AR012674A1 - Acidos sulfonilaminocarboxilicos, procedimiento para su preparacion, compuestos intermediarios para su exclusivo uso en dichos procedimientos medicamentos, procedimiento para la preparacion de medicamentos, uso de dichos compuestos para la preparacion de medicamentos. - Google Patents

Acidos sulfonilaminocarboxilicos, procedimiento para su preparacion, compuestos intermediarios para su exclusivo uso en dichos procedimientos medicamentos, procedimiento para la preparacion de medicamentos, uso de dichos compuestos para la preparacion de medicamentos.

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Publication number
AR012674A1
AR012674A1 ARP980102139A ARP980102139A AR012674A1 AR 012674 A1 AR012674 A1 AR 012674A1 AR P980102139 A ARP980102139 A AR P980102139A AR P980102139 A ARP980102139 A AR P980102139A AR 012674 A1 AR012674 A1 AR 012674A1
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AR
Argentina
Prior art keywords
preparation
phenyl
drugs
procedure
ring
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ARP980102139A
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English (en)
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Gompel Marie
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Publication date
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Publication of AR012674A1 publication Critical patent/AR012674A1/es

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
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    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/44—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
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    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl

Abstract

Acidos sulfonilaminocarboxilicos caracterizados porque comprenden la formula I y/o a una forma estereoisomera del compuesto de la formula I y/o auna sal fisiologicamente compatible del compuesto de la formula I, representando ene lla R2 y R3 en comun un anillo con un grupo carboxilo situadoen un extremo de la formula parcial II, en la que r representa el numero entero cero, 1, 2 o 3 y/o uno de los átomos de carbono que hay en el anillo estáreemplazado por -O-, -S- o -(R7)N-, en que R7 representa 1) un átomo de hidrogeno, 2) alquilo (C1-6), 3) fenilo, en que el fenilo está sin sustituir osustituido como se describe en 2.1 hasta 2.14, o 4) bencilo, en que el bencilo está sin sustituir o sustituido como sedescribe en 2.1 hasta 2.14, o 5)R2N-C(=NH)- teniendo R2 el significado mencionado más arriba, y/o los átomos de carbono que hay en el anillo de la formula parcial II están sustituidos una vezo multiples veces con alquilo (C1-6), fenilo, fenil-(CH2)m- o HO-, representando 1) un átomo de hidrogeno, 2) alquilo (C1-6)-, 3) HO-C(O)-alquilo(C21-6)- 4) fenil-(CH2)n-, en que el fenil está sin sustituir o sustituido una vez o dos veces como se describe en 2.1 hasta 2.14, o con -NH-C(O)-alquilo(C1-3 ) yn representa el numero entero cero, 1 o 2, o representantdo 5) picolilo, o 6) formando R4 y R5, en comun con el grupo amino situado en elanillo, un anillo de 4 a 7 eslabones, en el que eventualmente uno de los átomos de carbono está reemplazado por -O-, -S- o -NH- o dos átomos de C contiguos delanillo de 4 a 7 eslabones son parte de un radical bencilo, A a) un enlace covalente, b) -O-, c) -CH=CH- o d) -C:::C-, B a) -(CH2)m-, en que m tiene elsignificado antes mencionado, b) -O- (CH2)p, en que p significa un numero entero de 1 a 5, o c) -CH=CH- y X -CH=CH-, un átomo de oxígeno de azufre,
ARP980102139A 1997-05-09 1998-05-07 Acidos sulfonilaminocarboxilicos, procedimiento para su preparacion, compuestos intermediarios para su exclusivo uso en dichos procedimientos medicamentos, procedimiento para la preparacion de medicamentos, uso de dichos compuestos para la preparacion de medicamentos. AR012674A1 (es)

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DE19719621A DE19719621A1 (de) 1997-05-09 1997-05-09 Sulfonylaminocarbonsäuren

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JPH1160551A (ja) 1999-03-02
HUP9801044A3 (en) 2000-09-28
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CA2237099A1 (en) 1998-11-09
CN1280267C (zh) 2006-10-18
HU224959B1 (en) 2006-04-28
US7160903B2 (en) 2007-01-09
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CZ143898A3 (cs) 1998-11-11
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