inc Procedimiento para alquilar sulfonamidas impedidas estericamente
IL144850A0 (en) * 1999-03-22 2002-06-30 Pfizer Resorcinol derivatives

Also Published As

Publication number Publication date
YU18601A (sh) 2003-07-07
US6504037B2 (en) 2003-01-07
AU2647701A (en) 2001-09-20
CN1325838A (zh) 2001-12-12
IL141915A0 (en) 2002-03-10
BR0100982A (pt) 2001-12-04
KR20010096608A (ko) 2001-11-07
CA2340486A1 (en) 2001-09-15
ZA200102070B (en) 2002-09-13
ID29673A (id) 2001-09-20
CZ2001930A3 (cs) 2001-10-17
PL346463A1 (en) 2001-09-24
HK1040987A1 (zh) 2002-06-28
US20050143594A1 (en) 2005-06-30
JP2001294549A (ja) 2001-10-23
AU782397B2 (en) 2005-07-21
RU2213087C2 (ru) 2003-09-27
US20030088113A1 (en) 2003-05-08
US6861564B2 (en) 2005-03-01
IN192530B (es) 2004-04-24
US20020032352A1 (en) 2002-03-14
EP1134207A1 (en) 2001-09-19
KR100432303B1 (ko) 2004-05-20

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