CO2021015698A2 - Moduladores de thr-β y métodos de uso de estos - Google Patents
Moduladores de thr-β y métodos de uso de estosInfo
- Publication number
- CO2021015698A2 CO2021015698A2 CONC2021/0015698A CO2021015698A CO2021015698A2 CO 2021015698 A2 CO2021015698 A2 CO 2021015698A2 CO 2021015698 A CO2021015698 A CO 2021015698A CO 2021015698 A2 CO2021015698 A2 CO 2021015698A2
- Authority
- CO
- Colombia
- Prior art keywords
- formula
- methods
- thr
- modulators
- iiid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
En la presente se divulgan compuestos de la Fórmula I: (I) TL-La-CE-HD o una sal, profármaco, amida o éster aceptable desde el punto de vista farmacéutico de estos, donde i) TL es una porción de la Fórmula IIa, IIb, IIIa, IIIb, IIIc o IIId; ii) CE es una porción de la Fórmula IV; iii) HD es una porción de la Fórmula V o VI; donde los sustituyentes son como se definen en la presente. También se divulgan composiciones farmacéuticas que comprenden los compuestos anteriores y métodos para tratar enfermedades mediante la administración o el contacto de un paciente con uno o más de los compuestos anteriores. (IIa) (IIb) (IIIa) (IIIb) (IIIc) (IIId)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962845252P | 2019-05-08 | 2019-05-08 | |
US201962944052P | 2019-12-05 | 2019-12-05 | |
US202063005661P | 2020-04-06 | 2020-04-06 | |
PCT/US2020/031904 WO2020227549A1 (en) | 2019-05-08 | 2020-05-07 | MODULATORS OF THR-β AND METHODS OF USE THEREOF |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2021015698A2 true CO2021015698A2 (es) | 2022-01-17 |
Family
ID=70919081
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2021/0015698A CO2021015698A2 (es) | 2019-05-08 | 2021-11-23 | Moduladores de thr-β y métodos de uso de estos |
Country Status (17)
Country | Link |
---|---|
US (2) | US11091467B2 (es) |
EP (1) | EP3965884A1 (es) |
JP (1) | JP2022532706A (es) |
KR (1) | KR20220017917A (es) |
CN (1) | CN114096531A (es) |
AU (1) | AU2020267576A1 (es) |
BR (1) | BR112021021718A2 (es) |
CA (1) | CA3139101A1 (es) |
CL (1) | CL2021002883A1 (es) |
CO (1) | CO2021015698A2 (es) |
IL (1) | IL287720A (es) |
MA (1) | MA55890A (es) |
MX (1) | MX2021013472A (es) |
PE (1) | PE20220255A1 (es) |
SG (1) | SG11202111552YA (es) |
TW (1) | TW202108569A (es) |
WO (1) | WO2020227549A1 (es) |
Families Citing this family (18)
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WO2020227549A1 (en) * | 2019-05-08 | 2020-11-12 | Aligos Therapeutics, Inc. | MODULATORS OF THR-β AND METHODS OF USE THEREOF |
CA3158379A1 (en) * | 2019-11-26 | 2021-06-03 | Hejun Lv | 1,2,4-triazine-3,5-dione compound, preparation method therefor, and application thereof |
WO2021129465A1 (zh) * | 2019-12-26 | 2021-07-01 | 苏州科睿思制药有限公司 | 一种Resmetirom晶型及其制备方法和用途 |
CN113278013B (zh) * | 2020-02-20 | 2022-09-23 | 昆药集团股份有限公司 | 2,6-二取代的1,2,4-三嗪-3,5-二酮化合物及其制备方法和应用 |
WO2022053028A1 (zh) * | 2020-09-10 | 2022-03-17 | 南京明德新药研发有限公司 | 1,2,4-三嗪-3,5(2h,4h)-二酮类化合物及其应用 |
JP2023541870A (ja) * | 2020-09-10 | 2023-10-04 | ▲蘇▼州科睿思制▲葯▼有限公司 | レスメチロム(resmetirom)の結晶形態、その調製方法、及びその使用について |
AU2021376281A1 (en) * | 2020-11-06 | 2023-06-15 | Aligos Therapeutics, Inc. | Pyridazinone derivatives as thyroid receptor agonists and uses thereof |
JP2023548541A (ja) * | 2020-11-06 | 2023-11-17 | アリゴス セラピューティクス,インコーポレーテッド | オキシインドール及びその使用方法 |
CN112645936B (zh) * | 2020-12-17 | 2022-03-01 | 山东第一医科大学(山东省医学科学院) | 取代的哒嗪酮类化合物及其用途 |
CN114907327A (zh) * | 2021-02-10 | 2022-08-16 | 杭州领业医药科技有限公司 | Resmetirom的晶型及其制备方法和用途 |
AU2022228569A1 (en) * | 2021-03-03 | 2023-10-12 | Terns Pharmaceuticals, Inc. | Thyroid hormone receptor beta agonist compounds |
CN115073429A (zh) * | 2021-03-15 | 2022-09-20 | 昆药集团股份有限公司 | 一种1,2,4-三嗪-3,5-二酮类化合物的盐型、晶型及其制备方法 |
CN117279911A (zh) * | 2021-05-21 | 2023-12-22 | 深圳微芯生物科技股份有限公司 | 一种杂环化合物及其应用 |
WO2023023474A1 (en) * | 2021-08-16 | 2023-02-23 | Senya Pharmaceuticals, Inc. | Tr-beta modulators, pharmaceutical compositions, and therapeutic applications |
AU2022339846A1 (en) | 2021-09-01 | 2024-03-14 | Aligos Therapeutics, Inc. | Pnpla3-targeting short interfering rna (sirna) molecules and uses thereof |
WO2023039076A1 (en) | 2021-09-08 | 2023-03-16 | Aligos Therapeutics, Inc. | Modified short interfering nucleic acid (sina) molecules and uses thereof |
CN116354934A (zh) * | 2021-12-28 | 2023-06-30 | 中国科学院上海药物研究所 | 一类喹啉类化合物及其制备方法、药物组合物和用途 |
CN115650928B (zh) * | 2022-12-28 | 2023-03-31 | 凯思凯旭(上海)医药科技有限公司 | 一种多环类甲状腺激素β受体激动剂及其用途 |
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-
2020
- 2020-05-07 WO PCT/US2020/031904 patent/WO2020227549A1/en unknown
- 2020-05-07 EP EP20729390.3A patent/EP3965884A1/en active Pending
- 2020-05-07 KR KR1020217039735A patent/KR20220017917A/ko unknown
- 2020-05-07 CN CN202080047744.2A patent/CN114096531A/zh active Pending
- 2020-05-07 US US16/869,211 patent/US11091467B2/en active Active
- 2020-05-07 PE PE2021001847A patent/PE20220255A1/es unknown
- 2020-05-07 BR BR112021021718A patent/BR112021021718A2/pt unknown
- 2020-05-07 MX MX2021013472A patent/MX2021013472A/es unknown
- 2020-05-07 SG SG11202111552YA patent/SG11202111552YA/en unknown
- 2020-05-07 JP JP2021566558A patent/JP2022532706A/ja active Pending
- 2020-05-07 CA CA3139101A patent/CA3139101A1/en active Pending
- 2020-05-07 MA MA055890A patent/MA55890A/fr unknown
- 2020-05-07 AU AU2020267576A patent/AU2020267576A1/en active Pending
- 2020-05-08 TW TW109115446A patent/TW202108569A/zh unknown
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2021
- 2021-05-25 US US17/330,232 patent/US20210355112A1/en active Pending
- 2021-10-31 IL IL287720A patent/IL287720A/en unknown
- 2021-11-03 CL CL2021002883A patent/CL2021002883A1/es unknown
- 2021-11-23 CO CONC2021/0015698A patent/CO2021015698A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
SG11202111552YA (en) | 2021-11-29 |
PE20220255A1 (es) | 2022-02-16 |
CL2021002883A1 (es) | 2022-10-28 |
WO2020227549A8 (en) | 2021-05-27 |
EP3965884A1 (en) | 2022-03-16 |
IL287720A (en) | 2021-12-01 |
US11091467B2 (en) | 2021-08-17 |
US20210355112A1 (en) | 2021-11-18 |
MX2021013472A (es) | 2022-01-06 |
TW202108569A (zh) | 2021-03-01 |
CA3139101A1 (en) | 2020-11-12 |
US20200354345A1 (en) | 2020-11-12 |
BR112021021718A2 (pt) | 2022-01-18 |
KR20220017917A (ko) | 2022-02-14 |
MA55890A (fr) | 2022-03-16 |
CN114096531A (zh) | 2022-02-25 |
JP2022532706A (ja) | 2022-07-19 |
AU2020267576A1 (en) | 2021-12-09 |
WO2020227549A1 (en) | 2020-11-12 |
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