AR014908A1 - Compuestos derivados ureido y tioureido de 4-amino-2(5h)-furanonas y 4-amino-2(5h)-tiofenonas, su uso, un procedimiento para prepararlos, ycomposiciones farmaceuticas que los contienen - Google Patents
Compuestos derivados ureido y tioureido de 4-amino-2(5h)-furanonas y 4-amino-2(5h)-tiofenonas, su uso, un procedimiento para prepararlos, ycomposiciones farmaceuticas que los contienenInfo
- Publication number
- AR014908A1 AR014908A1 ARP980104400A ARP980104400A AR014908A1 AR 014908 A1 AR014908 A1 AR 014908A1 AR P980104400 A ARP980104400 A AR P980104400A AR P980104400 A ARP980104400 A AR P980104400A AR 014908 A1 AR014908 A1 AR 014908A1
- Authority
- AR
- Argentina
- Prior art keywords
- amino
- alkyl
- phenyl
- sulfur
- oxygen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/66—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compuestos derivados ureido y tioureido de 4-amino-2(5H)-furanonas y 4-amino-2(5H)-tiofenonas de formula general (I), donde: A es oxígeno o azufre;X es oxígeno o azufre; R1 y R2 son, de manera independiente, hidrogeno o un grupo alquiloC1 -6; R se selecciona entre: alquilo C1-10, cicloalquilo C3-7,alquiltio C1-4, alquilsulfinilo C1-4, alquil-sulfonilo C1-4, hidroxialquilo C1-4; naftilo, fenilo, fenilo sustituido con entre 1 y 3 grupos que seseleccionan entre: alquilo C1-4;cloro, bromo, yodo o fluor; perfluoalquilo C1-4; hidroxi; alcoxi C1-4; amino; mono- o di-alquilamino C1-4; aminosulfonilo;alquilsulfonamido C1-4; fenil- o tolil-sulfonamido; carboxi; alcoxicarbonilo C1-4; amidocarbonilo o alquilamidocarboniloC1-4; c arboxaldehido;alquilcarbonilo C1-4; nitro; feniltio; cianometilo; y feniloxi opcionalmente sustituido o fenil-alquilo C1-4 opcionalmente sustituido, o bien R es unheterociclo aromático o no aromático de 5- o 6- miembros que contiene de 1a 3 hete roátomos que se seleccionan entre oxígeno, azufre y nitrogeno, que puedeestar opcionalmente benzocondensado, los estereoisomeros puros o sus mezclas así como también las sales de los mismos con ácidos o basesfarmacéuticamenteaceptables, para su uso como medicamentos, en particular, como agentes antitumorales.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97115391 | 1997-09-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR014908A1 true AR014908A1 (es) | 2001-04-11 |
Family
ID=8227318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980104400A AR014908A1 (es) | 1997-09-05 | 1998-09-03 | Compuestos derivados ureido y tioureido de 4-amino-2(5h)-furanonas y 4-amino-2(5h)-tiofenonas, su uso, un procedimiento para prepararlos, ycomposiciones farmaceuticas que los contienen |
Country Status (16)
Country | Link |
---|---|
US (2) | US6333346B1 (es) |
EP (1) | EP1009747A1 (es) |
JP (1) | JP2001515894A (es) |
KR (1) | KR20010023549A (es) |
CN (1) | CN1278256A (es) |
AR (1) | AR014908A1 (es) |
AU (1) | AU748490B2 (es) |
BR (1) | BR9812629A (es) |
CA (1) | CA2302284A1 (es) |
CO (1) | CO4970714A1 (es) |
HR (1) | HRP980480A2 (es) |
MA (1) | MA24668A1 (es) |
PE (1) | PE107599A1 (es) |
TR (1) | TR200000589T2 (es) |
WO (1) | WO1999012917A1 (es) |
ZA (1) | ZA988096B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1309593B1 (it) * | 1999-03-05 | 2002-01-24 | Novuspharma Spa | Composti eterociclici ad attivita' antitumorale. |
KR20010094519A (ko) * | 2000-03-31 | 2001-11-01 | 서경배 | 2,2,4,5-사중 치환된 3(2h)-퓨라논 유도체의 제조 방법 |
GB9928696D0 (en) | 1999-12-03 | 2000-02-02 | Swan Thomas & Co Ltd | Optical devices and methods of manufacture thereof |
IT1315267B1 (it) | 1999-12-23 | 2003-02-03 | Novuspharma Spa | Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale |
US20060211759A1 (en) * | 2001-07-26 | 2006-09-21 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Bis-heterocyclic compounds with antitumour and chemosensitising activity |
WO2003018575A1 (en) * | 2001-08-24 | 2003-03-06 | Wyeth Holdings Corporation | 5-substituted-3(2h)-furanones useful for inhibition of farnesyl-protein transferase |
EP2386551A1 (en) * | 2002-07-09 | 2011-11-16 | Fasgen Inc. | Novel compounds, pharmaceutical compositions containing same, and methods of use for same |
KR20040018295A (ko) * | 2002-08-22 | 2004-03-03 | 임철부 | 항암 활성을 갖는 티오우레이도 세라마이드 유도체 및 이화합물을 함유하는 약학적 조성물 |
KR100555655B1 (ko) * | 2002-11-20 | 2006-03-03 | 임철부 | 항암 활성을 갖는 우레이도 또는 티오우레이도 유도체 및이 화합물을 함유하는 약학조성물 |
CN1301253C (zh) * | 2003-07-31 | 2007-02-21 | 中国人民解放军军事医学科学院毒物药物研究所 | 五元硫杂环类化合物及其用于制备治疗和预防肥胖相关疾病的药物的用途 |
CN101161645B (zh) * | 2007-11-27 | 2010-06-23 | 南京大学 | 尿素类衍生物及其制备方法与用途 |
CN101560175B (zh) * | 2009-05-08 | 2012-10-10 | 南京大学 | 一类硫脲类衍生物及其制备方法与用途 |
CN106800544B (zh) * | 2017-01-19 | 2019-09-06 | 华南师范大学 | 3-卤-4-联苯胺基-2(5h)-呋喃酮类化合物及其在制备抗肿瘤药物中的应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE27894E (en) * | 1972-05-15 | 1974-01-22 | Hydroxy-j-(j-phenylureido)crotonic acid, gamma lactone compounds | |
AR206143A1 (es) * | 1974-04-17 | 1976-06-30 | Du Pont | Procedimiento para la preparacion de compuestos de 1 - t - alquil - 3 - (2,5 - dihidro - 5 - oxo - 3 - furil) ureas |
SE7702004L (sv) * | 1976-03-24 | 1977-09-25 | Du Pont | Antihypertensiva furylkarbamider |
JPS63174983A (ja) * | 1987-01-16 | 1988-07-19 | Sumitomo Chem Co Ltd | アミノブテノリド誘導体、その製造法およびそれを有効成分とする除草剤 |
-
1998
- 1998-08-24 CO CO98048243A patent/CO4970714A1/es unknown
- 1998-08-31 HR HR97115391.1A patent/HRP980480A2/hr not_active Application Discontinuation
- 1998-09-01 JP JP2000510725A patent/JP2001515894A/ja active Pending
- 1998-09-01 US US09/485,709 patent/US6333346B1/en not_active Expired - Fee Related
- 1998-09-01 MA MA25237A patent/MA24668A1/fr unknown
- 1998-09-01 EP EP98948889A patent/EP1009747A1/en not_active Withdrawn
- 1998-09-01 CN CN98810803A patent/CN1278256A/zh active Pending
- 1998-09-01 KR KR1020007002197A patent/KR20010023549A/ko not_active Application Discontinuation
- 1998-09-01 WO PCT/EP1998/005524 patent/WO1999012917A1/en not_active Application Discontinuation
- 1998-09-01 BR BR9812629-6A patent/BR9812629A/pt not_active IP Right Cessation
- 1998-09-01 CA CA002302284A patent/CA2302284A1/en not_active Abandoned
- 1998-09-01 TR TR2000/00589T patent/TR200000589T2/xx unknown
- 1998-09-01 PE PE1998000812A patent/PE107599A1/es not_active Application Discontinuation
- 1998-09-01 AU AU95350/98A patent/AU748490B2/en not_active Ceased
- 1998-09-03 AR ARP980104400A patent/AR014908A1/es unknown
- 1998-09-04 ZA ZA9808096A patent/ZA988096B/xx unknown
-
2001
- 2001-11-08 US US09/986,310 patent/US20020058694A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN1278256A (zh) | 2000-12-27 |
BR9812629A (pt) | 2000-08-22 |
ZA988096B (en) | 2000-03-22 |
TR200000589T2 (tr) | 2000-07-21 |
US6333346B1 (en) | 2001-12-25 |
CO4970714A1 (es) | 2000-11-07 |
EP1009747A1 (en) | 2000-06-21 |
HRP980480A2 (en) | 1999-06-30 |
KR20010023549A (ko) | 2001-03-26 |
AU9535098A (en) | 1999-03-29 |
JP2001515894A (ja) | 2001-09-25 |
WO1999012917A1 (en) | 1999-03-18 |
US20020058694A1 (en) | 2002-05-16 |
PE107599A1 (es) | 1999-11-03 |
AU748490B2 (en) | 2002-06-06 |
MA24668A1 (fr) | 1999-07-01 |
CA2302284A1 (en) | 1999-03-18 |
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