ES2052181T3 - Derivados de 2-oxo-1-oxa-8-azaespiro(4,5)decano, procesos para su preparacion y composiciones farmaceuticas de los mismos. - Google Patents
Derivados de 2-oxo-1-oxa-8-azaespiro(4,5)decano, procesos para su preparacion y composiciones farmaceuticas de los mismos.Info
- Publication number
- ES2052181T3 ES2052181T3 ES90308785T ES90308785T ES2052181T3 ES 2052181 T3 ES2052181 T3 ES 2052181T3 ES 90308785 T ES90308785 T ES 90308785T ES 90308785 T ES90308785 T ES 90308785T ES 2052181 T3 ES2052181 T3 ES 2052181T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- oxa
- oxo
- processes
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA INVENCION EXPONE UNOS DERIVADOS 2-OXO-1-OXA-8-AZASPIRO(4,5)DECANO DE FORMULA (I); EN LA QUE X REPRESENTA UN ATOMO DE OXIGENO O UN GRUPO NR DONDE R REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C1-12 O CICLOALQUILO C3-6, NO CARBOCICLICO C6-10 ARILO O UN GRUPO CARBOCICLICO C6-10 ARILO-C1-4 ALQUILO SUSTITUIDO OPCIONALMENTE EN EL ANILLO AROMATICO POR UNO O MAS ATOMOS HALOGENOS, O GRUPOS ALQUILO C1-4 O ALCOXI C1-4; R1 Y R2 JUNTOS REPRESENTAN UN GRUPO METILENO O CUANDO X ES UN GRUPO >NR, UNO DE LOS R1 Y R2 PUEDE REPRESENTAR ADICIONALMENTE UN GRUPO HIDROXIL Y EL OTRO UN GRUPO METIL; Z REPRESENTA UN ATOMO DE HIDROGENO O HALOGENO O UN GRUPO TRIHALOMETIL O UNO ALCANOIL C2-4; Y N ES 2 O 3; Y TODOS LOS ISOMEROS OPTICOS Y SUS MEZCLAS Y TODAS SUS SALES DE AMERICIO CUATERNARIAS Y LAS DE ADICION ACIDA. LA INVENCION EXPONE ADEMAS, LAS COMPOSICIONES FARMACEUTICAS QUE CONTIENEN A ESOS COMPONENTES Y EL PROCESO PARA SU PREPARACION. LOS COMPONENTES DE FORMULA (I) POSEEN PROPIEDADES PSICOTROPICAS Y ANTIALERGICAS Y UNA BAJA TOXICIDAD. ADEMAS, PUEDEN SE UTILES PARA EL TRATAMIENTO DE ENFERMEDADES PSIQUIATRICAS Y ALERGICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU894093A HU204529B (en) | 1989-08-10 | 1989-08-10 | Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2052181T3 true ES2052181T3 (es) | 1994-07-01 |
Family
ID=10966862
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90308785T Expired - Lifetime ES2052181T3 (es) | 1989-08-10 | 1990-08-09 | Derivados de 2-oxo-1-oxa-8-azaespiro(4,5)decano, procesos para su preparacion y composiciones farmaceuticas de los mismos. |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0414422B1 (es) |
JP (1) | JPH0377885A (es) |
KR (1) | KR950001022B1 (es) |
AT (1) | ATE103921T1 (es) |
AU (1) | AU623545B2 (es) |
DD (1) | DD299427A5 (es) |
DE (1) | DE69007905T2 (es) |
DK (1) | DK0414422T3 (es) |
ES (1) | ES2052181T3 (es) |
HU (1) | HU204529B (es) |
IL (1) | IL95321A (es) |
NZ (1) | NZ234845A (es) |
ZA (1) | ZA906301B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU204530B (en) * | 1989-08-10 | 1992-01-28 | Richter Gedeon Vegyeszet | Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them |
HU204054B (en) * | 1989-08-10 | 1991-11-28 | Richter Gedeon Vegyeszet | Process for producing new 1-oxa-2-oxo-8-azaspiro(4,5)decane derivatives and pharmaceutical compositions comprising same |
YU150489A (sh) * | 1989-08-10 | 1992-12-21 | W.L. Gore & Co. Gmbh. | Uređaj za ispitivanje odevnih predmeta na nepromočivost |
KR940003491B1 (ko) * | 1989-08-10 | 1994-04-23 | 리히터 게데온 베기에스제티 기아르 알.티 | 4,4-이중 치환된 피페리딘 유도체와 그 제조방법 및 상기 화합물을 함유하는 약제학적 조성물 |
FR2691459B1 (fr) * | 1992-05-25 | 1995-06-09 | Adir | Nouveaux derives de la phenothiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
WO2001034119A2 (en) | 1999-11-12 | 2001-05-17 | Abbott Laboratories | Inhibitors of crystallization in a solid dispersion |
DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
CN102176190A (zh) | 2003-09-26 | 2011-09-07 | 索尼计算机娱乐公司 | 便携式电子装置 |
AU2005211499A1 (en) | 2004-02-10 | 2005-08-18 | F. Hoffmann-La Roche Ag | Chemokine CCR5 receptor modulators |
CN101646679A (zh) | 2007-03-29 | 2010-02-10 | 弗·哈夫曼-拉罗切有限公司 | 杂环抗病毒化合物 |
WO2019195789A1 (en) | 2018-04-06 | 2019-10-10 | Camp4 Therapeutics Corporation | Phenothiazine derivatives and uses thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1256404A (en) * | 1968-06-07 | 1971-12-08 | Dainippon Pharmaceutical Co | 0-oxa-3,8-diazaspiro(4,5)decan-2,4-diones |
DE2118339A1 (de) * | 1971-04-15 | 1972-10-26 | Yoshitomi Pharmaceutical Industries Ltd, Osaka (Japan) | Pipendinspiroverbindungen |
US4255432A (en) * | 1979-09-06 | 1981-03-10 | Syntex (U.S.A.) Inc. | 8-[2-3-Indolyl)ethyl]-1-oxa-3-,8-diazaspiro[4.5]decan-2-ones, pharmaceutical compositions thereof and methods of use thereof |
FR2615515B1 (fr) * | 1987-05-22 | 1989-06-30 | Adir | Nouveaux derives du spiro 4, 5 decane, leur procede de preparation et les compositions pharmaceutiques les renfermant |
YU150489A (sh) * | 1989-08-10 | 1992-12-21 | W.L. Gore & Co. Gmbh. | Uređaj za ispitivanje odevnih predmeta na nepromočivost |
-
1989
- 1989-08-10 HU HU894093A patent/HU204529B/hu not_active IP Right Cessation
-
1990
- 1990-08-09 ZA ZA906301A patent/ZA906301B/xx unknown
- 1990-08-09 JP JP2209359A patent/JPH0377885A/ja active Pending
- 1990-08-09 NZ NZ234845A patent/NZ234845A/en unknown
- 1990-08-09 DD DD90343353A patent/DD299427A5/de not_active IP Right Cessation
- 1990-08-09 EP EP90308785A patent/EP0414422B1/en not_active Expired - Lifetime
- 1990-08-09 AU AU60802/90A patent/AU623545B2/en not_active Ceased
- 1990-08-09 AT AT90308785T patent/ATE103921T1/de not_active IP Right Cessation
- 1990-08-09 ES ES90308785T patent/ES2052181T3/es not_active Expired - Lifetime
- 1990-08-09 KR KR1019900012255A patent/KR950001022B1/ko active IP Right Grant
- 1990-08-09 DE DE69007905T patent/DE69007905T2/de not_active Expired - Fee Related
- 1990-08-09 DK DK90308785.6T patent/DK0414422T3/da active
- 1990-08-09 IL IL9532190A patent/IL95321A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HU204529B (en) | 1992-01-28 |
KR910004633A (ko) | 1991-03-29 |
ATE103921T1 (de) | 1994-04-15 |
ZA906301B (en) | 1991-06-26 |
AU623545B2 (en) | 1992-05-14 |
EP0414422A3 (en) | 1991-07-24 |
NZ234845A (en) | 1992-03-26 |
DD299427A5 (de) | 1992-04-16 |
AU6080290A (en) | 1991-02-14 |
IL95321A0 (en) | 1991-06-30 |
JPH0377885A (ja) | 1991-04-03 |
DE69007905D1 (de) | 1994-05-11 |
EP0414422B1 (en) | 1994-04-06 |
KR950001022B1 (ko) | 1995-02-07 |
EP0414422A2 (en) | 1991-02-27 |
HUT55784A (en) | 1991-06-28 |
IL95321A (en) | 1994-02-27 |
DE69007905T2 (de) | 1994-07-21 |
DK0414422T3 (da) | 1994-05-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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