EA199900161A1 - Производные пиридазино [4,5-в]-хинолин-5-оксида, их получение и применение в качестве антагонистов глицина - Google Patents

Производные пиридазино [4,5-в]-хинолин-5-оксида, их получение и применение в качестве антагонистов глицина

Info

Publication number
EA199900161A1
EA199900161A1 EA199900161A EA199900161A EA199900161A1 EA 199900161 A1 EA199900161 A1 EA 199900161A1 EA 199900161 A EA199900161 A EA 199900161A EA 199900161 A EA199900161 A EA 199900161A EA 199900161 A1 EA199900161 A1 EA 199900161A1
Authority
EA
Eurasian Patent Office
Prior art keywords
qhinolin
pyridazino
glycin
antagonists
application
Prior art date
Application number
EA199900161A
Other languages
English (en)
Other versions
EA001711B1 (ru
Inventor
Войцех Даниш
Маркус Гольд
Иварс Калвиньш
Кристофер Грэхам Рафаэль Парсонс
Ирина Пискунова
Евгений Рожков
Original Assignee
Мерц + Ко. Гмбх Унд Ко.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерц + Ко. Гмбх Унд Ко. filed Critical Мерц + Ко. Гмбх Унд Ко.
Publication of EA199900161A1 publication Critical patent/EA199900161A1/ru
Publication of EA001711B1 publication Critical patent/EA001711B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

Пиридил-фталазин-дионы, имеющие формулу (I)где R1 и R2 выбирают из группы, включающей водород, галоген и метокси, или где Rи Rвместе образуют метилендиокси, и их фармацевтически приемлемые соли и фармацевтические композиции, содержащие эффективное глицин-антагонистическое количество этих соединений, используемые для борьбы с неврологическими нарушениями, связанными с эксцитотоксичностью и дисфункцией глутаматергической нейротрансмиссии в требующем лечения живом животном, включая человека.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900161A 1996-07-25 1997-07-25 Производные пиридазино [4,5-b] хинолин-5-оксида или их фармацевтически приемлемые соли, их применение в качестве антагонистов глицина, фармацевтическая композиция, способ получения производных пиридазино [ 4,5-b] хинолин-5-оксида или их соли холина EA001711B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/686,346 US5776935A (en) 1996-07-25 1996-07-25 Pyrido-phtalazin diones and their use against neurological disorders associated with excitotoxicity and malfunctioning of glutamatergic neurotransmission
PCT/EP1997/004057 WO1998004556A1 (en) 1996-07-25 1997-07-25 Pyridazino [4,5-b]-quinoline 5-oxide derivatives, their preparation and their use as glycine antagonists

Publications (2)

Publication Number Publication Date
EA199900161A1 true EA199900161A1 (ru) 1999-10-28
EA001711B1 EA001711B1 (ru) 2001-06-25

Family

ID=24755940

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900161A EA001711B1 (ru) 1996-07-25 1997-07-25 Производные пиридазино [4,5-b] хинолин-5-оксида или их фармацевтически приемлемые соли, их применение в качестве антагонистов глицина, фармацевтическая композиция, способ получения производных пиридазино [ 4,5-b] хинолин-5-оксида или их соли холина

Country Status (31)

Country Link
US (1) US5776935A (ru)
EP (1) EP0931081B1 (ru)
JP (1) JP3595342B2 (ru)
KR (1) KR100598206B1 (ru)
CN (1) CN1093860C (ru)
AR (1) AR004158A1 (ru)
AT (1) ATE224894T1 (ru)
AU (1) AU719993B2 (ru)
BR (1) BR9710569A (ru)
CA (1) CA2261923C (ru)
CZ (1) CZ289293B6 (ru)
DE (1) DE69715893T2 (ru)
DK (1) DK0931081T3 (ru)
EA (1) EA001711B1 (ru)
ES (1) ES2180041T3 (ru)
FI (1) FI112946B (ru)
GE (1) GEP20022801B (ru)
HK (1) HK1020193A1 (ru)
HU (1) HU223780B1 (ru)
IL (1) IL128225A (ru)
LT (1) LT4591B (ru)
LV (1) LV12260B (ru)
NO (1) NO310820B1 (ru)
PL (1) PL189572B1 (ru)
PT (1) PT931081E (ru)
SI (1) SI9720048B (ru)
SK (1) SK283536B6 (ru)
TW (1) TW402605B (ru)
UA (1) UA63911C2 (ru)
WO (1) WO1998004556A1 (ru)
ZA (1) ZA976612B (ru)

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* Cited by examiner, † Cited by third party
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US20030176435A1 (en) * 2002-12-17 2003-09-18 Brown Dean Gordon Compounds and methods for the treatment of pain
US6444702B1 (en) 2000-02-22 2002-09-03 Neuromolecular, Inc. Aminoadamantane derivatives as therapeutic agents
EP1427404A4 (en) * 2001-08-20 2005-10-26 Maiken Nedergaard TREATMENT OF GLIAL TUMORS WITH GLUTAMATE ANTAGONISTS
EP1298581A1 (fr) * 2001-09-27 2003-04-02 C.S.E.M. Centre Suisse D'electronique Et De Microtechnique Sa Procédé et dispositif pour calculer les valeurs des neurones d'un réseau neuronal
US7105185B2 (en) 2001-10-03 2006-09-12 Herbalscience, Llc Kavalactone profile
US20050069596A1 (en) * 2001-10-03 2005-03-31 Gow Robert T. Compositions and methods comprising kava and anti-anxiety compounds
US7291352B2 (en) 2001-10-03 2007-11-06 Herbalscience Llc Methods and compositions for oral delivery of Areca and mate' or theobromine
US7037524B2 (en) * 2001-10-03 2006-05-02 Herbalscience, Llc Oral delivery of a botanical
US7029707B2 (en) * 2001-10-03 2006-04-18 Herbalscience, Llc Method of producing a processed kava product having an altered kavalactone distribution and processed kava products produced using the same
US7001620B2 (en) 2001-10-03 2006-02-21 Herbal Science, Llc Kavalactone product
US20050037025A1 (en) * 2002-10-03 2005-02-17 Gow Robert T. Methods and compositions comprising kava and mate' or theobromine
US20040082543A1 (en) * 2002-10-29 2004-04-29 Pharmacia Corporation Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain
US7294353B2 (en) * 2003-10-24 2007-11-13 Herbalscience, Llc Methods and compositions comprising ilex
CN1917892A (zh) * 2003-10-24 2007-02-21 草本制药科学有限责任公司 包含冬青的方法和组合物
US20060280791A1 (en) * 2005-04-08 2006-12-14 Ju Tzuchi R Pharmaceutical formulations
WO2009038752A2 (en) * 2007-09-20 2009-03-26 Cortex Pharmaceuticals, Inc. 3-substituted 1,2,3-triazin-4-one's and 3-substituted 1,3-pyrimidinone's for enhancing glutamatergic synaptic responses
EP2264035A1 (en) * 2009-06-04 2010-12-22 Merz Pharma GmbH & Co. KGaA Glycine B antagonists
US9737531B2 (en) 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
MX2019015120A (es) 2017-06-12 2022-07-14 Glytech Llc Composicion y metodo para el tratamiento de la depresion y psicosis en humanos.
USD895157S1 (en) 2018-03-06 2020-09-01 IsoTruss Indsutries LLC Longitudinal beam
CN109912503B (zh) * 2019-04-01 2022-04-08 江南大学 一种2,3-二酰基喹啉类化合物的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9208511D0 (en) * 1991-05-09 1992-06-03 Ici Plc Compounds
US5597922A (en) * 1994-07-29 1997-01-28 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Glycine receptor antagonist pharmacophore

Also Published As

Publication number Publication date
LV12260B (en) 1999-08-20
SK10399A3 (en) 2000-01-18
AR004158A1 (es) 1998-11-04
HUP9903104A3 (en) 2000-04-28
NO990306D0 (no) 1999-01-22
EP0931081B1 (en) 2002-09-25
CN1228778A (zh) 1999-09-15
IL128225A0 (en) 1999-11-30
SK283536B6 (sk) 2003-09-11
GEP20022801B (en) 2002-09-25
TW402605B (en) 2000-08-21
IL128225A (en) 2005-09-25
AU719993B2 (en) 2000-05-18
LT99007A (en) 1999-07-26
WO1998004556A1 (en) 1998-02-05
DE69715893D1 (de) 2002-10-31
FI990134A (fi) 1999-03-24
PT931081E (pt) 2003-02-28
HUP9903104A2 (hu) 2000-03-28
BR9710569A (pt) 1999-08-17
CN1093860C (zh) 2002-11-06
JP2000515872A (ja) 2000-11-28
KR100598206B1 (ko) 2006-07-07
US5776935A (en) 1998-07-07
CZ289293B6 (cs) 2001-12-12
ATE224894T1 (de) 2002-10-15
CA2261923C (en) 2006-01-24
KR20000029568A (ko) 2000-05-25
NO990306L (no) 1999-03-15
SI9720048B (sl) 2002-02-28
JP3595342B2 (ja) 2004-12-02
PL189572B1 (pl) 2005-08-31
AU4296997A (en) 1998-02-20
CA2261923A1 (en) 1998-02-05
NO310820B1 (no) 2001-09-03
PL331323A1 (en) 1999-07-05
FI990134A0 (fi) 1999-01-25
CZ2019997A3 (cs) 1999-09-15
DE69715893T2 (de) 2003-01-30
FI112946B (fi) 2004-02-13
HK1020193A1 (en) 2000-03-31
UA63911C2 (ru) 2004-02-16
EP0931081A1 (en) 1999-07-28
ES2180041T3 (es) 2003-02-01
DK0931081T3 (da) 2003-01-27
LV12260A (lv) 1999-04-20
ZA976612B (en) 1998-02-10
EA001711B1 (ru) 2001-06-25
SI9720048A (sl) 1999-12-31
HU223780B1 (hu) 2005-01-28
LT4591B (lt) 1999-12-27

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Legal Events

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PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU