ZA979550B - Method for the preparation of methylidene malonate nanoparticles, nanoparticles which optionally contain one or more biologically active molecules, and pharmaceutical compositions containing them. - Google Patents

Method for the preparation of methylidene malonate nanoparticles, nanoparticles which optionally contain one or more biologically active molecules, and pharmaceutical compositions containing them.

Info

Publication number: ZA979550B
Authority: ZA; South Africa
Prior art keywords: nanoparticles; preparation; pharmaceutical compositions; biologically active; compositions containing
Prior art date: 1996-10-25

Application number

ZA9709550A

Other languages

English (en)

Inventor

Nicole Bru-Magniez

Xavier Guillon

Pascal Breton

Patrick Couvreur

Francois Lescure

Claude Roques-Carmes

Gerard Riess

Original Assignee

Virsol

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-25

Filing date

1997-10-24

Publication date

1998-05-12

1997-10-24 Application filed by Virsol filed Critical Virsol

1998-05-12 Publication of ZA979550B publication Critical patent/ZA979550B/xx

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F22/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides or nitriles thereof
- C08F22/10—Esters
- C08F22/12—Esters of phenols or saturated alcohols
- C08F22/14—Esters having no free carboxylic acid groups
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Nanotechnology (AREA)
Epidemiology (AREA)
Physics & Mathematics (AREA)
Oncology (AREA)
Optics & Photonics (AREA)
Biomedical Technology (AREA)
Polymers & Plastics (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
Medicinal Preparation (AREA)
Processes Of Treating Macromolecular Substances (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

ZA9709550A 1996-10-25 1997-10-24 Method for the preparation of methylidene malonate nanoparticles, nanoparticles which optionally contain one or more biologically active molecules, and pharmaceutical compositions containing them. ZA979550B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9613039A FR2755136B1 (fr)	1996-10-25	1996-10-25	Procede de preparation de nanoparticules de methylidene malonate, nanoparticules contenant eventuellement une ou plusieurs molecules biologiquement actives et compositions pharmaceutiques les contenant

Publications (1)

Publication Number	Publication Date
ZA979550B true ZA979550B (en)	1998-05-12

Family

ID=9497032

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9709550A ZA979550B (en)	1996-10-25	1997-10-24	Method for the preparation of methylidene malonate nanoparticles, nanoparticles which optionally contain one or more biologically active molecules, and pharmaceutical compositions containing them.

Country Status (23)

Country	Link
US (2)	US6211273B1 (xx)
EP (1)	EP0934059B1 (xx)
JP (1)	JP2001504530A (xx)
KR (1)	KR20000052813A (xx)
CN (1)	CN1237903A (xx)
AR (1)	AR009127A1 (xx)
AT (1)	ATE245171T1 (xx)
AU (1)	AU736097B2 (xx)
BR (1)	BR9712372A (xx)
CA (1)	CA2269783C (xx)
CZ (1)	CZ144099A3 (xx)
DE (1)	DE69723571T2 (xx)
FR (1)	FR2755136B1 (xx)
HU (1)	HUP9904359A3 (xx)
IL (1)	IL129355A0 (xx)
NO (1)	NO991942L (xx)
NZ (1)	NZ335094A (xx)
PL (1)	PL332957A1 (xx)
RU (1)	RU2214421C2 (xx)
SK (1)	SK55599A3 (xx)
TW (1)	TW503109B (xx)
WO (1)	WO1998018455A1 (xx)
ZA (1)	ZA979550B (xx)

Families Citing this family (40)

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FR2774096B1 (fr) *	1998-01-29	2000-04-07	Virsol	Nouveaux copolymeres tensioactifs a base de methylidene malonate
FR2778100B1 (fr) *	1998-04-29	2001-05-04	Virsol	Nouvelles microspheres a base de poly(methylidene malonate), leur procede de preparation et compositions pharmaceutiques les contenant
FR2789314B1 (fr)	1999-02-09	2001-04-27	Virsol	Materiau de suture de plaies a base de methylidene malonate
JP4611561B2 (ja) *	2000-04-12	2011-01-12	Ｄｉｃ株式会社	新規なビニル系樹脂およびその製造方法
GB2381792B (en) *	2000-04-12	2004-08-04	Dainippon Ink & Chemicals	Antifouling coating composituion
FR2812551B1 (fr) *	2000-08-07	2003-03-28	Virsol	Forme pharmaceutique comprenant un materiau support a base de methylidene malonate et un facteur de regulation cellulaire
AU2002211602A1 (en) *	2000-10-11	2002-04-22	Johns Hopkins University	Polymer controlled delivery of a therapeutic agent
KR100457824B1 (ko) *	2001-08-10	2004-11-18	한국화학연구원	용액 열분해법에 의한 나노 크기 2가 금속 산화물 분말의제조
JP3961312B2 (ja)	2002-02-26	2007-08-22	株式会社デンソー	内燃機関の制御装置
WO2008018932A2 (en) *	2006-05-01	2008-02-14	The Board Of Trustees Of The Leland Stanford Junior University	Method and use of nano-scale devices for reduction of tissue injury in ischemic and reperfusion injury
EP2123262A1 (en) *	2008-05-20	2009-11-25	Consorzio per il Centro di Biomedica Moleculare Scrl	Polyelectrolyte-encapsulated gold nanoparticles capable of crossing blood-brain barrier
US8106234B2 (en) *	2009-05-07	2012-01-31	OptMed, Inc	Methylidene malonate process
US8993795B2 (en)	2009-05-07	2015-03-31	Optmed Inc	Methylidene malonate process
US9279022B1 (en) *	2014-09-08	2016-03-08	Sirrus, Inc.	Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions
US9249265B1 (en)	2014-09-08	2016-02-02	Sirrus, Inc.	Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions
WO2012054633A2 (en)	2010-10-20	2012-04-26	Bioformix, Llc	Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent
US10414839B2 (en)	2010-10-20	2019-09-17	Sirrus, Inc.	Polymers including a methylene beta-ketoester and products formed therefrom
US9828324B2 (en)	2010-10-20	2017-11-28	Sirrus, Inc.	Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom
EP3517523A1 (en)	2011-10-19	2019-07-31	Sirrus, Inc.	Multifunctional monomers and methods for making them
EP3626784A1 (en)	2012-03-30	2020-03-25	Sirrus, Inc.	Ink and coating formulations and polymerizable systems for producing the same
JP6188252B2 (ja)	2012-03-30	2017-08-30	シラス・インコーポレイテッド	重合性組成物の活性化方法、重合系およびこれにより形成される製品
EP2831124B1 (en)	2012-03-30	2016-10-05	Sirrus, Inc.	Composite and laminate articles and polymerizable systems for producing the same
WO2013181600A2 (en)	2012-06-01	2013-12-05	Bioformix Inc.	Optical material and articles formed therefrom
WO2014078689A1 (en)	2012-11-16	2014-05-22	Bioformix Inc.	Plastics bonding systems and methods
JP6549038B2 (ja)	2012-11-30	2019-07-24	シラス・インコーポレイテッド	エレクトロニクス適用のための複合組成物
CN105008321A (zh)	2013-01-11	2015-10-28	瑟拉斯公司	经过双(羟甲基)丙二酸酯的途径获得亚甲基丙二酸酯的方法
US9416091B1 (en)	2015-02-04	2016-08-16	Sirrus, Inc.	Catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9315597B2 (en)	2014-09-08	2016-04-19	Sirrus, Inc.	Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
US10501400B2 (en)	2015-02-04	2019-12-10	Sirrus, Inc.	Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9334430B1 (en) *	2015-05-29	2016-05-10	Sirrus, Inc.	Encapsulated polymerization initiators, polymerization systems and methods using the same
US9217098B1 (en)	2015-06-01	2015-12-22	Sirrus, Inc.	Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound
JP6524262B2 (ja) *	2015-06-19	2019-06-05	シラス・インコーポレイテッド	ガラス転移温度の高いポリマー製造用の１，１−二置換アルケン化合物を含む組成物
US9518001B1 (en)	2016-05-13	2016-12-13	Sirrus, Inc.	High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation
US10196481B2 (en)	2016-06-03	2019-02-05	Sirrus, Inc.	Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof
US9567475B1 (en)	2016-06-03	2017-02-14	Sirrus, Inc.	Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US9617377B1 (en)	2016-06-03	2017-04-11	Sirrus, Inc.	Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US10428177B2 (en)	2016-06-03	2019-10-01	Sirrus, Inc.	Water absorbing or water soluble polymers, intermediate compounds, and methods thereof
KR102571880B1 (ko)	2017-06-02	2023-08-28	아르끄마 프랑스	경화성 조성물 및 이의 용도
WO2020123579A1 (en) *	2018-12-11	2020-06-18	Sirrus, Inc.	Polymerization of 1,1-dicarbonyl 1-alkenes
EP3999607A2 (en)	2019-07-19	2022-05-25	Arkema France	Curable compositions useful for obtaining non-sensitizing cured products

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Publication number	Priority date	Publication date	Assignee	Title
DE2965725D1 (en) *	1978-07-19	1983-07-28	Patrick Couvreur	Biodegradable nanoparticles, pharmaceutical compositions containing them and process for their preparation
FR2611705B1 (fr) *	1987-03-05	1989-07-13	Union Pharma Scient Appl	Procede de preparation de monesters ou diesters de l'acide endoethano-9, 10 dihydro-9, 10 anthracene bicarboxylique-11, 11, nouveaux monesters ou diesters ainsi prepares et utilisation de ceux-ci pour la preparation de methylenemalonates symetriques ou asymetriques
FR2722411B1 (fr) *	1994-07-18	1996-10-04	Union Pharma Scient Appl	Immunonanoparticules revetues d'anticorps monoclonaux anti-beta2 microglobuline et leur utilisation pour la prophylaxie et/ou le traitement de pathologies dues a une infection par le virus hiv

1996
- 1996-10-25 FR FR9613039A patent/FR2755136B1/fr not_active Expired - Lifetime
1997
- 1997-10-24 CN CN97199824A patent/CN1237903A/zh active Pending
- 1997-10-24 WO PCT/FR1997/001907 patent/WO1998018455A1/fr not_active Application Discontinuation
- 1997-10-24 TW TW086115768A patent/TW503109B/zh not_active IP Right Cessation
- 1997-10-24 BR BR9712372-2A patent/BR9712372A/pt not_active IP Right Cessation
- 1997-10-24 KR KR1019990703636A patent/KR20000052813A/ko not_active Application Discontinuation
- 1997-10-24 DE DE69723571T patent/DE69723571T2/de not_active Expired - Fee Related
- 1997-10-24 EP EP97912248A patent/EP0934059B1/fr not_active Expired - Lifetime
- 1997-10-24 HU HU9904359A patent/HUP9904359A3/hu unknown
- 1997-10-24 AU AU49509/97A patent/AU736097B2/en not_active Ceased
- 1997-10-24 PL PL97332957A patent/PL332957A1/xx unknown
- 1997-10-24 IL IL12935597A patent/IL129355A0/xx unknown
- 1997-10-24 CZ CZ991440A patent/CZ144099A3/cs unknown
- 1997-10-24 SK SK555-99A patent/SK55599A3/sk unknown
- 1997-10-24 JP JP52010798A patent/JP2001504530A/ja not_active Ceased
- 1997-10-24 US US09/284,455 patent/US6211273B1/en not_active Expired - Lifetime
- 1997-10-24 AR ARP970104915A patent/AR009127A1/es unknown
- 1997-10-24 ZA ZA9709550A patent/ZA979550B/xx unknown
- 1997-10-24 RU RU99110736/04A patent/RU2214421C2/ru not_active IP Right Cessation
- 1997-10-24 AT AT97912248T patent/ATE245171T1/de not_active IP Right Cessation
- 1997-10-24 CA CA002269783A patent/CA2269783C/en not_active Expired - Fee Related
1999
- 1999-04-23 NO NO991942A patent/NO991942L/no not_active Application Discontinuation
- 1999-04-23 NZ NZ335094A patent/NZ335094A/en unknown
2001
- 2001-01-29 US US09/770,303 patent/US6420468B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NO991942L (no)	1999-06-23
ATE245171T1 (de)	2003-08-15
HUP9904359A2 (hu)	2000-05-28
DE69723571D1 (de)	2003-08-21
CN1237903A (zh)	1999-12-08
CZ144099A3 (cs)	1999-09-15
US6420468B2 (en)	2002-07-16
NO991942D0 (no)	1999-04-23
US20010006989A1 (en)	2001-07-05
AU736097B2 (en)	2001-07-26
HUP9904359A3 (en)	2000-11-28
KR20000052813A (ko)	2000-08-25
CA2269783C (en)	2005-01-11
DE69723571T2 (de)	2004-06-03
IL129355A0 (en)	2000-02-17
SK55599A3 (en)	2000-03-13
FR2755136A1 (fr)	1998-04-30
EP0934059A1 (fr)	1999-08-11
PL332957A1 (en)	1999-10-25
RU2214421C2 (ru)	2003-10-20
EP0934059B1 (fr)	2003-07-16
NZ335094A (en)	2001-05-25
JP2001504530A (ja)	2001-04-03
TW503109B (en)	2002-09-21
FR2755136B1 (fr)	1999-01-22
AU4950997A (en)	1998-05-22
US6211273B1 (en)	2001-04-03
CA2269783A1 (en)	1998-05-07
WO1998018455A1 (fr)	1998-05-07
AR009127A1 (es)	2000-03-08
BR9712372A (pt)	2000-01-25

Publication	Publication Date	Title
ZA979550B (en)	1998-05-12	Method for the preparation of methylidene malonate nanoparticles, nanoparticles which optionally contain one or more biologically active molecules, and pharmaceutical compositions containing them.
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ZA981132B (en)	1999-10-19	Methods, compositions and articles for reducing or preventing the effects of inflammation.
IL136938A0 (en)	2001-06-14	11β-HALOGEN-7α-SUBSTITUTED ESTRATRIENES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND METHODS FOR THE PREPARATION THEREOF
CY2396B1 (en)	2004-09-10	Pharmaceutical composition of fenofibrate with high biological availability and method for preparingsame.
ZA991489B (en)	1999-09-30	Oxaliplatin solution formulations and the method of use thereof.
ZA987540B (en)	2000-02-21	Process for the preparation of stanol esters, and use thereof.
IL135920A0 (en)	2001-05-20	2-aryl -8-oxodihydropurine derivative, process for the preparation thereof, pharmaceutical composition containing the same and intermediate therefor
HUP0000851A3 (en)	2002-04-29	Novel pyrimidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
HK1030144A1 (en)	2001-04-27	Method for treatment of liver tumours and pharmaceutical compositions for use therein.
AU5667598A (en)	1998-07-31	Biologically active substances, method for obtaining and compositions containing them
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IL137494A0 (en)	2001-07-24	Polypeptide compounds, process for the preparation thereof and pharmaceutical compositions containing the same
HK1015789A1 (en)	1999-10-22	Propanolamine derivatives, processes for their preparation, pharmaceuticals comprising these compounds, and their use.
AU1166895A (en)	1995-08-24	Polysubstituted 3-acylamino-5-phenyl-1,4-benzodiazepin-2-onederivatives, process for their preparation and the pharmaceutical compositions containing them
IL136942A0 (en)	2001-06-14	Polyethoxylated castor oil, compositions containing the same and processes for the preparation thereof
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