AR025386A1 - Moduladores de los receptores activados del proliferador de peroxisomas - Google Patents
Moduladores de los receptores activados del proliferador de peroxisomasInfo
- Publication number
- AR025386A1 AR025386A1 ARP000104410A ARP000104410A AR025386A1 AR 025386 A1 AR025386 A1 AR 025386A1 AR P000104410 A ARP000104410 A AR P000104410A AR P000104410 A ARP000104410 A AR P000104410A AR 025386 A1 AR025386 A1 AR 025386A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- independently
- cycloalkyl
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
Abstract
La presente se dirige a compuestos representados por la Formula estructural (1) y sus sales, solvatos e hidratos farmacéuticamente aceptables y a métodosde preparacion, métodos de utilizacion y composiciones farmacéuticas que tienen compuestosrepres entados por la Formula estructural (1) y sus sales, solvatos ehidratos farmacéuticamente aceptables. En la Formula estructural (1), n es 2, 3 o 4; V es O o S; W es O, S o SO2; R1 es H, alquilo C1-4, fenilo otrifluorometilo; R2 son cada uno,independi entemente, H, alquilo C1-6, aril-alquilo C1-6, cicloalquil-alquilo C1-4, arilo, cicloalquilo o, junto con el feniloal que están unidos, forman naftilo o 1,2,3,4-tetrahidronaftilo; R3 son cada uno, independientemente, H, alquilo C1-6,aril-alquilo C1- 6, cicloalquil-alquiloC1-4, arilo o cicloalquilo; R4 son cada uno, independientemente, H, alquilo C1-4, arilo o benzoílo; R5 son cada uno, independientemente, H, arilo substituido ono substituido o un heteroarilo, siempre que almenos un R5 sea un ar ilo substituido o no substituido o un heteroarilo substituido o no substituido; y R6 es H,alquilo C1-4 o aminoalquilo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15116299P | 1999-08-27 | 1999-08-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR025386A1 true AR025386A1 (es) | 2002-11-27 |
Family
ID=22537578
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000104410A AR025386A1 (es) | 1999-08-27 | 2000-08-25 | Moduladores de los receptores activados del proliferador de peroxisomas |
Country Status (13)
Country | Link |
---|---|
US (3) | US6417212B1 (es) |
EP (1) | EP1206457B1 (es) |
JP (1) | JP2003508389A (es) |
AR (1) | AR025386A1 (es) |
AT (1) | ATE252091T1 (es) |
AU (1) | AU7073400A (es) |
CA (1) | CA2382966A1 (es) |
DE (1) | DE60005973T2 (es) |
DK (1) | DK1206457T3 (es) |
ES (1) | ES2204684T3 (es) |
PE (1) | PE20010529A1 (es) |
PT (1) | PT1206457E (es) |
WO (1) | WO2001016120A1 (es) |
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EP1005344A4 (en) * | 1996-12-31 | 2003-03-19 | Salk Inst For Biological Studi | TREATMENT OF LIPOSARCOMAS WITH A COMBINATION OF THIAZOLIDINEDIONS AND SELECTIVE RETINOID-X RECEPTOR AGONISTS |
US5814647A (en) * | 1997-03-04 | 1998-09-29 | Board Of Regents, The University Of Texas System | Use of troglitazone and related compounds for the treatment of the climacteric symptoms |
AU6773598A (en) * | 1997-03-26 | 1998-10-20 | Institut Pasteur | Treatment of gastrointestinal disease with ppar modulators |
CA2290944C (en) * | 1997-05-30 | 2012-03-06 | Bruce M. Spiegelman | Pgc-1, a novel brown fat ppar.gamma. coactivator |
US5925657A (en) * | 1997-06-18 | 1999-07-20 | The General Hospital Corporation | Use of PPARγ agonists for inhibition of inflammatory cytokine production |
AU8588798A (en) * | 1997-07-25 | 1999-02-16 | Institut Pasteur | Human peroxisome proliferator activated receptor gamma (ppargamma) gene re gulatory sequences and uses therefor |
HUP0101022A1 (hu) * | 1997-10-17 | 2001-10-28 | Aventis Pharmaceuticals Products Inc. | Kinolinszármazékok gyógyászati alkalmazása |
WO1999019313A1 (en) * | 1997-10-27 | 1999-04-22 | Dr. Reddy's Research Foundation | Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them |
DE69832520T2 (de) * | 1997-12-12 | 2006-08-10 | Purdue Research Foundation, West Lafayette | Verwendung von konjugierten linoleinsäure zur behandlung von type ii diabetes |
KR20010033355A (ko) * | 1997-12-19 | 2001-04-25 | 폴락 돈나 엘. | 아릴티아졸리딘디온 유도체 |
AU1887999A (en) * | 1998-01-29 | 1999-08-16 | Dr. Reddy's Research Foundation | Novel alkanoic acids and their use in medicine, process for their preparation and pharmaceutical compositions containing them |
KR100620337B1 (ko) * | 1998-03-10 | 2006-09-13 | 오노 야꾸힝 고교 가부시키가이샤 | 카르복실산 유도체와 그 유도체를 유효 성분으로서함유하는 약제 |
GB2335597A (en) | 1998-03-27 | 1999-09-29 | Glaxo Group Ltd | Stereoisomers of Troglitazone in the Treatment of Diabetes |
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KR100388120B1 (ko) * | 1998-05-11 | 2003-06-18 | 다케다 야쿠힌 고교 가부시키가이샤 | 저혈당 및 저지질혈 활성을 갖는 옥시이미노알칸산 유도체 |
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MA26662A1 (fr) * | 1998-07-21 | 2004-12-20 | Smithkline Beecham Plc | Derives de thiazolidinedione, compositions pharmaceutiques les contenant et leur utilisation |
OA11579A (en) * | 1998-07-21 | 2004-06-01 | Smithkline Beecham Plc | Use of glucose uptake enhancer for reducing apoptosis. |
GB9817118D0 (en) * | 1998-08-07 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
-
2000
- 2000-08-23 AU AU70734/00A patent/AU7073400A/en not_active Abandoned
- 2000-08-23 DE DE60005973T patent/DE60005973T2/de not_active Expired - Lifetime
- 2000-08-23 AT AT00959401T patent/ATE252091T1/de not_active IP Right Cessation
- 2000-08-23 EP EP00959401A patent/EP1206457B1/en not_active Expired - Lifetime
- 2000-08-23 CA CA002382966A patent/CA2382966A1/en not_active Abandoned
- 2000-08-23 PT PT00959401T patent/PT1206457E/pt unknown
- 2000-08-23 DK DK00959401T patent/DK1206457T3/da active
- 2000-08-23 JP JP2001519687A patent/JP2003508389A/ja not_active Withdrawn
- 2000-08-23 US US09/644,457 patent/US6417212B1/en not_active Expired - Fee Related
- 2000-08-23 WO PCT/US2000/023358 patent/WO2001016120A1/en active IP Right Grant
- 2000-08-23 ES ES00959401T patent/ES2204684T3/es not_active Expired - Lifetime
- 2000-08-25 AR ARP000104410A patent/AR025386A1/es unknown
- 2000-08-25 PE PE2000000876A patent/PE20010529A1/es not_active Application Discontinuation
-
2002
- 2002-04-11 US US10/121,373 patent/US6610696B2/en not_active Expired - Fee Related
-
2003
- 2003-05-07 US US10/434,425 patent/US6825222B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE60005973D1 (de) | 2003-11-20 |
ATE252091T1 (de) | 2003-11-15 |
US6417212B1 (en) | 2002-07-09 |
WO2001016120A1 (en) | 2001-03-08 |
WO2001016120A9 (en) | 2002-07-11 |
DE60005973T2 (de) | 2004-05-13 |
PT1206457E (pt) | 2004-03-31 |
US6825222B2 (en) | 2004-11-30 |
JP2003508389A (ja) | 2003-03-04 |
AU7073400A (en) | 2001-03-26 |
PE20010529A1 (es) | 2001-05-18 |
EP1206457A1 (en) | 2002-05-22 |
US20030045558A1 (en) | 2003-03-06 |
US6610696B2 (en) | 2003-08-26 |
ES2204684T3 (es) | 2004-05-01 |
CA2382966A1 (en) | 2001-03-08 |
DK1206457T3 (da) | 2004-02-16 |
EP1206457B1 (en) | 2003-10-15 |
US20040019090A1 (en) | 2004-01-29 |
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