BR9812629A - Derivados de ureìdo e tioureìdo de 4-amino-2(5h)-furanonas e 4-amino-2(5h)-tiofenonas como agentes antitumorais - Google Patents

Derivados de ureìdo e tioureìdo de 4-amino-2(5h)-furanonas e 4-amino-2(5h)-tiofenonas como agentes antitumorais

Info

Publication number
BR9812629A
BR9812629A BR9812629-6A BR9812629A BR9812629A BR 9812629 A BR9812629 A BR 9812629A BR 9812629 A BR9812629 A BR 9812629A BR 9812629 A BR9812629 A BR 9812629A
Authority
BR
Brazil
Prior art keywords
amino
furanones
derivatives
sulfur
oxygen
Prior art date
Application number
BR9812629-6A
Other languages
English (en)
Inventor
Ernesto Menta
Nicoletta Pescalli
Marco Conti
Gerd Zimmermann
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of BR9812629A publication Critical patent/BR9812629A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/66—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS DE UREìDO E TIOUREìDO DE 4-AMINO-2(5H)-FURANONAS E 4-AMINO-2(5H)-TIOFENONAS COMO AGENTES ANTITUMORAIS"<D>. Objetos da presente invenção são compostos de fórmula geral (I), em que A é oxigênio ou enxofre; X é oxigênio ou enxofre; R1 e R2 são, independentemente hidrogênio ou um grupo alquila com de 1 a 6 átomos de carbono; R é selecionado de alquila, cicloalquila, alquilsulfinila, alquilsulfonila, hidroxialquila, naftila, grupo fenila que pode ser não substituído ou substituído; ou R é um heterociclo de 5 ou 6 membros contendo de 1 a 3 heteroátomos selecionados de oxigênio, enxofre e nitrogênio, que pode ser opcionalmente benzocondensado, os estereoisómeros puros ou misturas dos mesmos bem como sais dos mesmo com ácidos ou bases farmaceuticamente aceitáveis, para uso como medicamentos, em particular como agentes antitumorais.
BR9812629-6A 1997-09-05 1998-09-01 Derivados de ureìdo e tioureìdo de 4-amino-2(5h)-furanonas e 4-amino-2(5h)-tiofenonas como agentes antitumorais BR9812629A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97115391 1997-09-05
PCT/EP1998/005524 WO1999012917A1 (en) 1997-09-05 1998-09-01 Ureido and thioureido derivatives of 4-amino-2(5h)-furanones and 4-amino-2(5h)-thiophenones as antitumor agents

Publications (1)

Publication Number Publication Date
BR9812629A true BR9812629A (pt) 2000-08-22

Family

ID=8227318

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9812629-6A BR9812629A (pt) 1997-09-05 1998-09-01 Derivados de ureìdo e tioureìdo de 4-amino-2(5h)-furanonas e 4-amino-2(5h)-tiofenonas como agentes antitumorais

Country Status (16)

Country Link
US (2) US6333346B1 (pt)
EP (1) EP1009747A1 (pt)
JP (1) JP2001515894A (pt)
KR (1) KR20010023549A (pt)
CN (1) CN1278256A (pt)
AR (1) AR014908A1 (pt)
AU (1) AU748490B2 (pt)
BR (1) BR9812629A (pt)
CA (1) CA2302284A1 (pt)
CO (1) CO4970714A1 (pt)
HR (1) HRP980480A2 (pt)
MA (1) MA24668A1 (pt)
PE (1) PE107599A1 (pt)
TR (1) TR200000589T2 (pt)
WO (1) WO1999012917A1 (pt)
ZA (1) ZA988096B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1309593B1 (it) * 1999-03-05 2002-01-24 Novuspharma Spa Composti eterociclici ad attivita' antitumorale.
KR20010094519A (ko) * 2000-03-31 2001-11-01 서경배 2,2,4,5-사중 치환된 3(2ｈ)-퓨라논 유도체의 제조 방법
GB9928696D0 (en) 1999-12-03 2000-02-02 Swan Thomas & Co Ltd Optical devices and methods of manufacture thereof
IT1315267B1 (it) 1999-12-23 2003-02-03 Novuspharma Spa Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale
US20060211759A1 (en) * 2001-07-26 2006-09-21 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Bis-heterocyclic compounds with antitumour and chemosensitising activity
WO2003018575A1 (en) * 2001-08-24 2003-03-06 Wyeth Holdings Corporation 5-substituted-3(2h)-furanones useful for inhibition of farnesyl-protein transferase
EP2386551A1 (en) * 2002-07-09 2011-11-16 Fasgen Inc. Novel compounds, pharmaceutical compositions containing same, and methods of use for same
KR20040018295A (ko) * 2002-08-22 2004-03-03 임철부 항암 활성을 갖는 티오우레이도 세라마이드 유도체 및 이화합물을 함유하는 약학적 조성물
KR100555655B1 (ko) * 2002-11-20 2006-03-03 임철부 항암 활성을 갖는 우레이도 또는 티오우레이도 유도체 및이 화합물을 함유하는 약학조성물
CN1301253C (zh) * 2003-07-31 2007-02-21 中国人民解放军军事医学科学院毒物药物研究所 五元硫杂环类化合物及其用于制备治疗和预防肥胖相关疾病的药物的用途
CN101161645B (zh) * 2007-11-27 2010-06-23 南京大学 尿素类衍生物及其制备方法与用途
CN101560175B (zh) * 2009-05-08 2012-10-10 南京大学 一类硫脲类衍生物及其制备方法与用途
CN106800544B (zh) * 2017-01-19 2019-09-06 华南师范大学 3-卤-4-联苯胺基-2(5h)-呋喃酮类化合物及其在制备抗肿瘤药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE27894E (en) * 1972-05-15 1974-01-22 Hydroxy-j-(j-phenylureido)crotonic acid, gamma lactone compounds
AR206143A1 (es) * 1974-04-17 1976-06-30 Du Pont Procedimiento para la preparacion de compuestos de 1 - t - alquil - 3 - (2,5 - dihidro - 5 - oxo - 3 - furil) ureas
SE7702004L (sv) * 1976-03-24 1977-09-25 Du Pont Antihypertensiva furylkarbamider
JPS63174983A (ja) * 1987-01-16 1988-07-19 Sumitomo Chem Co Ltd アミノブテノリド誘導体、その製造法およびそれを有効成分とする除草剤

Also Published As

Publication number Publication date
CN1278256A (zh) 2000-12-27
ZA988096B (en) 2000-03-22
TR200000589T2 (tr) 2000-07-21
AR014908A1 (es) 2001-04-11
US6333346B1 (en) 2001-12-25
CO4970714A1 (es) 2000-11-07
EP1009747A1 (en) 2000-06-21
HRP980480A2 (en) 1999-06-30
KR20010023549A (ko) 2001-03-26
AU9535098A (en) 1999-03-29
JP2001515894A (ja) 2001-09-25
WO1999012917A1 (en) 1999-03-18
US20020058694A1 (en) 2002-05-16
PE107599A1 (es) 1999-11-03
AU748490B2 (en) 2002-06-06
MA24668A1 (fr) 1999-07-01
CA2302284A1 (en) 1999-03-18

Similar Documents

Publication Publication Date Title
BRPI0014526B8 (pt) compostos cíclicos de seis elementos contendo nitrogênio aromático, composição farmacêutica e uso do mesmo
BR9812629A (pt) Derivados de ureìdo e tioureìdo de 4-amino-2(5h)-furanonas e 4-amino-2(5h)-tiofenonas como agentes antitumorais
HUP0400694A2 (hu) A rotamáz enzim aktivitásának kis molekulájú inhibitorai, valamint ezeket a vegyületeket tartalmazó gyógyászati készítmények
HUP0302468A2 (hu) Alfa V integrin receptor antagonisták és ezeket tartalmazó gyógyszerkészítmények
NO20013379D0 (no) 4-okso-1,4-dihydro-3-kinolinkarboksamider som antivirusmidler
AU2910600A (en) Phenyl urea and phenyl thiourea derivatives
HUP0004259A2 (hu) VLA-4 által mediált leukocita adhéziót gátló szubsztituált fenilalanin-származékok, ezeket tartalmazó gyógyászati készítmények
HUP0300850A2 (hu) Gyűrűs béta-aminosav-származékok mint mátrix metalloproteázok és a TNF-alfa inhibitorok és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
KR880009922A (ko) 프롤리날 유도체
KR940021063A (ko) 퀴놀론카르복실산 유도체, 이의 제조방법 및 용도
HUP0003934A2 (hu) Bizonyos diaril-imidazol-származékok, at NPY specifikus ligandumok új osztályába tartozó diaril-imidazol-származékokat tartalmazó gyógyászati készítmények és ezek alkalmazása
ES2051772T3 (es) 2-sustituido-e-fusionado-(1,2,4)-triazol(1,5-c)pirimidinas, composiciones farmaceuticas y sus usos.
ES2172580T3 (es) 1,3-oxatiolanos sustituidos con propiedades antiviricas.
ES8501362A1 (es) Un procedimiento para la preparacion de nuevos derivados arilfenolicos.
NZ330078A (en) Active oxygen carriers containing pterin derivatives and salts thereof for use as cosmetic agents and feed
DK0488897T3 (da) Guanidinderivater, fremgangsmåde til fremstilling heraf samt farmaceutiske midler indeholdende disse
DK163581C (da) Kondenserede pyrazol-3-oxo-propannitrilderivater og fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende forbindelserne
BR9913183A (pt) Composto, uso do mesmo, processo para prepará-lo, processo para tratar um indivìduo humano ou animal, e, composição farmacêutica
HUP0105407A2 (hu) Triazolo[1,5-a]kinolinszármazékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények, valamint intermedierek
ES2160726T3 (es) Derivados de piperazin-2,5-diona como moduladores de resistencia a multiples farmacos.
DK624989D0 (da) Hidtil ukendte forbindelser
ATE74138T1 (de) Heptanoyl-glu-asp-ala-amino-saeureimmunstimulanten.
AR008826A1 (es) Derivados de xanteno y acridina, procedimiento para su preparacion y medicamentos que los contienen
ATE250594T1 (de) Als entzündungshemmende mittel nützliche dihydrobenzofurane und verwandte verbindungen
ECSP982657A (es) Ureido y tioureido derivados de 4- amino -2(5h)-furanonas y 4- amino-2 tiofenonas como agentes antitumorales

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6O,7O,8O E A 9O ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007.